MetaADEDB 2.0 @ LMMD
Midazolam
(DDLIGBOFAVUZHB-UHFFFAOYSA-N)
Structure
SMILES
Clc1ccc2c(c1)C(=NCc1n2c(C)nc1)c1ccccc1F
Type(s)
Approved; Illicit
ATC code(s)
N05CD08
Molecular Formula:
C18H13ClFN3
Molecular Weight:
325.767
Log P:
3.7598
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
30.18
CAS Number(s):
59467-70-8
Synonym(s)
1.
Midazolam
2.
Dormicum
3.
Midazolam Hydrochloride
4.
Midazolam Maleate
5.
Ro 21-3981
6.
Versed
7.
Hydrochloride, Midazolam
8.
Maleate, Midazolam
9.
Ro 21 3981
10.
Ro 213981
External Link(s)
MeSHD008874
PubChem Compound4192
BindingDB21363
ChEBI6931
CHEMBLCHEMBL655
DrugBankDB00683
DrugCentral1802
IUPHAR/BPS Guide to PHARMACOLOGY3342
KEGGcpd:C07524
dr:D00550
Therapeutic Target DatabaseD0U6LM
ZINC95626706
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 85
Canada Vigilance: 44		Canada Vigilance
US FAERS
2AmnesiaFAERS: 17

View details

1803833
1811430
2021203
2223335
2619791
2979684
3112263
3800022
8235775
8373576
8668567
9054704
11092773
12762176
12845417
14616644
15596721
15698896
16006177
16423438
16546038
19733366
 		CTD
OFFSIDES
US FAERS
3AgitationFAERS: 15
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
4AnxietyFAERS: 13OFFSIDES
SIDER
US FAERS
5HypotensionFAERS: 13
Canada Vigilance: 5

View details

352195
1675391
2358560
2920683
2955719
3202310
8053578
8669676
9249836
10566717
11339727
11675907
11675908
15295727
15496697
16128939
17892610
20171707
 		CTD
SIDER
Canada Vigilance
US FAERS
6Hepatic EncephalopathyFAERS: 11US FAERS
7Respiratory DepressionFAERS: 11
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
8DeliriumFAERS: 107978604
17175823		CTD
SIDER
US FAERS
9Unresponsive to stimuliFAERS: 10
Canada Vigilance: 3		Canada Vigilance
OFFSIDES
US FAERS
10Depressed Level of ConsciousnessFAERS: 9
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
11Respiratory arrestFAERS: 9SIDER
US FAERS
12TremorFAERS: 98123277
17604593		CTD
SIDER
US FAERS
13BradycardiaFAERS: 87943770CTD
SIDER
US FAERS
14Medication ErrorFAERS: 8US FAERS
15Memory impairmentFAERS: 8
Canada Vigilance: 1		Canada Vigilance
US FAERS
16Product quality issueFAERS: 8US FAERS
17SomnolenceFAERS: 8
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
18VomitingFAERS: 8
Canada Vigilance: 2		12920432
15930401		CTD
SIDER
Canada Vigilance
US FAERS
19Cardiac ArrestFAERS: 7SIDER
US FAERS
20NauseaFAERS: 712920432CTD
OFFSIDES
SIDER
US FAERS
21Product measured potency issueFAERS: 7US FAERS
22AngerFAERS: 6SIDER
US FAERS
23CryingFAERS: 6
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
24Incorrect dose administeredFAERS: 6
Canada Vigilance: 1		Canada Vigilance
US FAERS
25Post-Traumatic Stress DisorderFAERS: 6US FAERS
26Procedural complicationFAERS: 6OFFSIDES
US FAERS
27ScreamingFAERS: 6US FAERS
28Anaphylactoid ReactionFAERS: 5SIDER
US FAERS
29BronchospasmFAERS: 5SIDER
US FAERS
30Feeling abnormalFAERS: 5SIDER
US FAERS
31Incorrect route of drug administrationFAERS: 5US FAERS
32LethargyFAERS: 5OFFSIDES
SIDER
US FAERS
33PainFAERS: 5

