MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Enalapril

(GBXSMTUPTTWBMN-XIRDDKMYSA-N)

Structure

SMILES: CCOC(=O)[C@@H](N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C)CCc1ccccc1
Type(s): Approved; Vet_approved
ATC code(s): C09AA02; C09BA02; C09BB02; C09BB06
Molecular Formula:: C20H28N2O5
Molecular Weight:: 376.447
Log P:: 1.9334
Hydrogen Bond Acceptor:: 7
Hydrogen Bond Donor:: 2
TPSA:: 95.94
CAS Number(s):: 75847-73-3; 76095-16-4

Synonym(s)

Enalapril

Enalapril Maleate

MK-421

MK421

Renitec

Renitek

MK 421

Maleate, Enalapril

External Link(s)

MeSH	D004656
PubChem Compound	5388962 40466924
BindingDB	50017129
ChEBI	4784
CHEMBL	CHEMBL578
DrugBank	DB00584
DrugCentral	1005
IUPHAR/BPS Guide to PHARMACOLOGY	6322
KEGG	cpd:C06977 dr:D07892
Therapeutic Target Database	D00SEB
ZINC	3791297

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Angioedema	FAERS: 89 Canada Vigilance: 4	View details 1315673 1316863 1319709 1325341 1581715 1737969 1815536 1910723 1941343 2008223 2167396 2233075 2297216 2302280 2552575 2555035 2840522 2846101 3027913 3032324 3034372 7606082 7629487 7968889 8182239 8358121 8380620 8579032 8668896 8758027 9188926 9775809 11129038 11244322 11753189 12126067 12173515 12222553 12744557 14595286 14751650 15039478 15464190 16043683 16684302 16737005 17380227 17941760 18281733 18320317 18768723 19694749	CTD OFFSIDES Canada Vigilance US FAERS
2	Dizziness	FAERS: 17 Canada Vigilance: 6	2846101 8519044 12654706	CTD Canada Vigilance US FAERS
3	Hypotension	FAERS: 16	View details 1452551 1801390 1879978 1883120 1934231 1938827 2084665 2541310 2556058 2846101 2849806 2862409 2883575 2998536 3014079 3018566 3022272 3022372 7596934 7951836 8017639 8053578 8157899 8340338 8494162 8527259 8579032 8645963 9129851 10565607 10894321 11642085 16227653	CTD US FAERS
4	Drug ineffective	FAERS: 14 Canada Vigilance: 10		Canada Vigilance US FAERS
5	Dysphonia	FAERS: 13		US FAERS
6	Hypersensitivity	FAERS: 12 Canada Vigilance: 1		Canada Vigilance US FAERS
7	Product substitution issue	FAERS: 12 Canada Vigilance: 14		Canada Vigilance US FAERS
8	Acute kidney injury	FAERS: 10	View details 2368707 2827563 2829674 2837670 2849806 3013264 3029744 3035393 3036457 6321850 8416678 8529299 8645963 8856229 9403220 9798462 12698328 14629192 15662077 16147831 16197366	CTD US FAERS
9	Nausea	FAERS: 10 Canada Vigilance: 7	8519044	CTD Canada Vigilance US FAERS
10	Choking	FAERS: 9		US FAERS
11	Intestinal angioedema	FAERS: 9		US FAERS
12	Lip swelling	FAERS: 9		US FAERS
13	Syncope	FAERS: 9	View details 2560100 2846101 3018566 7884028 8417930 10406995	CTD US FAERS
14	Erythema	FAERS: 8	8453893	CTD US FAERS
15	Fatigue	FAERS: 8 Canada Vigilance: 1	2688328 8579032 9653007	CTD Canada Vigilance US FAERS
16	Headache	FAERS: 7 Canada Vigilance: 4	2846101 8519044	CTD Canada Vigilance US FAERS
17	Medication Error	FAERS: 7		US FAERS
18	Overdose	FAERS: 6		OFFSIDES US FAERS
19	Swelling	FAERS: 6		US FAERS
