MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Streptozocin

(ZSJLQEPLLKMAKR-GKHCUFPYSA-N)

Structure

SMILES: OC[C@H]1O[C@H](O)[C@@H]([C@H]([C@@H]1O)O)NC(=O)N(N=O)C
Type(s): Approved; Investigational
ATC code(s): L01AD04
Molecular Formula:: C8H15N3O7
Molecular Weight:: 265.221
Log P:: -2.5000
Hydrogen Bond Acceptor:: 10
Hydrogen Bond Donor:: 5
TPSA:: 151.92
CAS Number(s):: 18883-66-4; 66395-18-4

Synonym(s)

Streptozocin

Streptozotocin

2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose

Streptozotocine

Zanosar

External Link(s)

MeSH	D013311
PubChem Compound	29327
ChEBI	9288
CHEMBL	CHEMBL1603
DrugBank	DB00428
KEGG	cpd:C07313 dr:D05932
Therapeutic Target Database	D0I8RR
ZINC	3977737

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acute kidney injury	6281169	CTD
2	Adenocarcinoma	4261143	CTD
3	Adrenocortical carcinoma	11106117	CTD
4	Albuminuria	View details 7589874 8206591 10553876 11508272 11912544 14647892 15818713 16037304 18569938 19673932 19895808 21832210 22116744 22733486 23376009 23611540 24413998 25503068 29291386 29420703 29988851	CTD
5	Aminoaciduria		SIDER
6	Anuria		SIDER
7	Anxiety Disorders	21069392	CTD
8	Asthenozoospermia	8417201 26499206	CTD
9	Atherosclerosis	16020748 24508943	CTD
10	Auditory neuropathy	18164131	CTD
11	Azotemia	186169 4261143	CTD
12	Blood urea increased		SIDER
13	Body Weight Changes	30927557	CTD
14	Bone Diseases	25617479	CTD
15	Bradycardia	View details 1481903 3525850 3544871 7564366	CTD
16	Brain Diseases, Metabolic	18515212	CTD
17	Brain Injuries	27566243	CTD
18	Burning sensation		SIDER
19	Carcinoid Tumor	16051944	CTD
20	Cardiomegaly	1481903 10779124 31323227	CTD
21	Cardiomyopathy, Dilated	12198386	CTD
22	Cataract	153477 25541468 30958922	CTD
23	Chemical and Drug Induced Liver Injury	View details 21416479 21630391 23647015 26071184 26286521 26944432 30144451 30927557 31100278	CTD
24	Cognition Disorders	View details 12270754 12859423 18208924 18343489 18515212 19374888 19464315 19494442 20600246 20683499 24055495 27702591 28259689 28499986 29382564 30481507	CTD
25	Dementia	View details 19494442 19705549 20369229 28499986	CTD
26	Demyelinating Diseases	19840221	CTD
27	Depressive disorder	19502549	CTD
28	Diabetes Mellitus, Experimental	View details 124711 153477 658620 1374869 1472065 1481903 1533192 1640849 1692544 1826492 1828768 1999276 2149364 2177838 2449932 2475585 2835966 2975197 3044883 3335240 3525850 3600285 3802581 3817338 6225876 6379147 6708725 7564366 7589874 7637645 7649603 7759858 7830882 7843773 7856696 8012888 8069975 8177907 8206591 8331284 8412499 8417201 8483299 8591707 8740154 9171957 9243097 9323440 9523171 9525068 9602473 9695876 9739991 9868179 10052637 10447556 10485912 10553876 10700396 10777035 10779124 10780678 10826407 10828832 11055810 11099694 11226682 11260395 11357483 11357882 11424224 11508272 11696579 11711510 11890746 11912544 12058330 12083368 12093613 12123627 12137914 12203022 12377873 12434137 12446591 12458661 12535201 12540624 12592403 12644472 12736908 12845431 12888618 12900435 12967931 14514642 14586741 14594557 14610266 14622824 14647892 14706871 14766238 14871415 14987854 15053821 15059549 15298345 15309289 15322501 15362513 15563877 15587404 15590127 15645163 15720826 15793251 15818713 15821039 15831366 15855331 15862027 15954931 15957552 15964614 16020748 16037304 16045816 16139267 16177186 16281504 16286809 16306357 16336586 16380481 16380483 16409969 16423284 16443766 16445588 16523407 16581090 16584726 16595661 16620296 16684804 16685413 16732983 16797897 16841179 16919431 16979161 16980342 17002671 17042909 17063547 17082237 17098815 17117553 