MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kidney Failure, Chronic

(UMLS:C0022661)

Definition:: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
UMLS ID:: C0022661
MeSH ID:: D007676

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.780.750.500

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.780.750.500

Synonym(s)

Kidney Failure, Chronic

CHRONIC RENAL FAILURE

CRF - Chronic Renal Failure

CRF - Chronic renal failure

Chronic Renal Disease

Chronic Renal Failure

Chronic kidney failure

Chronic renal failure

Chronic renal failure syndrome

10.

Chronic renal failure syndrome, NOS

11.

Chronic renal failure, unspecified

12.

ESCRF - End stage chronic renal failure

13.

ESRD (end stage renal disease)

14.

ESRD - End stage renal disease

15.

ESRF - End stage renal failure

16.

End Stage Renal Disease

17.

End stage chronic renal failure

18.

End stage kidney disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2,8-dihydroxyadenine	21705322	CTD
2	4-cresol sulfate	19914995	CTD
3	Acetaminophen	3050572 7969358 11752356	CTD
4	Acyclovir	14606623 16138435	CTD
5	Albuterol	2384735	CTD
6	Allopurinol	8842764	CTD
7	Amoxicillin	1855326	CTD
8	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	12203209	CTD
9	Aspirin	5101354 11752356 15882284	CTD
10	Atazanavir Sulfate	20523203	CTD
11	Atrazine	26177651	CTD
12	Cadmium Compounds	23343055	CTD
13	Calcitriol	3439654 6760236 15354979	CTD
14	Calcium Carbonate	4126071	CTD
15	Carboplatin	14738305	CTD
16	Carvedilol	15960146	CTD
17	Cidofovir	10589927 11773481	CTD
18	Ciprofloxacin	12911170	CTD
19	Cocaine	10745478 11532684 15335299	CTD
20	Copper	16518626	CTD
21	Daunorubicin	1895550 2250403 2352357	CTD
22	Doxorubicin	View details 9102927 11014987 15960146 16707910	CTD
23	Enalapril	View details 2555956 8157899 16631587 19225048 20006961 21937979	CTD
24	Folic Acid	4810836	CTD
25	Foscarnet	9740173	CTD
26	Furosemide	786692	CTD
27	Glucose	9551423	CTD
28	Hydrochlorothiazide	15018153	CTD
29	Hydrogen Peroxide	16518626	CTD
30	Ibuprofen	1561566 7914617	CTD
31	Icodextrin	View details 9551423 10649708 10752708 18552274	CTD
32	Ifosfamide	View details 7983965 8625132 8874474 8950339 9569955 15503294	CTD
33	Indican	21483698	CTD
34	Indinavir	17502722 19226409 20523203	CTD
35	Indomethacin	6986554	CTD
36	Irbesartan	11104169 11765585	CTD
37	Ketoprofen	3173609	CTD
38	Kynurenic Acid	21483698	CTD
39	Lamivudine	11263401	CTD
40	Lisinopril	16988746	CTD
41	Lithium	View details 1378968 2517543 2770247 3739727 4090985 6516842 6657461 7884032 8376615 9101586 9408819 9789472 11200820 11418269 12148451 15601320 19940841 20430244	CTD
42	Lomustine	7443446	CTD
43	Losartan	View details 9355076 11227361 11765585 16187699 16761903 17494885 21937979	CTD
44	Lovastatin	8918723	CTD
45	Malondialdehyde	16518626	CTD
46	Mefenamic Acid	2314551	CTD
47	Melatonin	12019361	CTD
48	Melphalan	4571885	CTD
