MetaADEDB 2.0 @ LMMD
Rifabutin
(ZWBTYMGEBZUQTK-PVLSIAFMSA-N)
Structure
SMILES
CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c2c(c(c3C)O)c(O)c(=NC(=O)/C(=C\C=C\[C@@H]([C@@H]([C@H]([C@H]([C@H]([C@@H]([C@@H]1C)OC(=O)C)C)O)C)O)C)/C)c1=NC3(Nc21)CCN(CC3)CC(C)C
Type(s)
Approved; Investigational
ATC code(s)
J04AB04
Molecular Formula:
C46H62N4O11
Molecular Weight:
847.005
Log P:
3.6965
Hydrogen Bond Acceptor:
15
Hydrogen Bond Donor:
5
TPSA:
209.04
CAS Number(s):
72559-06-9
Synonym(s)
1.
Rifabutin
2.
Alfacid
3.
Ansamycin
4.
Ansatipin
5.
Ansatipine
6.
LM-427
7.
Mycobutin
8.
Rifabutine
9.
LM 427
10.
LM427
External Link(s)
MeSHD017828
PubChem Compound135398743
ChEBI45367
DrugBankDB00615
DrugCentral2376
KEGGcpd:C07235
dr:D00424
ZINC169621215
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1LeukopeniaFAERS: 911310523CTD
SIDER
US FAERS
2NauseaFAERS: 7OFFSIDES
SIDER
US FAERS
3HeadacheFAERS: 6SIDER
US FAERS
4White blood cell count decreasedFAERS: 5SIDER
US FAERS
5Mental status changesFAERS: 4US FAERS
6AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
7Drug ineffectiveFAERS: 3US FAERS
8MalaiseFAERS: 3US FAERS
9Myocardial InfarctionFAERS: 3US FAERS
10PancytopeniaFAERS: 3SIDER
US FAERS
11ThrombocytopeniaFAERS: 3SIDER
US FAERS
12UveitisFAERS: 39101573CTD
SIDER
US FAERS
13VomitingFAERS: 3SIDER
US FAERS
14Abdominal discomfortFAERS: 2US FAERS
15Back PainFAERS: 2US FAERS
16General physical health deteriorationFAERS: 2OFFSIDES
US FAERS
17Night sweatsFAERS: 2US FAERS
18PainFAERS: 2SIDER
US FAERS
19RetchingFAERS: 2US FAERS
20RhabdomyolysisFAERS: 2OFFSIDES
US FAERS
21TuberculosisFAERS: 2US FAERS
22Weight decreasedFAERS: 2US FAERS
23AIDS cholangiopathyFAERS: 1OFFSIDES
US FAERS
24Abdominal PainFAERS: 1SIDER
US FAERS
25AgitationFAERS: 1US FAERS
26Amyotrophic Lateral SclerosisFAERS: 1US FAERS
27AnorexiaFAERS: 1OFFSIDES
SIDER
US FAERS
28ArthralgiaFAERS: 1SIDER
US FAERS
29Blood glucose increasedFAERS: 1US FAERS
30BronchiectasisFAERS: 1US FAERS
31ChillsFAERS: 1US FAERS
32ChromaturiaFAERS: 1SIDER
US FAERS
33ConjunctivitisFAERS: 1US FAERS
34ConstipationFAERS: 1US FAERS
35CryingFAERS: 1US FAERS
36DizzinessFAERS: 1US FAERS
37Drug effect incompleteFAERS: 1US FAERS
38DysgeusiaFAERS: 1SIDER
US FAERS
39EructationFAERS: 1SIDER
US FAERS
40Eye painFAERS: 1OFFSIDES
US FAERS
41Hepatic InfectionFAERS: 1OFFSIDES
US FAERS
42HepatomegalyFAERS: 1US FAERS
43HepatotoxicityFAERS: 1US FAERS
44HypoxiaFAERS: 1OFFSIDES
US FAERS
45Incorrect dose administeredFAERS: 1OFFSIDES
US FAERS
46Intentional drug misuseFAERS: 1US FAERS
47Keratic precipitatesFAERS: 1US FAERS
48Lupus vasculitisFAERS: 1US FAERS
49MalabsorptionFAERS: 1US FAERS
50Musculoskeletal stiffnessFAERS: 1US FAERS
51MyalgiaFAERS: 1SIDER
US FAERS
52PolyarthritisFAERS: 1US FAERS
53Polymyalgia RheumaticaFAERS: 1OFFSIDES
US FAERS
54Product administration errorFAERS: 1US FAERS
55Product quality issueFAERS: 1US FAERS
56Product taste abnormalFAERS: 1US FAERS
57Respiratory FailureFAERS: 1US FAERS
58Throat irritationFAERS: 1US FAERS
59TremorFAERS: 1US FAERS
60UrticariaFAERS: 1US FAERS
61jaundiceFAERS: 1SIDER
US FAERS
62Acquired Immunodeficiency Syndrome9101573CTD
