MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Syphilis

(UMLS:C0039128)

Definition:: A contagious venereal disease caused by the spirochete TREPONEMA PALLIDUM.
UMLS ID:: C0039128
MeSH ID:: D013587

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.400.840.744|C01.252.810.859|C01.252.847.840.744|C01.539.778.281.859

Classification 2:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.668.281.859

Classification 3:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.711.281.859

Synonym(s)

Syphilis

Infection by Treponema pallidum

Lues

Luetic disease

SYPHILIS

Syphilis, NOS

Syphilis, stage unspecified

Syphilis, unspecified

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Triamcinolone Acetonide	FAERS: 5		US FAERS
2	teriflunomide	FAERS: 4		US FAERS
3	Alendronate	FAERS: 3		US FAERS
4	Carbamazepine	FAERS: 2		US FAERS
5	Finasteride	FAERS: 2		US FAERS
6	Octreotide	FAERS: 2		US FAERS
7	Odefsey	FAERS: 2		US FAERS
8	Telbivudine	FAERS: 2		US FAERS
9	Tenofovir	FAERS: 2		OFFSIDES US FAERS
10	Varenicline	FAERS: 2		US FAERS
11	apremilast	FAERS: 2		US FAERS
12	4-hydroxybutyric acid	FAERS: 1		US FAERS
13	Acyclovir	FAERS: 1		US FAERS
14	Afatinib	FAERS: 1		US FAERS
15	Cladribine	FAERS: 1		US FAERS
16	Clozapine	FAERS: 1		US FAERS
17	Darunavir	FAERS: 1		OFFSIDES US FAERS
18	Dexamethasone	FAERS: 1		US FAERS
19	Emtricitabine, Rilpivirine, Tenofovir Drug Combination	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
20	Fluoxetine	FAERS: 1		US FAERS
21	Imiquimod	FAERS: 1		US FAERS
22	Leflunomide	FAERS: 1		US FAERS
23	Naproxen	FAERS: 1		US FAERS
24	Norgestrel	FAERS: 1		US FAERS
25	Olanzapine	FAERS: 1		US FAERS
26	Prednisone	FAERS: 1		US FAERS
27	Pregabalin	FAERS: 1		US FAERS
28	Thalidomide	FAERS: 1		US FAERS
29	Zoledronic Acid	FAERS: 1		US FAERS
30	ambrisentan	FAERS: 1		US FAERS
31	apixaban	FAERS: 1		US FAERS
32	Aluminum Hydroxide			OFFSIDES
33	Arsenicals		20284337	CTD
34	Doxycycline		8108759	CTD
35	Emtricitabine			SIDER
36	Etoricoxib			OFFSIDES
37	Indinavir			OFFSIDES
38	Lamivudine			OFFSIDES
39	Medroxyprogesterone Acetate			OFFSIDES
40	Medroxyprogesterone			OFFSIDES
41	Methamphetamine		20679964	CTD
42	Mexiletine			OFFSIDES
43	Nevirapine			OFFSIDES
44	Nitrazepam			OFFSIDES
45	Oxaprozin			OFFSIDES
46	Penicillin G			OFFSIDES
47	Tenofovir			OFFSIDES
48	Tolterodine Tartrate			OFFSIDES
49	abacavir			OFFSIDES
50	distigmine			OFFSIDES
51	rofecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Chlamydia Infections	52.4%
2	Gonorrhea	52.4%
3	Lymphogranuloma Venereum	38.7%
4	Borrelia Infections	36.7%
5	Leptospirosis	36.7%
6	Lyme Disease	33.4%
7	Relapsing Fever	33.4%
8	Lyme Neuroborreliosis	30.8%
9	Erythema Chronicum Migrans	29.4%
10	Central Nervous System Bacterial Infections	27.3%