20	Abdominal Pain	FAERS: 5	View details 8066414 8519044 15464190 18320317	CTD OFFSIDES US FAERS
21	Bradycardia	FAERS: 5	2084665 15662077	CTD OFFSIDES US FAERS
22	Hypoxia	FAERS: 5	21263376	CTD US FAERS
23	Pathological fracture	FAERS: 5		US FAERS
24	Respiratory Failure	FAERS: 5		OFFSIDES US FAERS
25	Asthenia	FAERS: 4 Canada Vigilance: 2	8519044	CTD Canada Vigilance US FAERS
26	Lichen Planus	FAERS: 4		US FAERS
27	Pharmaceutical product complaint	FAERS: 4		US FAERS
28	Therapeutic response unexpected with drug substitution	FAERS: 4		US FAERS
29	Urticaria	FAERS: 4 Canada Vigilance: 3		Canada Vigilance US FAERS
30	Abdominal discomfort	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
31	Acquired C1 inhibitor deficiency	FAERS: 3		US FAERS
32	Anuria	FAERS: 3	7951836 8527259 9546244	CTD US FAERS
33	Blood creatinine increased	FAERS: 3		OFFSIDES US FAERS
34	Burning sensation	FAERS: 3		US FAERS
35	Cholestatic liver injury	FAERS: 3		US FAERS
36	Drug exposure during pregnancy	FAERS: 3		US FAERS
37	Feeling abnormal	FAERS: 3		US FAERS
38	Idiosyncratic drug reaction	FAERS: 3		US FAERS
39	Leukocytosis	FAERS: 3		US FAERS
40	Metabolic acidosis	FAERS: 3		US FAERS
41	Pancreatitis	FAERS: 3		US FAERS
42	Prescription drug used without a prescription	FAERS: 3		US FAERS
43	Tachycardia	FAERS: 3 Canada Vigilance: 1	6094050 8781749 9421286	CTD Canada Vigilance US FAERS
44	Toxicity to various agents	FAERS: 3		US FAERS
45	Actinic keratosis	FAERS: 2		US FAERS
46	Aphonia	FAERS: 2		US FAERS
47	Ascites	FAERS: 2	14651558	CTD US FAERS
48	Back Pain	FAERS: 2		US FAERS
49	Basal cell carcinoma	FAERS: 2		US FAERS
50	Blood sodium decreased	FAERS: 2		US FAERS
51	Cardiac Arrest	FAERS: 2		US FAERS
52	Cholangitis	FAERS: 2		US FAERS
53	Drug abuse	FAERS: 2		US FAERS
54	Drug administration error	FAERS: 2		US FAERS
55	Hepatosplenomegaly	FAERS: 2		US FAERS
56	Hepatotoxicity	FAERS: 2		US FAERS
57	Lethargy	FAERS: 2		US FAERS
58	Myalgia	FAERS: 2		US FAERS
59	Myocardial Infarction	FAERS: 2	View details 1294422 8203335 10413075 15469907 16908757 18806606	CTD US FAERS
60	Neck Pain	FAERS: 2		US FAERS
61	Oropharyngeal pain	FAERS: 2		US FAERS
62	Petechiae	FAERS: 2		US FAERS
63	Poisoning	FAERS: 2	22155090	CTD US FAERS
64	Polymyalgia Rheumatica	FAERS: 2		US FAERS
65	Precancerous skin lesion	FAERS: 2		US FAERS
66	Product quality issue	FAERS: 2		US FAERS
67	Pruritus	FAERS: 2 Canada Vigilance: 4	2688328 8066414	CTD Canada Vigilance US FAERS
68	Suicide attempt	FAERS: 2		US FAERS
69	Throat irritation	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
70	Thrombocytopenia	FAERS: 2		US FAERS
71	Thrombotic stroke	FAERS: 2		US FAERS
72	Unevaluable event	FAERS: 2		US FAERS
73	Urinary Incontinence	FAERS: 2	9572189	CTD US FAERS
74	Vomiting	FAERS: 2 Canada Vigilance: 2	2688328 8066414	CTD Canada Vigilance US FAERS
75	Acantholysis	FAERS: 1		US FAERS
76	Activities of daily living impaired	FAERS: 1		US FAERS
77	Alkalosis	FAERS: 1		US FAERS
78	Alopecia	FAERS: 1		US FAERS
