MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kidney Papillary Necrosis

(UMLS:C0022667)

Definition:: A complication of kidney diseases characterized by cell death involving KIDNEY PAPILLA in the KIDNEY MEDULLA. Damages to this area may hinder the kidney to concentrate urine resulting in POLYURIA. Sloughed off necrotic tissue may block KIDNEY PELVIS or URETER. Necrosis of multiple renal papillae can lead to KIDNEY FAILURE.
UMLS ID:: C0022667
MeSH ID:: D007681

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.493

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.493

Synonym(s)

Kidney Papillary Necrosis

Medullary necrosis

Necrosis;renal;papillary

Necrotising papillitis

Necrotizing papillitis

Necrotizing renal papillitis

PAPILLARY KIDNEY NECROSIS

PAPILLARY NECROSIS

PAPILLITIS, RENAL, NECROTIZING

10.

Papillary necrosis

11.

RENAL PAPILLARY NECROSIS

12.

RENAL PAPILLITIS NECROTIZING

13.

Renal Papillary Necrosis

14.

Renal medullary necrosis

15.

Renal papillary necrosis

16.

kidney; necrosis, papillary

17.

medullary; necrosis

18.

necrosis papillary

19.

necrosis; kidney, papillary

Associated Drug(s)

	Name	Reference(s)	Data Source
1	2-anisidine	28321044	CTD
2	2-bromoethylamine	1334993 9502396 20233945	CTD
3	Acetaminophen	View details 1203171 1919871 2362779 3050572 3559797 6025602 6126946 6590001 6776978 7412682	CTD
4	Acetic Acid	1488776	CTD
5	Allopurinol	620206	CTD
6	Aminopyrine	5640170	CTD
7	Antipyrine	View details 1201638 3365839 6827393 7412682	CTD
8	Aspirin	View details 22385 713267 887037 978313 1003266 1139519 1201638 1203171 1745559 1919871 2362779 2708025 3764937 4638853 4704495 5101354 5454357 6344630 6776978 6827393 6827395 7253164 7294057 7381645 7412682 12512867	CTD
9	Bilirubin	4640596	CTD
10	Caffeine	View details 1203171 2240058 4638853 5454357 7412682	CTD
11	Codeine	4123621 4638853 4704495	CTD
12	Cyclophosphamide	1488776	CTD
13	Dapsone	620206	CTD
14	Diethylhexyl Phthalate	3102426	CTD
15	Dihydroergotamine	8782036	CTD
16	Fenoprofen	486229 12512867	CTD
17	Flufenamic Acid	12512867	CTD
18	Flurbiprofen	1949951	CTD
19	Ibuprofen	View details 861066 6953356 7306246 10423592 12512867	CTD
20	Indinavir	11545487 18191366 18553024	CTD
21	Indomethacin	View details 277165 861066 972771 3102426 4548752 6125715 6953356 9502396 12512867	CTD
22	Ketoprofen	6953356	CTD
23	Ketorolac	8782036	CTD
24	Mefenamic Acid	View details 2240058 3126948 6105396 12512867	CTD
25	Mesalamine	5128205	CTD
26	Naproxen	View details 6699841 6953356 12512867 12774222 15198071	CTD
27	Pentazocine	7253164	CTD
28	Phenylbutazone	View details 277165 861066 972771 3764320 4548752 5569932 6649337 6869982 7744695 12512867	CTD
