MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vulvodynia

(UMLS:C0406670)

Definition:: Complex pain syndrome with unknown etiology, characterized by constant or intermittent generalized vulva pain (Generalized vulvodynia) or localized burning sensations in the VESTIBULE area when pressure is applied (Vestibulodynia, or Vulvar Vestibulitis Syndrome). Typically, vulvar tissue with vulvodynia appears normal without infection or skin disease. Vulvodynia impacts negatively on a woman's quality of life as it interferes with sexual and daily activities.
UMLS ID:: C0406670
MeSH ID:: D056650

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.944.951

Synonym(s)

Vulvodynia

Burning (of);vulva

Burning vulva

Pain of vulva

Pain;vulva

Vulva painful

Vulval pain

Vulvar pain

Vulvodynia, unspecified

10.

burning vulva

11.

discomfort of vulva

12.

pain of vulva

13.

pain vulva

14.

vulva burning

15.

vulva pain

16.

vulval pain

17.

vulvar burning

18.

vulvar discomfort

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Aminolevulinic Acid		17847765	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Vulvitis	48.4%
2	Vulvovaginitis	35.1%
3	Endometriosis	34.4%
4	Uterine Diseases	34.4%
5	Vaginal Diseases	34.4%
6	Endometrioma	34.4%
7	Pruritus Vulvae	32.6%
8	Vulvar Neoplasms	29%
9	Endometritis	26.2%
10	Infertility	23.6%
11	Endometrial Hyperplasia	22.6%
12	Pyometra	22.6%
13	Vaginitis	22.6%
14	Vaginal Discharge	22.6%
15	Salpingitis	22.3%
16	Candidiasis, Vulvovaginal	22.1%
17	Uterine Inversion	18.5%
18	Urologic Diseases	18.1%
19	Oophoritis	16.9%
20	Uterine Cervicitis	16.8%
21	Leukorrhea	16.8%
22	Parametritis	16.8%
23	Pregnancy Complications	16.4%
24	Uterine Neoplasms	16.1%
25	Vaginal Neoplasms	16.1%
26	Uterine Cancer	16.1%
27	Ovarian Diseases	15.6%
28	Adnexitis	15.2%
29	Uterine hemorrhage	15.2%
30	Vaginal Fistula	15.2%
31	Pelvic Inflammatory Disease	15.2%
32	Uterine Prolapse	15.1%
33	Vaginal Prolapse	15.1%
34	Sexually Transmitted Diseases	14.9%
35	Uterine Rupture	14.2%
36	Genital Herpes	14%
37	Urogenital Abnormalities	13.5%
38	Uterine Cervical Incompetence	13.4%
39	Fallopian Tube Neoplasms	13.3%
40	Endometrial Neoplasms	12%
41	Dyspareunia	11.7%
42	Bacterial Vaginosis	11.6%
43	Trichomonas Vaginitis	11.4%
44	Uterine Perforation	11.4%
45	Ovarian Hyperstimulation Syndrome	11.4%
46	Metrorrhagia	11.2%
47	Vesicovaginal Fistula	10.4%
48	Urinary Bladder Diseases	10.1%
49	Kidney Diseases	10.1%
50	Ureteral Diseases	10.1%
51	Urethral Diseases	10.1%
52	Urination Disorders	10.1%
53	Urolithiasis	10.1%
54	Genital Neoplasms, Female	9.9%
55	ovarian neoplasm	9.1%
56	Corpus Luteum Cyst	8.7%
57	Ovarian Cysts	8.7%
58	Anovulation	8.5%
59	Menorrhagia	8.5%
60	Polyhydramnios	8.5%
61	Obstetric Labor Complications	8.5%
62	Ectopic Pregnancy	8.5%
63	Pregnancy, Prolonged	8.5%
64	Puerperal Disorders	8.5%
65	Oligohydramnios	8.5%
66	Prenatal Injuries	8.5%
67	Premature Menopause	8.4%
68	Bladder Exstrophy	8.3%
69	Epispadias	8.3%
70	Tuberculosis, Renal	8.2%
71	Anuria	7.8%
72	Ureterolithiasis	7.8%
73	Nephrolithiasis	7.8%
74	Carcinoma, Endometrioid	7.7%
75	Urinary tract infection	7.7%
76	Urologic Neoplasms	7.6%
77	Horseshoe Kidney	7.6%
78	Multicystic Dysplastic Kidney	7.4%
79	Endometrial Stromal Sarcoma	7.2%
80	Polycystic Ovary Syndrome	7.1%
81	Bladder neck obstruction	6.8%
82	Abruptio Placentae	6.6%
83	Placenta Accreta	6.6%
84	Urinary Bladder Fistula	6.5%
85	Bladder Neoplasm	6.5%
86	Cystitis	6.5%
87	Hydronephrosis	6.5%
88	Hyperoxaluria	6.5%
89	Kidney Cortex Necrosis	6.5%
90	Kidney Neoplasm	6.5%
91	Kidney Papillary Necrosis	6.5%
92	Nephritis	6.5%
93	Nephrosclerosis	6.5%
94	Nephrosis	6.5%
95	Perinephritis	6.5%
96	Kidney Failure	6.5%
97	Uremia	6.5%
98	Ureteral Neoplasms	6.5%
99	Ureteral obstruction	6.5%
100	Ureterocele	6.5%
101	Urethral Neoplasms	6.5%
102	Urethral Obstruction	6.5%