79	Angiotensin converting enzyme inhibitor foetopathy	FAERS: 1		US FAERS
80	Anorexia	FAERS: 1	2688328	CTD US FAERS
81	Anxiety	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
82	Arthritis	FAERS: 1		US FAERS
83	Bile duct necrosis	FAERS: 1		US FAERS
84	Biopsy liver abnormal	FAERS: 1		US FAERS
85	Blindness	FAERS: 1		US FAERS
86	Blood lactate dehydrogenase increased	FAERS: 1		US FAERS
87	Blood potassium increased	FAERS: 1		US FAERS
88	Blood pressure fluctuation	FAERS: 1		OFFSIDES US FAERS
89	Blood pressure inadequately controlled	FAERS: 1 Canada Vigilance: 4		Canada Vigilance OFFSIDES US FAERS
90	Blood urea increased	FAERS: 1		US FAERS
91	Bronchitis	FAERS: 1		OFFSIDES US FAERS
92	Bronchopneumonia	FAERS: 1		OFFSIDES US FAERS
93	Cerebral Infarction	FAERS: 1	9143594	CTD US FAERS
94	Chest Pain	FAERS: 1		OFFSIDES US FAERS
95	Chest discomfort	FAERS: 1		US FAERS
96	Cholelithiasis	FAERS: 1		US FAERS
97	Cholestasis	FAERS: 1	12420643 14651558	CTD US FAERS
98	Chromaturia	FAERS: 1		US FAERS
99	Contraindicated drug prescribed	FAERS: 1		US FAERS
100	Dehydration	FAERS: 1		OFFSIDES US FAERS
101	Diabetes Mellitus	FAERS: 1		US FAERS
102	Documented hypersensitivity to administered product	FAERS: 1		US FAERS
103	Drooling	FAERS: 1		US FAERS
104	Drug dispensing error	FAERS: 1		US FAERS
105	Drug dose omission	FAERS: 1		US FAERS
106	Dyspepsia	FAERS: 1		OFFSIDES US FAERS
107	Ear discomfort	FAERS: 1		US FAERS
108	Eczema	FAERS: 1		US FAERS
109	Endotracheal intubation complication	FAERS: 1		US FAERS
110	Extra dose administered	FAERS: 1		US FAERS
111	Eye pain	FAERS: 1		US FAERS
112	Flushing	FAERS: 1	3000654	CTD US FAERS
113	Gastroenteritis	FAERS: 1		US FAERS
114	General physical health deterioration	FAERS: 1		US FAERS
115	Hemiparesis	FAERS: 1		US FAERS
116	Hepatic Encephalopathy	FAERS: 1		US FAERS
117	Hepatic necrosis	FAERS: 1		US FAERS
118	Hepatitis	FAERS: 1		US FAERS
119	Hyperkeratosis	FAERS: 1		OFFSIDES US FAERS
120	Hypocalciuria	FAERS: 1		US FAERS
121	Hypotensive Transfusion Reaction	FAERS: 1		US FAERS
122	Idiopathic angioedema	FAERS: 1		US FAERS
123	Inappropriate affect	FAERS: 1		US FAERS
124	Incorrect product storage	FAERS: 1		US FAERS
125	Joint swelling	FAERS: 1		US FAERS
126	Left Ventricular Hypertrophy	FAERS: 1		OFFSIDES US FAERS
127	Leukoencephalomyelitis	FAERS: 1		US FAERS
128	Malaise	FAERS: 1 Canada Vigilance: 3		Canada Vigilance US FAERS
129	Middle insomnia	FAERS: 1		US FAERS
130	Nystagmus	FAERS: 1		US FAERS
131	Oligohydramnios	FAERS: 1	2301491 7951836 16147831	CTD US FAERS
132	Pain	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
133	Palpitations	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
134	Pemphigus	FAERS: 1		US FAERS
135	Peripheral swelling	FAERS: 1		US FAERS
136	Peritoneal Dialysis	FAERS: 1		OFFSIDES US FAERS
137	Pharyngotonsillitis	FAERS: 1		US FAERS
138	Pneumonia	FAERS: 1	19114890	CTD US FAERS
139	Pneumothorax	FAERS: 1		US FAERS
140	Polyuria	FAERS: 1		US FAERS