63AgranulocytosisSIDER
64Alanine Aminotransferase IncreasedSIDER
65AngioedemaOFFSIDES
66Anti-HBc antibodyOFFSIDES
67AphasiaSIDER
68ApoptosisOFFSIDES
69ArthritisOFFSIDES
70Aspartate Aminotransferase IncreasedSIDER
71Atypical mycobacterial lymphadenitisOFFSIDES
72Bacteria stool identifiedOFFSIDES
73Blood alkaline phosphatase increasedOFFSIDES
SIDER
74Blood and lymphatic system disordersSIDER
75Blood bilirubin abnormalOFFSIDES
76Blood creatine increasedOFFSIDES
77Blood electrolytes abnormalOFFSIDES
78Bone painOFFSIDES
79Brain ContusionOFFSIDES
80Bronchoalveolar lavage abnormalOFFSIDES
81BronchospasmSIDER
82CD4 lymphocytes increasedOFFSIDES
83Chemotherapeutic drug level increasedOFFSIDES
84Chest PainSIDER
85Chest discomfortSIDER
86Chest pressureSIDER
87CholangiolitisOFFSIDES
88Clostridium difficile colitisSIDER
89ColitisOFFSIDES
90Creatinine renal clearance decreasedOFFSIDES
91Cross resistanceSIDER
92CyanosisOFFSIDES
93Cytomegalovirus test positiveOFFSIDES
94DermatitisSIDER
95Drug dispensing errorOFFSIDES
96Drug level below therapeuticOFFSIDES
97DyspepsiaSIDER
98Dyspnoea exacerbatedOFFSIDES
99Emotional distressSIDER
100EndocarditisOFFSIDES
101EndophthalmitisOFFSIDES
102EosinophiliaSIDER
103Erythema MultiformeOFFSIDES
104Fanconi SyndromeOFFSIDES
105Fatty LiverOFFSIDES
106Feeling abnormalSIDER
107FlatulenceSIDER
108Fluid overloadOFFSIDES
109Gamma-Glutamyltransferase IncreasedOFFSIDES
110Gastrointestinal PainSIDER
111GlomerulonephritisOFFSIDES
112Granulomatous liver diseaseOFFSIDES
113HIV Wasting SyndromeOFFSIDES
114Hepatitis B surface antigen positiveOFFSIDES
115Hepatitis BOFFSIDES
116HepatitisSIDER
117Histiocytosis haematophagicOFFSIDES
118HypersensitivitySIDER
119HypopyonOFFSIDES
120Immune reconstitution syndromeOFFSIDES
121ImmunosuppressionOFFSIDES
122InfectionOFFSIDES
123Intestinal ObstructionOFFSIDES
124Intestinal PerforationOFFSIDES
125Intraocular inflammationOFFSIDES
126IridocyclitisOFFSIDES
127IritisOFFSIDES
128Kidney FailureOFFSIDES
129Large intestine perforationOFFSIDES
130Leukopenia neonatalOFFSIDES
131LipaseOFFSIDES
132Lymph Node TuberculosisOFFSIDES
133Lymphocytic infiltrationOFFSIDES
134LymphopeniaSIDER
135Musculoskeletal discomfortSIDER
136Mycobacterium avium-intracellulare Infection11310523CTD
137MyositisSIDER
138Nasal discomfortOFFSIDES
139NeutropeniaSIDER
140Neutrophil count decreasedOFFSIDES
SIDER
141OverdoseOFFSIDES
142PancreatitisOFFSIDES
143Panuveitis16321897CTD
144Pathogen resistanceSIDER
145Pneumocystis jiroveci pneumoniaOFFSIDES
146PneumothoraxOFFSIDES
147Polyomavirus-associated nephropathyOFFSIDES
148PolyuriaOFFSIDES
149PruritusSIDER
150Renal tubular acidosisOFFSIDES
151Renal tubular disorderOFFSIDES
152Renal tubular necrosisOFFSIDES
153Retinal Vasculitis9101573
16321897
CTD
154Sense of oppressionOFFSIDES
155ShockSIDER
156Skin discomfortOFFSIDES
157Skin lesionOFFSIDES
158Sputum retentionOFFSIDES
159ToxoplasmosisOFFSIDES
160Transaminases increasedOFFSIDES
161Tuberculosis, Pulmonary16321897CTD
162VitritisOFFSIDES
163Wrist deformityOFFSIDES
164effusionOFFSIDES
165pseudomembranous colitisSIDER
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