MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Ovarian Hyperstimulation Syndrome

(UMLS:C0085083)

Definition:: A complication of OVULATION INDUCTION in infertility treatment. It is graded by the severity of symptoms which include OVARY enlargement, multiple OVARIAN FOLLICLES; OVARIAN CYSTS; ASCITES; and generalized EDEMA. The full-blown syndrome may lead to RENAL FAILURE, respiratory distress, and even DEATH. Increased capillary permeability is caused by the vasoactive substances, such as VASCULAR ENDOTHELIAL GROWTH FACTORS, secreted by the overly-stimulated OVARIES.
UMLS ID:: C0085083
MeSH ID:: D016471

Classification 1:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.056.630.642

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.630.642

Synonym(s)

Ovarian Hyperstimulation Syndrome

OVARIAN HYPERSTIMULATION SYNDROME

Ovarian hyperstimulation syndrome

Secondary Meig's syndrome

ovarian hyperstimulation syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Clomiphene	FAERS: 12 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	Tamoxifen	FAERS: 8		US FAERS
3	Cabergoline	FAERS: 4		OFFSIDES US FAERS
4	Goserelin	FAERS: 3		SIDER US FAERS
5	Leuprolide	FAERS: 3		US FAERS
6	Leuprolide	FAERS: 3		OFFSIDES US FAERS
7	Triptorelin Pamoate	FAERS: 3		US FAERS
8	Metformin	FAERS: 2		US FAERS
9	candesartan cilexetil	FAERS: 2		OFFSIDES US FAERS
10	cetrorelix	FAERS: 2		SIDER US FAERS
11	Anastrozole	FAERS: 1		US FAERS
12	Ceftriaxone	FAERS: 1		US FAERS
13	Deferasirox	FAERS: 1		US FAERS
14	Letrozole	FAERS: 1		US FAERS
15	Nafarelin	FAERS: 1		US FAERS
16	Norgestrel	FAERS: 1		US FAERS
17	Ortho Evra	FAERS: 1		US FAERS
18	Progesterone	FAERS: 1		OFFSIDES SIDER US FAERS
19	Tamoxifen	FAERS: 1		OFFSIDES US FAERS
20	Thyroxine	FAERS: 1		US FAERS
21	Urofollitropin	FAERS: 1		SIDER US FAERS
22	ganirelix	FAERS: 1		US FAERS
23	17 alpha-Hydroxyprogesterone Caproate		11719720 12960445	CTD
24	Atropine			OFFSIDES
25	Bromocriptine		12727942	CTD
26	Clomiphene		2572776	CTD SIDER
27	Desogestrel			OFFSIDES
28	Desogestrel			OFFSIDES
29	Estradiol			OFFSIDES
30	Estradiol		11719720 12960445	CTD
31	Gonadotropin-Releasing Hormone			SIDER
32	Indomethacin		2112558	CTD
33	Nafarelin			SIDER
34	candesartan			OFFSIDES
35	eletriptan			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Oophoritis	47.9%
2	Corpus Luteum Cyst	39.1%
3	Ovarian Cysts	39.1%
4	Anovulation	38.3%
5	ovarian neoplasm	32.8%
6	Polycystic Ovary Syndrome	28.7%
7	Salpingitis	24.1%
8	granulosa cell tumor	20.7%
9	Carcinoma, Ovarian Epithelial	20.7%
10	Endometritis	20.6%
11	Hypogonadism	20.1%
12	Delayed Puberty	20.1%
13	Precocious Puberty	20.1%
14	Hypogonadotropic hypogonadism	20.1%
15	Testotoxicosis	20.1%
16	Premature Menopause	19.9%
17	Carcinoma, Endometrioid	19.7%
18	Endometriosis	19.1%
19	Uterine Diseases	19.1%