49	Mesalamine	View details 9740571 10393373 11205659 12187103 19174096 20699041	CTD
50	Methamphetamine	9794581	CTD
51	Methoxyflurane	4739327 4859609 5061073	CTD
52	Mitomycin	View details 6340628 6796250 6810311 9016902	CTD
53	N-Methyl-3,4-methylenedioxyamphetamine	9794581	CTD
54	Naproxen	1855326 3684403	CTD
55	Nevirapine	11263401	CTD
56	Niacin	19878707	CTD
57	Nicorandil	22622455	CTD
58	Olmesartan Medoxomil	15018153	CTD
59	Paraquat	26177651	CTD
60	Permethrin	26177651	CTD
61	Probenecid	8842764	CTD
62	Propylthiouracil	10344375	CTD
63	Puromycin Aminonucleoside	3323599 15039144 21937979	CTD
64	Ramipril	9851320	CTD
65	Saridon	5101354 8669433	CTD
66	Selenium	16518626	CTD
67	Simvastatin	12410059	CTD
68	Sodium Bicarbonate	9574465	CTD
69	Streptozocin	6459048	CTD
70	Sulfasalazine	1353741	CTD
71	Sulindac	3884224	CTD
72	Tacrolimus	10831087	CTD
73	Tenofovir	17502722 19226409 20523203	CTD
74	Zidovudine	11263401	CTD
75	alachlor	26177651	CTD
76	benazepril	8928272 11867951 17494885	CTD
77	eprosartan	15504943	CTD
78	hippuric acid	21483698	CTD
79	imazethapyr	26177651	CTD
80	indoleacetic acid	21483698	CTD
81	maxacalcitol	14714959	CTD
82	metolachlor	26177651	CTD
83	pendimethalin	26177651	CTD
84	phenylacetic acid	21483698	CTD
85	pircophen	2084385	CTD
86	pirfenidone	20006961	CTD
87	turmeric extract	19225048	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Acute kidney injury	36.4%
2	Hydronephrosis	29.2%
3	Hyperoxaluria	29.2%
4	Kidney Cortex Necrosis	29.2%
5	Kidney Papillary Necrosis	29.2%
6	Nephritis	29.2%
7	Nephrosclerosis	29.2%
8	Nephrosis	29.2%
9	Perinephritis	29.2%
10	Uremia	29.2%
11	Oxalosis	29.2%
12	Anuria	28.3%
13	Nephrolithiasis	28.3%
14	Urinary Bladder Diseases	24.1%
15	Ureteral Diseases	24.1%
16	Urethral Diseases	24.1%
17	Urination Disorders	24.1%
18	Urolithiasis	24.1%
19	Diabetes Insipidus	23.8%
20	Hepatorenal Syndrome	23.8%
21	Diabetic Nephropathy	23.5%
22	Renal hypertension	23.5%
23	Renal Artery Obstruction	23.5%
24	Renal Artery Stenosis	23.5%
25	Nephrocalcinosis	23.3%
26	Tuberculosis, Renal	22.2%
27	Kidney Neoplasm	19.7%
28	Urinary tract infection	19.6%
29	Ureterolithiasis	17.5%
30	Glomerulonephritis	17.3%
31	Nephritis, Interstitial	17.3%
32	Lipoid nephrosis	17.3%
33	Nephrotic Syndrome	17.3%
34	Pyelitis	17.3%
35	Pyonephrosis	17.3%
36	Nephrogenic Diabetes Insipidus	17.3%
37	Congenital Nephrogenic Diabetes Insipidus	17.3%
38	AIDS-Associated Nephropathy	16.7%
39	Multicystic Dysplastic Kidney	15.4%
40	Pyelonephritis	15.3%
41	Urogenital Abnormalities	14.8%
42	Kidney Calculi	14.6%
43	Azotemia	14.1%
44	Bladder neck obstruction	13.9%
45	Hypertension, Renovascular	13.9%
46	Cystitis	13.1%
47	Ureteral obstruction	13.1%
48	Ureterocele	13.1%
49	Urethral Obstruction	13.1%
50	Urethritis	13.1%
51	Vesico-Ureteral Reflux	13.1%
52	Urinary Retention	13.1%
53	Bladder Exstrophy	13%
54	Epispadias	13%
55	Renal Osteodystrophy	12.9%
56	Renal rickets	12.9%
57	Pyelocystitis	12.8%
58	Polycystic Kidney Diseases	11.7%
