MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Epididymitis

(UMLS:C0014534)

Definition:: Inflammation of the EPIDIDYMIS. Its clinical features include enlarged epididymis, a swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
UMLS ID:: C0014534
MeSH ID:: D004823

Classification:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.199

Synonym(s)

Epididymitis

EPIDIDYMITIS

Epididymis inflamed

Epididymitis, NOS

Inflammation of epididymis

epididymis; inflammation

epididymitis

inflammation; epididymis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 51		US FAERS
2	Isotretinoin	FAERS: 18		US FAERS
3	rofecoxib	FAERS: 15		OFFSIDES US FAERS
4	Carbamazepine	FAERS: 5		US FAERS
5	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
6	Atomoxetine Hydrochloride	FAERS: 4		US FAERS
7	Atorvastatin	FAERS: 4 Canada Vigilance: 2		Canada Vigilance US FAERS
8	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 3		US FAERS
9	Dimethyl Fumarate	FAERS: 3		US FAERS
10	Dutasteride	FAERS: 3		OFFSIDES US FAERS
11	Everolimus	FAERS: 3		US FAERS
12	Fingolimod Hydrochloride	FAERS: 3		US FAERS
13	Lenalidomide	FAERS: 3		US FAERS
14	Minocycline	FAERS: 3		US FAERS
15	tofacitinib	FAERS: 3		US FAERS
16	Clozapine	FAERS: 2		OFFSIDES US FAERS
17	Gefitinib	FAERS: 2		US FAERS
18	Imatinib Mesylate	FAERS: 2		US FAERS
19	Lisinopril	FAERS: 2		US FAERS
20	Lopinavir	FAERS: 2		US FAERS
21	Losartan	FAERS: 2		US FAERS
22	Ruxolitinib phosphate	FAERS: 2		US FAERS
23	ceritinib	FAERS: 2		US FAERS
24	empagliflozin	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
25	testosterone undecanoate	FAERS: 2		US FAERS
26	4-hydroxybutyric acid	FAERS: 1		US FAERS
27	Adzenys XR-ODT	FAERS: 1		US FAERS
28	Alprostadil	FAERS: 1		US FAERS
29	Amiodarone	FAERS: 1		US FAERS
30	Amoxicillin	FAERS: 1		US FAERS
31	Bedaquiline fumarate	FAERS: 1		US FAERS
32	Betamethasone	FAERS: 1		US FAERS
33	Cetirizine	FAERS: 1		US FAERS
34	Ciprofloxacin	FAERS: 1	7645562	CTD US FAERS
35	Dabigatran	FAERS: 1		US FAERS
36	Dapagliflozin and metformin hydrochloride	FAERS: 1		US FAERS
37	Diclofenac	FAERS: 1		US FAERS
38	Droxidopa	FAERS: 1		US FAERS
39	Epoprostenol	FAERS: 1		US FAERS
40	Gabapentin	FAERS: 1		OFFSIDES SIDER US FAERS
41	Lamotrigine	FAERS: 1		SIDER US FAERS
42	Levetiracetam	FAERS: 1		US FAERS
43	Liraglutide	FAERS: 1		US FAERS
44	Minocycline	FAERS: 1		US FAERS
45	Minoxidil	FAERS: 1		US FAERS
46	Naltrexone	FAERS: 1		US FAERS
47	Omacor	FAERS: 1		SIDER US FAERS
48	Pamidronate	FAERS: 1		US FAERS
49	Paroxetine	FAERS: 1		SIDER US FAERS
50	Ramipril	FAERS: 1		US FAERS
51	Sulfasalazine	FAERS: 1		US FAERS
52	Tamsulosin	FAERS: 1		US FAERS
53	Terazosin	FAERS: 1		US FAERS
54	Tiotropium Bromide	FAERS: 1		US FAERS
55	Trazodone	FAERS: 1		US FAERS
56	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
57	Zoledronic Acid	FAERS: 1		US FAERS
58	apremilast	FAERS: 1		US FAERS
59	carfilzomib	FAERS: 1		US FAERS
60	mirabegron	FAERS: 1		US FAERS
61	nefazodone	FAERS: 1		US FAERS
62	saxagliptin	FAERS: 1		US FAERS
63	Acebutolol			OFFSIDES
64	Acetylcysteine			OFFSIDES
65	Amiodarone		9679920	CTD SIDER
66	Amisulpride			OFFSIDES
67	Ampicillin	Canada Vigilance: 1		Canada Vigilance OFFSIDES
68	Aripiprazole			SIDER
69	Atomoxetine Hydrochloride			OFFSIDES
70	Atorvastatin			SIDER
