MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Premature Ejaculation

(UMLS:C0033038)

Definition:: The emission of SEMEN and seminal fluid during the act of preparation for sexual intercourse, i.e. before there is penetration, or shortly after penetration.
UMLS ID:: C0033038
MeSH ID:: D061686

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.644.743

Classification 2:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.835.700

Synonym(s)

Premature Ejaculation

EJACULATION PREMATURE

Ejaculates too soon

Ejaculatio praecox

Ejaculation, premature

Premature ejaculation

Premature orgasm - male

Premature;ejaculation

dysfunction; sexual, premature ejaculation

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sildenafil Citrate	FAERS: 143 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Finasteride	FAERS: 51 Canada Vigilance: 3		Canada Vigilance US FAERS
3	Tadalafil	FAERS: 20		US FAERS
4	Vardenafil Dihydrochloride	FAERS: 15		SIDER US FAERS
5	Atomoxetine Hydrochloride	FAERS: 14		US FAERS
6	Sertraline	FAERS: 9		SIDER US FAERS
7	Carbamazepine	FAERS: 5		US FAERS
8	Duloxetine Hydrochloride	FAERS: 5		US FAERS
9	Sertraline	FAERS: 5		US FAERS
10	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
11	Modafinil	FAERS: 3		US FAERS
12	Paroxetine	FAERS: 3		US FAERS
13	Valproic Acid	FAERS: 3		US FAERS
14	Venlafaxine Hydrochloride	FAERS: 3		US FAERS
15	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
16	Citalopram	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
17	Citalopram	FAERS: 2		US FAERS
18	Citalopram	FAERS: 2		US FAERS
19	Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 2		US FAERS
20	Fingolimod Hydrochloride	FAERS: 2		US FAERS
21	Latanoprost	FAERS: 2		US FAERS
22	Morphine	FAERS: 2		US FAERS
23	Olanzapine	FAERS: 2		US FAERS
24	Paroxetine	FAERS: 2		US FAERS
25	Rosuvastatin Calcium	FAERS: 2		US FAERS
26	Tamsulosin	FAERS: 2		US FAERS
27	Valsartan	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
28	Adzenys XR-ODT	FAERS: 1		US FAERS
29	Aripiprazole	FAERS: 1		SIDER US FAERS
30	Arthrotec	FAERS: 1		US FAERS
31	Atomoxetine Hydrochloride	FAERS: 1		US FAERS
32	Atorvastatin	FAERS: 1		US FAERS
33	Bupropion	FAERS: 1		US FAERS
34	Citalopram hydrochloride	FAERS: 1		US FAERS
35	Citalopram	FAERS: 1		US FAERS
36	Clozapine	FAERS: 1		US FAERS
37	Dutasteride	FAERS: 1		SIDER US FAERS
38	Fluoxetine	FAERS: 1		US FAERS
39	Fluoxetine	FAERS: 1		US FAERS
40	Lamotrigine	FAERS: 1		US FAERS
41	Levomilnacipran	FAERS: 1		US FAERS
42	Lisdexamfetamine Dimesylate	FAERS: 1		US FAERS
43	Loratadine and pseudoephedrine sulfate	FAERS: 1		US FAERS
44	Methylphenidate	FAERS: 1		US FAERS
45	Paliperidone Palmitate	FAERS: 1		US FAERS
46	Paliperidone Palmitate	FAERS: 1		US FAERS
47	Quetiapine Fumarate	FAERS: 1		US FAERS
48	Quetiapine Fumarate	FAERS: 1		US FAERS
49	Tamsulosin	FAERS: 1		US FAERS
50	Topiramate	FAERS: 1		SIDER US FAERS
51	Tramadol	FAERS: 1		US FAERS
52	Varenicline	FAERS: 1		US FAERS
53	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
54	Vilazodone Hydrochloride	FAERS: 1		US FAERS
55	avanafil	FAERS: 1		SIDER US FAERS
56	empagliflozin	FAERS: 1		US FAERS
57	rofecoxib	FAERS: 1		US FAERS
58	sibutramine	FAERS: 1		US FAERS
59	telmisartan, hydrochlorothiazide drug combination	FAERS: 1		US FAERS
60	Bumetanide			SIDER
