MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Focal glomerulosclerosis

(UMLS:C0017668)

Definition:: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.
UMLS ID:: C0017668
MeSH ID:: D005923

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.570.363.660

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.570.363.640

Synonym(s)

Focal glomerulosclerosis

FGS - Focal glomerulosclerosis

FSGS

FSGS - Focal Segmental Glomerulosclerosis

FSGS - Focal segmental glomerulosclerosis

Focal Segmental Glomerulosclerosis

Focal and segmental glomerular sclerosis

Focal and segmental glomerulosclerosis

Focal glomerular sclerosis

10.

Focal segmental glomerulosclerosis

11.

GLOMERULOSCLEROSIS FOCAL

12.

GLOMERULOSCLEROSIS, FOCAL

13.

HYALINOSIS, FOCAL

14.

focal glomerular sclerosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Cyclosporine	FAERS: 15	OFFSIDES US FAERS
2	Isotretinoin	FAERS: 7	US FAERS
3	Pamidronate	FAERS: 7	US FAERS
4	Sirolimus	FAERS: 7	OFFSIDES US FAERS
5	Mesalamine	FAERS: 3	US FAERS
6	Rosuvastatin Calcium	FAERS: 2	US FAERS
7	Mycophenolic Acid	FAERS: 1	OFFSIDES US FAERS
8	Valproic Acid	FAERS: 1	US FAERS
9	rofecoxib	FAERS: 1	US FAERS
10	1 alpha-hydroxyergocalciferol		OFFSIDES
11	Amoxicillin		OFFSIDES
12	Atazanavir Sulfate		OFFSIDES
13	Caffeine		OFFSIDES
14	Cefuroxime		OFFSIDES
15	Cephalexin		OFFSIDES
16	Chlorhexidine		OFFSIDES
17	Cinacalcet		OFFSIDES
18	Ciprofloxacin		OFFSIDES
19	Clotrimazole		OFFSIDES
20	Dermazin		OFFSIDES
21	Didanosine		OFFSIDES
22	Dioctyl Sulfosuccinic Acid		OFFSIDES
23	Dipyridamole		OFFSIDES
24	Doxycycline		OFFSIDES
25	Erythromycin		OFFSIDES
26	Estrogens, Conjugated (USP)		OFFSIDES
27	Fludrocortisone		OFFSIDES
28	Flutamide		OFFSIDES
29	Fluvastatin		OFFSIDES
30	Glatiramer Acetate		OFFSIDES
31	Ibandronic Acid		OFFSIDES
32	Isradipine		OFFSIDES
33	Ketoprofen		OFFSIDES
34	Lactulose		OFFSIDES
35	Lenalidomide		OFFSIDES
36	Lopinavir/Ritonavir		OFFSIDES
37	Methyldopa		OFFSIDES
38	Midodrine		OFFSIDES
39	Mometasone Furoate		OFFSIDES
40	Nitrofurantoin		OFFSIDES
41	Opalmon		OFFSIDES
42	Pamidronate		OFFSIDES
43	Pentoxifylline		OFFSIDES
44	Piperacillin, Tazobactam Drug Combination		OFFSIDES
45	Prednisolone		OFFSIDES
46	Rabeprazole		OFFSIDES
47	Ramipril		OFFSIDES
48	Ribavirin		OFFSIDES
49	Ritonavir		OFFSIDES
50	Sevelamer		OFFSIDES
51	Sevelamer		OFFSIDES
52	Sunitinib		OFFSIDES
53	Terbinafine		OFFSIDES
54	Torsemide		OFFSIDES
55	Tretinoin		OFFSIDES
56	Valganciclovir		OFFSIDES
57	abacavir		OFFSIDES
58	alfacalcidol		OFFSIDES
59	calcium acetate		OFFSIDES
