MetaADEDB 2.0 @ LMMD
Lopinavir/Ritonavir
(OFFWOVJBSQMVPI-RMLGOCCBSA-N)
Structure
SMILES
O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@@H](N1CCCNC1=O)C(C)C)O)Cc1ccccc1)COc1c(C)cccc1C.O=C(N[C@H]([C@H](C[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)N(Cc1csc(n1)C(C)C)C)O)Cc1ccccc1)OCc1cncs1
Molecular Formula:
C74H96N10O10S2
Molecular Weight:
1349.750
Log P:
12.4545
Hydrogen Bond Acceptor:
22
Hydrogen Bond Donor:
8
TPSA:
322.26
CAS Number(s):
369372-47-4
Synonym(s)
1.
Lopinavir/Ritonavir
External Link(s)
PubChem Compound11979606
ChEBI145924
KEGGdr:D02498
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 8
Canada Vigilance: 1		Canada Vigilance
US FAERS
2Virologic failureFAERS: 6US FAERS
3Drug resistanceFAERS: 5
Canada Vigilance: 1		Canada Vigilance
US FAERS
4StillbirthFAERS: 4US FAERS
5EncephalitisFAERS: 3OFFSIDES
US FAERS
6Medication residueFAERS: 3OFFSIDES
US FAERS
7treatment failureFAERS: 3US FAERS
8Blood creatinine increasedFAERS: 2US FAERS
9Exposure during breast feedingFAERS: 2US FAERS
10Maternal exposure during pregnancyFAERS: 2US FAERS
11Toxicity to various agentsFAERS: 2US FAERS
12Alanine Aminotransferase IncreasedFAERS: 1US FAERS
13Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
14Blood brain barrier defectFAERS: 1US FAERS
15Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
16Blood triglycerides increasedFAERS: 1OFFSIDES
US FAERS
17Chest PainFAERS: 1OFFSIDES
US FAERS
18Cholestasis of pregnancyFAERS: 1OFFSIDES
US FAERS
19Congenital diaphragmatic herniaFAERS: 1US FAERS
20Drug exposure during pregnancyFAERS: 1US FAERS
21DysarthriaFAERS: 1US FAERS
22DysphoniaFAERS: 1US FAERS
23Echocardiogram abnormalFAERS: 1US FAERS
24FlushingFAERS: 1US FAERS
25Gonadal DysgenesisFAERS: 1US FAERS
26HypersensitivityFAERS: 1US FAERS
27Immune reconstitution syndromeFAERS: 1OFFSIDES
US FAERS
28Infectious peritonitisFAERS: 1US FAERS
29Initial insomniaFAERS: 1US FAERS
30Intestinal ObstructionFAERS: 1US FAERS
31Low set earsFAERS: 1US FAERS
32MacroglossiaFAERS: 1US FAERS
33NarcolepsyFAERS: 1US FAERS
34NauseaFAERS: 1OFFSIDES
US FAERS
35NephrolithiasisFAERS: 1US FAERS
36OverdoseFAERS: 1US FAERS
37Patent ductus arteriosusFAERS: 1US FAERS
38Pathogen resistanceFAERS: 1US FAERS
39PruritusFAERS: 1US FAERS
40Rebound effectFAERS: 1US FAERS
41Retroviral rebound syndromeFAERS: 1US FAERS
42Throat irritationFAERS: 1US FAERS
43Thyroid hormones decreasedFAERS: 1US FAERS
44TremorFAERS: 1US FAERS
45Ventricular hypertrophyFAERS: 1US FAERS
46VomitingFAERS: 1US FAERS
47nervous system disorderFAERS: 1US FAERS
48AIDS Dementia ComplexOFFSIDES
49Abdominal PainOFFSIDES
50AbscessOFFSIDES
51Accidental overdoseOFFSIDES
52AcidosisOFFSIDES
53Acute bronchitisOFFSIDES
54Acute myocardial infarctionOFFSIDES
55Acute respiratory failureOFFSIDES
56AdenitisOFFSIDES
57AdrenalitisOFFSIDES
58Amaurosis FugaxOFFSIDES
59AminoaciduriaOFFSIDES
60Anal FistulaOFFSIDES
61AnorexiaOFFSIDES
62Anticonvulsant drug level increasedOFFSIDES
63Aphthous StomatitisOFFSIDES
64AppendicitisOFFSIDES
65ArthritisOFFSIDES
66AscitesOFFSIDES
67AstheniaOFFSIDES
68BlepharoptosisOFFSIDES
69Blighted ovumOFFSIDES
70Blood HIV RNAOFFSIDES
71Blood alkaline phosphatase increasedOFFSIDES
72Blood amylase increasedOFFSIDES
73Blood lactate dehydrogenase decreasedOFFSIDES
74Blood phosphorus decreasedOFFSIDES
75Blood uric acidOFFSIDES
76Blood zinc decreasedOFFSIDES
77Body TemperatureOFFSIDES
