MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Endometrial Hyperplasia

(UMLS:C0014173)

Definition:: Benign proliferation of the ENDOMETRIUM in the UTERUS. Endometrial hyperplasia is classified by its cytology and glandular tissue. There are simple, complex (adenomatous without atypia), and atypical hyperplasia representing also the ascending risk of becoming malignant.
UMLS ID:: C0014173
MeSH ID:: D004714

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.852.228

Synonym(s)

Endometrial Hyperplasia

ENDOMETRIAL HYPERPLASIA

Endometrial hyperplasia

Endometrial hyperplasia, NOS

Endometrial hyperplasia, unspecified

Hyperplasia of Endometrium

Hyperplasia of the Endometrium

Hyperplasia of the endometrium

Hyperplasia;endometrium

10.

Hyperplastic endometrium

11.

endometrial hyperplasia

12.

endometrium hyperplasia

13.

endometrium; hyperplasia

14.

hyperplasia endometrial

15.

hyperplasia; endometrial

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Norgestrel	FAERS: 53 Canada Vigilance: 2	12554277 16824305	CTD OFFSIDES Canada Vigilance US FAERS
2	Raloxifene Hydrochloride	FAERS: 16		US FAERS
3	Tamoxifen	FAERS: 12		US FAERS
4	Medroxyprogesterone Acetate	FAERS: 10 Canada Vigilance: 1	2826865 11695813	CTD OFFSIDES Canada Vigilance US FAERS
5	Anastrozole	FAERS: 8		OFFSIDES US FAERS
6	Mifepristone	FAERS: 7		US FAERS
7	NuvaRing	FAERS: 7		US FAERS
8	Tamoxifen	FAERS: 7	View details 1683314 7677689 10726629 12627041 19827879	CTD OFFSIDES US FAERS
9	Estrogens, Conjugated (USP)	FAERS: 6 Canada Vigilance: 42		Canada Vigilance US FAERS
10	Duavee	FAERS: 5		US FAERS
11	Estradiol	FAERS: 5 Canada Vigilance: 1		Canada Vigilance OFFSIDES SIDER US FAERS
12	Fingolimod Hydrochloride	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
13	Toremifene	FAERS: 5		US FAERS
14	Isotretinoin	FAERS: 4		US FAERS
15	Ospemifene	FAERS: 4		US FAERS
16	Progesterone	FAERS: 4		OFFSIDES SIDER US FAERS
17	Arthrotec	FAERS: 3		US FAERS
18	Clozapine	FAERS: 3		US FAERS
19	Nafarelin	FAERS: 3		US FAERS
20	Teriparatide	FAERS: 3		US FAERS
21	rofecoxib	FAERS: 3		OFFSIDES US FAERS
22	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 2		US FAERS
23	Cabergoline	FAERS: 2		US FAERS
24	Copper	FAERS: 2		US FAERS
25	Ipratropium	FAERS: 2		US FAERS
26	Letrozole	FAERS: 2		OFFSIDES SIDER US FAERS
27	Mitotane	FAERS: 2		US FAERS
28	Risperidone	FAERS: 2		US FAERS
29	Thyroxine	FAERS: 2		US FAERS
30	Toremifene	FAERS: 2		SIDER US FAERS
31	Acetaminophen	FAERS: 1		US FAERS
32	Aspirin	FAERS: 1		US FAERS
33	Bosentan	FAERS: 1		OFFSIDES US FAERS
34	Estriol	FAERS: 1	16402032	CTD US FAERS
35	Fulvestrant	FAERS: 1		US FAERS
36	Iloprost	FAERS: 1		US FAERS
37	Leuprolide	FAERS: 1		US FAERS
38	Lopinavir	FAERS: 1		US FAERS
39	Methotrexate	FAERS: 1		US FAERS
40	Omeprazole	FAERS: 1		US FAERS
41	Pamidronate	FAERS: 1		US FAERS
42	Pregabalin	FAERS: 1		US FAERS
