MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Urethritis

(UMLS:C0041976)

Definition:: Inflammation involving the URETHRA. Similar to CYSTITIS, clinical symptoms range from vague discomfort to painful urination (DYSURIA), urethral discharge, or both.
UMLS ID:: C0041976
MeSH ID:: D014526

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.767.851

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.767.851

Synonym(s)

Urethritis

Inflammation of urethra

URETHRITIS

Urethritis non specific

Urethritis, NOS

inflammation of urethra

urethritis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 22		US FAERS
2	Isotretinoin	FAERS: 13	7116351 9228237	CTD US FAERS
3	Levofloxacin	FAERS: 3		US FAERS
4	Thyroxine	FAERS: 3		US FAERS
5	Canagliflozin	FAERS: 2		US FAERS
6	Clonazepam	FAERS: 2		US FAERS
7	Estrogens, Conjugated (USP)	FAERS: 2		US FAERS
8	Foscarnet	FAERS: 2		US FAERS
9	Lamotrigine	FAERS: 2		US FAERS
10	MDV 3100	FAERS: 2		US FAERS
11	Mefloquine	FAERS: 2		US FAERS
12	Mitomycin	FAERS: 2		US FAERS
13	Teriparatide	FAERS: 2		US FAERS
14	benzoylecgonine	FAERS: 2		US FAERS
15	empagliflozin	FAERS: 2		US FAERS
16	rofecoxib	FAERS: 2		OFFSIDES US FAERS
17	tofacitinib	FAERS: 2		US FAERS
18	Allopurinol	FAERS: 1		US FAERS
19	Atomoxetine Hydrochloride	FAERS: 1		US FAERS
20	Axitinib	FAERS: 1		US FAERS
21	Azithromycin	FAERS: 1		SIDER US FAERS
22	Buprenorphine	FAERS: 1		US FAERS
23	Cimetidine	FAERS: 1		US FAERS
24	Ciprofloxacin	FAERS: 1		OFFSIDES US FAERS
25	Copper	FAERS: 1		US FAERS
26	Crizotinib	FAERS: 1		US FAERS
27	Deferasirox	FAERS: 1		US FAERS
28	Exenatide	FAERS: 1		US FAERS
29	Fingolimod Hydrochloride	FAERS: 1		US FAERS
30	Fluoxetine	FAERS: 1		US FAERS
31	Ketamine	FAERS: 1		US FAERS
32	Lansoprazole	FAERS: 1		US FAERS
33	Leflunomide	FAERS: 1		US FAERS
34	Methotrexate	FAERS: 1		US FAERS
35	Methylprednisolone Acetate	FAERS: 1		US FAERS
36	NuvaRing	FAERS: 1		US FAERS
37	Omeprazole	FAERS: 1		US FAERS
38	Solifenacin Succinate	FAERS: 1		US FAERS
39	Tenofovir	FAERS: 1		US FAERS
40	Tiotropium Bromide	FAERS: 1		US FAERS
41	Vardenafil Dihydrochloride	FAERS: 1		US FAERS
42	atovaquone, proguanil drug combination	FAERS: 1		US FAERS
43	insulin glulisine	FAERS: 1		US FAERS
44	macitentan	FAERS: 1		US FAERS
45	pazopanib	FAERS: 1		US FAERS
46	Amoxicillin-Potassium Clavulanate Combination		10494743	CTD
47	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination			OFFSIDES
48	Atazanavir Sulfate			OFFSIDES
49	Busulfan			OFFSIDES
50	Cidofovir			SIDER
51	Doxycycline		10534208	CTD
52	Emtricitabine			SIDER
53	Everolimus			SIDER
54	Fluoxetine			SIDER
55	Flurbiprofen			SIDER
56	Ganciclovir			OFFSIDES
57	Hydromorphone			OFFSIDES
58	Ibuprofen			OFFSIDES
59	Ketoconazole		2742021	CTD
60	Minocycline		2943086 14998631	CTD
61	Mirtazapine			SIDER