View details

352195
2358560
6117301
7645789
9054704
10566717
11558979
12707139
18716494
20820150
 		CTD
OFFSIDES
SIDER
US FAERS
34Post procedural complicationFAERS: 5OFFSIDES
US FAERS
35Product impurityFAERS: 5US FAERS
36StrabismusFAERS: 5US FAERS
37DizzinessFAERS: 43112263CTD
OFFSIDES
SIDER
US FAERS
38Kounis SyndromeFAERS: 4US FAERS
39Paradoxical drug reactionFAERS: 4US FAERS
40Pharmaceutical product complaintFAERS: 4US FAERS
41Respiratory FailureFAERS: 4OFFSIDES
SIDER
US FAERS
42TachycardiaFAERS: 4352195
8669676
9415834		CTD
SIDER
US FAERS
43UrticariaFAERS: 4SIDER
US FAERS
44Atrial FibrillationFAERS: 39698967CTD
US FAERS
45Drug resistanceFAERS: 3US FAERS
46HeadacheFAERS: 3SIDER
US FAERS
47HydrocephalusFAERS: 3US FAERS
48Intentional product use issueFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
49MyoclonusFAERS: 3

View details

7711342
8033934
11064794
11349753
12635389
17959958
18226283
18230263
18486797
24535067
 		CTD
US FAERS
50OverdoseFAERS: 3US FAERS
51Product formulation issueFAERS: 3US FAERS
52Product label issueFAERS: 3US FAERS
53Respiratory distressFAERS: 3US FAERS
54Sedation complicationFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
55Seizure like phenomenaFAERS: 3US FAERS
56Slow response to stimuliFAERS: 3US FAERS
57Therapeutic product effect incompleteFAERS: 3US FAERS
58AstheniaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
SIDER
US FAERS
59Device programming errorFAERS: 2US FAERS
60DisorientationFAERS: 2
Canada Vigilance: 4		Canada Vigilance
SIDER
US FAERS
61Drug administration errorFAERS: 2OFFSIDES
US FAERS
62Drug ineffective for unapproved indicationFAERS: 2US FAERS
63DystoniaFAERS: 22108778
2278124
16154341		CTD
US FAERS
64Emotional disorderFAERS: 2SIDER
US FAERS
65ErythemaFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
66HypersensitivityFAERS: 2SIDER
US FAERS
67HyperventilationFAERS: 2SIDER
US FAERS
68Hyporesponsive to stimuliFAERS: 2US FAERS
69HypoxiaFAERS: 2
Canada Vigilance: 2		2122773
20084309		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
70Incorrect drug dosage form administeredFAERS: 2US FAERS
71Mental status changesFAERS: 2OFFSIDES
US FAERS
72MonoparesisFAERS: 2US FAERS
73Neonatal hypotensionFAERS: 2US FAERS
74No adverse eventFAERS: 2US FAERS
75ParanoiaFAERS: 2US FAERS
76Poor quality drug administeredFAERS: 2US FAERS
77Poor quality product administeredFAERS: 2US FAERS
78Procedural hypotensionFAERS: 2US FAERS
79RestlessnessFAERS: 2US FAERS
80SneezingFAERS: 2SIDER
US FAERS
81Suspected product tamperingFAERS: 2US FAERS
82VertigoFAERS: 212920432CTD
SIDER
US FAERS
83Accidental overdoseFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
84Activities of daily living impairedFAERS: 1US FAERS
85ArthralgiaFAERS: 1US FAERS
86ArthropathyFAERS: 1US FAERS
87Blood creatine phosphokinase increasedFAERS: 1OFFSIDES
US FAERS
88Blood glucose increasedFAERS: 1US FAERS
89Brain DeathFAERS: 1OFFSIDES
US FAERS
90Bronchial ObstructionFAERS: 1OFFSIDES
US FAERS
91BruxismFAERS: 1US FAERS
92CREST SyndromeFAERS: 1US FAERS
93CatatoniaFAERS: 1OFFSIDES
US FAERS
94Cerebrovascular accidentFAERS: 1US FAERS
95Chest PainFAERS: 1OFFSIDES
US FAERS
96ChokingFAERS: 1US FAERS
97Cold sweatFAERS: 1US FAERS
98ConstipationFAERS: 1SIDER
US FAERS
99Contrast media allergyFAERS: 1US FAERS
100Conversion disorderFAERS: 1US FAERS
101DehydrationFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
102Drug abuseFAERS: 1US FAERS
103Drug diversionFAERS: 1US FAERS
104Drug effect incompleteFAERS: 1US FAERS
105DysarthriaFAERS: 13202310
12624310		CTD
SIDER
US FAERS
106DysphoniaFAERS: 1SIDER
US FAERS
107DysuriaFAERS: 1OFFSIDES
US FAERS
108Educational problemFAERS: 1US FAERS
109EpilepsyFAERS: 11537365
9768791
11400034		CTD
OFFSIDES
US FAERS
110Extra dose administeredFAERS: 1US FAERS
111ExtravasationFAERS: 1US FAERS
112FatigueFAERS: 1SIDER
US FAERS
113FrustrationFAERS: 1US FAERS
114Gastrointestinal PainFAERS: 1US FAERS
115General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
116HostilityFAERS: 1SIDER
US FAERS
117HypersomniaFAERS: 1US FAERS
118HypophagiaFAERS: 1US FAERS
119Hypotonic-hyporesponsive episodeFAERS: 1US FAERS
120Iatrogenic injuryFAERS: 1US FAERS
121Impaired work abilityFAERS: 1US FAERS
122IncoherentFAERS: 1US FAERS
123Incorrect drug administration rateFAERS: 1US FAERS
124Incorrect product administration durationFAERS: 1US FAERS
125Incorrect route of product administrationFAERS: 1US FAERS
126Increased upper airway secretionFAERS: 1US FAERS
127Increased viscosity of bronchial secretionFAERS: 1US FAERS
128Injection site erythemaFAERS: 1US FAERS
129Injection site urticariaFAERS: 1US FAERS
130LaryngospasmFAERS: 1SIDER
US FAERS
131Long QT SyndromeFAERS: 1US FAERS
132MalaiseFAERS: 1US FAERS
133Mental impairmentFAERS: 1US FAERS
134MoaningFAERS: 1US FAERS
135Muscle tightnessFAERS: 1US FAERS
136MydriasisFAERS: 1US FAERS
137Obsessive thoughtsFAERS: 1US FAERS
138Panic DisorderFAERS: 1US FAERS
139ParamnesiaFAERS: 1US FAERS
140Personality ChangeFAERS: 1US FAERS
141Pharyngolaryngeal PainFAERS: 1US FAERS
142PneumoniaFAERS: 1US FAERS
143PoisoningFAERS: 1US FAERS
144Postoperative ileusFAERS: 1US FAERS
145Prescribed overdoseFAERS: 1US FAERS
146Product label confusionFAERS: 1US FAERS
147Product monitoring errorFAERS: 1US FAERS
148Product packaging quantity issueFAERS: 1US FAERS
149Product use in unapproved indicationFAERS: 1US FAERS
150PruritusFAERS: 1SIDER
US FAERS
151Pulmonary function test decreasedFAERS: 1SIDER
US FAERS
152Quality of life decreasedFAERS: 1US FAERS
153RegurgitationFAERS: 1US FAERS
154ShockFAERS: 1SIDER
US FAERS
155Similar reaction on previous exposure to drugFAERS: 1US FAERS
156Simple Partial SeizuresFAERS: 1US FAERS
157SoporFAERS: 1US FAERS
158Suicide attemptFAERS: 1US FAERS
159Syringe issueFAERS: 1US FAERS
160Therapeutic response unexpectedFAERS: 1US FAERS
161Therapy non-responderFAERS: 1US FAERS
162Tongue bitingFAERS: 1US FAERS
163Toxic Epidermal NecrolysisFAERS: 1US FAERS
164Toxicity to various agentsFAERS: 1US FAERS
165Unevaluable eventFAERS: 1US FAERS
166Urinary IncontinenceFAERS: 1US FAERS
167Vulvovaginal burning sensationFAERS: 1US FAERS
168Wrong technique in drug usage processFAERS: 1OFFSIDES
US FAERS
169Abdominal PainOFFSIDES
170AbscessOFFSIDES
171AcidosisOFFSIDES
172Acute bronchitisOFFSIDES
173Acute respiratory failureOFFSIDES
174Aggressive reactionSIDER
175Airway Obstruction3265527
3296165
7586106		CTD
176Akathisia, Drug-Induced2108778
9415834		CTD
177Alanine Aminotransferase IncreasedOFFSIDES
178Alcoholic IntoxicationOFFSIDES
179Alertness decreasedSIDER
180AlveolitisOFFSIDES
181AmenorrheaOFFSIDES
182Ammonia increasedOFFSIDES
183Amnesia, Anterograde