43	Qlaira	FAERS: 1		US FAERS
44	Rivaroxaban	FAERS: 1		US FAERS
45	Temozolomide	FAERS: 1		US FAERS
46	Thyroxine	FAERS: 1		US FAERS
47	Triamcinolone Acetonide	FAERS: 1		US FAERS
48	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
49	etonogestrel	FAERS: 1		US FAERS
50	exemestane	FAERS: 1		SIDER US FAERS
51	17 alpha-Hydroxyprogesterone Caproate		11695813	CTD
52	Atomoxetine Hydrochloride			OFFSIDES
53	Chlorhexidine			OFFSIDES
54	Chlorpheniramine			OFFSIDES
55	Ciclopirox			OFFSIDES
56	Cisapride			OFFSIDES
57	Clomiphene			OFFSIDES
58	Clomipramine			SIDER
59	Dextropropoxyphene			OFFSIDES
60	Diethylstilbestrol		16402032	CTD
61	Diflunisal			OFFSIDES
62	Epoprostenol			OFFSIDES
63	Estrone			SIDER
64	Ethylene Glycol			OFFSIDES
65	Etodolac			OFFSIDES
66	Fenofibrate			OFFSIDES
67	Flurazepam			OFFSIDES
68	Gemfibrozil			OFFSIDES
69	Genistein		16402032 29217487	CTD
70	Glucovance			OFFSIDES
71	Goserelin	Canada Vigilance: 1		Canada Vigilance OFFSIDES
72	Lasofoxifene			SIDER
73	Lutein			OFFSIDES
74	Mupirocin			OFFSIDES
75	Naproxen			OFFSIDES
76	Nateglinide			OFFSIDES
77	Norethindrone Acetate			OFFSIDES
78	Oracon		934552	CTD
79	Orlistat	Canada Vigilance: 1		Canada Vigilance
80	Pamidronate			OFFSIDES
81	Phytoestrogens		16402032	CTD
82	Quinidine			OFFSIDES
83	Raloxifene Hydrochloride			OFFSIDES
84	Rivastigmine			OFFSIDES
85	Rosiglitazone		18334011	CTD
86	Silymarin			OFFSIDES
87	Sirolimus			OFFSIDES
88	Solifenacin Succinate			OFFSIDES
89	Trisequens			SIDER
90	Vitamin A			OFFSIDES
91	Vitamin D			OFFSIDES
92	Vitamin E			OFFSIDES
93	Zoledronic Acid			OFFSIDES
94	bisphenol A		28959593	CTD
95	chlorhexidine gluconate			OFFSIDES
96	estradiol benzoate, estradiol dienanthate, testosterone enantate drug combination	Canada Vigilance: 11		Canada Vigilance
97	estradiol, estriol drug combination			SIDER
98	estradiol, norethindrone drug combination	Canada Vigilance: 1		Canada Vigilance
99	flupentixol, melitracen drug combination			OFFSIDES
100	proligestone		11996393	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pyometra	48.4%
2	Endometritis	43.3%
3	Uterine Cervicitis	36%
4	Uterine Inversion	35.9%
5	Endometriosis	34.4%
6	Vaginal Diseases	34.4%
7	Vulvar Diseases	34.4%
8	Endometrioma	34.4%
9	Uterine hemorrhage	32.6%
10	Uterine Prolapse	32.3%
11	Vaginal Prolapse	32.3%
12	Uterine Neoplasms	29%
13	Uterine Cancer	29%
14	Uterine Rupture	27.5%
15	Uterine Cervical Incompetence	26.2%
16	Uterine Perforation	24.3%
17	Metrorrhagia	24.1%
18	Infertility	23.6%
19	Vaginitis	22.6%
20	Vulvitis	22.6%
21	Vaginal Discharge	22.6%
22	Vulvodynia	22.6%
23	Salpingitis	22.3%
24	Vulvovaginitis	22.3%
25	Endometrial Neoplasms	21.5%
26	Menorrhagia	18.2%
27	Urologic Diseases	18.1%
28	Oophoritis	16.9%
29	Leukorrhea	16.8%
30	Parametritis	16.8%
31	Pregnancy Complications	16.4%
32	Vaginal Neoplasms	16.1%
33	Vulvar Neoplasms	16.1%
34	Ovarian Diseases	15.6%