62	Mycophenolic Acid			OFFSIDES SIDER
63	Norfloxacin		8335312	CTD
64	Ofloxacin		2244013 8335312	CTD SIDER
65	Paclitaxel			OFFSIDES
66	Pantoprazole			SIDER
67	Paroxetine			SIDER
68	Phenmetrazine	Canada Vigilance: 1		Canada Vigilance
69	Pramipexole			SIDER
70	Pregabalin			SIDER
71	Rifampin		6619694	CTD
72	Ritonavir			SIDER
73	Sevelamer			OFFSIDES
74	Sevelamer			OFFSIDES
75	Sorafenib			OFFSIDES
76	Spectinomycin		2943086	CTD
77	Sumatriptan			SIDER
78	Tiagabine			SIDER
79	Topotecan			OFFSIDES
80	Tretinoin			OFFSIDES
81	baricitinib	Canada Vigilance: 1		Canada Vigilance
82	beta-D-Xylopyranose			SIDER
83	fexofenadine			OFFSIDES
84	imidapril			OFFSIDES
85	iodixanol			OFFSIDES
86	oxybutynin			SIDER
87	pantethine			OFFSIDES
88	polystyrene sulfonic acid			OFFSIDES
89	valrubicin			SIDER
90	zaleplon			SIDER
91	zopiclone			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Urethral Obstruction	47.5%
2	Bladder neck obstruction	37.7%
3	Urethral Stenosis	35.2%
4	Urethral stricture	35.2%
5	Epispadias	34.8%
6	Urinary Bladder Diseases	32.8%
7	Kidney Diseases	32.8%
8	Ureteral Diseases	32.8%
9	Urination Disorders	32.8%
10	Urolithiasis	32.8%
11	Urethral Neoplasms	31.8%
12	Anuria	28.4%
13	Ureterolithiasis	28.4%
14	Nephrolithiasis	28.4%
15	Urinary tract infection	26.5%
16	Cystitis	21.3%
17	Hydronephrosis	21.3%
18	Hyperoxaluria	21.3%
19	Kidney Cortex Necrosis	21.3%
20	Kidney Papillary Necrosis	21.3%
21	Nephritis	21.3%
22	Nephrosclerosis	21.3%
23	Nephrosis	21.3%
24	Perinephritis	21.3%
25	Kidney Failure	21.3%
26	Uremia	21.3%
27	Ureteral obstruction	21.3%
28	Ureterocele	21.3%
29	Vesico-Ureteral Reflux	21.3%
30	Urinary Retention	21.3%
31	Oxalosis	21.3%
32	Renal Insufficiency	21.3%
33	Kidney Calculi	20.9%
34	Ureteral Calculi	20.9%
35	Bladder Exstrophy	19.5%
36	Tuberculosis, Renal	19.4%
37	Pyelocystitis	19.1%
38	Urogenital Abnormalities	17.7%
39	Diabetes Insipidus	17.3%
40	Hepatorenal Syndrome	17.3%
41	Pyelonephritis	17.3%
42	Bacteriuria	17.1%
43	Diabetic Nephropathy	17.1%
44	Glycosuria	17.1%
45	Hematuria	17.1%
46	Renal hypertension	17.1%
47	Oliguria	17.1%
48	Polyuria	17.1%
49	Proteinuria	17.1%
50	Pyuria	17.1%
51	Renal Artery Obstruction	17.1%
52	Renal Artery Stenosis	17.1%
53	Urinary Calculi	17.1%
54	Cystocele	17%
55	Nephrocalcinosis	17%
56	Urinary Incontinence	17%
57	Urinary Bladder Fistula	16.8%
58	Bladder Neoplasm	16.8%
59	Kidney Neoplasm	16.8%
60	Ureteral Neoplasms	16.8%
61	Multicystic Dysplastic Kidney	16.3%
62	Glomerulonephritis	15.8%
63	Nephritis, Interstitial	15.8%
64	Lipoid nephrosis	15.8%
65	Nephrotic Syndrome	15.8%
66	Pyelitis	15.8%
67	Pyonephrosis	15.8%
68	Nephrogenic Diabetes Insipidus	15.8%
69	Congenital Nephrogenic Diabetes Insipidus	15.8%
70	Acute kidney injury	15.8%
71	Enuresis	14.4%
72	Glycosuria, Renal	14%
73	Balkan Nephropathy	13.1%