61	Clomipramine			SIDER
62	Lidocaine, Prilocaine Drug Combination		28408390 30047847	CTD
63	Pantoprazole	Canada Vigilance: 1		Canada Vigilance
64	p-Chloroamphetamine		23394880	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Erectile dysfunction	44.8%
2	Dyspareunia	35.4%
3	Sexual and Gender Disorders	27.9%
4	Gender Dysphoria	27.9%
5	Impotence, Vasculogenic	23.6%
6	Epididymitis	20.9%
7	Penile Diseases	20.9%
8	Prostatic Diseases	20.9%
9	Spermatic Cord Torsion	20.9%
10	Hemospermia	20.9%
11	Testicular Hydrocele	20.9%
12	Neurotic Disorders	18.2%
13	Genital Neoplasms, Male	16.7%
14	Testicular Diseases	15.8%
15	Varicocele	15.8%
16	Penile Neoplasms	15.6%
17	Prostatic Neoplasms	15.6%
18	Infertility	15.5%
19	Spermatocele	15.5%
20	Anxiety Disorders	14.6%
21	Avoidant Personality Disorder	14.6%
22	Dissociative disorder	14.6%
23	Disruptive, Impulse Control, and Conduct Disorders	14.6%
24	Intermittent Explosive Disorder	14.6%
25	Kleptomania	14.6%
26	Narcissistic Personality Disorder	14.6%
27	Personality Disorders	14.6%
28	Somatoform Disorder	14.6%
29	Dissociation	14.6%
30	Motor Disorders	14.6%
31	Mood Disorders	14.6%
32	Schizophrenia Spectrum and Other Psychotic Disorders	14.6%
33	Neurodevelopmental Disorders	14.6%
34	Neurocognitive Disorders	14.6%
35	Feeding and Eating Disorders	14.6%
36	Separation Anxiety Disorder	14%
37	Balanitis	13.6%
38	Benign prostatic hypertrophy	13.6%
39	Phimosis	13.6%
40	Priapism	13.6%
41	prostatitis	13.6%
42	Prostatic Adenoma	13.6%
43	Benign Prostatic Hyperplasia	13.6%
44	Prostatic Hypertrophy	13.6%
45	Prostatic Hyperplasia	13.6%
46	Prostatic Neoplasms, Castration-Resistant	11.5%
47	Drug abuse	11.3%
48	Substance Dependence	11.3%
49	Substance-Related Disorders	11.3%
50	Drug Dependence	11.3%
51	Sexually Transmitted Diseases	10.7%
52	Cryptorchidism	10.2%
53	Hypospadias	10.2%
54	Genital Herpes	10.2%
55	Orchitis	10.2%
56	Azoospermia	10.1%
57	Oligospermia	10.1%
58	Asthenozoospermia	10.1%
59	Teratozoospermia	10.1%
60	Aspermia	10.1%
61	Adjustment Disorders	9.3%
62	Affective Disorders, Psychotic	9.3%
63	Agoraphobia	9.3%
64	Anorexia Nervosa	9.3%
65	Antisocial Personality Disorder	9.3%
66	Bipolar Disorder	9.3%
67	Body Dysmorphic Disorders	9.3%
68	Borderline Personality Disorder	9.3%
69	Capgras Syndrome	9.3%
70	Child Behavior Disorders	9.3%
71	Developmental Disabilities	9.3%
72	Child Development Disorders, Pervasive	9.3%
73	Claustrophobia	9.3%
74	Cognition Disorders	9.3%
75	Conversion disorder	9.3%
76	Cyclothymic Disorder	9.3%
77	Dependent Personality Disorder	9.3%
78	Depressive disorder	9.3%
79	Developmental Coordination Disorder	9.3%
80	Exhibitionism	9.3%
81	Factitious Disorders	9.3%
82	Firesetting Behavior	9.3%
83	Head Banging	9.3%
84	Histrionic Personality Disorder	9.3%
85	Hypochondriasis	9.3%
86	Masochism	9.3%
87	Melancholia	9.3%
88	Motor Skills Disorders	9.3%
89	Dissociative Identity Disorder	9.3%
90	Neurasthenia	9.3%
91	Obsessive-Compulsive Disorder	9.3%
92	Oppositional Defiant Disorder	9.3%
93	Panic Disorder	9.3%
94	Paranoid Personality Disorder	9.3%
95	Pedophilia	9.3%
96	Pseudodementia	9.3%
97	Psychotic Disorders	9.3%
98	Sadism	9.3%
99	Schizoaffective Disorder	9.3%
100	Schizoid Personality Disorder	9.3%
101	Schizophrenia	9.3%
102	Schizophrenia, Childhood	9.3%
103	Schizotypal Personality Disorder	9.3%