29	Prednisone	12774222	CTD
30	Rifampin	3476051	CTD
31	Saridon	View details 887037 1003266 1139519 1201638 1203171 3412544 3489155 4638853 4704495 5101354 5454357 5660814 6776978 7294057 7412682 12512867	CTD
32	Semustine	2937179	CTD
33	Sulindac	6126946	CTD
34	Sumatriptan	8782036	CTD
35	alclofenac	22385	CTD
36	aspirin, codeine, phenacetin drug combination	1201638	CTD
37	chlorozotocin	2937179	CTD
38	fenamic acid	20233945 22301952	CTD
39	nefiracetam	16105799	CTD
40	propoxyphene napsylate	6126946	CTD
41	propyleneimine	9134698	CTD
42	salicylamide	7412682	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hydronephrosis	47.5%
2	Hyperoxaluria	47.5%
3	Kidney Cortex Necrosis	47.5%
4	Nephritis	47.5%
5	Nephrosclerosis	47.5%
6	Nephrosis	47.5%
7	Perinephritis	47.5%
8	Kidney Failure	47.5%
9	Uremia	47.5%
10	Oxalosis	47.5%
11	Renal Insufficiency	47.5%
12	Anuria	45.9%
13	Nephrolithiasis	45.9%
14	Diabetes Insipidus	38.7%
15	Hepatorenal Syndrome	38.7%
16	Pyelonephritis	38.7%
17	Diabetic Nephropathy	38.2%
18	Renal hypertension	38.2%
19	Renal Artery Obstruction	38.2%
20	Renal Artery Stenosis	38.2%
21	Nephrocalcinosis	37.9%
22	Glomerulonephritis	35.2%
23	Nephritis, Interstitial	35.2%
24	Lipoid nephrosis	35.2%
25	Nephrotic Syndrome	35.2%
26	Pyelitis	35.2%
27	Pyonephrosis	35.2%
28	Nephrogenic Diabetes Insipidus	35.2%
29	Congenital Nephrogenic Diabetes Insipidus	35.2%
30	Acute kidney injury	35.2%
31	Tuberculosis, Renal	34.5%
32	Urinary Bladder Diseases	32.8%
33	Ureteral Diseases	32.8%
34	Urethral Diseases	32.8%
35	Urination Disorders	32.8%
36	Urolithiasis	32.8%
37	Kidney Neoplasm	31.8%
38	Pyelocystitis	29.9%
39	Kidney Calculi	29.5%
40	Balkan Nephropathy	29.2%
41	Focal glomerulosclerosis	29.2%
42	Kidney Failure, Chronic	29.2%
43	Azotemia	28.7%
44	Ureterolithiasis	28.4%
45	Hypertension, Renovascular	28.2%
46	Multicystic Dysplastic Kidney	27.7%
47	AIDS-Associated Nephropathy	27%
48	Urinary tract infection	26.5%
49	Bladder neck obstruction	24.7%
50	Glomerulonephritis, Membranoproliferative	24.5%
51	Polycystic Kidney Diseases	23.7%
52	Renal Aminoacidurias	23.5%
53	Fanconi Syndrome	23.5%
54	Pseudohypoaldosteronism	23.5%
55	Liddle Syndrome	23.5%
56	Hemolytic-Uremic Syndrome	23.4%
57	Glycosuria, Renal	22.6%
58	Cystitis	21.3%
59	Ureteral obstruction	21.3%
60	Ureterocele	21.3%
61	Urethral Obstruction	21.3%
62	Urethritis	21.3%
63	Vesico-Ureteral Reflux	21.3%
64	Urinary Retention	21.3%
65	Ureteral Calculi	20.9%
66	Renal Osteodystrophy	20.9%
67	Renal rickets	20.9%
68	Mesoblastic Nephroma	20.6%
69	Renal Cell Carcinoma	20.5%
70	Papillary Renal Cell Carcinoma	20.5%
71	Renal tubular acidosis	20.1%
72	Anti-Glomerular Basement Membrane Disease	19.9%
73	Lupus Nephritis	19.7%
74	Bladder Exstrophy	19.5%