View details

2502317
3092849
3105566
3300755
12790253
14604717
14642292
15290003
16866739
17694911
17697220
 		CTD
184Analgesic drug level above therapeuticOFFSIDES
185Anaphylactic shockSIDER
186Anoxic EncephalopathyOFFSIDES
187Antidepressant drug clearance decreasedOFFSIDES
188Aphasia12624310CTD
189Apnea

View details

352195
2122773
3296165
7102237
7586106
7645789
9621667
10536545
16387219
 		CTD
190Application site painSIDER
191ArgumentativenessSIDER
192AscitesOFFSIDES
193AspergillosisOFFSIDES
194Aspiration PneumoniaOFFSIDES
195AssaultSIDER
196Ataxia1963805
8731063
9972844		CTD
SIDER
197AtelectasisOFFSIDES
198Athetosis8123277CTD
SIDER
199AutomatismOFFSIDES
200Axillary vein thrombosisOFFSIDES
201Bacteria sputum identifiedOFFSIDES
202Bacteria urine identifiedOFFSIDES
203Basal Ganglia Diseases9915363
16154341
17604593		CTD
204Biliary DyskinesiaOFFSIDES
205BiopsyOFFSIDES
206Bipolar DisorderOFFSIDES
207BlepharoptosisOFFSIDES
208Blood GlucoseOFFSIDES
209Blood bicarbonateOFFSIDES
210Blood chloride decreasedOFFSIDES
211Blood chloride increasedOFFSIDES
212Blood count abnormalOFFSIDES
213Blood creatinine increasedOFFSIDES
214Blood iron decreasedOFFSIDES
215Blood potassium decreasedOFFSIDES
216Blood prolactin increasedOFFSIDES
217Blood sodium increasedOFFSIDES
218Blood urea increasedOFFSIDES
219Brain Diseases11093997
12574416		CTD
220Bronchoalveolar LavageOFFSIDES
221Bulbar palsyOFFSIDES
222CandiduriaOFFSIDES
223Carbon dioxide increasedSIDER
224Cardioactive drug levelOFFSIDES
225Cardiovascular Diseases11675908CTD
226Catalepsy8090801CTD
227Causalgia20447302CTD
228Cerebral aspergillosisOFFSIDES
229Cerebral disorderOFFSIDES
230Cervicobrachial syndromeOFFSIDES
231ChillsSIDER
232Choking sensationOFFSIDES
233Clonic movementsSIDER
234ClonusSIDER
235Cocaine-Related Disorders19800183CTD
236Cognition Disorders

View details

2116156
10989856
12496752
15552071
17697220
 		CTD
237ConfabulationOFFSIDES
238Confusion