59	Renal Aminoacidurias	11.6%
60	Fanconi Syndrome	11.6%
61	Pseudohypoaldosteronism	11.6%
62	Liddle Syndrome	11.6%
63	Hemolytic-Uremic Syndrome	11.6%
64	Balkan Nephropathy	11.5%
65	Focal glomerulosclerosis	11.5%
66	Glycosuria, Renal	11.2%
67	Bacteriuria	10.5%
68	Glycosuria	10.5%
69	Hematuria	10.5%
70	Oliguria	10.5%
71	Polyuria	10.5%
72	Proteinuria	10.5%
73	Pyuria	10.5%
74	Urinary Calculi	10.5%
75	Cystocele	10.5%
76	Urinary Incontinence	10.5%
77	Urinary Bladder Fistula	10.4%
78	Bladder Neoplasm	10.4%
79	Ureteral Neoplasms	10.4%
80	Urethral Neoplasms	10.4%
81	Ureteral Calculi	10.4%
82	Mesoblastic Nephroma	10.2%
83	Renal Cell Carcinoma	10.1%
84	Papillary Renal Cell Carcinoma	10.1%
85	Renal tubular acidosis	9.9%
86	Zellweger Syndrome	9.8%
87	Genital Diseases, Male	9.7%
88	Glomerulonephritis, Membranoproliferative	9.6%
89	Pregnancy Complications	9.5%
90	Infertility	9.3%
91	Enuresis	8.9%
92	Nephroblastoma	8.3%
93	Anti-Glomerular Basement Membrane Disease	7.9%
94	Lupus Nephritis	7.8%
95	Urethral Stenosis	7.8%
96	Urethral stricture	7.8%
97	Hyperphosphaturia	7.7%
98	Polycystic Kidney, Autosomal Dominant	7.7%
99	Cystinuria	7.7%
100	Atypical Hemolytic Uremic Syndrome	7.6%
101	Hypospadias	7.6%
102	Urologic Neoplasms	7.4%
103	Horseshoe Kidney	7.4%
104	Endometriosis	7.2%
105	Uterine Diseases	7.2%
106	Vaginal Diseases	7.2%
107	Vulvar Diseases	7.2%
108	Endometrioma	7.2%
109	Sexually Transmitted Diseases	6.5%
110	Hermaphroditism	6.3%
111	Disorders of Sex Development	6.3%
112	Albuminuria	6.2%
113	Hemoglobinuria	6.2%
114	Urge Incontinence	6.2%
115	Genital Herpes	6.2%
116	Genital Neoplasms, Male	6%
117	Genital Neoplasms, Female	5.5%
118	Diurnal Enuresis	5.2%
119	Epididymitis	4.9%
120	Penile Diseases	4.9%
121	Prostatic Diseases	4.9%
122	Spermatic Cord Torsion	4.9%
123	Hemospermia	4.9%
124	Testicular Hydrocele	4.9%
125	Uterine Inversion	4.8%
126	Uterine Neoplasms	4.8%
127	Vaginal Neoplasms	4.8%
128	Vulvar Neoplasms	4.8%
129	Uterine Cancer	4.8%
130	Endometritis	4.8%
131	Denys-Drash Syndrome	4.7%
132	Polyhydramnios	4.7%
133	Obstetric Labor Complications	4.7%
134	Ectopic Pregnancy	4.7%
135	Pregnancy, Prolonged	4.7%
136	Puerperal Disorders	4.7%
137	Oligohydramnios	4.7%
138	Prenatal Injuries	4.7%
139	Vesicovaginal Fistula	4.4%
140	Dyspareunia	4.1%
141	Penile Neoplasms	4.1%
142	Prostatic Neoplasms	4.1%
143	Endometrial Hyperplasia	4%
144	Pyometra	4%
145	Vaginitis	4%
146	Vulvitis	4%
147	Vaginal Discharge	4%
148	Vulvodynia	4%
149	Uterine Rupture	3.9%
150	Cryptorchidism	3.9%
151	Fallopian Tube Neoplasms	3.8%
152	Testicular Diseases	3.8%
153	Varicocele	3.8%
154	Spermatocele	3.7%
155	Fetal Diseases	3.7%
156	Pregnancy Complications, Cardiovascular	3.7%
157	Pregnancy Complications, Neoplastic	3.7%
158	Abruptio Placentae	3.7%
159	Placenta Accreta	3.7%
160	Salpingitis	3.6%
161	Vulvovaginitis	3.6%
162	Pregnancy Complications, Hematologic	3.6%
163	Pregnancy Complications, Infectious	3.6%