75	Epispadias	19.5%
76	Polycystic Kidney, Autosomal Dominant	19.5%
77	Cystinuria	19.4%
78	Atypical Hemolytic Uremic Syndrome	19.3%
79	Urogenital Abnormalities	17.7%
80	Bacteriuria	17.1%
81	Glycosuria	17.1%
82	Hematuria	17.1%
83	Oliguria	17.1%
84	Polyuria	17.1%
85	Proteinuria	17.1%
86	Pyuria	17.1%
87	Urinary Calculi	17.1%
88	Cystocele	17%
89	Urinary Incontinence	17%
90	Urinary Bladder Fistula	16.8%
91	Bladder Neoplasm	16.8%
92	Ureteral Neoplasms	16.8%
93	Urethral Neoplasms	16.8%
94	Nephroblastoma	16.7%
95	Zellweger Syndrome	15.8%
96	Urethral Stenosis	15.8%
97	Urethral stricture	15.8%
98	Hyperphosphaturia	15.6%
99	Enuresis	14.4%
100	Albuminuria	12.6%
101	Hemoglobinuria	12.6%
102	Infertility	12.6%
103	Urge Incontinence	12.6%
104	Genital Diseases, Male	11.8%
105	Denys-Drash Syndrome	11.5%
106	Hypospadias	10.6%
107	Pregnancy Complications	10.6%
108	Diurnal Enuresis	10.6%
109	Urologic Neoplasms	10.1%
110	Horseshoe Kidney	10.1%
111	Endometriosis	9.9%
112	Uterine Diseases	9.9%
113	Vaginal Diseases	9.9%
114	Vulvar Diseases	9.9%
115	Endometrioma	9.9%
116	Vesicovaginal Fistula	8.9%
117	Sexually Transmitted Diseases	8.8%
118	Endometritis	8.5%
119	Hermaphroditism	8.5%
120	Disorders of Sex Development	8.5%
121	Genital Herpes	8.3%
122	Familial Hypophosphatemic Rickets	8.2%
123	Genital Neoplasms, Male	8.2%
124	Uterine Neoplasms	7.8%
125	Vaginal Neoplasms	7.8%
126	Vulvar Neoplasms	7.8%
127	Uterine Cancer	7.8%
128	Genital Neoplasms, Female	7.4%
129	Uterine Inversion	7.4%
130	Salpingitis	7.3%
131	Vulvovaginitis	7.3%
132	Fallopian Tube Neoplasms	6.8%
133	Epididymitis	6.7%
134	Penile Diseases	6.7%
135	Prostatic Diseases	6.7%
136	Spermatic Cord Torsion	6.7%
137	Hemospermia	6.7%
138	Testicular Hydrocele	6.7%
139	Dyspareunia	6.7%
140	Penile Neoplasms	6.6%
141	Prostatic Neoplasms	6.6%
142	Endometrial Hyperplasia	6.5%
143	Pyometra	6.5%
144	Vaginitis	6.5%
145	Vulvitis	6.5%
146	Vaginal Discharge	6.5%
147	Vulvodynia	6.5%
148	Uterine Rupture	6%
149	Oophoritis	5.8%
150	Endometrial Neoplasms	5.8%
151	Polyhydramnios	5.6%
152	Obstetric Labor Complications	5.6%
153	Ectopic Pregnancy	5.6%
154	Pregnancy, Prolonged	5.6%
155	Puerperal Disorders	5.6%
156	Oligohydramnios	5.6%
157	Prenatal Injuries	5.6%
158	Cryptorchidism	5.6%
159	Gonadal Dysgenesis	5.5%
160	Adrenogenital Syndrome	5.5%
161	Ovotesticular Disorders of Sex Development	5.5%
162	Uterine Cervical Incompetence	5.3%
163	Testicular Diseases	5.1%
164	Varicocele	5.1%
165	Spermatocele	5%
166	Ovarian Diseases	5%
167	ovarian neoplasm	5%
168	Abruptio Placentae	5%
169	Placenta Accreta	5%
170	Adnexitis	4.9%
171	Pruritus Vulvae	4.9%
172	Uterine hemorrhage	4.9%
173	Vaginal Fistula	4.9%
174	Pelvic Inflammatory Disease	4.9%
