MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Orchitis

(UMLS:C0029191)

Definition:: Inflammation of a TESTIS. It has many features of EPIDIDYMITIS, such as swollen SCROTUM; PAIN; PYURIA; and FEVER. It is usually related to infections in the URINARY TRACT, which likely spread to the EPIDIDYMIS and then the TESTIS through either the VAS DEFERENS or the lymphatics of the SPERMATIC CORD.
UMLS ID:: C0029191
MeSH ID:: D009920

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.829.493

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.829.493

Synonym(s)

Orchitis

Inflammation of testicles

Inflammation of testis

Inflammation;testes

Non-specific orchitis

Non-specific orchitis, NOS

ORCHITIS

Orchitis, NOS

Testicular inflammation

10.

Testiculitis

11.

didymytis

12.

inflammation of testis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 27		US FAERS
2	rofecoxib	FAERS: 10		US FAERS
3	Clozapine	FAERS: 8		OFFSIDES US FAERS
4	Carbamazepine	FAERS: 5		US FAERS
5	Ciprofloxacin	FAERS: 4		US FAERS
6	Atomoxetine Hydrochloride	FAERS: 3		US FAERS
7	Atorvastatin	FAERS: 3		US FAERS
8	benzoylecgonine	FAERS: 3		US FAERS
9	empagliflozin	FAERS: 3		US FAERS
10	testosterone undecanoate	FAERS: 3		US FAERS
11	Amphetamine	FAERS: 2		US FAERS
12	Atorvastatin	FAERS: 2		US FAERS
13	Carboplatin	FAERS: 2		US FAERS
14	Ceftriaxone	FAERS: 2		US FAERS
15	Fingolimod Hydrochloride	FAERS: 2		US FAERS
16	Minocycline	FAERS: 2		US FAERS
17	PCI 32765	FAERS: 2		US FAERS
18	Risperidone	FAERS: 2		US FAERS
19	Ruxolitinib phosphate	FAERS: 2		US FAERS
20	Sitagliptin Phosphate	FAERS: 2		US FAERS
21	Sorafenib	FAERS: 2		US FAERS
22	Sunitinib	FAERS: 2		US FAERS
23	Tadalafil	FAERS: 2		US FAERS
24	Zoledronic Acid	FAERS: 2		OFFSIDES US FAERS
25	ambrisentan	FAERS: 2		US FAERS
26	tofacitinib	FAERS: 2		US FAERS
27	ziprasidone	FAERS: 2		US FAERS
28	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1		US FAERS
29	Alprostadil	FAERS: 1		US FAERS
30	Amiodarone	FAERS: 1		SIDER US FAERS
31	Betamethasone	FAERS: 1		US FAERS
32	Canagliflozin	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
33	Capecitabine	FAERS: 1		US FAERS
34	Cladribine	FAERS: 1		US FAERS
35	Dasatinib	FAERS: 1		US FAERS
36	Dimethyl Fumarate	FAERS: 1		US FAERS
37	Dutasteride	FAERS: 1		OFFSIDES US FAERS
38	Epoprostenol	FAERS: 1		US FAERS
39	Everolimus	FAERS: 1		US FAERS
40	Exenatide	FAERS: 1		US FAERS
41	Insulin Glargine	FAERS: 1		US FAERS
42	Lenalidomide	FAERS: 1		US FAERS
43	Levetiracetam	FAERS: 1		US FAERS
44	Levofloxacin	FAERS: 1		US FAERS
45	Methocarbamol	FAERS: 1		US FAERS
46	Mycophenolic Acid	FAERS: 1		US FAERS
47	Octreotide	FAERS: 1		US FAERS
