MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Nephrogenic Diabetes Insipidus

(UMLS:C0162283)

Definition:: A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
UMLS ID:: C0162283
MeSH ID:: D018500

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.135.500

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.135.500

Synonym(s)

Nephrogenic Diabetes Insipidus

DIABETES INSIPIDUS NEPHROGENIC

NDI - Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus

Nephrogenic diabetes insipidus, NOS

diabete insipidus nephrogenic

diabetes insipidus nephrogenic

diabetes; insipidus, nephrogenic

nephrogenic diabetes insipidus

10.

nephrogenic; diabetes insipidus

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Lithium Carbonate	FAERS: 55	OFFSIDES US FAERS
2	Lithium	FAERS: 45 Canada Vigilance: 2	Canada Vigilance OFFSIDES SIDER US FAERS
3	liposomal amphotericin B	FAERS: 10	OFFSIDES SIDER US FAERS
4	Hydrochlorothiazide	FAERS: 7	US FAERS
5	Pemetrexed	FAERS: 6	OFFSIDES US FAERS
6	Haloperidol	FAERS: 5	OFFSIDES US FAERS
7	Tenofovir	FAERS: 5	OFFSIDES US FAERS
8	candesartan	FAERS: 4	US FAERS
9	Ifosfamide	FAERS: 3	SIDER US FAERS
10	Temozolomide	FAERS: 3	OFFSIDES US FAERS
11	Tolvaptan	FAERS: 3	US FAERS
12	Bendamustine Hydrochloride	FAERS: 2	US FAERS
13	Clozapine	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
14	Mesalamine	FAERS: 2	US FAERS
15	Sevoflurane	FAERS: 2	US FAERS
16	Tacrolimus	FAERS: 2	US FAERS
17	Tramadol	FAERS: 2	US FAERS
18	exemestane	FAERS: 2	OFFSIDES US FAERS
19	ziprasidone	FAERS: 2	US FAERS
20	Anidulafungin	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
21	Asenapine	FAERS: 1	US FAERS
22	Azacitidine	FAERS: 1	US FAERS
23	Ceftriaxone	FAERS: 1	US FAERS
24	Cinacalcet	FAERS: 1	US FAERS
25	Colchicine	FAERS: 1	US FAERS
26	Deferasirox	FAERS: 1	US FAERS
27	Goserelin	FAERS: 1	OFFSIDES US FAERS
28	Hydrocortisone	FAERS: 1	US FAERS
29	Irbesartan	FAERS: 1	US FAERS
30	Ketamine	FAERS: 1	US FAERS
31	Methylphenidate	FAERS: 1	US FAERS
32	Micafungin	FAERS: 1	OFFSIDES US FAERS
33	Nafcillin	FAERS: 1	US FAERS
34	Olmesartan Medoxomil	FAERS: 1	US FAERS
35	Piperacillin sodium and Tazobactam sodium	FAERS: 1	US FAERS
36	Risperidone	FAERS: 1	US FAERS
37	Tenofovir	FAERS: 1	OFFSIDES SIDER US FAERS
38	Teriparatide	FAERS: 1	US FAERS
39	Valacyclovir	FAERS: 1	US FAERS
40	Valproic Acid	FAERS: 1	US FAERS
41	Valproic Acid	FAERS: 1	OFFSIDES US FAERS
42	Valsartan	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
43	Vasopressins	FAERS: 1	US FAERS
44	lithium citrate	FAERS: 1	US FAERS
45	Amiloride		OFFSIDES
46	Azathioprine		OFFSIDES
47	Beclomethasone		OFFSIDES
48	Beclomethasone		OFFSIDES
49	Benztropine		OFFSIDES
50	Bupropion		OFFSIDES
51	Carbimazole		OFFSIDES
52	Cefazolin		OFFSIDES
53	Cefotaxime		OFFSIDES
54	Chlorthalidone		OFFSIDES
55	Clomipramine		OFFSIDES
56	Clopenthixol		OFFSIDES
57	Clorazepate Dipotassium		OFFSIDES