11	Skin Diseases, Bacterial	26.3%
12	Bacteremia	26.2%
13	Human Ehrlichiosis	25.1%
14	Gram-Positive Bacterial Infections	24.8%
15	Bacterial Vaginosis	24.5%
16	Bacterial Endocarditis	23.9%
17	Human anaplasmosis	22.8%
18	Mycetoma	22.4%
19	Erysipelas	22.4%
20	Staphylococcal Skin Infections	22.4%
21	Japanese Spotted Fever	22.2%
22	Impetigo	21.6%
23	Bordetella Infections	20.9%
24	Brucellosis	20.9%
25	Campylobacter infection	20.9%
26	Enterobacteriaceae Infections	20.9%
27	Pseudomonas Infections	20.9%
28	Q Fever	20.9%
29	Vibrio Infections	20.9%
30	Helicobacter Infections	20.9%
31	Neisseriaceae Infections	20.9%
32	Burkholderia Infections	20.9%
33	Flavobacteriaceae Infections	20.9%
34	Moraxellaceae Infections	20.9%
35	Burkholderia cepacia Infection	20.9%
36	Erythrasma	20.7%
37	Ecthyma	20.4%
38	Subacute Bacterial Endocarditis	20.4%
39	Ulcerative stomatitis	19.9%
40	Neurosyphilis	19.4%
41	Pneumonia, Bacterial	19.4%
42	Hidradenitis Suppurativa	19.2%
43	Pertussis	18.2%
44	Rocky Mountain Spotted Fever	17.9%
45	Rhinoscleroma	17.8%
46	Gram-Negative Bacterial Infections	17.8%
47	Mycoses	17.7%
48	Syphilis	16.7%
49	Staphylococcal Scalded Skin Syndrome	16.4%
50	Urinary tract infection	16%
51	Central Nervous System Infection	15.6%
52	Ophthalmia Neonatorum	15.4%
53	Trachoma	15.4%
54	Actinomycetales Infections	15.3%
55	Clostridium Infections	15.3%
56	Listeriosis	15.3%
57	Staphylococcal Infections	15.3%
58	Streptococcal Infections	15.3%
59	Bacillaceae Infections	15.3%
60	Clostridium difficile infection	15.3%
61	Meningitis, Haemophilus	15.1%
62	Hordeolum	15.1%
63	Furunculosis	15%
64	furuncle	15%
65	Bacterial conjunctivitis	15%
66	Meningitis, Listeria	14.8%
67	Pregnancy Complications, Infectious	14.7%
68	Dermatomycoses	14.6%
69	Pelvic Infection	14.5%
70	Wound Infection	14.5%
71	Soft Tissue Infection	14.5%
72	Community-Acquired Infections	14.5%
73	Acinetobacter Infections	14.3%
74	Bacteroides Infections	14.3%
75	Cholera	14.3%
76	Escherichia coli Infections	14.3%
77	Haemophilus Infections	14.3%
78	Klebsiella Infections	14.3%
79	Meningococcal Infections	14.3%
80	Mycoplasma Infections	14.3%
81	Pasteurella Infections	14.3%
82	Proteus Infections	14.3%
83	Rickettsia Infections	14.3%
84	Salmonella infections	14.3%
85	Scrub Typhus	14.3%
86	Serratia Infections	14.3%
87	Ureaplasma Infections	14.3%
88	Erysipelothrix infection	13.8%
89	carbuncle	13.5%
90	Infection	13.4%
91	Infertility	13.3%
92	Meningitis, Pneumococcal	13.2%
93	Eye Infection	13.1%
94	Respiratory Tract Infections	13.1%
95	Panophthalmitis	12.9%
96	Bone Diseases, Infectious	12.8%
97	Skin Diseases, Infectious	12.8%
98	Arthritis, Infectious	12.7%
99	Suppuration	12.7%
100	Candidiasis, Chronic Mucocutaneous	12.7%
