MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Premature Menopause

(UMLS:C0025322)

Definition:: The premature cessation of menses (MENSTRUATION) when the last menstrual period occurs in a woman under the age of 40. It is due to the depletion of OVARIAN FOLLICLES. Premature MENOPAUSE can be caused by diseases; OVARIECTOMY; RADIATION; chemicals; and chromosomal abnormalities.
UMLS ID:: C0025322
MeSH ID:: D008594

Classification 1:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.056.630.250

Classification 2:

Name:

Reproductive and Urinary Physiological Phenomena
MeSH Tree Number(s):: G08.686.157.500.500|G08.686.841.249.500.500

Synonym(s)

Premature Menopause

Climacterium praecox

Early menopause

Hypergonadotropic amenorrhea

Menopause praecox

Menopause, Premature

Menopause, praecox

Menopause, premature

PREMATURE MENOPAUSE

10.

Premature Ovarian Failure

11.

Premature menopause

12.

Premature ovarian failure

13.

Premature ovarian insufficiency

14.

Premature;menopause

15.

Primary ovarian insufficiency

16.

early menopause

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 50 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Medroxyprogesterone Acetate	FAERS: 13	US FAERS
3	NuvaRing	FAERS: 8	US FAERS
4	Risperidone	FAERS: 7	US FAERS
5	Ciprofloxacin	FAERS: 6	US FAERS
6	Alendronate	FAERS: 4	US FAERS
7	Dasatinib	FAERS: 4	US FAERS
8	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 3	US FAERS
9	Cyclophosphamide	FAERS: 3	US FAERS
10	Hydroxyurea	FAERS: 3	US FAERS
11	Thalidomide	FAERS: 3	US FAERS
12	Valproic Acid	FAERS: 3	US FAERS
13	Varenicline	FAERS: 3	US FAERS
14	Venlafaxine Hydrochloride	FAERS: 3	US FAERS
15	Busulfan	FAERS: 2	US FAERS
16	Dimethyl Fumarate	FAERS: 2	US FAERS
17	Doxorubicin	FAERS: 2	SIDER US FAERS
18	Glatiramer Acetate	FAERS: 2	US FAERS
19	Isotretinoin	FAERS: 2	US FAERS
20	Letrozole	FAERS: 2	US FAERS
21	Leuprolide	FAERS: 2	US FAERS
22	Mitoxantrone	FAERS: 2	US FAERS
23	Temozolomide	FAERS: 2	US FAERS
24	ambrisentan	FAERS: 2	US FAERS
25	entecavir	FAERS: 2	US FAERS
26	liposomal doxorubicin	FAERS: 2	US FAERS
27	teriflunomide	FAERS: 2	US FAERS
28	4-hydroxybutyric acid	FAERS: 1	US FAERS
29	Acitretin	FAERS: 1	US FAERS
30	Cabergoline	FAERS: 1	US FAERS
31	Carbamazepine	FAERS: 1	US FAERS
32	Celecoxib	FAERS: 1	US FAERS
33	Citalopram	FAERS: 1	US FAERS
34	Copper	FAERS: 1	US FAERS
35	Duavee	FAERS: 1	US FAERS
36	Duloxetine Hydrochloride	FAERS: 1	US FAERS
37	Estradiol	FAERS: 1	US FAERS
38	Estrogens, Conjugated (USP)	FAERS: 1	US FAERS
39	Ethinyl Estradiol-Norgestrel Combination	FAERS: 1	US FAERS
40	Fingolimod Hydrochloride	FAERS: 1	US FAERS
41	GS-7340	FAERS: 1	US FAERS
42	Goserelin	FAERS: 1	US FAERS
43	Imatinib Mesylate	FAERS: 1	US FAERS
44	LCZ 696	FAERS: 1	US FAERS
45	Lurasidone Hydrochloride	FAERS: 1	US FAERS
46	Ospemifene	FAERS: 1	US FAERS
47	Pamidronate	FAERS: 1	US FAERS
48	Paroxetine	FAERS: 1	US FAERS
49	Sertraline	FAERS: 1	US FAERS
50	Sertraline	FAERS: 1	US FAERS
51	Spironolactone	FAERS: 1	US FAERS
52	Testosterone	FAERS: 1	US FAERS
53	drospirenone and ethinyl estradiol combination	FAERS: 1	US FAERS
54	elagolix	FAERS: 1	US FAERS
55	etonogestrel	FAERS: 1	US FAERS
56	norgestimate, ethinyl estradiol drug combination	FAERS: 1	US FAERS
57	Ifosfamide		SIDER
58	Medroxyprogesterone		SIDER
59	Thyroxine	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Postmenopause	44.7%
2	Andropause	36.8%
3	Puberty	36.2%