48	Paroxetine	FAERS: 1		US FAERS
49	Solifenacin Succinate	FAERS: 1		US FAERS
50	Somatuline Autogel	FAERS: 1		US FAERS
51	Tenofovir	FAERS: 1		OFFSIDES US FAERS
52	Thalidomide	FAERS: 1		SIDER US FAERS
53	Tiotropium Bromide	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
54	Varenicline	FAERS: 1		US FAERS
55	Vemurafenib	FAERS: 1		US FAERS
56	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
57	eltrombopag	FAERS: 1		US FAERS
58	ivacaftor	FAERS: 1		US FAERS
59	mirabegron	FAERS: 1		US FAERS
60	paricalcitol	FAERS: 1		US FAERS
61	pomalidomide	FAERS: 1		US FAERS
62	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
63	Acarbose			OFFSIDES
64	Amisulpride			OFFSIDES
65	Ampicillin	Canada Vigilance: 1		Canada Vigilance OFFSIDES
66	Azathioprine			OFFSIDES
67	Beclomethasone			OFFSIDES
68	Bisacodyl			OFFSIDES
69	Bleomycin			OFFSIDES
70	Bortezomib			OFFSIDES
71	Bupropion			OFFSIDES
72	Busulfan			OFFSIDES
73	Cadmium Chloride		22271428	CTD
74	Cefuroxime			OFFSIDES
75	Chlorhexidine			OFFSIDES
76	Clonazepam			OFFSIDES
77	Cyclophosphamide			OFFSIDES
78	Deferasirox			OFFSIDES
79	Dioctyl Sulfosuccinic Acid			OFFSIDES
80	Doxycycline			OFFSIDES
81	Fenofibrate			OFFSIDES
82	Fluorouracil			OFFSIDES
83	Fluoxetine	Canada Vigilance: 1		Canada Vigilance
84	Fluoxetine			SIDER
85	Gabapentin			OFFSIDES
86	Ganciclovir			OFFSIDES
87	Gatifloxacin			OFFSIDES
88	Goserelin			OFFSIDES
89	Leucovorin			OFFSIDES
90	Losartan			OFFSIDES
91	Melphalan			OFFSIDES
92	Mesna			OFFSIDES
93	Metformin			OFFSIDES
94	Metolazone			OFFSIDES
95	Moxifloxacin			OFFSIDES
96	Nisoldipine			OFFSIDES
97	Nitrendipine			OFFSIDES
98	Nitrofurantoin			OFFSIDES
99	Pamidronate			OFFSIDES
100	Phosphates			OFFSIDES
101	Pramipexole			SIDER
102	Prednisone acetate			OFFSIDES
103	Pregabalin			SIDER
104	Procarbazine			OFFSIDES
105	Pyridoxine			OFFSIDES
106	Quetiapine Fumarate			SIDER
107	Rabeprazole			SIDER
108	Ribavirin			OFFSIDES
109	Sevelamer			OFFSIDES
110	Sevelamer			OFFSIDES
111	Sotalol			OFFSIDES
112	Stavudine			OFFSIDES
113	Tamsulosin			OFFSIDES
114	Terazosin			OFFSIDES
115	Tetracycline			OFFSIDES
116	Tretinoin			OFFSIDES
117	Vancomycin			OFFSIDES
118	Vardenafil Dihydrochloride			OFFSIDES
119	Venlafaxine Hydrochloride			SIDER
120	Vincristine			OFFSIDES
121	balsalazide			OFFSIDES
122	benzonatate			OFFSIDES
123	chlorhexidine gluconate			OFFSIDES
124	fexofenadine			OFFSIDES
125	lomefloxacin			SIDER
126	nefazodone			OFFSIDES
127	pimecrolimus			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cryptorchidism	34.8%
2	Testicular Neoplasms	20.9%
3	Epididymitis	20.5%
4	Hypogonadism	20.5%
5	Penile Diseases	20.5%
6	Prostatic Diseases	20.5%