164	Fetal Death	3.5%
165	Perinatal death	3.5%
166	Morning Sickness	3.5%
167	Gonadal Dysgenesis	3.4%
168	Adrenogenital Syndrome	3.4%
169	Ovotesticular Disorders of Sex Development	3.4%
170	Familial Hypophosphatemic Rickets	3.3%
171	Chorioamnionitis	3.2%
172	Ovarian Diseases	3.1%
173	Adnexitis	3%
174	Pruritus Vulvae	3%
175	Uterine hemorrhage	3%
176	Vaginal Fistula	3%
177	Pelvic Inflammatory Disease	3%
178	Uterine Prolapse	3%
179	Vaginal Prolapse	3%
180	Puerperal Infection	2.9%
181	Postpartum Hemorrhage	2.9%
182	Oophoritis	2.9%
183	Endometrial Neoplasms	2.9%
184	Gestational Diabetes	2.8%
185	ovarian neoplasm	2.8%
186	Uterine Cervical Incompetence	2.8%
187	Balanitis	2.7%
188	Benign prostatic hypertrophy	2.7%
189	Phimosis	2.7%
190	Priapism	2.7%
191	prostatitis	2.7%
192	Prostatic Adenoma	2.7%
193	Benign Prostatic Hyperplasia	2.7%
194	Prostatic Hypertrophy	2.7%
195	Prostatic Hyperplasia	2.7%
196	Abortion, Habitual	2.4%
197	Dystocia	2.4%
198	Eclampsia	2.4%
199	Fetal Membranes, Premature Rupture	2.4%
200	Placental Insufficiency	2.4%
201	Pre-Eclampsia	2.4%
202	Prenatal Exposure Delayed Effects	2.4%
203	HELLP Syndrome	2.4%
204	Placenta, Retained	2.4%
205	Prostatic Neoplasms, Castration-Resistant	2.4%
206	Hyperandrogenism	2.4%
207	Uterine Cervicitis	2.4%
208	Leukorrhea	2.4%
209	Parametritis	2.4%
210	Carcinoma, Endometrioid	2.1%
211	Testicular Neoplasms	2.1%
212	Premature Ejaculation	2.1%
213	Erectile dysfunction	2.1%
214	Orchitis	2%
215	Abortion, Veterinary	1.9%
216	Pregnancy Complications, Parasitic	1.9%
217	Candidiasis, Vulvovaginal	1.9%
218	Bacterial Vaginosis	1.8%
219	Lactation Disorder	1.8%
220	Mastitis	1.8%
221	Depression, Postpartum	1.8%
222	Embryo Loss	1.8%
223	Fetal Resorption	1.8%
224	Hyperemesis Gravidarum	1.8%
225	Trichomonas Vaginitis	1.8%
226	Uterine Perforation	1.8%
227	Ovarian Hyperstimulation Syndrome	1.8%
228	Metrorrhagia	1.8%
229	Chlamydia Infections	1.7%
230	Gonorrhea	1.7%
231	Turner Syndrome	1.6%
232	Azoospermia	1.6%
233	Oligospermia	1.6%
234	Impotence, Vasculogenic	1.6%
235	Asthenozoospermia	1.6%
236	Teratozoospermia	1.6%
237	Aspermia	1.6%
238	Kallmann Syndrome	1.5%
239	Syphilis	1.5%
240	granulosa cell tumor	1.5%
241	Carcinoma, Ovarian Epithelial	1.5%
242	Fetal Growth Retardation	1.5%
243	Trophoblastic Neoplasms	1.5%
244	Embolism, Amniotic Fluid	1.5%
245	Fetal Hypoxia	1.5%
246	Fetal Alcohol Spectrum Disorders	1.5%
247	Corpus Luteum Cyst	1.5%
248	Ovarian Cysts	1.5%
249	Breech Presentation	1.5%
250	Anovulation	1.4%
251	Menorrhagia	1.4%
252	Stillbirth	1.4%
253	Premature Menopause	1.4%
254	Klinefelter Syndrome	1.3%
255	Premature Birth	1.3%
256	Endometrial Stromal Sarcoma	1.2%
257	Lymphogranuloma Venereum	1.1%
258	Meconium Aspiration Syndrome	1.1%
259	Galactorrhea	1%
260	Polycystic Ovary Syndrome	1%
261	Leydig Cell Tumor	0.7%
262	Choriocarcinoma	0.7%
263	Hydatidiform Mole	0.5%
264	Hydrops Fetalis	0.5%

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