71	Benzbromarone			OFFSIDES
72	Bisacodyl			OFFSIDES
73	Bortezomib			SIDER
74	Budesonide			OFFSIDES
75	Bupropion			OFFSIDES
76	Capecitabine			OFFSIDES
77	Cefaclor			OFFSIDES
78	Chlorhexidine			OFFSIDES
79	Chloride ion			OFFSIDES
80	Citalopram			OFFSIDES
81	Clomipramine			SIDER
82	Cortisone			OFFSIDES
83	Cytarabine			OFFSIDES
84	Delavirdine			SIDER
85	Doxazosin			SIDER
86	Eptifibatide			OFFSIDES
87	Erythromycin			OFFSIDES
88	Famotidine			OFFSIDES
89	Fluoxetine	Canada Vigilance: 1		Canada Vigilance
90	Fluoxetine			SIDER
91	Ganciclovir			OFFSIDES
92	Goserelin			OFFSIDES
93	Ketoconazole			OFFSIDES
94	Lamivudine			OFFSIDES
95	Leuprolide			SIDER
96	Linezolid			OFFSIDES
97	Meloxicam			OFFSIDES
98	Mesalamine			SIDER
99	Methocarbamol			OFFSIDES
100	Metolazone			OFFSIDES
101	Misoprostol			OFFSIDES
102	Moxifloxacin			OFFSIDES
103	Mycophenolic Acid			SIDER
104	Nandrolone			SIDER
105	Nateglinide			OFFSIDES
106	Oxandrolone			SIDER
107	Oxymetholone			SIDER
108	Pamidronate			OFFSIDES
109	Pantoprazole			SIDER
110	Pentoxifylline			OFFSIDES
111	Pergolide			SIDER
112	Piperacillin, Tazobactam Drug Combination			OFFSIDES
113	Piperacillin			OFFSIDES
114	Pramipexole			SIDER
115	Pregabalin			SIDER
116	Probenecid			OFFSIDES
117	Pyridoxine			OFFSIDES
118	Ribavirin			OFFSIDES
119	Saquinavir			SIDER
120	Selegiline			SIDER
121	Sildenafil Citrate			OFFSIDES
122	Stavudine			OFFSIDES
123	Tenofovir			OFFSIDES
124	Tenofovir			OFFSIDES
125	Testosterone			SIDER
126	Thiamine			OFFSIDES
127	Tramadol			OFFSIDES
128	Tretinoin			OFFSIDES
129	Vardenafil Dihydrochloride			OFFSIDES
130	Voriconazole			SIDER
131	abacavir			OFFSIDES
132	beraprost			OFFSIDES
133	cevimeline			SIDER
134	chlorhexidine gluconate			OFFSIDES
135	cifenline			OFFSIDES
136	dihydroxyaluminum sodium carbonate			OFFSIDES
137	irsogladine			OFFSIDES
138	lipoteichoic acid		29311626	CTD
139	lomefloxacin			SIDER
140	loxoprofen			OFFSIDES
141	mizoribine			OFFSIDES
142	naftopidil			OFFSIDES
143	nefazodone			OFFSIDES
144	oxybutynin			OFFSIDES
145	rasagiline			SIDER
146	ropinirole			SIDER
147	sibutramine			SIDER
148	tipranavir			OFFSIDES
149	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Penile Diseases	42.9%
2	Prostatic Diseases	42.9%
3	Spermatic Cord Torsion	42.9%
4	Hemospermia	42.9%
5	Testicular Hydrocele	42.9%
6	Balanitis	31%
7	Benign prostatic hypertrophy	31%
8	Phimosis	31%
9	Priapism	31%
10	prostatitis	31%
11	Prostatic Adenoma	31%
12	Benign Prostatic Hyperplasia	31%
13	Prostatic Hypertrophy	31%
14	Prostatic Hyperplasia	31%
15	Testicular Diseases	28.6%
16	Varicocele	28.6%
17	Penile Neoplasms	28.2%
18	Prostatic Neoplasms	28.2%
19	Genital Neoplasms, Male	28.1%
20	Infertility	27.9%
21	Spermatocele	27.9%
22	Azoospermia	25.4%
23	Oligospermia	25.4%
24	Impotence, Vasculogenic	25.4%
25	Asthenozoospermia	25.4%
26	Teratozoospermia	25.4%
27	Aspermia	25.4%
28	Prostatic Neoplasms, Castration-Resistant	23%
29	Premature Ejaculation	20.9%
30	Erectile dysfunction	20.9%
31	Orchitis	20.5%
32	Cryptorchidism	17.8%
33	Hypospadias	17.8%
34	Sexually Transmitted Diseases	17.4%
35	Genital Herpes	16.3%
36	Dyspareunia	15.4%
37	Urologic Diseases	15%
38	Testicular Neoplasms	11.6%
39	Urogenital Abnormalities	11.1%
40	Urinary Bladder Diseases	9.3%
41	Kidney Diseases	9.3%
42	Ureteral Diseases	9.3%
43	Urethral Diseases	9.3%