58	Cyclophosphamide		SIDER
59	Dapsone		OFFSIDES
60	Deamino Arginine Vasopressin		OFFSIDES
61	Demeclocycline		SIDER
62	Dexmedetomidine		OFFSIDES
63	Didanosine		OFFSIDES
64	Dioctyl Sulfosuccinic Acid		OFFSIDES
65	Emtricitabine		SIDER
66	Famotidine		OFFSIDES
67	Flurbiprofen		OFFSIDES
68	Furosemide		OFFSIDES
69	Glipizide		OFFSIDES
70	Glycerol		OFFSIDES
71	Indomethacin		OFFSIDES
72	Ketorolac		OFFSIDES
73	Ketorolac Tromethamine		OFFSIDES
74	Loxapine		OFFSIDES
75	Maloprim		OFFSIDES
76	Methocarbamol		OFFSIDES
77	Mometasone Furoate		OFFSIDES
78	Nafcillin		OFFSIDES
79	Nitrazepam		OFFSIDES
80	Phenobarbital		OFFSIDES
81	Pioglitazone		OFFSIDES
82	Piperacillin, Tazobactam Drug Combination	Canada Vigilance: 1	Canada Vigilance OFFSIDES
83	Streptozocin		SIDER
84	Sulfadiazine		OFFSIDES
85	Sulpiride		OFFSIDES
86	Sumatriptan		OFFSIDES
87	Telmisartan		OFFSIDES
88	Thiamine		OFFSIDES
89	Trichlormethiazide		OFFSIDES
90	Triiodothyronine		OFFSIDES
91	Vancomycin		OFFSIDES
92	Voriconazole		OFFSIDES
93	alpha-Tocopherol		OFFSIDES
94	azulene		OFFSIDES
95	cloxazolam		OFFSIDES
96	efavirenz		SIDER
97	eicosapentaenoic acid ethyl ester		OFFSIDES
98	fosamprenavir		OFFSIDES
99	posaconazole		OFFSIDES
100	zotepine		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hydronephrosis	35.2%
2	Hyperoxaluria	35.2%
3	Kidney Cortex Necrosis	35.2%
4	Kidney Papillary Necrosis	35.2%
5	Nephritis	35.2%
6	Nephrosclerosis	35.2%
7	Nephrosis	35.2%
8	Perinephritis	35.2%
9	Kidney Failure	35.2%
10	Uremia	35.2%
11	Oxalosis	35.2%
12	Renal Insufficiency	35.2%
13	Anuria	34.1%
14	Nephrolithiasis	34.1%
15	Hepatorenal Syndrome	28.7%
16	Diabetic Nephropathy	28.3%
17	Renal hypertension	28.3%
18	Renal Artery Obstruction	28.3%
19	Renal Artery Stenosis	28.3%
20	Nephrocalcinosis	28.2%
21	Urinary Bladder Diseases	27%
22	Ureteral Diseases	27%
23	Urethral Diseases	27%
24	Urination Disorders	27%
25	Urolithiasis	27%
26	Tuberculosis, Renal	26.2%
27	Kidney Neoplasm	23.7%
28	Glomerulonephritis	23.2%
29	Nephritis, Interstitial	23.2%
30	Lipoid nephrosis	23.2%
31	Nephrotic Syndrome	23.2%
32	Pyelitis	23.2%
33	Pyonephrosis	23.2%
34	Acute kidney injury	23.2%
35	Pyelonephritis	23%
36	Urinary tract infection	21.9%
37	Ureterolithiasis	21.1%
38	AIDS-Associated Nephropathy	20.1%
39	Kidney Calculi	19.6%
40	Multicystic Dysplastic Kidney	19.5%
41	Azotemia	19%
42	Hypertension, Renovascular	18.6%
43	Pyelocystitis	18.5%
44	Bladder neck obstruction	17.5%
45	Balkan Nephropathy	17.3%
46	Focal glomerulosclerosis	17.3%
47	Kidney Failure, Chronic	17.3%
48	Cystitis	15.8%
49	Ureteral obstruction	15.8%
50	Ureterocele	15.8%
51	Urethral Obstruction	15.8%
52	Urethritis	15.8%
53	Urogenital Abnormalities	15.8%
54	Vesico-Ureteral Reflux	15.8%
55	Urinary Retention	15.8%
56	Polycystic Kidney Diseases	15.7%
57	Renal Osteodystrophy	15.6%
58	Renal rickets	15.6%
59	Renal Aminoacidurias	15.5%
60	Fanconi Syndrome	15.5%