104	Stereotypic Movement Disorder	9.3%
105	Transvestism	9.3%
106	Trichotillomania	9.3%
107	Voyeurism	9.3%
108	Attention Deficit and Disruptive Behavior Disorders	9.3%
109	Hyperkinetic Heart Syndrome	9.3%
110	Reactive Attachment Disorder	9.3%
111	Paranoia	9.3%
112	Compulsive Personality Disorder	9.3%
113	Bulimia Nervosa	9.3%
114	Urologic Diseases	9.1%
115	Sleep Wake Disorders	8.8%
116	Psychoses, Substance-Induced	8.1%
117	Urogenital Abnormalities	7.2%
118	Marijuana Abuse	7%
119	Opioid-Related Disorders	7%
120	Nicotine Dependence	7%
121	Opioid abuse	7%
122	Parasomnia	7%
123	Phencyclidine Abuse	7%
124	Substance Abuse, Intravenous	7%
125	Substance Withdrawal Syndrome	7%
126	Tobacco Use Disorder	7%
127	Alcohol-Related Disorders	7%
128	Amphetamine-Related Disorders	7%
129	Cocaine-Related Disorders	7%
130	Dyssomnias	7%
131	Gambling	6.9%
132	Dementia	6.9%
133	Combat Disorders	6.8%
134	Dysthymic Disorder	6.8%
135	Hysteria	6.8%
136	Schizophrenia, Catatonic	6.8%
137	Schizophrenia, Disorganized	6.8%
138	Post-Traumatic Stress Disorder	6.8%
139	Attention Deficit Disorder	6.8%
140	Seasonal Affective Disorder	6.8%
141	Conduct Disorder	6.8%
142	Social Communication Disorder	6.8%
143	Psychological Trauma	6.8%
144	Hoarding Disorder	6.8%
145	Phonological Disorder	6.8%
146	Enuresis	6.8%
147	Testicular Neoplasms	6.8%
148	Psychoses, Alcoholic	6.1%
149	Neonatal Abstinence Syndrome	5.6%
150	Autistic Disorder	5.6%
151	Asperger Syndrome	5.6%
152	Restless Legs Syndrome	5.4%
153	Mutism	5.3%
154	Selective Mutism	5.3%
155	Urinary Bladder Diseases	5.2%
156	Kidney Diseases	5.2%
157	Ureteral Diseases	5.2%
158	Urethral Diseases	5.2%
159	Urination Disorders	5.2%
160	Urolithiasis	5.2%
161	Alcohol Use Disorder	5.1%
162	Alcoholic Intoxication	5.1%
163	Heroin Dependence	5.1%
164	Morphine Dependence	5.1%
165	Alcohol abuse	5.1%
166	Depression, Postpartum	5.1%
167	Sleep Talking	5.1%
168	Sleep Disorders, Intrinsic	5.1%
169	Kluver-Bucy Syndrome	5%
170	Premenstrual Dysphoric Disorder	5%
171	Alcohol Withdrawal Delirium	5%
172	Diurnal Enuresis	5%
173	Bladder Exstrophy	4.8%
174	Epispadias	4.8%
175	Tuberculosis, Renal	4.8%
176	Consciousness Disorders	4.6%
177	Mental Retardation	4.6%
178	Depressed Level of Consciousness	4.6%
179	Mental deficiency	4.6%
180	Intellectual Disability	4.6%
181	Amnesia	4.5%
182	Delirium	4.5%
183	Dissociative Amnesia	4.5%
184	Global Amnesia	4.5%
185	Anuria	4.4%
186	Ureterolithiasis	4.4%
187	Nephrolithiasis	4.4%
188	Huntington Disease	4.4%
189	Multicystic Dysplastic Kidney	4.3%
190	Chlamydia Infections	4.2%
191	Gonorrhea	4.2%
192	Disorders of Excessive Somnolence	4.2%
193	Sleep Initiation and Maintenance Disorders	4.2%
194	Night Terrors	4.2%
195	Somnambulism	4.2%
196	Urinary tract infection	4.2%
197	Transient Insomnia	4.2%
198	Sleep Paralysis	4.2%
199	Chronic Insomnia	4.2%
200	REM Sleep Behavior Disorder	4.2%
201	Hypersomnia	4.2%
202	Urologic Neoplasms	4.1%
203	Horseshoe Kidney	4.1%
204	Sleep Bruxism	4.1%
205	Presenile dementia	4%
206	Senile dementia	4%
207	Binge Drinking	4%
208	Creutzfeldt-Jakob disease	4%
209	Dyscalculia	4%
210	Alexia, Pure	4%
211	Bladder neck obstruction	3.9%
212	Urinary Bladder Fistula	3.8%
213	Bladder Neoplasm	3.8%
214	Kidney Neoplasm	3.8%
215	Ureteral Neoplasms	3.8%
216	Urethral Neoplasms	3.8%