60	chlorhexidine gluconate		OFFSIDES
61	efavirenz		OFFSIDES
62	fludrocortisone acetate		OFFSIDES
63	mizoribine		OFFSIDES
64	temocapril hydrochloride		OFFSIDES
65	testosterone enanthate		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Glomerulonephritis, Membranoproliferative	41.5%
2	Nephritis, Interstitial	36.4%
3	Pyelitis	36.4%
4	Anti-Glomerular Basement Membrane Disease	33.9%
5	Lupus Nephritis	33.5%
6	Pyelonephritis	32.1%
7	Hydronephrosis	29.2%
8	Hyperoxaluria	29.2%
9	Kidney Cortex Necrosis	29.2%
10	Kidney Papillary Necrosis	29.2%
11	Nephrosclerosis	29.2%
12	Nephrosis	29.2%
13	Perinephritis	29.2%
14	Kidney Failure	29.2%
15	Uremia	29.2%
16	Oxalosis	29.2%
17	Renal Insufficiency	29.2%
18	Anuria	28.3%
19	Nephrolithiasis	28.3%
20	Urinary Bladder Diseases	24.1%
21	Ureteral Diseases	24.1%
22	Urethral Diseases	24.1%
23	Urination Disorders	24.1%
24	Urolithiasis	24.1%
25	Balkan Nephropathy	24.1%
26	Diabetes Insipidus	23.8%
27	Hepatorenal Syndrome	23.8%
28	Diabetic Nephropathy	23.5%
29	Renal hypertension	23.5%
30	Renal Artery Obstruction	23.5%
31	Renal Artery Stenosis	23.5%
32	Nephrocalcinosis	23.3%
33	Tuberculosis, Renal	22.2%
34	Pyelocystitis	21.3%
35	Kidney Neoplasm	19.7%
36	Urinary tract infection	19.6%
37	Ureterolithiasis	17.5%
38	Lipoid nephrosis	17.3%
39	Nephrotic Syndrome	17.3%
40	Pyonephrosis	17.3%
41	Nephrogenic Diabetes Insipidus	17.3%
42	Congenital Nephrogenic Diabetes Insipidus	17.3%
43	Acute kidney injury	17.3%
44	AIDS-Associated Nephropathy	16.7%
45	Multicystic Dysplastic Kidney	15.4%
46	Urogenital Abnormalities	14.8%
47	Kidney Calculi	14.6%
48	Azotemia	14.1%
49	Bladder neck obstruction	13.9%
50	Hypertension, Renovascular	13.9%
51	Cystitis	13.1%
52	Ureteral obstruction	13.1%
53	Ureterocele	13.1%
54	Urethral Obstruction	13.1%
55	Urethritis	13.1%
56	Vesico-Ureteral Reflux	13.1%
57	Urinary Retention	13.1%
58	Bladder Exstrophy	13%
59	Epispadias	13%
60	Renal Osteodystrophy	12.9%
61	Renal rickets	12.9%
62	Polycystic Kidney Diseases	11.7%
63	Renal Aminoacidurias	11.6%
64	Fanconi Syndrome	11.6%
65	Pseudohypoaldosteronism	11.6%
66	Liddle Syndrome	11.6%
67	Hemolytic-Uremic Syndrome	11.6%
68	Kidney Failure, Chronic	11.5%
69	Glycosuria, Renal	11.2%
70	Bacteriuria	10.5%
71	Glycosuria	10.5%
72	Hematuria	10.5%
73	Oliguria	10.5%
74	Polyuria	10.5%
75	Proteinuria	10.5%
76	Pyuria	10.5%
77	Urinary Calculi	10.5%
78	Cystocele	10.5%
79	Urinary Incontinence	10.5%
80	Urinary Bladder Fistula	10.4%
81	Bladder Neoplasm	10.4%
82	Ureteral Neoplasms	10.4%
83	Urethral Neoplasms	10.4%
84	Ureteral Calculi	10.4%
85	Mesoblastic Nephroma	10.2%