61	Pseudohypoaldosteronism	15.5%
62	Liddle Syndrome	15.5%
63	Hemolytic-Uremic Syndrome	15.5%
64	Bladder Exstrophy	15.1%
65	Epispadias	15.1%
66	Glycosuria, Renal	15%
67	Glomerulonephritis, Membranoproliferative	14.5%
68	Ureteral Calculi	13.9%
69	Mesoblastic Nephroma	13.7%
70	Renal Cell Carcinoma	13.6%
71	Papillary Renal Cell Carcinoma	13.6%
72	Renal tubular acidosis	13.3%
73	Bacteriuria	12.7%
74	Glycosuria	12.7%
75	Hematuria	12.7%
76	Oliguria	12.7%
77	Polyuria	12.7%
78	Proteinuria	12.7%
79	Pyuria	12.7%
80	Urinary Calculi	12.7%
81	Cystocele	12.6%
82	Urinary Incontinence	12.6%
83	Urinary Bladder Fistula	12.5%
84	Bladder Neoplasm	12.5%
85	Ureteral Neoplasms	12.5%
86	Urethral Neoplasms	12.5%
87	Anti-Glomerular Basement Membrane Disease	11.8%
88	Zellweger Syndrome	11.8%
89	Lupus Nephritis	11.7%
90	Polycystic Kidney, Autosomal Dominant	11.6%
91	Cystinuria	11.5%
92	Atypical Hemolytic Uremic Syndrome	11.5%
93	Nephroblastoma	11.1%
94	Enuresis	10.7%
95	Genital Diseases, Male	10.4%
96	Urethral Stenosis	10.4%
97	Urethral stricture	10.4%
98	Infertility	10.4%
99	Hyperphosphaturia	10.4%
100	Pregnancy Complications	9.8%
101	Hypospadias	8.6%
102	Albuminuria	8.3%
103	Hemoglobinuria	8.3%
104	Urge Incontinence	8.3%
105	Urologic Neoplasms	8.3%
106	Horseshoe Kidney	8.3%
107	Endometriosis	8.1%
108	Uterine Diseases	8.1%
109	Vaginal Diseases	8.1%
110	Vulvar Diseases	8.1%
111	Endometrioma	8.1%
112	Sexually Transmitted Diseases	7.2%
113	Hermaphroditism	7%
114	Disorders of Sex Development	7%
115	Diurnal Enuresis	7%
116	Denys-Drash Syndrome	7%
117	Genital Herpes	6.9%
118	Genital Neoplasms, Male	6.7%
119	Genital Neoplasms, Female	6.1%
120	Endometritis	6%
121	Vesicovaginal Fistula	5.9%
122	Uterine Neoplasms	5.8%
123	Vaginal Neoplasms	5.8%
124	Vulvar Neoplasms	5.8%
125	Uterine Cancer	5.8%
126	Uterine Inversion	5.7%
127	Epididymitis	5.5%
128	Penile Diseases	5.5%
129	Prostatic Diseases	5.5%
130	Spermatic Cord Torsion	5.5%
131	Hemospermia	5.5%
132	Testicular Hydrocele	5.5%
133	Polyhydramnios	5%
134	Obstetric Labor Complications	5%
135	Ectopic Pregnancy	5%
136	Pregnancy, Prolonged	5%
137	Puerperal Disorders	5%
138	Oligohydramnios	5%
139	Prenatal Injuries	5%
140	Dyspareunia	5%
141	Familial Hypophosphatemic Rickets	4.9%
142	Penile Neoplasms	4.9%
143	Prostatic Neoplasms	4.9%
144	Endometrial Hyperplasia	4.8%
145	Pyometra	4.8%
146	Vaginitis	4.8%
147	Vulvitis	4.8%
148	Vaginal Discharge	4.8%
149	Vulvodynia	4.8%
150	Fallopian Tube Neoplasms	4.8%
151	Salpingitis	4.8%
152	Vulvovaginitis	4.8%
153	Uterine Rupture	4.6%
154	Cryptorchidism	4.4%
155	Testicular Diseases	4.2%
156	Varicocele	4.2%
157	Spermatocele	4.1%
158	Abruptio Placentae	4.1%
159	Placenta Accreta	4.1%
160	Gonadal Dysgenesis	4.1%
161	Adrenogenital Syndrome	4.1%
162	Ovotesticular Disorders of Sex Development	4.1%
163	Fetal Diseases	3.9%
164	Pregnancy Complications, Cardiovascular	3.9%
165	Pregnancy Complications, Neoplastic	3.9%