20	Vaginal Diseases	19.1%
21	Vulvar Diseases	19.1%
22	Endometrioma	19.1%
23	Adnexitis	18.4%
24	Pelvic Inflammatory Disease	18.4%
25	Parametritis	16.1%
26	Testicular Diseases	15.3%
27	Infertility	14.6%
28	Hermaphroditism	14.4%
29	Disorders of Sex Development	14.4%
30	Fallopian Tube Neoplasms	12.6%
31	Urologic Diseases	11.9%
32	Adrenal Gland Diseases	11.7%
33	Parathyroid Diseases	11.7%
34	Thyroid Diseases	11.7%
35	Endometrial Hyperplasia	11.4%
36	Pyometra	11.4%
37	Vaginitis	11.4%
38	Vulvitis	11.4%
39	Vaginal Discharge	11.4%
40	Vulvodynia	11.4%
41	Vulvovaginitis	11.2%
42	Uterine Inversion	10.6%
43	Sexually Transmitted Diseases	10.2%
44	Pregnancy Complications	9.9%
45	Orchitis	9.9%
46	Kallmann Syndrome	9.8%
47	Uterine Neoplasms	9.7%
48	Vaginal Neoplasms	9.7%
49	Vulvar Neoplasms	9.7%
50	Uterine Cancer	9.7%
51	Genital Herpes	9.7%
52	Urogenital Abnormalities	9.5%
53	Gonadal Dysgenesis	9%
54	Adrenogenital Syndrome	9%
55	Ovotesticular Disorders of Sex Development	9%
56	Bone Diseases, Endocrine	8.8%
57	Endocrine Gland Neoplasms	8.8%
58	Diabetes Mellitus	8.7%
59	Uterine Rupture	8.6%
60	Klinefelter Syndrome	8.6%
61	Pituitary Diseases	8.6%
62	Pruritus Vulvae	8.6%
63	Uterine hemorrhage	8.6%
64	Vaginal Fistula	8.6%
65	Uterine Prolapse	8.5%
66	Vaginal Prolapse	8.5%
67	Adrenal Gland Neoplasms	8.1%
68	Hyperandrogenism	7.7%
69	Uterine Cervicitis	7.5%
70	Leukorrhea	7.5%
71	Testicular Neoplasms	7.5%
72	Gestational Diabetes	7.1%
73	Diabetes Insipidus	7%
74	Dyspareunia	7%
75	Dwarfism	7%
76	Uterine Cervical Incompetence	6.9%
77	Candidiasis, Vulvovaginal	6.8%
78	Parathyroid Neoplasms	6.8%
79	Thyroid Neoplasm	6.8%
80	Thyroid carcinoma	6.8%
81	Adrenal Cortex Diseases	6.7%
82	Euthyroid Sick Syndromes	6.7%
83	Goiter	6.7%
84	Hyperparathyroidism	6.7%
85	Hyperthyroidism	6.7%
86	Hyperthyroxinemia	6.7%
87	Hypoparathyroidism	6.7%
88	Hypothyroidism	6.7%
89	Thyroiditis	6.7%
90	Secondary hypothyroidism	6.7%
91	Primary Hyperthyroidism	6.7%
92	Primary Hypothyroidism	6.7%
93	Cryptorchidism	6.7%
94	Endometrial Neoplasms	6.4%
95	Urinary Bladder Diseases	6.3%
96	Kidney Diseases	6.3%
97	Ureteral Diseases	6.3%
98	Urethral Diseases	6.3%
99	Urination Disorders	6.3%
100	Urolithiasis	6.3%
101	Genital Neoplasms, Female	6.2%
102	Vesicovaginal Fistula	5.9%
103	Bacterial Vaginosis	5.8%
104	Bladder Exstrophy	5.7%
105	Epispadias	5.7%
106	Trichomonas Vaginitis	5.7%
107	Uterine Perforation	5.7%
108	Tuberculosis, Renal	5.7%
109	Metrorrhagia	5.6%
110	Diabetic Nephropathy	5.6%
111	Turner Syndrome	5.2%
112	Urinary tract infection	5.1%
113	Polyhydramnios	5%
114	Obstetric Labor Complications	5%
115	Ectopic Pregnancy	5%
116	Pregnancy, Prolonged	5%
117	Puerperal Disorders	5%
118	Oligohydramnios	5%
119	Prenatal Injuries	5%
120	Urologic Neoplasms	5%
121	Horseshoe Kidney	5%
122	Empty Sella Syndrome	5%
123	Hyperpituitarism	5%