17145126 17177138 17270171 17434477 17442507 17534120 17548264 17589825 17627248 17697867 17709884 17725854 17854708 17874149 17890855 18093596 18173414 18203848 18211931 18227068 18266981 18284379 18291360 18331706 18332268 18377884 18413206 18544896 18569938 18583417 18603373 18675532 18715473 18777112 18829990 18945756 18983991 18998217 18999900 19002579 19007766 19038238 19059388 19071154 19074809 19133311 19166939 19190261 19202557 19236438 19246972 19279317 19298542 19356108 19369054 19383439 19388005 19496084 19497428 19502549 19561140 19586609 19587355 19616452 19626998 19665520 19682476 19690068 19693696 19695236 19820293 19840221 19844130 19895808 19931367 19951573 19957251 19960420 20003708 20053369 20086057 20108212 20123097 20148083 20211156 20224876 20228414 20307515 20307516 20349157 20363216 20399799 20424226 20433812 20474069 20574430 20620209 20643114 20654064 20665664 20696151 20709041 20711301 20732820 20801139 20816776 20821229 20821936 20828602 20828608 20832942 20869956 20951120 21069392 21078310 21128592 21136691 21139377 21163323 21183729 21300041 21373835 21381899 21382363 21416479 21439094 21439372 21450970 21630391 21664865 21666113 21791967 21821013 21832210 21912612 22031849 22056647 22058332 22081404 22116744 22170771 22172158 22191573 22198047 22228707 22287284 22342832 22406263 22429817 22456468 22476978 22538082 22540856 22675305 22713545 22733486 22744176 22775417 22785018 22790776 22886793 22940631 22956389 22960630 23122718 23147376 23200776 23267840 23319174 23333261 23376009 23406761 23458895 23499715 23611540 23612842 23733546 23767859 23792339 23795780 23859249 23927877 23993977 24001619 24136780 24167738 24263156 24269735 24413998 24440807 24513509 24530320 24632065 24658657 24707343 24740756 24752916 24760747 24781736 24810525 24854284 24877639 24880026 24923654 24927960 24946264 24954035 24967692 25050809 25057273 25191525 25199697 25240712 25246140 25362599 25446853 25541178 25541468 25559857 25617479 25617480 25635252 25641191 25665769 25808216 25849131 25986969 25999625 26006044 26071184 26286521 26341651 26343954 26362499 26474837 26499206 26522834 26616445 26654777 26677078 26690102 26700463 26721197 26748309 26887929 26944432 26972669 27038876 27109771 27131411 27206737 27270450 27350165 27417257 27488359 27542954 27566243 27616468 27629361 27769711 27783111 27939242 28039404 28259689 28330423 28625491 28648635 28700904 28757134 28822685 28856781 28904557 29059224 29216956 29223569 29247773 29291386 29382564 29409856 29420703 29421519 29526571 29614383 29935216 29944876 30144451 30365938 30421503 30582900 30583000 30611788 30657622 30802477 30817903 30927557 30958922 30980806 31009641 31063766 31100278 31173751 31499052	CTD
29	Diabetes Mellitus	View details 145871 1445173 1825617 2055425 2709684 3155884 3156984 6727808 7624867 7728901 11057757 11216864 11324466 11353731 11589752 12398930 12956402 15720789 15942051 16285004 16289604 16731828 16752005 16879496 17982899 17989502 18758938 23500772 23665085 23786522	CTD
30	Diabetic Angiopathies	View details 19690068 20474069 22198047 22456468 26690102	CTD
31	Diabetic Cardiomyopathies	View details 3044883 6225876 6708725 7564366 11375343 15587404 15645163 16025228 16045816 16129698 16685413 16980342 17909696 18203848 18332268 18703049 18945756 19561140 19951573 19957251 20828608 21136691 21416479 22429817 23677724 24889822 24927960 25050809 28178614 28700904 31323227	CTD