View details

2068441
2502317
2800580
3092849
8123277
11737177
 		CTD
239Congenital tricuspid valve incompetenceOFFSIDES
240Cystatin C increasedOFFSIDES
241Cytolytic hepatitisOFFSIDES
242DeafnessOFFSIDES
243DebridementOFFSIDES
244Deglutition Disorders17604593CTD
245Delayed Emergence from Anesthesia9212121
16905092		CTD
246Dental abscessOFFSIDES
247DependenceSIDER
248Depressed moodSIDER
249DermatitisSIDER
250Device related infectionOFFSIDES
251DiarrheaOFFSIDES
252Diastolic dysfunctionOFFSIDES
253Difficulty focusing eyesSIDER
254Diplopia17555939CTD
OFFSIDES
SIDER
255Disorders of Excessive Somnolence11422855CTD
256Disseminated Intravascular CoagulationOFFSIDES
257DroolingSIDER
258DrowsinessOFFSIDES
SIDER
259Drug Overdose8693299CTD
260Drug abuserOFFSIDES
261Drug addictOFFSIDES
262Drug exposure during pregnancyOFFSIDES
263Drug exposure via breast milkOFFSIDES
264Drug toxicityOFFSIDES
265Drug withdrawal convulsionsSIDER
266Drug withdrawal syndromeSIDER
267Dry skinOFFSIDES
268Dyskinesia, Drug-Induced2108778
11064794		CTD
269DyspepsiaSIDER
270Dyspnea18385262CTD
271Ear tube insertionOFFSIDES
272Echocardiogram abnormalOFFSIDES
273EczemaOFFSIDES
274EncephalitisOFFSIDES
275EnterocolitisOFFSIDES
276EpidermolysisOFFSIDES
277Erectile dysfunctionOFFSIDES
278Euphoric moodOFFSIDES
SIDER
279Eustachian tube disorderOFFSIDES
280ExcoriationOFFSIDES
281Extremity necrosisOFFSIDES
282Feeding disorder neonatalOFFSIDES
283Felt faintSIDER
284FormicationOFFSIDES
285FractureSIDER
286GaggingSIDER
287GalactorrheaOFFSIDES
288Gamma-Glutamyltransferase IncreasedOFFSIDES
289Gastrointestinal toxicityOFFSIDES
290Gingival erythemaOFFSIDES
291GranulomaOFFSIDES
292Grip strengthOFFSIDES
293Hallucinations

View details

2800580
8273531
18095969
18716494
 		CTD
294Heart Diseases1833259CTD
295Heparin-induced thrombocytopeniaOFFSIDES
296Histiocytosis haematophagicOFFSIDES
297Hyperalgesia9239313
10323274
12707139		CTD
298Hypercapnia10594454CTD
SIDER
299HyperkinesiaSIDER
300HypokinesiaCanada Vigilance: 1Canada Vigilance
301HypotensiveSIDER
302Hypoventilation3296165
7457966		CTD
SIDER
303Immunoglobulins abnormalOFFSIDES
304IncontinenceOFFSIDES
305IndurationSIDER
306InfectionOFFSIDES
307Injection site coldnessSIDER
308Injection site painSIDER
309Instillation site painSIDER
310Intention tremorOFFSIDES
311Intestinal infarctionOFFSIDES
312Intracranial Hypertension6128856CTD
313Intraoperative Complications1293657
1811430
9054704		CTD
314IntubationOFFSIDES
315Joint sprainOFFSIDES
316Kidney FailureOFFSIDES
317Left Ventricular HypertrophyOFFSIDES
318Leukopenia neonatalOFFSIDES
319Life expectancy shortenedOFFSIDES
320LightheadednessSIDER
321Local reactionSIDER
322Malignant neoplasm progressionOFFSIDES
323Mechanical ventilationOFFSIDES
324Memory Disorders9357875
12574416
30172622		CTD
325Mental disorders1811430
3592209		CTD
326Mesenteric vascular insufficiencyOFFSIDES
327Metastases to abdominal cavityOFFSIDES
328Mood swingsSIDER
329Multiple MyelomaOFFSIDES
330Muscle Rigidity

View details

2644747
6420630
7880510
11064794
 		CTD
331Muscle Weakness12624310CTD
OFFSIDES
332Musculoskeletal PainOFFSIDES
333Musculoskeletal stiffnessSIDER
334NasopharyngitisSIDER
335NephrolithiasisOFFSIDES
336NervousnessSIDER
337Neurologic Manifestations8694368CTD
338Neutropenic infectionOFFSIDES
339Neutropenic sepsisOFFSIDES
340Nutritional condition abnormalOFFSIDES
341NystagmusSIDER
342Open woundOFFSIDES
343Oral Cavity FistulaOFFSIDES
344Organophosphate poisoning30172622CTD
345Oropharyngeal painOFFSIDES
346OsteomyelitisOFFSIDES
347OversedationSIDER
348Pain during injectionSIDER
349Pain, Postoperative