101	Cutaneous Candidiasis	12.7%
102	Cross Infection	12.7%
103	Septicemia	12.7%
104	Sepsis	12.7%
105	Cellulitis	12.5%
106	Joint Tuberculosis	12.4%
107	Tuberculosis, Osteoarticular	12.4%
108	Bone Tuberculosis	12.4%
109	Adnexitis	12%
110	Pelvic Inflammatory Disease	12%
111	Meningitis, Bacterial	11.9%
112	Opportunistic Infections	11.9%
113	Erythema Induratum	11.8%
114	Candidemia	11.7%
115	Fungemia	11.6%
116	Endotoxemia	11.5%
117	Brain Abscess	11.2%
118	Dysentery, Bacillary	11.1%
119	Psittacosis	11.1%
120	Paratyphoid Fever	11.1%
121	Plague	11.1%
122	Typhoid Fever	11.1%
123	TYPHUS	11.1%
124	Yersinia pseudotuberculosis Infections	11.1%
125	Bubonic Plague	11.1%
126	Tuberculosis, Meningeal	10.9%
127	Genital Herpes	10.7%
128	Actinomycosis	10.6%
129	Corynebacterium Infections	10.6%
130	Gas Gangrene	10.6%
131	Mycobacterium Infections	10.6%
132	Nocardia Infections	10.6%
133	Pneumococcal Infections	10.6%
134	Scarlet Fever	10.6%
135	Tetanus	10.6%
136	Pulmonary Nocardiosis	10.6%
137	Blastomycosis	10.6%
138	Tuberculosis, Renal	10.2%
139	Salmonella Infections, Animal	10%
140	Aspergillosis	9.8%
141	Candidiasis	9.8%
142	Coccidioidomycosis	9.8%
143	Histoplasmosis	9.8%
144	Paracoccidioidomycosis	9.8%
145	Zygomycosis	9.8%
146	Phaeohyphomycosis	9.8%
147	Pneumocystis Infections	9.8%
148	Syphilis, Congenital	9.8%
149	Salmonella food poisoning	9.7%
150	Bacteriuria	9.6%
151	Pyuria	9.6%
152	Urologic Diseases	9.5%
153	Neuroaspergillosis	9.4%
154	Chromoblastomycosis	9.4%
155	Dermatophytosis	9.4%
156	Sporotrichosis	9.4%
157	Tinea	9.4%
158	Tinea Versicolor	9.4%
159	Trichophytosis	9.4%
160	Hyalohyphomycosis	9.4%
161	Tuberculosis, Spinal	8.8%
162	Puerperal Infection	8.7%
163	Otomycosis	8.7%
164	Piedra	8.6%
165	Central Nervous System Fungal Infections	8.6%
166	Urogenital Abnormalities	8.5%
167	Candidiasis, Vulvovaginal	8.4%
168	Rheumatic Fever	8.4%
169	Diphtheria	8.3%
170	Leprosy	8.3%
171	Mycobacterium Infections, Nontuberculous	8.3%
172	Tuberculosis	8.3%
173	Mycobacterium abscessus Infection	8.3%
174	Waterhouse-Friderichsen Syndrome	8.3%
175	Enterocolitis, Pseudomembranous	8.3%
176	pseudomembranous colitis	8.3%
177	Endometriosis	8.1%
178	Uterine Diseases	8.1%
179	Vaginal Diseases	8.1%
180	Vulvar Diseases	8.1%
181	Endometrioma	8.1%
182	Invasive Pulmonary Aspergillosis	7.9%
183	Endophthalmitis	7.8%
184	Peritonitis	7.8%
185	Lung Diseases, Fungal	7.8%
186	Osteomyelitis	7.7%
187	Periostitis	7.7%
188	Surgical Wound Infection	7.7%
189	Abscess	7.7%
190	Empyema	7.7%
191	Botulism	7.6%
192	Genital Neoplasms, Male	7.4%
193	Rheumatic Heart Disease	7.3%
194	Mycobacterium avium-intracellulare Infection	7.1%
195	Lymph Node Tuberculosis	7.1%
196	Tuberculosis, Miliary	7.1%
197	Tuberculosis, Multidrug-Resistant	7.1%