7	Delayed Puberty	20.5%
8	Precocious Puberty	20.5%
9	Spermatic Cord Torsion	20.5%
10	Hemospermia	20.5%
11	Hypogonadotropic hypogonadism	20.5%
12	Testotoxicosis	20.5%
13	Testicular Hydrocele	20.5%
14	Genital Neoplasms, Male	16.4%
15	Varicocele	15.5%
16	Penile Neoplasms	15.5%
17	Prostatic Neoplasms	15.5%
18	Infertility	15.3%
19	Spermatocele	15.3%
20	Ovarian Diseases	15.1%
21	Hermaphroditism	13.6%
22	Disorders of Sex Development	13.6%
23	Balanitis	13.3%
24	Benign prostatic hypertrophy	13.3%
25	Phimosis	13.3%
26	Priapism	13.3%
27	prostatitis	13.3%
28	Prostatic Adenoma	13.3%
29	Benign Prostatic Hyperplasia	13.3%
30	Prostatic Hypertrophy	13.3%
31	Prostatic Hyperplasia	13.3%
32	Adrenal Gland Diseases	11.9%
33	Parathyroid Diseases	11.9%
34	Thyroid Diseases	11.9%
35	Prostatic Neoplasms, Castration-Resistant	11.4%
36	Leydig Cell Tumor	10.9%
37	Sexually Transmitted Diseases	10.6%
38	Premature Ejaculation	10.2%
39	Erectile dysfunction	10.2%
40	Hypospadias	10.1%
41	Genital Herpes	10.1%
42	Azoospermia	9.9%
43	Oligospermia	9.9%
44	Impotence, Vasculogenic	9.9%
45	Asthenozoospermia	9.9%
46	Teratozoospermia	9.9%
47	Aspermia	9.9%
48	Ovarian Hyperstimulation Syndrome	9.9%
49	Kallmann Syndrome	9.9%
50	Bone Diseases, Endocrine	8.9%
51	Endocrine Gland Neoplasms	8.9%
52	Urologic Diseases	8.9%
53	Gonadal Dysgenesis	8.8%
54	Adrenogenital Syndrome	8.8%
55	Ovotesticular Disorders of Sex Development	8.8%
56	Diabetes Mellitus	8.8%
57	Pituitary Diseases	8.7%
58	Klinefelter Syndrome	8.6%
59	ovarian neoplasm	8.6%
60	Adrenal Gland Neoplasms	8.2%
61	Dyspareunia	8.1%
62	Corpus Luteum Cyst	8%
63	Ovarian Cysts	8%
64	Anovulation	7.9%
65	Oophoritis	7.8%
66	Hyperandrogenism	7.7%
67	Urogenital Abnormalities	7.1%
68	Dwarfism	7%
69	Adrenal Cortex Diseases	6.8%
70	Euthyroid Sick Syndromes	6.8%
71	Goiter	6.8%
72	Hyperparathyroidism	6.8%
73	Hyperthyroidism	6.8%
74	Hyperthyroxinemia	6.8%
75	Hypoparathyroidism	6.8%
76	Hypothyroidism	6.8%
77	Parathyroid Neoplasms	6.8%
78	Thyroid Neoplasm	6.8%
79	Thyroiditis	6.8%
80	Thyroid carcinoma	6.8%
81	Secondary hypothyroidism	6.8%
82	Primary Hyperthyroidism	6.8%
83	Primary Hypothyroidism	6.8%
84	Diabetes Insipidus	6.7%
85	Polycystic Ovary Syndrome	5.9%
86	Diabetic Nephropathy	5.3%
87	granulosa cell tumor	5.3%
88	Carcinoma, Ovarian Epithelial	5.3%
89	Turner Syndrome	5.2%
90	Urinary Bladder Diseases	5.1%
91	Kidney Diseases	5.1%
92	Ureteral Diseases	5.1%
93	Urethral Diseases	5.1%
94	Urination Disorders	5.1%
95	Urolithiasis	5.1%
96	Empty Sella Syndrome	5%
97	Hyperpituitarism	5%
98	Hypopituitarism	5%
99	Hypophysitis	5%
100	Bladder Exstrophy	4.8%
101	Congenital Hypothyroidism	4.8%