View details

9649984
9751910
16192781
19329015
 		CTD
350PeriodontitisOFFSIDES
351Personality Disorders16387219
20868907		CTD
352Phlebitis2934001
2937337		CTD
SIDER
353Physical assaultSIDER
354PneumothoraxOFFSIDES
355Postoperative Complications

View details

7091735
7978134
8062564
17413431
17418428
 		CTD
356Postoperative Nausea and Vomiting

View details

3265527
15217656
15271701
15346702
 		CTD
357PresyncopeSIDER
358Prostate cancer recurrentOFFSIDES
359PsoriasisOFFSIDES
360Psychomotor Agitation

View details

11737177
12707139
17175823
18095969
20964769
 		CTD
361Psychomotor Disorders15552071
17697220		CTD
362Psychoses, Substance-Induced2800580CTD
363Psychotic Disorders18486797CTD
364Pulmonary radiation injuryOFFSIDES
365Purulent dischargeOFFSIDES
366RednessSIDER
367Reflex, Abnormal11735358
12657854		CTD
368Renal tubular acidosisOFFSIDES
369Respiration Disorders1833259CTD
370Respiratory Distress Syndrome, Newborn8033934CTD
371Respiratory Insufficiency1608855
2920683
7747857		CTD
SIDER
372Respiratory Tract Diseases2375138
15930401		CTD
373RetchingSIDER
374Retrograde amnesiaSIDER
375RhabdomyolysisOFFSIDES
376RhinitisOFFSIDES
377RhonchiSIDER
378Seizures

View details

1403792
1586424
2735539
7634817
8770346
10087439
12651682
14636342
15029526
15235984
15616057
16131771
16447789
17418694
17492380
18840131
19013687
19800183
21097996
 		CTD
379Septic ShockOFFSIDES
380SequestrectomyOFFSIDES
381Serotonin Syndrome15707818CTD
382Shallow breathingSIDER
383Sinus bradycardiaOFFSIDES
384SinusitisOFFSIDES
385Skin lacerationOFFSIDES
386Skin lesionOFFSIDES
387Skin necrosisSIDER
388Sleep Initiation and Maintenance Disorders6138071CTD
389Sleep Wake Disorders6138072CTD
390Slurred speechSIDER
391Snoring7586106
10536545		CTD
392Spinal column stenosisOFFSIDES
393Splenic InfarctionOFFSIDES
394Status Epilepticus

View details

1306008
11990208
12593465
15302747
15694567
18634420
20171707
30172622
 		CTD
395Stevens-Johnson SyndromeOFFSIDES
396StridorSIDER
397StuporCanada Vigilance: 1Canada Vigilance
398Substance Withdrawal Syndrome

View details

1996748
2728505
2920569
7775702
7841736
8347907
8570440
9750606
10583354
12144610
15298249
15714323
17373722
 		CTD
399Superficial ThrombophlebitisOFFSIDES
400Superior Vena Cava SyndromeOFFSIDES
401SwellingSIDER
402SyncopeSIDER
403TendinitisOFFSIDES
404TensionSIDER
405Tetanus2903605CTD
406Thrombophlebitis2619791
2938518
6117301		CTD
SIDER
407ThrombosisSIDER
408Tooth ExtractionOFFSIDES
409ToothacheSIDER
410Tranquillisation excessiveSIDER
411Upper airway obstructionSIDER
412Urethral fistulaOFFSIDES
413Urine flow decreasedOFFSIDES
414Vascular Diseases8514073CTD
415Ventricular FibrillationOFFSIDES
416Ventricular bigeminySIDER
417Visual ImpairmentSIDER
418Visual disturbanceSIDER
419WeltsSIDER
420WheezingSIDER
421Withdrawal seizuresSIDER
422YawningSIDER
423nervous system disorderCanada Vigilance: 1Canada Vigilance
SIDER
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