141	Product dose omission	FAERS: 1		US FAERS
142	Product physical consistency issue	FAERS: 1		US FAERS
143	Product use in unapproved indication	FAERS: 1		US FAERS
144	Proteinuria	FAERS: 1	View details 2407887 8196289 9397292 11045392 14651558 17284475 19147669	CTD US FAERS
145	Psoriasis	FAERS: 1		US FAERS
146	Quality of life decreased	FAERS: 1		US FAERS
147	Reaction to drug excipients	FAERS: 1		US FAERS
148	Renal Artery Stenosis	FAERS: 1		US FAERS
149	Renal pain	FAERS: 1		US FAERS
150	Renal tubular acidosis	FAERS: 1		US FAERS
151	Renal tubular necrosis	FAERS: 1		US FAERS
152	Respiratory distress	FAERS: 1		US FAERS
153	Shoulder Pain	FAERS: 1		US FAERS
154	Skin Erosion	FAERS: 1		US FAERS
155	Skin necrosis	FAERS: 1		US FAERS
156	Snoring	FAERS: 1		US FAERS
157	Somnolence	FAERS: 1		US FAERS
158	Tension	FAERS: 1		US FAERS
159	Tongue pruritus	FAERS: 1		US FAERS
160	Trismus	FAERS: 1		US FAERS
161	Troponin increased	FAERS: 1		US FAERS
162	Ultrasound Doppler abnormal	FAERS: 1		US FAERS
163	Vanishing bile duct syndrome	FAERS: 1		US FAERS
164	Vascular purpura	FAERS: 1		US FAERS
165	Weight decreased	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
166	Wheezing	FAERS: 1		US FAERS
167	Wrong technique in product usage process	FAERS: 1		US FAERS
168	AIDS Dementia Complex			OFFSIDES
169	Abdomen, Acute		7771884 7846433 15039478	CTD
170	Abdominal strangulated hernia			OFFSIDES
171	Abnormalities, Drug-Induced		2301491	CTD
172	Acute myocardial infarction			OFFSIDES
173	Airway Obstruction		View details 1325341 1815536 2233075 2302280	CTD
174	Albumin globulin ratio decreased			OFFSIDES
175	Albuminuria		View details 2852253 8282322 8591707 8743521 9269694 9861226 11045392 12654706 15257186 17167242 17198918 18679781	CTD
176	Allergy to arthropod sting			OFFSIDES
177	Anemia		View details 1580986 1630559 1992663 2474097 8140862 8963480 8964641 9363666 9434678 9690411 15680718 16507428 16840386	CTD
178	Anticonvulsant drug level below therapeutic			OFFSIDES
179	Anticonvulsant drug level decreased			OFFSIDES
180	Anticonvulsant drug level increased			OFFSIDES
181	Antipsychotic drug level increased			OFFSIDES
182	Application site erythema			OFFSIDES
183	Application site irritation			OFFSIDES
184	Application site pruritus			OFFSIDES
185	Application site reaction			OFFSIDES
186	Application site scab			OFFSIDES
187	Arthralgia		11244322	CTD
188	Aspiration Pneumonia			OFFSIDES
189	Ataxia			OFFSIDES
190	Atherosclerosis		15585195 17347482 19939336	CTD
191	Axillary vein thrombosis			OFFSIDES
192	Azotemia		6124829 8579032	CTD
193	B-cell lymphoma stage I			OFFSIDES
194	Back disorder			OFFSIDES
195	Bacteria sputum identified			OFFSIDES
196	Band neutrophil percentage increased			OFFSIDES
197	Blastomycosis			OFFSIDES
198	Blood Coagulation Disorders		16737005	CTD
199	Blood Glucose			OFFSIDES
200	Blood albumin decreased			OFFSIDES
201	Blood cholesterol			OFFSIDES
202	Blood cholinesterase decreased			OFFSIDES
203	Blood creatine phosphokinase decreased			OFFSIDES