4	Multiple Pregnancy	25.5%
5	Oophoritis	24.6%
6	Anovulation	22.3%
7	Menarche	21.3%
8	Ovarian Hyperstimulation Syndrome	19.9%
9	Salpingitis	19.1%
10	Corpus Luteum Cyst	16.9%
11	Ovarian Cysts	16.9%
12	Endometritis	16.3%
13	ovarian neoplasm	14.5%
14	Adnexitis	14.5%
15	Pelvic Inflammatory Disease	14.5%
16	Endometriosis	14.1%
17	Uterine Diseases	14.1%
18	Vaginal Diseases	14.1%
19	Vulvar Diseases	14.1%
20	Endometrioma	14.1%
21	Breech Presentation	13.5%
22	Fertilization	13.3%
23	Pregnancy	13.3%
24	Polycystic Ovary Syndrome	12.4%
25	Parametritis	12%
26	Infertility	11.5%
27	Bisexuality	10.6%
28	Homosexuality	10.6%
29	Fallopian Tube Neoplasms	10.4%
30	Carcinoma, Endometrioid	10.1%
31	granulosa cell tumor	9.4%
32	Carcinoma, Ovarian Epithelial	9.4%
33	Urologic Diseases	9.2%
34	Fetal Weight	9.2%
35	Vulvovaginitis	8.9%
36	Menopause	8.7%
37	Sexually Transmitted Diseases	8.6%
38	Endometrial Hyperplasia	8.4%
39	Unwanted pregnancy	8.4%
40	Pyometra	8.4%
41	Vaginitis	8.4%
42	Vulvitis	8.4%
43	Vaginal Discharge	8.4%
44	Vulvodynia	8.4%
45	Uterine Inversion	8.4%
46	Genital Herpes	8.2%
47	Uterine Neoplasms	8%
48	Vaginal Neoplasms	8%
49	Vulvar Neoplasms	8%
50	Uterine Cancer	8%
51	Diuresis	7.8%
52	Urogenital Abnormalities	7.8%
53	Pregnancy Complications	7.2%
54	Uterine Rupture	7.1%
55	Pruritus Vulvae	6.8%
56	Uterine hemorrhage	6.8%
57	Vaginal Fistula	6.8%
58	Uterine Prolapse	6.7%
59	Vaginal Prolapse	6.7%
60	Glomerular Filtration Rate	6.2%
61	Live Birth	6%
62	Dyspareunia	5.7%
63	Superovulation	5.6%
64	Candidiasis, Vulvovaginal	5.6%
65	Uterine Cervicitis	5.6%
66	Leukorrhea	5.6%
67	Uterine Cervical Incompetence	5.4%
68	Stillbirth	5.4%
69	Endometrial Neoplasms	5.3%
70	Vesicovaginal Fistula	5.2%
71	Bladder Exstrophy	4.9%
72	Epispadias	4.9%
73	Urinary Bladder Diseases	4.9%
74	Kidney Diseases	4.9%
75	Ureteral Diseases	4.9%
76	Urethral Diseases	4.9%
77	Urination Disorders	4.9%
78	Urolithiasis	4.9%
79	Tuberculosis, Renal	4.9%
80	Genital Neoplasms, Female	4.9%
81	Premature Menopause	4.8%
82	Bacterial Vaginosis	4.6%
83	Trichomonas Vaginitis	4.5%
84	Uterine Perforation	4.5%
85	Metrorrhagia	4.5%
86	Multicystic Dysplastic Kidney	4.3%
87	Anuria	4.2%
88	Ureterolithiasis	4.2%
89	Urinary tract infection	4.2%
90	Nephrolithiasis	4.2%
91	Urologic Neoplasms	4.1%
92	Horseshoe Kidney	4.1%
93	Menorrhagia	3.8%
94	Polyhydramnios	3.7%
95	Obstetric Labor Complications	3.7%
96	Ectopic Pregnancy	3.7%
97	Pregnancy, Prolonged	3.7%
98	Puerperal Disorders	3.7%
99	Oligohydramnios	3.7%
100	Prenatal Injuries	3.7%
101	Urinary Bladder Fistula	3.6%
102	Bladder Neoplasm	3.6%
103	Kidney Neoplasm	3.6%
104	Ureteral Neoplasms	3.6%
105	Urethral Neoplasms	3.6%
106	Hermaphroditism	3.6%
107	Disorders of Sex Development	3.6%
108	Hypospadias	3.5%
109	Bladder neck obstruction	3.4%
110	Abruptio Placentae	3.2%
111	Placenta Accreta	3.2%
112	Fetal Diseases	3.1%
113	Pregnancy Complications, Cardiovascular	3.1%
114	Pregnancy Complications, Neoplastic	3.1%
115	Chorioamnionitis	3.1%
116	Pregnancy Complications, Hematologic	3%
117	Pregnancy Complications, Infectious	3%
118	Fetal Death	3%
119	Perinatal death	3%
120	Morning Sickness	2.9%
121	Cystitis	2.9%
122	Hydronephrosis	2.9%
123	Hyperoxaluria	2.9%
124	Kidney Cortex Necrosis	2.9%
125	Kidney Papillary Necrosis	2.9%
126	Nephritis	2.9%
127	Nephrosclerosis	2.9%
128	Nephrosis	2.9%
129	Perinephritis	2.9%
130	Kidney Failure	2.9%
131	Uremia	2.9%
132	Ureteral obstruction	2.9%