35	Adnexitis	15.2%
36	Pruritus Vulvae	15.2%
37	Vaginal Fistula	15.2%
38	Pelvic Inflammatory Disease	15.2%
39	Sexually Transmitted Diseases	14.9%
40	Candidiasis, Vulvovaginal	14.1%
41	Genital Herpes	14%
42	Urogenital Abnormalities	13.5%
43	Fallopian Tube Neoplasms	13.3%
44	Endometrial Stromal Sarcoma	13%
45	Dyspareunia	11.7%
46	Bacterial Vaginosis	11.6%
47	Trichomonas Vaginitis	11.4%
48	Ovarian Hyperstimulation Syndrome	11.4%
49	Vesicovaginal Fistula	10.4%
50	Urinary Bladder Diseases	10.1%
51	Kidney Diseases	10.1%
52	Ureteral Diseases	10.1%
53	Urethral Diseases	10.1%
54	Urination Disorders	10.1%
55	Urolithiasis	10.1%
56	Genital Neoplasms, Female	9.9%
57	ovarian neoplasm	9.1%
58	Corpus Luteum Cyst	8.7%
59	Ovarian Cysts	8.7%
60	Anovulation	8.5%
61	Polyhydramnios	8.5%
62	Obstetric Labor Complications	8.5%
63	Ectopic Pregnancy	8.5%
64	Pregnancy, Prolonged	8.5%
65	Puerperal Disorders	8.5%
66	Oligohydramnios	8.5%
67	Prenatal Injuries	8.5%
68	Premature Menopause	8.4%
69	Bladder Exstrophy	8.3%
70	Epispadias	8.3%
71	Tuberculosis, Renal	8.2%
72	Anuria	7.8%
73	Ureterolithiasis	7.8%
74	Nephrolithiasis	7.8%
75	Carcinoma, Endometrioid	7.7%
76	Urinary tract infection	7.7%
77	Urologic Neoplasms	7.6%
78	Horseshoe Kidney	7.6%
79	Multicystic Dysplastic Kidney	7.4%
80	Polycystic Ovary Syndrome	7.1%
81	Bladder neck obstruction	6.8%
82	Abruptio Placentae	6.6%
83	Placenta Accreta	6.6%
84	Urinary Bladder Fistula	6.5%
85	Bladder Neoplasm	6.5%
86	Cystitis	6.5%
87	Hydronephrosis	6.5%
88	Hyperoxaluria	6.5%
89	Kidney Cortex Necrosis	6.5%
90	Kidney Neoplasm	6.5%
91	Kidney Papillary Necrosis	6.5%
92	Nephritis	6.5%
93	Nephrosclerosis	6.5%
94	Nephrosis	6.5%
95	Perinephritis	6.5%
96	Kidney Failure	6.5%
97	Uremia	6.5%
98	Ureteral Neoplasms	6.5%
99	Ureteral obstruction	6.5%
100	Ureterocele	6.5%
101	Urethral Neoplasms	6.5%
102	Urethral Obstruction	6.5%
103	Urethritis	6.5%
104	Vesico-Ureteral Reflux	6.5%
105	Urinary Retention	6.5%
106	Oxalosis	6.5%
107	Renal Insufficiency	6.5%
108	Hermaphroditism	6.1%
109	Disorders of Sex Development	6.1%
110	granulosa cell tumor	6.1%
111	Carcinoma, Ovarian Epithelial	6.1%
112	Hypospadias	6%
113	Fetal Diseases	6%
114	Pregnancy Complications, Cardiovascular	6%
115	Pregnancy Complications, Neoplastic	6%
116	Pregnancy Complications, Hematologic	5.7%
117	Pregnancy Complications, Infectious	5.7%
118	Chlamydia Infections	5.7%
119	Gonorrhea	5.7%
120	Fetal Death	5.6%
121	Perinatal death	5.6%
122	Morning Sickness	5.6%
123	Kidney Calculi	5.4%
124	Ureteral Calculi	5.4%
125	Chorioamnionitis	5.3%
126	Pyelocystitis	5.3%
127	Diabetes Insipidus	5%
128	Hepatorenal Syndrome	5%
129	Puerperal Infection	5%
130	Abortion, Habitual	4.9%
131	Bacteriuria	4.9%
132	Diabetic Nephropathy	4.9%
133	Dystocia	4.9%
134	Eclampsia	4.9%
135	Fetal Membranes, Premature Rupture	4.9%
136	Glycosuria	4.9%
137	Hematuria	4.9%