204	Blood glucose decreased			OFFSIDES
205	Blood glucose fluctuation			OFFSIDES
206	Blood pH decreased			OFFSIDES
207	Blood phosphorus			OFFSIDES
208	Blood potassium decreased			OFFSIDES
209	Blood urea abnormal			OFFSIDES
210	Bone fragmentation			OFFSIDES
211	Borderline Personality Disorder			OFFSIDES
212	Brachydactyly with hypertension		12811651	CTD
213	Brain Edema		19694749	CTD
214	Brain Infarction		19435785	CTD
215	Brain Injuries		20600611	CTD
216	Brain Ischemia		10408248	CTD
217	Cardioactive drug level			OFFSIDES
218	Cardiomegaly		View details 2883575 9336375 9535421 14744816 16908757 30623541	CTD
219	Cardiomyopathies		12413500	CTD
220	Cardiomyopathy dilated with Woolly hair and keratoderma		21193976	CTD
221	Cardiomyopathy, Dilated		9838955 18593848	CTD
222	Cardiovascular Diseases		12578880	CTD
223	Cerebral ventricle dilatation			OFFSIDES
224	Chemical and Drug Induced Liver Injury		View details 1479182 2688328 3032724 8066414 14642633 20593053 21416479 25231249	CTD
225	Chronic Obstructive Airway Disease			OFFSIDES
226	Clostridium difficile colitis			OFFSIDES
227	Colon adenoma			OFFSIDES
228	Congenital pulmonary hypertension			OFFSIDES
229	Congenital tricuspid valve incompetence			OFFSIDES
230	Constipation	Canada Vigilance: 1		Canada Vigilance
231	Coronary Artery Disease		9215232 11023927	CTD
232	Culture positive			OFFSIDES
233	Demyelination			OFFSIDES
234	Depressed Level of Consciousness			OFFSIDES
235	Diabetes Mellitus, Experimental		8591707 15362513	CTD
236	Diabetes mellitus inadequate control			OFFSIDES
237	Diabetic Angiopathies		17970755 21040718 22198047	CTD
238	Diabetic Cardiomyopathies		21416479	CTD
239	Diabetic Neuropathies		21040718 22198047	CTD
240	Diarrhea		15662077	CTD OFFSIDES
241	Discomfort	Canada Vigilance: 1		Canada Vigilance
242	Disease Progression		2883575	CTD
243	Disease recurrence			OFFSIDES
244	Diverticulitis			OFFSIDES
245	Drug Eruptions		View details 3032324 3034372 8453893 9360001	CTD
246	Drug Overdose		8527259 8645963	CTD
247	Dry skin			OFFSIDES
248	Dysgeusia		14984622	CTD
249	Edema		View details 7951836 11045392 14651558 19114890	CTD
250	Endodontic procedure			OFFSIDES
251	Endomyocardial Fibrosis		18820026 30623541	CTD
252	Enteritis			OFFSIDES
253	Enterobacter sepsis			OFFSIDES
254	Enterococcal infection			OFFSIDES
255	Eosinophilia		16737005	CTD
256	Erythema Induratum			OFFSIDES
257	Exanthema		2541310 6100872	CTD
258	Extravasation of Diagnostic and Therapeutic Materials		9622145	CTD
259	Extremity contracture			OFFSIDES
260	Fatty Liver		20593053	CTD
261	Fetal Growth Retardation		16147831	CTD
262	Fibrosis		View details 17164399 18806606 21416479 21565836	CTD
263	Gastric Dilatation			OFFSIDES
264	Gastrointestinal disorder postoperative			OFFSIDES
265	Giant Cell Arteritis		9513617	CTD
266	Gingival Hypertrophy			OFFSIDES
267	Glomerulonephritis		3027632 9848785 15496148	CTD
268	Glycosuria		6124829	CTD
269	Hallucinations, mixed			OFFSIDES