124	Hypopituitarism	5%
125	Hypophysitis	5%
126	Multicystic Dysplastic Kidney	5%
127	Anuria	4.9%
128	Ureterolithiasis	4.9%
129	Nephrolithiasis	4.9%
130	Congenital Hypothyroidism	4.8%
131	Menorrhagia	4.5%
132	Graves Disease	4.5%
133	Cushing Syndrome	4.4%
134	Hyperaldosteronism	4.4%
135	Hyperparathyroidism, Secondary	4.4%
136	Hypoaldosteronism	4.4%
137	Thyrotoxicosis	4.4%
138	Hyperparathyroidism, Primary	4.4%
139	Thyroid Hormone Resistance Syndrome	4.4%
140	Thyroid Nodule	4.4%
141	Urinary Bladder Fistula	4.2%
142	Bladder Neoplasm	4.2%
143	Kidney Neoplasm	4.2%
144	Ureteral Neoplasms	4.2%
145	Urethral Neoplasms	4.2%
146	Hypospadias	4.2%
147	Adrenocortical carcinoma	4.1%
148	Abruptio Placentae	4.1%
149	Placenta Accreta	4.1%
150	Bladder neck obstruction	4.1%
151	Latent Autoimmune Diabetes in Adults	4%
152	Diabetes Mellitus, Experimental	4%
153	Fetal Diseases	4%
154	Pregnancy Complications, Cardiovascular	4%
155	Pregnancy Complications, Neoplastic	4%
156	Pituitary Adenoma	3.9%
157	Pituitary Neoplasms	3.9%
158	Pregnancy Complications, Hematologic	3.8%
159	Pregnancy Complications, Infectious	3.8%
160	Denys-Drash Syndrome	3.8%
161	Fetal Death	3.8%
162	Perinatal death	3.8%
163	Morning Sickness	3.7%
164	Leydig Cell Tumor	3.7%
165	Prolactinoma	3.7%
166	Growth Hormone-Secreting Pituitary Adenoma	3.7%
167	Cystitis	3.7%
168	Hydronephrosis	3.7%
169	Hyperoxaluria	3.7%
170	Kidney Cortex Necrosis	3.7%
171	Kidney Papillary Necrosis	3.7%
172	Nephritis	3.7%
173	Nephrosclerosis	3.7%
174	Nephrosis	3.7%
175	Perinephritis	3.7%
176	Kidney Failure	3.7%
177	Uremia	3.7%
178	Ureteral obstruction	3.7%
179	Ureterocele	3.7%
180	Urethral Obstruction	3.7%
181	Urethritis	3.7%
182	Vesico-Ureteral Reflux	3.7%
183	Urinary Retention	3.7%
184	Oxalosis	3.7%
185	Renal Insufficiency	3.7%
186	Chorioamnionitis	3.6%
187	Addison Disease	3.3%
188	Diabetic Angiopathies	3.3%
189	Autoimmune thyroiditis	3.3%
190	Primary Adrenal Insufficiency	3.3%
191	Endometrial Stromal Sarcoma	3.3%
192	Puerperal Infection	3.3%
193	Diabetic Neuropathies	3.3%
194	Myxedema	3.3%
195	Diabetic Amyotrophy	3.3%
196	Diabetic Autonomic Neuropathy	3.3%
197	Diabetic Cardiomyopathies	3.3%
198	Postpartum Hemorrhage	3.3%
199	Pituitary Apoplexy	3.3%
200	Hyperprolactinemia	3.2%
201	Hyperglycemic Hyperosmolar Nonketotic Coma	3.2%
202	Diabetic Foot	3.2%
203	Hashimoto Disease	3.2%
204	Chlamydia Infections	3.2%
205	Gonorrhea	3.2%
206	Kidney Calculi	3.2%
207	Ureteral Calculi	3.2%
208	Nelson Syndrome	3.2%
209	Hepatorenal Syndrome	3%
210	Bacteriuria	3%
211	Glycosuria	3%
212	Hematuria	3%
213	Renal hypertension	3%
214	Oliguria	3%
215	Polyuria	3%
216	Proteinuria	3%
217	Pyuria	3%
218	Renal Artery Obstruction	3%
219	Renal Artery Stenosis	3%
220	Urinary Calculi	3%
221	Cystocele	2.9%
222	Nephrocalcinosis	2.9%
223	Urinary Incontinence	2.9%