138	Renal hypertension	4.9%
139	Oliguria	4.9%
140	Placental Insufficiency	4.9%
141	Polyuria	4.9%
142	Postpartum Hemorrhage	4.9%
143	Pre-Eclampsia	4.9%
144	Prenatal Exposure Delayed Effects	4.9%
145	Proteinuria	4.9%
146	Pyuria	4.9%
147	Renal Artery Obstruction	4.9%
148	Renal Artery Stenosis	4.9%
149	Urinary Calculi	4.9%
150	HELLP Syndrome	4.9%
151	Placenta, Retained	4.9%
152	Cystocele	4.9%
153	Nephrocalcinosis	4.9%
154	Urinary Incontinence	4.9%
155	Syphilis	4.8%
156	Glomerulonephritis	4.8%
157	Nephritis, Interstitial	4.8%
158	Lipoid nephrosis	4.8%
159	Nephrotic Syndrome	4.8%
160	Pyelitis	4.8%
161	Pyonephrosis	4.8%
162	Urethral Stenosis	4.8%
163	Nephrogenic Diabetes Insipidus	4.8%
164	Congenital Nephrogenic Diabetes Insipidus	4.8%
165	Acute kidney injury	4.8%
166	Urethral stricture	4.8%
167	Pyelonephritis	4.8%
168	Lymphogranuloma Venereum	4.6%
169	Gestational Diabetes	4.2%
170	Mesoblastic Nephroma	4.1%
171	Renal Cell Carcinoma	4.1%
172	Papillary Renal Cell Carcinoma	4.1%
173	Enuresis	4%
174	Balkan Nephropathy	4%
175	Focal glomerulosclerosis	4%
176	Kidney Failure, Chronic	4%
177	Gonadal Dysgenesis	3.9%
178	Adrenogenital Syndrome	3.9%
179	Ovotesticular Disorders of Sex Development	3.9%
180	Azotemia	3.7%
181	Albuminuria	3.6%
182	Glycosuria, Renal	3.6%
183	Hemoglobinuria	3.6%
184	Hypertension, Renovascular	3.6%
185	Urge Incontinence	3.6%
186	Abortion, Veterinary	3.5%
187	Pregnancy Complications, Parasitic	3.5%
188	Lactation Disorder	3.3%
189	Mastitis	3.3%
190	Depression, Postpartum	3.3%
191	Embryo Loss	3.3%
192	Nephroblastoma	3.3%
193	Fetal Resorption	3.3%
194	AIDS-Associated Nephropathy	3.3%
195	Hyperemesis Gravidarum	3.2%
196	Premature Birth	3.2%
197	Hyperandrogenism	3.2%
198	Glomerulonephritis, Membranoproliferative	3.2%
199	Denys-Drash Syndrome	3%
200	Polycystic Kidney Diseases	2.9%
201	Diurnal Enuresis	2.9%
202	Renal Aminoacidurias	2.9%
203	Fanconi Syndrome	2.9%
204	Pseudohypoaldosteronism	2.9%
205	Liddle Syndrome	2.9%
206	Hemolytic-Uremic Syndrome	2.9%
207	Fetal Growth Retardation	2.5%
208	Trophoblastic Neoplasms	2.5%
209	Embolism, Amniotic Fluid	2.5%
210	Fetal Hypoxia	2.5%
211	Fetal Alcohol Spectrum Disorders	2.5%
212	Anti-Glomerular Basement Membrane Disease	2.5%
213	Breech Presentation	2.4%
214	Lupus Nephritis	2.4%
215	Stillbirth	2.4%
216	Renal Osteodystrophy	2.4%
217	Renal rickets	2.4%
218	Renal tubular acidosis	2.4%
219	Polycystic Kidney, Autosomal Dominant	2.4%
220	Cystinuria	2.4%
221	Atypical Hemolytic Uremic Syndrome	2.4%
222	Galactorrhea	2.2%
223	Kallmann Syndrome	2.1%
224	Turner Syndrome	2.1%
225	Hyperphosphaturia	1.8%
226	Klinefelter Syndrome	1.8%
227	Zellweger Syndrome	1.8%
228	Meconium Aspiration Syndrome	1.7%
229	Choriocarcinoma	1.3%
230	Hydatidiform Mole	1.2%
231	Familial Hypophosphatemic Rickets	0.9%
232	Hydrops Fetalis	0.8%

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