175	Uterine Prolapse	4.9%
176	Vaginal Prolapse	4.9%
177	Uterine Cervicitis	4.9%
178	Leukorrhea	4.9%
179	Parametritis	4.9%
180	Candidiasis, Vulvovaginal	4.9%
181	Prostatic Neoplasms, Castration-Resistant	4.9%
182	Hyperandrogenism	4.8%
183	Carcinoma, Endometrioid	4.8%
184	Chorioamnionitis	4.4%
185	Fetal Diseases	4.4%
186	Pregnancy Complications, Cardiovascular	4.4%
187	Pregnancy Complications, Neoplastic	4.4%
188	Balanitis	4.4%
189	Benign prostatic hypertrophy	4.4%
190	Phimosis	4.4%
191	Priapism	4.4%
192	prostatitis	4.4%
193	Prostatic Adenoma	4.4%
194	Benign Prostatic Hyperplasia	4.4%
195	Prostatic Hypertrophy	4.4%
196	Prostatic Hyperplasia	4.4%
197	Pregnancy Complications, Hematologic	4.3%
198	Pregnancy Complications, Infectious	4.3%
199	Fetal Death	4.2%
200	Perinatal death	4.2%
201	Morning Sickness	4.2%
202	Puerperal Infection	4%
203	Postpartum Hemorrhage	3.9%
204	Bacterial Vaginosis	3.7%
205	Trichomonas Vaginitis	3.7%
206	Uterine Perforation	3.7%
207	Ovarian Hyperstimulation Syndrome	3.7%
208	Metrorrhagia	3.6%
209	Endometrial Stromal Sarcoma	3.6%
210	Chlamydia Infections	3.5%
211	Gonorrhea	3.5%
212	Gestational Diabetes	3.4%
213	Premature Ejaculation	3.4%
214	Erectile dysfunction	3.4%
215	granulosa cell tumor	3.3%
216	Carcinoma, Ovarian Epithelial	3.3%
217	Testicular Neoplasms	3.3%
218	Orchitis	3.3%
219	Abortion, Habitual	3.3%
220	Dystocia	3.3%
221	Eclampsia	3.3%
222	Fetal Membranes, Premature Rupture	3.3%
223	Placental Insufficiency	3.3%
224	Pre-Eclampsia	3.3%
225	Prenatal Exposure Delayed Effects	3.3%
226	HELLP Syndrome	3.3%
227	Placenta, Retained	3.3%
228	Azoospermia	3.3%
229	Oligospermia	3.3%
230	Impotence, Vasculogenic	3.3%
231	Asthenozoospermia	3.3%
232	Teratozoospermia	3.3%
233	Aspermia	3.3%
234	Turner Syndrome	3.2%
235	Kallmann Syndrome	3.1%
236	Syphilis	3%
237	Corpus Luteum Cyst	3%
238	Ovarian Cysts	3%
239	Anovulation	2.9%
240	Menorrhagia	2.9%
241	Premature Menopause	2.9%
242	Lymphogranuloma Venereum	2.9%
243	Klinefelter Syndrome	2.7%
244	Abortion, Veterinary	2.6%
245	Pregnancy Complications, Parasitic	2.6%
246	Lactation Disorder	2.5%
247	Mastitis	2.5%
248	Depression, Postpartum	2.5%
249	Embryo Loss	2.5%
250	Fetal Resorption	2.5%
251	Hyperemesis Gravidarum	2.4%
252	Polycystic Ovary Syndrome	2.4%
253	Premature Birth	2.2%
254	Fetal Growth Retardation	2%
255	Trophoblastic Neoplasms	2%
256	Embolism, Amniotic Fluid	2%
257	Fetal Hypoxia	2%
258	Fetal Alcohol Spectrum Disorders	2%
259	Breech Presentation	2%
260	Stillbirth	2%
261	Leydig Cell Tumor	1.8%
262	Galactorrhea	1.6%
263	Meconium Aspiration Syndrome	1.5%
264	Choriocarcinoma	1.1%
265	Hydatidiform Mole	1%
266	Hydrops Fetalis	0.7%

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