86	Renal Cell Carcinoma	10.1%
87	Papillary Renal Cell Carcinoma	10.1%
88	Renal tubular acidosis	9.9%
89	Zellweger Syndrome	9.8%
90	Genital Diseases, Male	9.7%
91	Pregnancy Complications	9.5%
92	Infertility	9.3%
93	Enuresis	8.9%
94	Nephroblastoma	8.3%
95	Urethral Stenosis	7.8%
96	Urethral stricture	7.8%
97	Hyperphosphaturia	7.7%
98	Polycystic Kidney, Autosomal Dominant	7.7%
99	Cystinuria	7.7%
100	Atypical Hemolytic Uremic Syndrome	7.6%
101	Hypospadias	7.6%
102	Urologic Neoplasms	7.4%
103	Horseshoe Kidney	7.4%
104	Endometriosis	7.2%
105	Uterine Diseases	7.2%
106	Vaginal Diseases	7.2%
107	Vulvar Diseases	7.2%
108	Endometrioma	7.2%
109	Sexually Transmitted Diseases	6.5%
110	Hermaphroditism	6.3%
111	Disorders of Sex Development	6.3%
112	Albuminuria	6.2%
113	Hemoglobinuria	6.2%
114	Urge Incontinence	6.2%
115	Genital Herpes	6.2%
116	Genital Neoplasms, Male	6%
117	Genital Neoplasms, Female	5.5%
118	Diurnal Enuresis	5.2%
119	Epididymitis	4.9%
120	Penile Diseases	4.9%
121	Prostatic Diseases	4.9%
122	Spermatic Cord Torsion	4.9%
123	Hemospermia	4.9%
124	Testicular Hydrocele	4.9%
125	Uterine Inversion	4.8%
126	Uterine Neoplasms	4.8%
127	Vaginal Neoplasms	4.8%
128	Vulvar Neoplasms	4.8%
129	Uterine Cancer	4.8%
130	Endometritis	4.8%
131	Denys-Drash Syndrome	4.7%
132	Polyhydramnios	4.7%
133	Obstetric Labor Complications	4.7%
134	Ectopic Pregnancy	4.7%
135	Pregnancy, Prolonged	4.7%
136	Puerperal Disorders	4.7%
137	Oligohydramnios	4.7%
138	Prenatal Injuries	4.7%
139	Vesicovaginal Fistula	4.4%
140	Dyspareunia	4.1%
141	Penile Neoplasms	4.1%
142	Prostatic Neoplasms	4.1%
143	Endometrial Hyperplasia	4%
144	Pyometra	4%
145	Vaginitis	4%
146	Vulvitis	4%
147	Vaginal Discharge	4%
148	Vulvodynia	4%
149	Uterine Rupture	3.9%
150	Cryptorchidism	3.9%
151	Fallopian Tube Neoplasms	3.8%
152	Testicular Diseases	3.8%
153	Varicocele	3.8%
154	Spermatocele	3.7%
155	Fetal Diseases	3.7%
156	Pregnancy Complications, Cardiovascular	3.7%
157	Pregnancy Complications, Neoplastic	3.7%
158	Abruptio Placentae	3.7%
159	Placenta Accreta	3.7%
160	Salpingitis	3.6%
161	Vulvovaginitis	3.6%
162	Pregnancy Complications, Hematologic	3.6%
163	Pregnancy Complications, Infectious	3.6%
164	Fetal Death	3.5%
165	Perinatal death	3.5%
166	Morning Sickness	3.5%
167	Gonadal Dysgenesis	3.4%
168	Adrenogenital Syndrome	3.4%
169	Ovotesticular Disorders of Sex Development	3.4%
170	Familial Hypophosphatemic Rickets	3.3%
171	Chorioamnionitis	3.2%
172	Ovarian Diseases	3.1%
173	Adnexitis	3%
174	Pruritus Vulvae	3%
175	Uterine hemorrhage	3%
176	Vaginal Fistula	3%