166	Oophoritis	3.9%
167	Endometrial Neoplasms	3.8%
168	Pregnancy Complications, Hematologic	3.8%
169	Pregnancy Complications, Infectious	3.8%
170	Fetal Death	3.7%
171	Perinatal death	3.7%
172	Ovarian Diseases	3.7%
173	Morning Sickness	3.7%
174	Adnexitis	3.6%
175	Pruritus Vulvae	3.6%
176	Uterine hemorrhage	3.6%
177	Vaginal Fistula	3.6%
178	Pelvic Inflammatory Disease	3.6%
179	Uterine Prolapse	3.6%
180	Vaginal Prolapse	3.6%
181	Uterine Cervical Incompetence	3.6%
182	Chorioamnionitis	3.6%
183	ovarian neoplasm	3.5%
184	Puerperal Infection	3.3%
185	Postpartum Hemorrhage	3.3%
186	Balanitis	3.2%
187	Benign prostatic hypertrophy	3.2%
188	Phimosis	3.2%
189	Priapism	3.2%
190	prostatitis	3.2%
191	Prostatic Adenoma	3.2%
192	Benign Prostatic Hyperplasia	3.2%
193	Prostatic Hypertrophy	3.2%
194	Prostatic Hyperplasia	3.2%
195	Prostatic Neoplasms, Castration-Resistant	3.2%
196	Hyperandrogenism	3.2%
197	Uterine Cervicitis	3.2%
198	Leukorrhea	3.2%
199	Parametritis	3.2%
200	Gestational Diabetes	3%
201	Carcinoma, Endometrioid	3%
202	Candidiasis, Vulvovaginal	2.9%
203	Abortion, Habitual	2.7%
204	Dystocia	2.7%
205	Eclampsia	2.7%
206	Fetal Membranes, Premature Rupture	2.7%
207	Placental Insufficiency	2.7%
208	Pre-Eclampsia	2.7%
209	Prenatal Exposure Delayed Effects	2.7%
210	HELLP Syndrome	2.7%
211	Placenta, Retained	2.7%
212	Premature Ejaculation	2.5%
213	Erectile dysfunction	2.5%
214	Testicular Neoplasms	2.5%
215	Bacterial Vaginosis	2.5%
216	Orchitis	2.4%
217	Trichomonas Vaginitis	2.4%
218	Uterine Perforation	2.4%
219	Ovarian Hyperstimulation Syndrome	2.4%
220	Metrorrhagia	2.4%
221	Chlamydia Infections	2.3%
222	Gonorrhea	2.3%
223	Abortion, Veterinary	2.1%
224	Pregnancy Complications, Parasitic	2.1%
225	Turner Syndrome	2.1%
226	Azoospermia	2.1%
227	Oligospermia	2.1%
228	Impotence, Vasculogenic	2.1%
229	Asthenozoospermia	2.1%
230	Teratozoospermia	2.1%
231	Aspermia	2.1%
232	granulosa cell tumor	2.1%
233	Carcinoma, Ovarian Epithelial	2.1%
234	Lactation Disorder	2%
235	Mastitis	2%
236	Depression, Postpartum	2%
237	Embryo Loss	2%
238	Kallmann Syndrome	2%
239	Fetal Resorption	2%
240	Hyperemesis Gravidarum	2%
241	Syphilis	2%
242	Endometrial Stromal Sarcoma	2%
243	Corpus Luteum Cyst	2%
244	Ovarian Cysts	2%
245	Anovulation	1.9%
246	Menorrhagia	1.9%
247	Premature Menopause	1.9%
248	Klinefelter Syndrome	1.8%
249	Lymphogranuloma Venereum	1.7%
250	Fetal Growth Retardation	1.7%
251	Trophoblastic Neoplasms	1.7%
252	Embolism, Amniotic Fluid	1.7%
253	Fetal Hypoxia	1.7%
254	Fetal Alcohol Spectrum Disorders	1.7%
255	Breech Presentation	1.6%
256	Stillbirth	1.6%
257	Premature Birth	1.6%
258	Polycystic Ovary Syndrome	1.4%
259	Meconium Aspiration Syndrome	1.2%
260	Galactorrhea	1.2%
261	Leydig Cell Tumor	1.1%
262	Choriocarcinoma	0.8%
263	Hydatidiform Mole	0.6%
264	Hydrops Fetalis	0.5%

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