103	Urethritis	6.5%
104	Vesico-Ureteral Reflux	6.5%
105	Urinary Retention	6.5%
106	Oxalosis	6.5%
107	Renal Insufficiency	6.5%
108	Hermaphroditism	6.1%
109	Disorders of Sex Development	6.1%
110	granulosa cell tumor	6.1%
111	Carcinoma, Ovarian Epithelial	6.1%
112	Hypospadias	6%
113	Fetal Diseases	6%
114	Pregnancy Complications, Cardiovascular	6%
115	Pregnancy Complications, Neoplastic	6%
116	Pregnancy Complications, Hematologic	5.7%
117	Pregnancy Complications, Infectious	5.7%
118	Chlamydia Infections	5.7%
119	Gonorrhea	5.7%
120	Fetal Death	5.6%
121	Perinatal death	5.6%
122	Morning Sickness	5.6%
123	Kidney Calculi	5.4%
124	Ureteral Calculi	5.4%
125	Chorioamnionitis	5.3%
126	Pyelocystitis	5.3%
127	Diabetes Insipidus	5%
128	Hepatorenal Syndrome	5%
129	Puerperal Infection	5%
130	Abortion, Habitual	4.9%
131	Bacteriuria	4.9%
132	Diabetic Nephropathy	4.9%
133	Dystocia	4.9%
134	Eclampsia	4.9%
135	Fetal Membranes, Premature Rupture	4.9%
136	Glycosuria	4.9%
137	Hematuria	4.9%
138	Renal hypertension	4.9%
139	Oliguria	4.9%
140	Placental Insufficiency	4.9%
141	Polyuria	4.9%
142	Postpartum Hemorrhage	4.9%
143	Pre-Eclampsia	4.9%
144	Prenatal Exposure Delayed Effects	4.9%
145	Proteinuria	4.9%
146	Pyuria	4.9%
147	Renal Artery Obstruction	4.9%
148	Renal Artery Stenosis	4.9%
149	Urinary Calculi	4.9%
150	HELLP Syndrome	4.9%
151	Placenta, Retained	4.9%
152	Cystocele	4.9%
153	Nephrocalcinosis	4.9%
154	Urinary Incontinence	4.9%
155	Syphilis	4.8%
156	Glomerulonephritis	4.8%
157	Nephritis, Interstitial	4.8%
158	Lipoid nephrosis	4.8%
159	Nephrotic Syndrome	4.8%
160	Pyelitis	4.8%
161	Pyonephrosis	4.8%
162	Urethral Stenosis	4.8%
163	Nephrogenic Diabetes Insipidus	4.8%
164	Congenital Nephrogenic Diabetes Insipidus	4.8%
165	Acute kidney injury	4.8%
166	Urethral stricture	4.8%
167	Pyelonephritis	4.8%
168	Lymphogranuloma Venereum	4.6%
169	Gestational Diabetes	4.2%
170	Mesoblastic Nephroma	4.1%
171	Renal Cell Carcinoma	4.1%
172	Papillary Renal Cell Carcinoma	4.1%
173	Enuresis	4%
174	Balkan Nephropathy	4%
175	Focal glomerulosclerosis	4%
176	Kidney Failure, Chronic	4%
177	Gonadal Dysgenesis	3.9%
178	Adrenogenital Syndrome	3.9%
179	Ovotesticular Disorders of Sex Development	3.9%
180	Azotemia	3.7%
181	Albuminuria	3.6%
182	Glycosuria, Renal	3.6%
183	Hemoglobinuria	3.6%
184	Hypertension, Renovascular	3.6%
185	Urge Incontinence	3.6%
186	Abortion, Veterinary	3.5%
187	Pregnancy Complications, Parasitic	3.5%
188	Lactation Disorder	3.3%
189	Mastitis	3.3%
190	Depression, Postpartum	3.3%
191	Embryo Loss	3.3%
192	Nephroblastoma	3.3%
193	Fetal Resorption	3.3%
194	AIDS-Associated Nephropathy	3.3%
195	Hyperemesis Gravidarum	3.2%
196	Premature Birth	3.2%
197	Hyperandrogenism	3.2%
198	Glomerulonephritis, Membranoproliferative	3.2%
199	Denys-Drash Syndrome	3%
200	Polycystic Kidney Diseases	2.9%
201	Diurnal Enuresis	2.9%
202	Renal Aminoacidurias	2.9%
203	Fanconi Syndrome	2.9%
204	Pseudohypoaldosteronism	2.9%
205	Liddle Syndrome	2.9%
206	Hemolytic-Uremic Syndrome	2.9%
207	Fetal Growth Retardation	2.5%
208	Trophoblastic Neoplasms	2.5%
209	Embolism, Amniotic Fluid	2.5%
210	Fetal Hypoxia	2.5%
211	Fetal Alcohol Spectrum Disorders	2.5%
212	Anti-Glomerular Basement Membrane Disease	2.5%
213	Breech Presentation	2.4%
214	Lupus Nephritis	2.4%
215	Stillbirth	2.4%
216	Renal Osteodystrophy	2.4%
217	Renal rickets	2.4%
218	Renal tubular acidosis	2.4%
219	Polycystic Kidney, Autosomal Dominant	2.4%
220	Cystinuria	2.4%
221	Atypical Hemolytic Uremic Syndrome	2.4%
222	Galactorrhea	2.2%
223	Kallmann Syndrome	2.1%
224	Turner Syndrome	2.1%
225	Hyperphosphaturia	1.8%
226	Klinefelter Syndrome	1.8%
227	Zellweger Syndrome	1.8%
228	Meconium Aspiration Syndrome	1.7%
229	Choriocarcinoma	1.3%
230	Hydatidiform Mole	1.2%
231	Familial Hypophosphatemic Rickets	0.9%
232	Hydrops Fetalis	0.8%

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