217	Narcolepsy	3.7%
218	Kleine-Levin Syndrome	3.7%
219	Pick Disease of the Brain	3.7%
220	Syphilis	3.7%
221	Leydig Cell Tumor	3.6%
222	Sleep Disorders, Circadian Rhythm	3.5%
223	Cataplexy	3.5%
224	Lymphogranuloma Venereum	3.5%
225	Hermaphroditism	3.4%
226	Disorders of Sex Development	3.4%
227	Cystitis	3.4%
228	Hydronephrosis	3.4%
229	Hyperoxaluria	3.4%
230	Kidney Cortex Necrosis	3.4%
231	Kidney Papillary Necrosis	3.4%
232	Nephritis	3.4%
233	Nephrosclerosis	3.4%
234	Nephrosis	3.4%
235	Perinephritis	3.4%
236	Kidney Failure	3.4%
237	Uremia	3.4%
238	Ureteral obstruction	3.4%
239	Ureterocele	3.4%
240	Urethral Obstruction	3.4%
241	Urethritis	3.4%
242	Vesico-Ureteral Reflux	3.4%
243	Urinary Retention	3.4%
244	Oxalosis	3.4%
245	Renal Insufficiency	3.4%
246	Sleep Deprivation	3.4%
247	Retrograde amnesia	3.3%
248	Amnesia, Anterograde	3.3%
249	Kidney Calculi	3.3%
250	Ureteral Calculi	3.3%
251	Pyelocystitis	3%
252	Lewy Body Disease	2.9%
253	Wernicke Encephalopathy	2.8%
254	AIDS Dementia Complex	2.8%
255	Amnesia, Transient Global	2.8%
256	Alexia	2.8%
257	Dyslexia	2.8%
258	Frontotemporal dementia	2.7%
259	Diabetes Insipidus	2.7%
260	Hepatorenal Syndrome	2.7%
261	Pyelonephritis	2.7%
262	Bacteriuria	2.7%
263	Diabetic Nephropathy	2.7%
264	Glycosuria	2.7%
265	Hematuria	2.7%
266	Renal hypertension	2.7%
267	Oliguria	2.7%
268	Polyuria	2.7%
269	Proteinuria	2.7%
270	Pyuria	2.7%
271	Renal Artery Obstruction	2.7%
272	Renal Artery Stenosis	2.7%
273	Urinary Calculi	2.7%
274	Cystocele	2.7%
275	Nephrocalcinosis	2.7%
276	Urinary Incontinence	2.7%
277	Glomerulonephritis	2.5%
278	Nephritis, Interstitial	2.5%
279	Lipoid nephrosis	2.5%
280	Nephrotic Syndrome	2.5%
281	Pyelitis	2.5%
282	Pyonephrosis	2.5%
283	Urethral Stenosis	2.5%
284	Nephrogenic Diabetes Insipidus	2.5%
285	Congenital Nephrogenic Diabetes Insipidus	2.5%
286	Acute kidney injury	2.5%
287	Urethral stricture	2.5%
288	Auditory Perceptual Disorders	2.5%
289	Mesoblastic Nephroma	2.5%
290	Renal Cell Carcinoma	2.4%
291	Papillary Renal Cell Carcinoma	2.4%
292	Jet Lag Syndrome	2.4%
293	Gonadal Dysgenesis	2.2%
294	Adrenogenital Syndrome	2.2%
295	Ovotesticular Disorders of Sex Development	2.2%
296	Dementia, Vascular	2.2%
297	Glycosuria, Renal	2.2%
298	Balkan Nephropathy	2.1%
299	Focal glomerulosclerosis	2.1%
300	Kidney Failure, Chronic	2.1%
301	Azotemia	2%
302	Nephroblastoma	2%
303	Albuminuria	2%
304	Hemoglobinuria	2%
305	Hypertension, Renovascular	2%
306	Urge Incontinence	2%
307	Hyperandrogenism	1.9%
308	AIDS-Associated Nephropathy	1.9%
309	Denys-Drash Syndrome	1.8%
310	Glomerulonephritis, Membranoproliferative	1.7%
311	Polycystic Kidney Diseases	1.7%
312	Renal Aminoacidurias	1.6%
313	Fanconi Syndrome	1.6%
314	Pseudohypoaldosteronism	1.6%
315	Liddle Syndrome	1.6%
316	Hemolytic-Uremic Syndrome	1.6%
317	Renal Osteodystrophy	1.5%
318	Renal rickets	1.5%
319	Renal tubular acidosis	1.4%
320	Anti-Glomerular Basement Membrane Disease	1.4%
321	Lupus Nephritis	1.4%
322	Polycystic Kidney, Autosomal Dominant	1.4%
323	Cystinuria	1.4%
324	Atypical Hemolytic Uremic Syndrome	1.4%
325	Turner Syndrome	1.3%
326	Kallmann Syndrome	1.2%
327	Zellweger Syndrome	1.1%
328	Hyperphosphaturia	1.1%
329	Klinefelter Syndrome	1.1%
330	Familial Hypophosphatemic Rickets	0.6%

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