133	Ureterocele	2.9%
134	Urethral Obstruction	2.9%
135	Urethritis	2.9%
136	Vesico-Ureteral Reflux	2.9%
137	Urinary Retention	2.9%
138	Oxalosis	2.9%
139	Renal Insufficiency	2.9%
140	Kidney Calculi	2.9%
141	Ureteral Calculi	2.9%
142	Endometrial Stromal Sarcoma	2.9%
143	Chlamydia Infections	2.8%
144	Gonorrhea	2.8%
145	Puerperal Infection	2.7%
146	Postpartum Hemorrhage	2.7%
147	Syphilis	2.5%
148	Gestational Diabetes	2.5%
149	Diabetes Insipidus	2.5%
150	Hepatorenal Syndrome	2.5%
151	Bacteriuria	2.4%
152	Diabetic Nephropathy	2.4%
153	Glycosuria	2.4%
154	Hematuria	2.4%
155	Renal hypertension	2.4%
156	Oliguria	2.4%
157	Polyuria	2.4%
158	Proteinuria	2.4%
159	Pyuria	2.4%
160	Renal Artery Obstruction	2.4%
161	Renal Artery Stenosis	2.4%
162	Urinary Calculi	2.4%
163	Cystocele	2.4%
164	Nephrocalcinosis	2.4%
165	Urinary Incontinence	2.4%
166	Pyelocystitis	2.4%
167	Mesoblastic Nephroma	2.1%
168	Renal Cell Carcinoma	2.1%
169	Papillary Renal Cell Carcinoma	2.1%
170	Enuresis	2.1%
171	Lymphogranuloma Venereum	2.1%
172	Gonadal Dysgenesis	2.1%
173	Adrenogenital Syndrome	2.1%
174	Ovotesticular Disorders of Sex Development	2.1%
175	Pyelonephritis	2%
176	Abortion, Habitual	2%
177	Dystocia	2%
178	Eclampsia	2%
179	Fetal Membranes, Premature Rupture	2%
180	Placental Insufficiency	2%
181	Pre-Eclampsia	2%
182	Prenatal Exposure Delayed Effects	2%
183	HELLP Syndrome	2%
184	Placenta, Retained	2%
185	Glycosuria, Renal	1.9%
186	Glomerulonephritis	1.9%
187	Nephritis, Interstitial	1.9%
188	Lipoid nephrosis	1.9%
189	Nephrotic Syndrome	1.9%
190	Pyelitis	1.9%
191	Pyonephrosis	1.9%
192	Urethral Stenosis	1.9%
193	Nephrogenic Diabetes Insipidus	1.9%
194	Congenital Nephrogenic Diabetes Insipidus	1.9%
195	Acute kidney injury	1.9%
196	Urethral stricture	1.9%
197	AIDS-Associated Nephropathy	1.8%
198	Nephroblastoma	1.8%
199	Hyperandrogenism	1.7%
200	Abortion, Veterinary	1.7%
201	Pregnancy Complications, Parasitic	1.7%
202	Azotemia	1.6%
203	Lactation Disorder	1.6%
204	Mastitis	1.6%
205	Depression, Postpartum	1.6%
206	Embryo Loss	1.6%
207	Fetal Resorption	1.6%
208	Hyperemesis Gravidarum	1.6%
209	Albuminuria	1.6%
210	Hemoglobinuria	1.6%
211	Hypertension, Renovascular	1.6%
212	Denys-Drash Syndrome	1.6%
213	Urge Incontinence	1.6%
214	Renal Osteodystrophy	1.4%
215	Renal rickets	1.4%
216	Balkan Nephropathy	1.4%
217	Focal glomerulosclerosis	1.4%
218	Kidney Failure, Chronic	1.4%
219	Polycystic Kidney Diseases	1.4%
220	Diurnal Enuresis	1.4%
221	Fetal Growth Retardation	1.4%
222	Trophoblastic Neoplasms	1.4%
223	Renal Aminoacidurias	1.4%
224	Fanconi Syndrome	1.4%
225	Pseudohypoaldosteronism	1.4%
226	Liddle Syndrome	1.4%
227	Hemolytic-Uremic Syndrome	1.4%
228	Embolism, Amniotic Fluid	1.4%
229	Fetal Hypoxia	1.4%
230	Fetal Alcohol Spectrum Disorders	1.4%
231	Glomerulonephritis, Membranoproliferative	1.2%
232	Turner Syndrome	1.2%
233	Renal tubular acidosis	1.2%
234	Premature Birth	1.2%
235	Zellweger Syndrome	1.1%
236	Kallmann Syndrome	1.1%
237	Meconium Aspiration Syndrome	1.1%
238	Anti-Glomerular Basement Membrane Disease	1%
239	Lupus Nephritis	1%
240	Polycystic Kidney, Autosomal Dominant	1%
241	Cystinuria	1%
242	Atypical Hemolytic Uremic Syndrome	1%
243	Hyperphosphaturia	1%
244	Klinefelter Syndrome	1%
245	Galactorrhea	1%
246	Choriocarcinoma	0.7%
247	Hydatidiform Mole	0.5%
248	Hydrops Fetalis	0.5%
249	Familial Hypophosphatemic Rickets	0.5%

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