74	Focal glomerulosclerosis	13.1%
75	Kidney Failure, Chronic	13.1%
76	Azotemia	12.9%
77	Albuminuria	12.6%
78	Hemoglobinuria	12.6%
79	Hypertension, Renovascular	12.6%
80	Infertility	12.6%
81	Urge Incontinence	12.6%
82	AIDS-Associated Nephropathy	12.1%
83	Genital Diseases, Male	11.8%
84	Glomerulonephritis, Membranoproliferative	11%
85	Mesoblastic Nephroma	10.9%
86	Renal Cell Carcinoma	10.8%
87	Papillary Renal Cell Carcinoma	10.8%
88	Polycystic Kidney Diseases	10.6%
89	Hypospadias	10.6%
90	Pregnancy Complications	10.6%
91	Diurnal Enuresis	10.6%
92	Renal Aminoacidurias	10.5%
93	Fanconi Syndrome	10.5%
94	Pseudohypoaldosteronism	10.5%
95	Liddle Syndrome	10.5%
96	Hemolytic-Uremic Syndrome	10.5%
97	Urologic Neoplasms	10.1%
98	Horseshoe Kidney	10.1%
99	Endometriosis	9.9%
100	Uterine Diseases	9.9%
101	Vaginal Diseases	9.9%
102	Vulvar Diseases	9.9%
103	Endometrioma	9.9%
104	Renal Osteodystrophy	9.4%
105	Renal rickets	9.4%
106	Renal tubular acidosis	9%
107	Vesicovaginal Fistula	8.9%
108	Anti-Glomerular Basement Membrane Disease	8.9%
109	Nephroblastoma	8.8%
110	Lupus Nephritis	8.8%
111	Sexually Transmitted Diseases	8.8%
112	Polycystic Kidney, Autosomal Dominant	8.7%
113	Cystinuria	8.7%
114	Atypical Hemolytic Uremic Syndrome	8.7%
115	Endometritis	8.5%
116	Hermaphroditism	8.5%
117	Disorders of Sex Development	8.5%
118	Genital Herpes	8.3%
119	Genital Neoplasms, Male	8.2%
120	Uterine Neoplasms	7.8%
121	Vaginal Neoplasms	7.8%
122	Vulvar Neoplasms	7.8%
123	Uterine Cancer	7.8%
124	Genital Neoplasms, Female	7.4%
125	Uterine Inversion	7.4%
126	Salpingitis	7.3%
127	Vulvovaginitis	7.3%
128	Zellweger Syndrome	7.1%
129	Hyperphosphaturia	7%
130	Denys-Drash Syndrome	6.9%
131	Fallopian Tube Neoplasms	6.8%
132	Epididymitis	6.7%
133	Penile Diseases	6.7%
134	Prostatic Diseases	6.7%
135	Spermatic Cord Torsion	6.7%
136	Hemospermia	6.7%
137	Testicular Hydrocele	6.7%
138	Dyspareunia	6.7%
139	Penile Neoplasms	6.6%
140	Prostatic Neoplasms	6.6%
141	Endometrial Hyperplasia	6.5%
142	Pyometra	6.5%
143	Vaginitis	6.5%
144	Vulvitis	6.5%
145	Vaginal Discharge	6.5%
146	Vulvodynia	6.5%
147	Uterine Rupture	6%
148	Oophoritis	5.8%
149	Endometrial Neoplasms	5.8%
150	Polyhydramnios	5.6%
151	Obstetric Labor Complications	5.6%
152	Ectopic Pregnancy	5.6%
153	Pregnancy, Prolonged	5.6%
154	Puerperal Disorders	5.6%
155	Oligohydramnios	5.6%
156	Prenatal Injuries	5.6%
157	Cryptorchidism	5.6%
158	Gonadal Dysgenesis	5.5%
159	Adrenogenital Syndrome	5.5%
160	Ovotesticular Disorders of Sex Development	5.5%
161	Uterine Cervical Incompetence	5.3%
162	Testicular Diseases	5.1%
163	Varicocele	5.1%
164	Spermatocele	5%
165	Ovarian Diseases	5%
166	ovarian neoplasm	5%
167	Abruptio Placentae	5%
168	Placenta Accreta	5%
169	Adnexitis	4.9%
170	Pruritus Vulvae	4.9%
171	Uterine hemorrhage	4.9%
172	Vaginal Fistula	4.9%