32	Diabetic Neuropathies	View details 1692544 1828768 2060723 2068089 2475585 3335240 7587852 8000974 8195800 8543945 9323440 9628756 10952660 11226682 11353731 11523311 12502508 12618307 14622824 15958131 16581090 17042909 17187935 17303110 17989505 18164131 18331706 18492948 18583417 18810243 18950446 18992286 19300402 19591853 19815945 19840219 19957886 20213226 20447294 20624991 20710117 22198047 24263156 24752916	CTD
33	Diabetic Retinopathy	View details 10485912 17065523 17117553 17662242 18211931 18779489 19074809 19279317 20445119 20654064 22058332	CTD
34	Dyslipidemias	View details 12123627 16037304 16523407 17177138 19695236 21078310 23927877 24140466 27270450 27488359 28946194 29382564 29988851 31499052	CTD
35	Endomyocardial Fibrosis	View details 12140129 18829990 24889822 31323227	CTD
36	Eosinophilia		SIDER
37	Erectile dysfunction	21664865	CTD
38	Erythema		SIDER
39	Extravasation		SIDER
40	Fatigue	30144451	CTD
41	Fatty Liver	24815820 27270450 27769711	CTD
42	Febrile Neutropenia		SIDER
43	Feeling abnormal		SIDER
44	Fetal Resorption	27109771	CTD
45	Fibrosis	View details 2149364 17589825 21381899 21416479 24707343 24967692 28904557 29291386 29953732 29988851	CTD
46	Follicular cyst	30421503	CTD
47	Glomerulonephritis	19895808	CTD
48	Glycosuria, Renal	11219485	CTD
49	Glycosuria	153477 3600285	CTD SIDER
50	Heart Diseases	View details 12093613 16423284 24954035 26972669	CTD
51	Heart Injuries	23500772	CTD
52	Heart failure	16045816	CTD
53	Hemorrhage	27521901	CTD
54	Hepatomegaly	27769711 31100278	CTD
55	Hepatotoxicity		SIDER
56	Hodgkin Disease	6459048	CTD
57	Hyperaldosteronism	2819817	CTD
58	Hyperalgesia	View details 7830882 8577488 10952660 11226682 11983324 12618307 12642375 14622824 15976016 16472913 16581090 16584726 17042909 17112505 17303110 17597604 17989504 17989505 18234883 18331706 18544896 18701828 18799818 18810243 18950446 18992286 19300402 19383439 19577366 19591853 19815945 19957886 20447294 20832942 24752916 30583000	CTD
59	Hypercholesterolemia	20696151 24815820 28178614	CTD
60	Hyperglycemia	View details 153477 1472065 1481903 2060723 3817338 7564366 7856696 8012888 8177907 9522273 9523171 9739991 10052637 10052646 10700396 11357483 11357882 11798618 12031899 12123627 12242689 12592403 15246841 15384252 15818713 16037304 16524951 16584726 16632197 17145126 17279352 17434477 17589825 17627248 17675792 18229453 18291360 18377884 18701828 18823964 18983991 19002579 19007766 19038238 19059388 19690068 19895808 20086057 20424226 20446767 20620209 20624991 20665664 20801139 20821229 21078310 21128592 21382363 21457706 21630391 21778425 21832210 22228707 22342832 22456468 22476978 22538082 22713545 22733486 22886793 22940631 23333261 23406761 23453443 23458895 23466488 23665085 23927877 24001619 24413998 24508943 24752916 24781736 24810525 24815820 24877639 24946264 25191525 25199697 25446853 25541178 25617480 25635252 25808216 25849131 25905778 25986969 25999625 26006044 26286521 26341651 26362499 26499206 26522834 26700463 26748309 26887929 27038876 27417257 27488359 27542954 27783111 28178614 28259689 28330423 28625491 28648635 28700904 28822685 28904557 28946194 29223569 29247773 29331653 29382564 29409856 29420703 29421519 29526571 29614383 29935216 29988851 30144451 30365938 30551545 30582900 30583000 30611788 30657622 30802477 30817903 30927557 30958922 30980806 31009641 31063766 31100278 31323227 31499052	CTD
61	Hyperinsulinism	18377884 29988851	CTD
62	Hyperlipoproteinemias	20696151	CTD
63	Hyperphagia	24810525	CTD
64	Hypertriglyceridemia	19397970 20696151	CTD
65	Hypertrophy	23733546 24810525	CTD
66	Hypoalphalipoproteinemias	20696151	CTD
67	Hypoglycemia	22940631	CTD
68	Hypokalemia	11219485	CTD
69	Hypophosphatemia	11219485	CTD
70	Hypotension	3544871	CTD
71	Hypothyroidism	7564366	CTD