198	Leprosy, Multibacillary	7.1%
199	Latent Tuberculosis	7.1%
200	Meningitis, Cryptococcal	7.1%
201	Dyspareunia	7.1%
202	Hypospadias	7.1%
203	Endometritis	7.1%
204	Epididymitis	7%
205	Penile Diseases	7%
206	Prostatic Diseases	7%
207	Spermatic Cord Torsion	7%
208	Hemospermia	7%
209	Testicular Hydrocele	7%
210	Superinfection	7%
211	Corneal Ulcer	6.9%
212	Spondylitis	6.9%
213	Appendicitis	6.9%
214	Pyomyositis	6.9%
215	Penile Neoplasms	6.9%
216	Prostatic Neoplasms	6.9%
217	Endotoxic shock	6.8%
218	Septic Shock	6.8%
219	Toxic Shock Syndrome	6.8%
220	Fusariosis	6.8%
221	Borderline leprosy	6.6%
222	Leprosy, Lepromatous	6.6%
223	Tuberculoid leprosy	6.6%
224	Extensively Drug-Resistant Tuberculosis	6.6%
225	Lemierre Syndrome	6.5%
226	Tuberculosis, Gastrointestinal	6.3%
227	Tuberculosis, Central Nervous System	6.2%
228	Testicular Diseases	6.2%
229	Varicocele	6.2%
230	Spermatocele	6.2%
231	Tinea Capitis	6.1%
232	Onychomycosis	6.1%
233	Arthritis, Reactive	6.1%
234	Mucormycosis	6%
235	Psoas Abscess	6%
236	Abdominal Abscess	6%
237	Bladder Exstrophy	6%
238	Epispadias	6%
239	Toxoplasmosis, Cerebral	5.7%
240	AIDS-Related Opportunistic Infections	5.7%
241	Tuberculosis, Pulmonary	5.7%
242	Salpingitis	5.6%
243	Vulvovaginitis	5.6%
244	Tinea Pedis	5.6%
245	Sexually Transmitted Diseases	5.4%
246	Uterine Neoplasms	5.4%
247	Vaginal Neoplasms	5.4%
248	Vulvar Neoplasms	5.4%
249	Uterine Cancer	5.4%
250	Oral candidiasis	5.3%
251	Pulmonary Aspergillosis	5.3%
252	Bronchopulmonary Aspergillosis	5.3%
253	Uterine Inversion	5.3%
254	Diverticulitis	5.3%
255	Multicystic Dysplastic Kidney	5.2%
256	Urinary Bladder Diseases	5.1%
257	Kidney Diseases	5.1%
258	Ureteral Diseases	5.1%
259	Urethral Diseases	5.1%
260	Urination Disorders	5.1%
261	Urolithiasis	5.1%
262	Oophoritis	5%
263	Anuria	4.9%
264	Ureterolithiasis	4.9%
265	Nephrolithiasis	4.9%
266	Endometrial Hyperplasia	4.8%
267	Pyometra	4.8%
268	Vaginitis	4.8%
269	Vulvitis	4.8%
270	Vaginal Discharge	4.8%
271	Vulvodynia	4.8%
272	Lung Abscess	4.8%
273	Uterine Rupture	4.7%
274	Diverticulum	4.7%
275	Diverticulosis	4.7%
276	Meningitis, Fungal	4.7%
277	Discitis	4.7%
278	Mastoiditis	4.7%
279	Petrositis	4.7%
280	Cryptorchidism	4.6%
281	Urologic Neoplasms	4.6%
282	Horseshoe Kidney	4.6%
283	Prostatic Neoplasms, Castration-Resistant	4.5%
284	Urinary Bladder Fistula	4.4%
285	Bladder Neoplasm	4.4%
286	Kidney Neoplasm	4.4%
287	Ureteral Neoplasms	4.4%
288	Urethral Neoplasms	4.4%
289	Bacterial Infections	4.3%
290	Ovarian Diseases	4.3%
291	Pruritus Vulvae	4.3%
292	Uterine hemorrhage	4.3%
293	Vaginal Fistula	4.3%
294	Uterine Prolapse	4.2%
295	Vaginal Prolapse	4.2%
296	Retropharyngeal Abscess	4.2%
297	Epidural Abscess	4.2%
298	Peritonsillar Abscess	4.2%
299	Balanitis	4.2%