173	Pelvic Inflammatory Disease	4.9%
174	Uterine Prolapse	4.9%
175	Vaginal Prolapse	4.9%
176	Uterine Cervicitis	4.9%
177	Leukorrhea	4.9%
178	Parametritis	4.9%
179	Candidiasis, Vulvovaginal	4.9%
180	Prostatic Neoplasms, Castration-Resistant	4.9%
181	Hyperandrogenism	4.8%
182	Carcinoma, Endometrioid	4.8%
183	Chorioamnionitis	4.4%
184	Fetal Diseases	4.4%
185	Pregnancy Complications, Cardiovascular	4.4%
186	Pregnancy Complications, Neoplastic	4.4%
187	Balanitis	4.4%
188	Benign prostatic hypertrophy	4.4%
189	Phimosis	4.4%
190	Priapism	4.4%
191	prostatitis	4.4%
192	Prostatic Adenoma	4.4%
193	Benign Prostatic Hyperplasia	4.4%
194	Prostatic Hypertrophy	4.4%
195	Prostatic Hyperplasia	4.4%
196	Pregnancy Complications, Hematologic	4.3%
197	Pregnancy Complications, Infectious	4.3%
198	Fetal Death	4.2%
199	Perinatal death	4.2%
200	Morning Sickness	4.2%
201	Puerperal Infection	4%
202	Postpartum Hemorrhage	3.9%
203	Bacterial Vaginosis	3.7%
204	Familial Hypophosphatemic Rickets	3.7%
205	Trichomonas Vaginitis	3.7%
206	Uterine Perforation	3.7%
207	Ovarian Hyperstimulation Syndrome	3.7%
208	Metrorrhagia	3.6%
209	Endometrial Stromal Sarcoma	3.6%
210	Chlamydia Infections	3.5%
211	Gonorrhea	3.5%
212	Gestational Diabetes	3.4%
213	Premature Ejaculation	3.4%
214	Erectile dysfunction	3.4%
215	granulosa cell tumor	3.3%
216	Carcinoma, Ovarian Epithelial	3.3%
217	Testicular Neoplasms	3.3%
218	Orchitis	3.3%
219	Abortion, Habitual	3.3%
220	Dystocia	3.3%
221	Eclampsia	3.3%
222	Fetal Membranes, Premature Rupture	3.3%
223	Placental Insufficiency	3.3%
224	Pre-Eclampsia	3.3%
225	Prenatal Exposure Delayed Effects	3.3%
226	HELLP Syndrome	3.3%
227	Placenta, Retained	3.3%
228	Azoospermia	3.3%
229	Oligospermia	3.3%
230	Impotence, Vasculogenic	3.3%
231	Asthenozoospermia	3.3%
232	Teratozoospermia	3.3%
233	Aspermia	3.3%
234	Turner Syndrome	3.2%
235	Kallmann Syndrome	3.1%
236	Syphilis	3%
237	Corpus Luteum Cyst	3%
238	Ovarian Cysts	3%
239	Anovulation	2.9%
240	Menorrhagia	2.9%
241	Premature Menopause	2.9%
242	Lymphogranuloma Venereum	2.9%
243	Klinefelter Syndrome	2.7%
244	Abortion, Veterinary	2.6%
245	Pregnancy Complications, Parasitic	2.6%
246	Lactation Disorder	2.5%
247	Mastitis	2.5%
248	Depression, Postpartum	2.5%
249	Embryo Loss	2.5%
250	Fetal Resorption	2.5%
251	Hyperemesis Gravidarum	2.4%
252	Polycystic Ovary Syndrome	2.4%
253	Premature Birth	2.2%
254	Fetal Growth Retardation	2%
255	Trophoblastic Neoplasms	2%
256	Embolism, Amniotic Fluid	2%
257	Fetal Hypoxia	2%
258	Fetal Alcohol Spectrum Disorders	2%
259	Breech Presentation	2%
260	Stillbirth	2%
261	Leydig Cell Tumor	1.8%
262	Galactorrhea	1.6%
263	Meconium Aspiration Syndrome	1.5%
264	Choriocarcinoma	1.1%
265	Hydatidiform Mole	1%
266	Hydrops Fetalis	0.7%

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