72	Inflammation	View details 17589825 18291360 23647015 24333387 24967692 27702591	CTD SIDER
73	Injection site pain		SIDER
74	Insulin Resistance	View details 1640849 18377884 20836762 24001619 24854284 24946264 25446853 25808216 26522834 27270450 27292126 28757134 29526571 29614383 29935216 29988851	CTD
75	Intestinal Diseases	31009641	CTD
76	Ketonuria		SIDER
77	Ketosis	29420703	CTD
78	Kidney Calculi	2827466	CTD
79	Kidney Diseases	View details 135666 185926 199092 11798618 12093613 12956402 15053821 16037304 18413206 19246972 19369054 19616452 20732820 21450970 21630391 23376009 23767859 24877639 24923654 25665769 27292126 29526571 31063766	CTD
80	Kidney Failure, Chronic	6459048	CTD
81	Lethargy		SIDER
82	Leukopenia	135666 142579	CTD SIDER
83	Leukostasis	10485912	CTD
84	Leydig Cell Tumor	6225653	CTD
85	Liver Cirrhosis	26286521	CTD
86	Liver diseases	View details 135666 199092 4352784 15384252 31499052	CTD
87	Liver neoplasms	227055 2532796 6225653	CTD
88	Memory Disorders	View details 10672254 11212865 19705549 20369229 21069392 22062134 23060470 23087135 23562514 24333387 24902786 25037167 26511841 27087133 30481507 31029786	CTD
89	Micronuclei, Chromosome-Defective	25665769	CTD
90	Motor Skills Disorders	24752916	CTD
91	Movement Disorders	19840221	CTD
92	Myelosuppression		SIDER
93	Myocardial Reperfusion Injury	21912612	CTD
94	Nausea	View details 135666 142579 4261143 4352784	CTD SIDER
95	Necrosis	View details 17098815 23733546 25240712 27417257 27521901	CTD SIDER
96	Neoplasms	4260577	CTD
97	Nephritis, Interstitial	186169	CTD
98	Nephritis	21832210 29988851	CTD
99	Nephrogenic Diabetes Insipidus		SIDER
100	Nephrosclerosis	9523171 23611540 27542954	CTD
101	Nerve Degeneration	19957886	CTD
102	Neural Tube Defects	26073000 26887929	CTD
103	Neuralgia	16472913 18992286 19840219	CTD
104	Neurobehavioral Manifestations	24877639	CTD
105	Neutropenia		SIDER
106	Non-alcoholic Fatty Liver Disease	23647015 29127188	CTD
107	Obesity	18377884	CTD
108	Oligospermia	8417201 26499206	CTD
109	Pain	16305795	CTD SIDER
110	Pancreatic Diseases	View details 21078310 23927877 23954466 26064446 26721197 27521901 29526571	CTD
111	Pancytopenia		SIDER
112	Peripheral Nervous System Diseases	1533192 8483299	CTD
113	Peroneal Neuropathies	2868874	CTD
114	Polydipsia	17589825 24810525 30144451	CTD
115	Polyuria	View details 2949606 7987072 9602473 15053821 17589825 20086057 29331653 30144451	CTD
116	Prenatal Injuries	26887929 27109771	CTD
117	Prostatic Diseases	28904557	CTD
118	Protein urine present		SIDER
119	Proteinuria	View details 3538860 4261143 9523171 11219485 15053821 15322501 17270171 17890855 24877639 25617480 26341651	CTD SIDER
120	Reflex, Abnormal	3525850	CTD
121	Renal Aminoacidurias	11219485	CTD
122	Renal Insufficiency	2827466 4352784 29988851	CTD
123	Renal hypouricemia	11219485	CTD
124	Renal tubular acidosis		SIDER
125	Reperfusion Injury	12540624	CTD
126	Retinal Degeneration	12592403	CTD
127	Sarcoma	135666	CTD
128	Testicular Diseases	29953732	CTD
129	Thrombocytopenia	135666 142579	CTD SIDER
130	Thrombosis	227055	CTD
131	Uremia	11219485	CTD
132	Urinary Bladder Diseases	2055425 17989502	CTD
133	Urologic Diseases	67817	CTD
134	Vascular Diseases	20732820	CTD
135	Vasculitis	9131432	CTD
136	Ventricular Dysfunction, Left	View details 16780994 16909474 22675305 23677724 24810525 24889822 28178614 28856781 31323227	CTD
137	Ventricular Dysfunction	23500772	CTD
138	Ventricular Remodeling	15362513	CTD
139	Violent		SIDER
140	Vomiting	4261143 4352784	CTD SIDER
141	Weight Gain	View details 26522834 27350165 29614383 29988851	CTD
142	insulinoma	199092 6225653	CTD SIDER

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