300	Benign prostatic hypertrophy	4.2%
301	Phimosis	4.2%
302	Priapism	4.2%
303	prostatitis	4.2%
304	Prostatic Adenoma	4.2%
305	Benign Prostatic Hyperplasia	4.2%
306	Prostatic Hypertrophy	4.2%
307	Prostatic Hyperplasia	4.2%
308	Hermaphroditism	4.1%
309	Disorders of Sex Development	4.1%
310	Fallopian Tube Neoplasms	4.1%
311	Liver Abscess	4.1%
312	Pregnancy Complications	4.1%
313	Bladder neck obstruction	4%
314	Vesicovaginal Fistula	3.8%
315	Kidney Calculi	3.7%
316	Ureteral Calculi	3.7%
317	Premature Ejaculation	3.7%
318	Erectile dysfunction	3.7%
319	Orchitis	3.7%
320	Endometrial Neoplasms	3.6%
321	Uterine Cervical Incompetence	3.4%
322	ovarian neoplasm	3.4%
323	Testicular Neoplasms	3.3%
324	Uterine Cervicitis	3.2%
325	Leukorrhea	3.2%
326	Parametritis	3.2%
327	Genital Neoplasms, Female	3.1%
328	Cystitis	3%
329	Hydronephrosis	3%
330	Hyperoxaluria	3%
331	Kidney Cortex Necrosis	3%
332	Kidney Papillary Necrosis	3%
333	Nephritis	3%
334	Nephrosclerosis	3%
335	Nephrosis	3%
336	Perinephritis	3%
337	Kidney Failure	3%
338	Uremia	3%
339	Ureteral obstruction	3%
340	Ureterocele	3%
341	Urethral Obstruction	3%
342	Urethritis	3%
343	Vesico-Ureteral Reflux	3%
344	Urinary Retention	3%
345	Oxalosis	3%
346	Renal Insufficiency	3%
347	Trichomonas Vaginitis	2.8%
348	Uterine Perforation	2.8%
349	Ovarian Hyperstimulation Syndrome	2.8%
350	Metrorrhagia	2.8%
351	Pyelocystitis	2.8%
352	Carcinoma, Endometrioid	2.8%
353	Azoospermia	2.8%
354	Oligospermia	2.8%
355	Impotence, Vasculogenic	2.8%
356	Asthenozoospermia	2.8%
357	Teratozoospermia	2.8%
358	Aspermia	2.8%
359	Diabetes Insipidus	2.7%
360	Hepatorenal Syndrome	2.7%
361	Diabetic Nephropathy	2.7%
362	Glycosuria	2.7%
363	Hematuria	2.7%
364	Renal hypertension	2.7%
365	Oliguria	2.7%
366	Polyuria	2.7%
367	Proteinuria	2.7%
368	Renal Artery Obstruction	2.7%
369	Renal Artery Stenosis	2.7%
370	Urinary Calculi	2.7%
371	Cystocele	2.7%
372	Nephrocalcinosis	2.7%
373	Urinary Incontinence	2.7%
374	Mesoblastic Nephroma	2.7%
375	Renal Cell Carcinoma	2.7%
376	Papillary Renal Cell Carcinoma	2.7%
377	Aspergillosis, Allergic Bronchopulmonary	2.7%
378	Corpus Luteum Cyst	2.5%
379	Ovarian Cysts	2.5%
380	Liver Abscess, Amebic	2.5%
381	Anovulation	2.5%
382	Menorrhagia	2.5%
383	Premature Menopause	2.5%
384	Glycosuria, Renal	2.5%
385	Enuresis	2.5%
386	Gonadal Dysgenesis	2.4%
387	Adrenogenital Syndrome	2.4%
388	Ovotesticular Disorders of Sex Development	2.4%
389	Pyelonephritis	2.4%
390	Nephroblastoma	2.3%
391	Hyperandrogenism	2.3%
392	Denys-Drash Syndrome	2.2%
393	granulosa cell tumor	2.2%
394	Carcinoma, Ovarian Epithelial	2.2%
395	AIDS-Associated Nephropathy	2.2%
396	Chorioamnionitis	2.1%
397	Polyhydramnios	2.1%
398	Obstetric Labor Complications	2.1%
399	Ectopic Pregnancy	2.1%