270	Headache Disorders, Primary		17965960	CTD
271	Heart Diseases		9700987	CTD
272	Heart failure		View details 1330361 1879978 2024540 2057035 2068028 2376053 2844087 2849806 2883575 2994984 3013264 3018566 3022272 3036457 7560723 8110005 8125425 9123633 10979640 12514674 12723015 14674695 15051632 15161998 15167280 15548724 15576437 15680718 15681692 16285075 17546280 18528751 21565836 25231249	CTD
273	Hemorrhage		19114890	CTD
274	Heparin-induced thrombocytopenia			OFFSIDES
275	Hepatomegaly		14651558	CTD
276	Hydronephrosis			OFFSIDES
277	Hydrops Fetalis		16147831	CTD
278	Hypercholesterolemia		20847891	CTD
279	Hyperglycemia		8591707 9861226	CTD
280	Hyperkalemia		View details 2849806 3022272 3022372 3036457 8579032 8606734 11045392 11161080	CTD
281	Hyperpigmentation			OFFSIDES
282	Hyperplasia		14744816	CTD
283	Hyperreflexia			OFFSIDES
284	Hypertension, Renovascular		View details 1639466 2136812 2994932 3000654 8282322	CTD
285	Hypoglycemia		7951836	CTD
286	Hypokalemia		1623802 6100872	CTD
287	Hyponatremia		View details 3022372 10835739 12087354 19685582	CTD
288	Hypotension, Orthostatic		1691407	CTD
289	Hypovolemia		2823245	CTD
290	Impaired gastric emptying			OFFSIDES
291	Incision site complication			OFFSIDES
292	Infant, Premature, Diseases		8645963	CTD
293	Inflammation		18765277 21265103	CTD
294	Infusion site mobility decreased			OFFSIDES
295	Intestinal Diseases		15464190	CTD
296	Intestinal Obstruction			OFFSIDES
297	Jaundice, Obstructive		2342045	CTD
298	Joint Instability	Canada Vigilance: 1		Canada Vigilance
299	Joint injury			OFFSIDES
300	Joint sprain			OFFSIDES
301	Keratitis sicca			OFFSIDES
302	Kidney Cortex Necrosis		19761811	CTD
303	Kidney Diseases		View details 2301491 2407887 2541310 2846102 7951836 10903974 12110003 12883983 12954793 14659064 16014107 16772709	CTD
304	Kidney Failure, Chronic		View details 2555956 8157899 16631587 19225048 20006961 21937979	CTD
305	Kidney Failure			OFFSIDES
306	Large intestine perforation			OFFSIDES
307	Leprosy			OFFSIDES
308	Limb injury			OFFSIDES
309	Lipase			OFFSIDES
310	Liver Cirrhosis, Experimental		17347453	CTD
311	Liver Cirrhosis		18765277 21664615	CTD
312	Liver Failure, Acute		11141678	CTD
313	Liver diseases		1880490	CTD
314	Lymph Node Tuberculosis			OFFSIDES
315	Macroglossia		7968889 12173515	CTD
316	Malignant Hypertension			OFFSIDES
317	Mastoiditis			OFFSIDES
318	Medical device removal			OFFSIDES
319	Mitral Valve Insufficiency		9838955	CTD
320	Morphea			OFFSIDES
321	Motor retardation			OFFSIDES
322	Movement Disorders		22107891	CTD
323	Moyamoya Disease		9143594	CTD
324	Multiple sclerosis relapse			OFFSIDES
325	Muscle Cramp		2846101	CTD
326	Muscle Hypertonia		2404862	CTD
327	Myocardial Ischemia		2560100 9129851	CTD
328	Necrosis		7564367	CTD
329	Neointima		19258495	CTD
330	Neoplasms		21153712	CTD
331	Nephritis		22822941	CTD
332	Nephrogenic Fibrosing Dermopathy			OFFSIDES
333	Nephrosclerosis		18812665	CTD
334	Nephrotic Syndrome			OFFSIDES
335	Nervous tension			OFFSIDES