44	Urination Disorders	9.3%
45	Urolithiasis	9.3%
46	Chlamydia Infections	8.2%
47	Gonorrhea	8.2%
48	Anuria	8%
49	Ureterolithiasis	8%
50	Nephrolithiasis	8%
51	Bladder Exstrophy	7.9%
52	Epispadias	7.9%
53	Tuberculosis, Renal	7.8%
54	Lymphogranuloma Venereum	7.3%
55	Multicystic Dysplastic Kidney	7.3%
56	Bladder neck obstruction	7.3%
57	Leydig Cell Tumor	7.3%
58	Syphilis	7%
59	Urinary tract infection	7%
60	Urologic Neoplasms	6.9%
61	Horseshoe Kidney	6.9%
62	Cystitis	6.7%
63	Hydronephrosis	6.7%
64	Hyperoxaluria	6.7%
65	Kidney Cortex Necrosis	6.7%
66	Kidney Papillary Necrosis	6.7%
67	Nephritis	6.7%
68	Nephrosclerosis	6.7%
69	Nephrosis	6.7%
70	Perinephritis	6.7%
71	Kidney Failure	6.7%
72	Uremia	6.7%
73	Ureteral obstruction	6.7%
74	Ureterocele	6.7%
75	Urethral Obstruction	6.7%
76	Urethritis	6.7%
77	Vesico-Ureteral Reflux	6.7%
78	Urinary Retention	6.7%
79	Oxalosis	6.7%
80	Renal Insufficiency	6.7%
81	Urinary Bladder Fistula	6.6%
82	Bladder Neoplasm	6.6%
83	Kidney Neoplasm	6.6%
84	Ureteral Neoplasms	6.6%
85	Urethral Neoplasms	6.6%
86	Pyelocystitis	6.2%
87	Kidney Calculi	6.1%
88	Ureteral Calculi	6.1%
89	Pyelonephritis	5.8%
90	Hermaphroditism	5.6%
91	Disorders of Sex Development	5.6%
92	Glomerulonephritis	5.5%
93	Nephritis, Interstitial	5.5%
94	Lipoid nephrosis	5.5%
95	Nephrotic Syndrome	5.5%
96	Pyelitis	5.5%
97	Pyonephrosis	5.5%
98	Urethral Stenosis	5.5%
99	Nephrogenic Diabetes Insipidus	5.5%
100	Congenital Nephrogenic Diabetes Insipidus	5.5%
101	Acute kidney injury	5.5%
102	Urethral stricture	5.5%
103	Diabetes Insipidus	5.1%
104	Hepatorenal Syndrome	5.1%
105	Bacteriuria	5%
106	Diabetic Nephropathy	5%
107	Glycosuria	5%
108	Hematuria	5%
109	Renal hypertension	5%
110	Oliguria	5%
111	Polyuria	5%
112	Proteinuria	5%
113	Pyuria	5%
114	Renal Artery Obstruction	5%
115	Renal Artery Stenosis	5%
116	Urinary Calculi	5%
117	Cystocele	5%
118	Nephrocalcinosis	5%
119	Urinary Incontinence	5%
120	Balkan Nephropathy	4.9%
121	Focal glomerulosclerosis	4.9%
122	Kidney Failure, Chronic	4.9%
123	Mesoblastic Nephroma	4.7%
124	Renal Cell Carcinoma	4.6%
125	Papillary Renal Cell Carcinoma	4.6%
126	Azotemia	4.2%
127	Albuminuria	4.1%
128	Hemoglobinuria	4.1%
129	Hypertension, Renovascular	4.1%
130	Urge Incontinence	4.1%
131	Enuresis	4.1%
132	Glycosuria, Renal	4.1%
133	Gonadal Dysgenesis	4%
134	Adrenogenital Syndrome	4%
135	Ovotesticular Disorders of Sex Development	4%
136	Glomerulonephritis, Membranoproliferative	3.9%
137	Nephroblastoma	3.7%
138	Hyperandrogenism	3.6%
139	Denys-Drash Syndrome	3.5%
140	Polycystic Kidney Diseases	3.3%
141	AIDS-Associated Nephropathy	3.3%
142	Diurnal Enuresis	3.3%
143	Renal Aminoacidurias	3.3%
144	Fanconi Syndrome	3.3%
145	Pseudohypoaldosteronism	3.3%
146	Liddle Syndrome	3.3%
147	Hemolytic-Uremic Syndrome	3.3%
148	Anti-Glomerular Basement Membrane Disease	3%
149	Lupus Nephritis	3%
150	Polycystic Kidney, Autosomal Dominant	2.9%
151	Cystinuria	2.9%
152	Atypical Hemolytic Uremic Syndrome	2.9%
153	Renal tubular acidosis	2.7%
154	Renal Osteodystrophy	2.5%
155	Renal rickets	2.5%
156	Kallmann Syndrome	2.4%
157	Turner Syndrome	2.3%
158	Hyperphosphaturia	2%
159	Klinefelter Syndrome	2%
160	Zellweger Syndrome	1.8%
161	Familial Hypophosphatemic Rickets	1.1%

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