400	Pregnancy, Prolonged	2.1%
401	Puerperal Disorders	2.1%
402	Oligohydramnios	2.1%
403	Prenatal Injuries	2.1%
404	Abruptio Placentae	2%
405	Placenta Accreta	2%
406	Glomerulonephritis	2%
407	Nephritis, Interstitial	2%
408	Lipoid nephrosis	2%
409	Nephrotic Syndrome	2%
410	Pyelitis	2%
411	Pyonephrosis	2%
412	Urethral Stenosis	2%
413	Nephrogenic Diabetes Insipidus	2%
414	Congenital Nephrogenic Diabetes Insipidus	2%
415	Acute kidney injury	2%
416	Urethral stricture	2%
417	Endometrial Stromal Sarcoma	2%
418	Fetal Diseases	1.9%
419	Pregnancy Complications, Cardiovascular	1.9%
420	Pregnancy Complications, Neoplastic	1.9%
421	Polycystic Ovary Syndrome	1.9%
422	Renal Osteodystrophy	1.9%
423	Renal rickets	1.9%
424	Pregnancy Complications, Hematologic	1.9%
425	Fetal Death	1.8%
426	Perinatal death	1.8%
427	Morning Sickness	1.8%
428	Azotemia	1.8%
429	Postpartum Hemorrhage	1.8%
430	Albuminuria	1.8%
431	Hemoglobinuria	1.8%
432	Hypertension, Renovascular	1.8%
433	Urge Incontinence	1.8%
434	Turner Syndrome	1.7%
435	Gestational Diabetes	1.7%
436	Polycystic Kidney Diseases	1.6%
437	Diurnal Enuresis	1.6%
438	Renal Aminoacidurias	1.6%
439	Fanconi Syndrome	1.6%
440	Pseudohypoaldosteronism	1.6%
441	Liddle Syndrome	1.6%
442	Hemolytic-Uremic Syndrome	1.6%
443	Zellweger Syndrome	1.5%
444	Balkan Nephropathy	1.5%
445	Focal glomerulosclerosis	1.5%
446	Kidney Failure, Chronic	1.5%
447	Leydig Cell Tumor	1.5%
448	Renal tubular acidosis	1.5%
449	Glomerulonephritis, Membranoproliferative	1.4%
450	Kallmann Syndrome	1.4%
451	Hyperphosphaturia	1.2%
452	Klinefelter Syndrome	1.2%
453	Anti-Glomerular Basement Membrane Disease	1.2%
454	Lupus Nephritis	1.2%
455	Polycystic Kidney, Autosomal Dominant	1.2%
456	Cystinuria	1.2%
457	Atypical Hemolytic Uremic Syndrome	1.2%
458	Abortion, Habitual	1.2%
459	Dystocia	1.2%
460	Eclampsia	1.2%
461	Fetal Membranes, Premature Rupture	1.2%
462	Placental Insufficiency	1.2%
463	Pre-Eclampsia	1.2%
464	Prenatal Exposure Delayed Effects	1.2%
465	HELLP Syndrome	1.2%
466	Placenta, Retained	1.2%
467	Abortion, Veterinary	1%
468	Pregnancy Complications, Parasitic	1%
469	Lactation Disorder	1%
470	Mastitis	1%
471	Depression, Postpartum	1%
472	Embryo Loss	1%
473	Fetal Resorption	1%
474	Hyperemesis Gravidarum	1%
475	Fetal Growth Retardation	0.9%
476	Trophoblastic Neoplasms	0.9%
477	Embolism, Amniotic Fluid	0.9%
478	Fetal Hypoxia	0.9%
479	Fetal Alcohol Spectrum Disorders	0.9%
480	Breech Presentation	0.9%
481	Stillbirth	0.9%
482	Meconium Aspiration Syndrome	0.8%
483	Premature Birth	0.7%
484	Familial Hypophosphatemic Rickets	0.7%
485	Galactorrhea	0.6%
486	Choriocarcinoma	0.5%
487	Hydrops Fetalis	0.4%
488	Hydatidiform Mole	0.4%

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