336	Neuralgia			OFFSIDES
337	Neurilemmoma			OFFSIDES
338	Obesity		20847891	CTD
339	Occult blood positive			OFFSIDES
340	Oliguria		7951836 8529299 16147831	CTD
341	Oral mucosal eruption	Canada Vigilance: 1		Canada Vigilance
342	Osteoporosis		18847324	CTD
343	PROTHROMBIN TIME			OFFSIDES
344	Pancreatic enzymes increased			OFFSIDES
345	Paresthesia		1336423 7560723 9861226	CTD
346	Peripheral Nervous System Diseases		20847891	CTD
347	Peripheral Vascular Diseases		20847891	CTD
348	Plaque, Atherosclerotic		20720404	CTD
349	Plasmacytoma			OFFSIDES
350	Polyarteritis Nodosa		1971779	CTD
351	Polycythemia		9285312 15848608 17284475	CTD
352	Post procedural complication			OFFSIDES
353	Postoperative Complications		8494162 16840386 19685582	CTD
354	Postoperative infection			OFFSIDES
355	Prenatal Exposure Delayed Effects		2301491 8157899 17284475	CTD
356	Prenatal Injuries		2829674 7951836	CTD
357	Prescribed overdose			OFFSIDES
358	Procedural complication			OFFSIDES
359	Protein-losing gastroenteropathy			OFFSIDES
360	Pulmonary Fibrosis		17265423	CTD
361	Pulmonary Hypertension			OFFSIDES
362	Rectal tenesmus			OFFSIDES
363	Renal Artery Obstruction		2254726 2508894 9546244	CTD
364	Renal Insufficiency		View details 1315003 1883120 1938827 2068028 2251614 2835640 2994984 3014079 3022272 3022372 3028221 6099740 8110005 8601255 8606734 9155634 9861226 10539815 15728788 17284475	CTD
365	Renal cyst			OFFSIDES
366	Reticulocyte count increased			OFFSIDES
367	Sclerosis		8591707	CTD
368	Seizures		22107891	CTD
369	Sensation Disorders		14506449	CTD
370	Septic Shock			OFFSIDES
371	Sinus bradycardia			OFFSIDES
372	Sjogren's Syndrome		9513617	CTD
373	Skin hypertrophy			OFFSIDES
374	Skin tightness			OFFSIDES
375	Sleep Apnea, Obstructive		16438479	CTD
376	Stenotrophomonas infection			OFFSIDES
377	Stevens-Johnson Syndrome		25811541	CTD
378	Subcutaneous nodule			OFFSIDES
379	Substance Withdrawal Syndrome		12050568 17965960 20428619	CTD
380	Synovectomy			OFFSIDES
381	Taste Disorders		6100872	CTD
382	Therapeutic response unexpected	Canada Vigilance: 1		Canada Vigilance
383	Therapy change	Canada Vigilance: 1		Canada Vigilance
384	Therapy non-responder			OFFSIDES
385	Tinea Pedis			OFFSIDES
386	Tonsillitis			OFFSIDES
387	Trisomy 21			OFFSIDES
388	Ultrasound scan abnormal			OFFSIDES
389	Uremia		17513326	CTD
390	Ureteral obstruction		12473537	CTD
391	Urine nitrogen			OFFSIDES
392	Vasculitis, Leukocytoclastic, Cutaneous		9797501	CTD
393	Vasculitis		8453893 9513617	CTD
394	Venous occlusion			OFFSIDES
395	Ventricular Dysfunction, Left		View details 2376053 7581081 8125425 8203335 9060793 12019275 18418421 18593848 18820026 22052614 30623541	CTD
396	Ventricular Dysfunction		21273767	CTD
397	Ventricular Remodeling		View details 12546633 12667963 15051632 15362513	CTD
398	Vertebrobasilar Insufficiency		2541568	CTD
399	jaundice		View details 2688328 8066414 11141678 14651558	CTD

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