224	Multiple Endocrine Neoplasia	2.9%
225	Pancreatic Neoplasm	2.9%
226	Syphilis	2.8%
227	Pyelocystitis	2.8%
228	Abortion, Habitual	2.7%
229	Dystocia	2.7%
230	Eclampsia	2.7%
231	Fetal Membranes, Premature Rupture	2.7%
232	Placental Insufficiency	2.7%
233	Pre-Eclampsia	2.7%
234	Prenatal Exposure Delayed Effects	2.7%
235	HELLP Syndrome	2.7%
236	Placenta, Retained	2.7%
237	Renal Osteodystrophy	2.7%
238	Renal rickets	2.7%
239	Gigantism	2.6%
240	Acromegaly	2.6%
241	Diabetic Ketoacidosis	2.6%
242	Enuresis	2.5%
243	Glomerulonephritis	2.4%
244	Nephritis, Interstitial	2.4%
245	Lipoid nephrosis	2.4%
246	Nephrotic Syndrome	2.4%
247	Pyelitis	2.4%
248	Pyonephrosis	2.4%
249	Urethral Stenosis	2.4%
250	Nephrogenic Diabetes Insipidus	2.4%
251	Mesoblastic Nephroma	2.4%
252	Congenital Nephrogenic Diabetes Insipidus	2.4%
253	Acute kidney injury	2.4%
254	Urethral stricture	2.4%
255	Renal Cell Carcinoma	2.4%
256	Papillary Renal Cell Carcinoma	2.4%
257	Lymphogranuloma Venereum	2.4%
258	Pyelonephritis	2.4%
259	Abortion, Veterinary	2.2%
260	Pregnancy Complications, Parasitic	2.2%
261	Glycosuria, Renal	2.1%
262	AIDS-Associated Nephropathy	2.1%
263	Lactation Disorder	2.1%
264	Mastitis	2.1%
265	Depression, Postpartum	2.1%
266	Embryo Loss	2.1%
267	Fetal Resorption	2%
268	Hyperemesis Gravidarum	2%
269	Diabetic Retinopathy	2%
270	Azotemia	2%
271	Nephroblastoma	2%
272	Albuminuria	1.9%
273	Hemoglobinuria	1.9%
274	Hypertension, Renovascular	1.9%
275	Urge Incontinence	1.9%
276	Multiple Endocrine Neoplasia Type 1	1.9%
277	Balkan Nephropathy	1.8%
278	Focal glomerulosclerosis	1.8%
279	Kidney Failure, Chronic	1.8%
280	Fetal Growth Retardation	1.7%
281	Trophoblastic Neoplasms	1.7%
282	Embolism, Amniotic Fluid	1.7%
283	Fetal Hypoxia	1.7%
284	Fetal Alcohol Spectrum Disorders	1.7%
285	Breech Presentation	1.6%
286	Polycystic Kidney Diseases	1.6%
287	Stillbirth	1.6%
288	Premature Birth	1.6%
289	Diurnal Enuresis	1.6%
290	Renal Aminoacidurias	1.6%
291	Fanconi Syndrome	1.6%
292	Pseudohypoaldosteronism	1.6%
293	Liddle Syndrome	1.6%
294	Hemolytic-Uremic Syndrome	1.6%
295	Glomerulonephritis, Membranoproliferative	1.5%
296	Carcinoma, Pancreatic Ductal	1.4%
297	Renal tubular acidosis	1.4%
298	Anti-Glomerular Basement Membrane Disease	1.2%
299	Zellweger Syndrome	1.2%
300	Lupus Nephritis	1.2%
301	Meconium Aspiration Syndrome	1.2%
302	Galactorrhea	1.2%
303	insulinoma	1.2%
304	Polycystic Kidney, Autosomal Dominant	1.2%
305	Gastrinoma	1.2%
306	Glucagonoma	1.2%
307	Cystinuria	1.2%
308	Atypical Hemolytic Uremic Syndrome	1.2%
309	Waterhouse-Friderichsen Syndrome	1.2%
310	Hyperphosphaturia	1.1%
311	Vipoma	1.1%
312	Choriocarcinoma	0.8%
313	Adrenoleukodystrophy	0.7%
314	Hydatidiform Mole	0.6%
315	Hydrops Fetalis	0.5%
316	Familial Hypophosphatemic Rickets	0.5%

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