78Bone painOFFSIDES
79BradycardiaOFFSIDES
80Brain ContusionOFFSIDES
81Breast tendernessOFFSIDES
82CD4 Lymphocytes DecreasedOFFSIDES
83CYTOMEGALOVIRUS ANTIGENOFFSIDES
84Cardioactive drug levelOFFSIDES
85CataractOFFSIDES
86CellulitisOFFSIDES
87Cervical myelopathyOFFSIDES
88Chemotherapeutic drug level increasedOFFSIDES
89ChromaturiaOFFSIDES
90CirrhosisOFFSIDES
91Citrobacter infectionOFFSIDES
92Clostridium difficile infectionCanada Vigilance: 1Canada Vigilance
93ClumsinessOFFSIDES
94ColitisOFFSIDES
95Congenital mitochondrial cytopathyOFFSIDES
96Corynebacterium sepsisOFFSIDES
97Cubital Tunnel SyndromeOFFSIDES
98Cytolytic hepatitisOFFSIDES
99Cytomegalovirus chorioretinitisOFFSIDES
100Dental cariesOFFSIDES
101DiabetesOFFSIDES
102Diabetes InsipidusOFFSIDES
103DiarrheaOFFSIDES
104Disseminated Intravascular CoagulationOFFSIDES
105Drug toxicityOFFSIDES
106Drug withdrawal headacheOFFSIDES
107Dry skinOFFSIDES
108Duodenal UlcerOFFSIDES
109Ear congestionOFFSIDES
110EnteritisOFFSIDES
111EnterocolitisOFFSIDES
112EpilepsyOFFSIDES
113Esophageal StenosisOFFSIDES
114Facial NeuralgiaOFFSIDES
115Facial wastingOFFSIDES
116Fanconi SyndromeOFFSIDES
117Fat redistributionOFFSIDES
118Feeling ColdOFFSIDES
119Focal glomerulosclerosisOFFSIDES
120FolliculitisOFFSIDES
121Gamma-Glutamyltransferase IncreasedOFFSIDES
122GammopathyOFFSIDES
123Gastric ulcerOFFSIDES
124GastroduodenitisOFFSIDES
125General physical conditionOFFSIDES
126General physical health deteriorationOFFSIDES
127Genital HerpesOFFSIDES
128GlobulinuriaOFFSIDES
129GoiterOFFSIDES
130Hepatitis COFFSIDES
131HepatosplenomegalyOFFSIDES
132HypertransaminasaemiaOFFSIDES
133Ileal ulcerOFFSIDES
134ImpetigoOFFSIDES
135Infection in an immunocompromised hostOFFSIDES
136Joint injuryOFFSIDES
137Kidney FailureOFFSIDES
138Large intestine perforationOFFSIDES
139Leukopenia neonatalOFFSIDES
140Lip erosionOFFSIDES
141LipaseOFFSIDES
142Lipodystrophy acquiredOFFSIDES
143LipohypertrophyOFFSIDES
144Live BirthOFFSIDES
145Localised intraabdominal fluid collectionOFFSIDES
146Lymphocytic infiltrationOFFSIDES
147LymphomaOFFSIDES
148Markedly reduced dietary intakeOFFSIDES
149Multi-organ disorderOFFSIDES
150Muscle WeaknessOFFSIDES
151Musculoskeletal stiffnessOFFSIDES
152Myocardial calcificationOFFSIDES
153Myoclonic EpilepsyOFFSIDES
154Nephrotic SyndromeOFFSIDES
155NoduleOFFSIDES
156NystagmusOFFSIDES
157Ocular icterusOFFSIDES
158OsteolysisOFFSIDES
159OsteopeniaOFFSIDES
160OsteoporosisOFFSIDES
161Oxygen consumption decreasedOFFSIDES
162Pain of skinOFFSIDES
163PallorOFFSIDES
164Pelvic venous thrombosisOFFSIDES
165Perianal abscessOFFSIDES
166PeritonitisOFFSIDES
167Pneumocystis jiroveci pneumoniaOFFSIDES
168PneumothoraxOFFSIDES
169PolyneuropathyOFFSIDES
170Pre-EclampsiaOFFSIDES
171Productive CoughOFFSIDES
172PyelonephritisOFFSIDES
173Renal ColicOFFSIDES
174Renal tubular acidosisOFFSIDES
175Renal tubular disorderOFFSIDES
176Renal tubular necrosisOFFSIDES
177Retinal Vein OcclusionOFFSIDES
178RhinorrheaOFFSIDES
179Ruptured cerebral aneurysmOFFSIDES
180SalmonellaOFFSIDES
181SarcoidosisOFFSIDES
182Septic ShockOFFSIDES
183Skin IndurationOFFSIDES
184Spinal cord herniationOFFSIDES
185Therapy regimen changedOFFSIDES
186ThrombophlebitisOFFSIDES
187Tinea PedisOFFSIDES
188Ultrasound antenatal screenOFFSIDES
189Vasculitis gastrointestinalOFFSIDES
190Zinc deficiencyOFFSIDES
191furuncleOFFSIDES
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