177	Pelvic Inflammatory Disease	3%
178	Uterine Prolapse	3%
179	Vaginal Prolapse	3%
180	Puerperal Infection	2.9%
181	Postpartum Hemorrhage	2.9%
182	Oophoritis	2.9%
183	Endometrial Neoplasms	2.9%
184	Gestational Diabetes	2.8%
185	ovarian neoplasm	2.8%
186	Uterine Cervical Incompetence	2.8%
187	Balanitis	2.7%
188	Benign prostatic hypertrophy	2.7%
189	Phimosis	2.7%
190	Priapism	2.7%
191	prostatitis	2.7%
192	Prostatic Adenoma	2.7%
193	Benign Prostatic Hyperplasia	2.7%
194	Prostatic Hypertrophy	2.7%
195	Prostatic Hyperplasia	2.7%
196	Abortion, Habitual	2.4%
197	Dystocia	2.4%
198	Eclampsia	2.4%
199	Fetal Membranes, Premature Rupture	2.4%
200	Placental Insufficiency	2.4%
201	Pre-Eclampsia	2.4%
202	Prenatal Exposure Delayed Effects	2.4%
203	HELLP Syndrome	2.4%
204	Placenta, Retained	2.4%
205	Prostatic Neoplasms, Castration-Resistant	2.4%
206	Hyperandrogenism	2.4%
207	Uterine Cervicitis	2.4%
208	Leukorrhea	2.4%
209	Parametritis	2.4%
210	Carcinoma, Endometrioid	2.1%
211	Testicular Neoplasms	2.1%
212	Premature Ejaculation	2.1%
213	Erectile dysfunction	2.1%
214	Orchitis	2%
215	Abortion, Veterinary	1.9%
216	Pregnancy Complications, Parasitic	1.9%
217	Candidiasis, Vulvovaginal	1.9%
218	Bacterial Vaginosis	1.8%
219	Lactation Disorder	1.8%
220	Mastitis	1.8%
221	Depression, Postpartum	1.8%
222	Embryo Loss	1.8%
223	Fetal Resorption	1.8%
224	Hyperemesis Gravidarum	1.8%
225	Trichomonas Vaginitis	1.8%
226	Uterine Perforation	1.8%
227	Ovarian Hyperstimulation Syndrome	1.8%
228	Metrorrhagia	1.8%
229	Chlamydia Infections	1.7%
230	Gonorrhea	1.7%
231	Turner Syndrome	1.6%
232	Azoospermia	1.6%
233	Oligospermia	1.6%
234	Impotence, Vasculogenic	1.6%
235	Asthenozoospermia	1.6%
236	Teratozoospermia	1.6%
237	Aspermia	1.6%
238	Kallmann Syndrome	1.5%
239	Syphilis	1.5%
240	granulosa cell tumor	1.5%
241	Carcinoma, Ovarian Epithelial	1.5%
242	Fetal Growth Retardation	1.5%
243	Trophoblastic Neoplasms	1.5%
244	Embolism, Amniotic Fluid	1.5%
245	Fetal Hypoxia	1.5%
246	Fetal Alcohol Spectrum Disorders	1.5%
247	Corpus Luteum Cyst	1.5%
248	Ovarian Cysts	1.5%
249	Breech Presentation	1.5%
250	Anovulation	1.4%
251	Menorrhagia	1.4%
252	Stillbirth	1.4%
253	Premature Menopause	1.4%
254	Klinefelter Syndrome	1.3%
255	Premature Birth	1.3%
256	Endometrial Stromal Sarcoma	1.2%
257	Lymphogranuloma Venereum	1.1%
258	Meconium Aspiration Syndrome	1.1%
259	Galactorrhea	1%
260	Polycystic Ovary Syndrome	1%
261	Leydig Cell Tumor	0.7%
262	Choriocarcinoma	0.7%
263	Hydatidiform Mole	0.5%
264	Hydrops Fetalis	0.5%

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