102	Epispadias	4.8%
103	Tuberculosis, Renal	4.7%
104	Graves Disease	4.5%
105	Cushing Syndrome	4.4%
106	Hyperaldosteronism	4.4%
107	Hyperparathyroidism, Secondary	4.4%
108	Hypoaldosteronism	4.4%
109	Thyrotoxicosis	4.4%
110	Hyperparathyroidism, Primary	4.4%
111	Thyroid Hormone Resistance Syndrome	4.4%
112	Anuria	4.4%
113	Thyroid Nodule	4.4%
114	Ureterolithiasis	4.4%
115	Nephrolithiasis	4.4%
116	Multicystic Dysplastic Kidney	4.3%
117	Chlamydia Infections	4.2%
118	Gonorrhea	4.2%
119	Adrenocortical carcinoma	4.2%
120	Urinary tract infection	4.1%
121	Gestational Diabetes	4.1%
122	Latent Autoimmune Diabetes in Adults	4.1%
123	Urologic Neoplasms	4.1%
124	Horseshoe Kidney	4.1%
125	Diabetes Mellitus, Experimental	4%
126	Pituitary Adenoma	3.9%
127	Pituitary Neoplasms	3.9%
128	Denys-Drash Syndrome	3.9%
129	Bladder neck obstruction	3.8%
130	Urinary Bladder Fistula	3.8%
131	Bladder Neoplasm	3.8%
132	Kidney Neoplasm	3.8%
133	Ureteral Neoplasms	3.8%
134	Urethral Neoplasms	3.8%
135	Prolactinoma	3.7%
136	Growth Hormone-Secreting Pituitary Adenoma	3.7%
137	Syphilis	3.7%
138	Carcinoma, Endometrioid	3.6%
139	Lymphogranuloma Venereum	3.5%
140	Addison Disease	3.4%
141	Diabetic Angiopathies	3.4%
142	Autoimmune thyroiditis	3.4%
143	Primary Adrenal Insufficiency	3.4%
144	Diabetic Neuropathies	3.3%
145	Myxedema	3.3%
146	Diabetic Amyotrophy	3.3%
147	Diabetic Autonomic Neuropathy	3.3%
148	Diabetic Cardiomyopathies	3.3%
149	Cystitis	3.3%
150	Hydronephrosis	3.3%
151	Hyperoxaluria	3.3%
152	Kidney Cortex Necrosis	3.3%
153	Kidney Papillary Necrosis	3.3%
154	Nephritis	3.3%
155	Nephrosclerosis	3.3%
156	Nephrosis	3.3%
157	Perinephritis	3.3%
158	Kidney Failure	3.3%
159	Uremia	3.3%
160	Ureteral obstruction	3.3%
161	Ureterocele	3.3%
162	Urethral Obstruction	3.3%
163	Urethritis	3.3%
164	Vesico-Ureteral Reflux	3.3%
165	Urinary Retention	3.3%
166	Oxalosis	3.3%
167	Renal Insufficiency	3.3%
168	Hyperglycemic Hyperosmolar Nonketotic Coma	3.3%
169	Pituitary Apoplexy	3.3%
170	Hashimoto Disease	3.3%
171	Hyperprolactinemia	3.3%
172	Diabetic Foot	3.3%
173	Nelson Syndrome	3.2%
174	Kidney Calculi	3.2%
175	Ureteral Calculi	3.2%
176	Pyelocystitis	3%
177	Multiple Endocrine Neoplasia	2.9%
178	Pancreatic Neoplasm	2.9%
179	Hepatorenal Syndrome	2.7%
180	Pyelonephritis	2.7%
181	Gigantism	2.7%
182	Bacteriuria	2.6%
183	Glycosuria	2.6%
184	Hematuria	2.6%
185	Renal hypertension	2.6%
186	Oliguria	2.6%
187	Polyuria	2.6%
188	Proteinuria	2.6%
189	Pyuria	2.6%
190	Renal Artery Obstruction	2.6%
191	Renal Artery Stenosis	2.6%
192	Urinary Calculi	2.6%
193	Acromegaly	2.6%
194	Cystocele	2.6%
195	Nephrocalcinosis	2.6%
196	Urinary Incontinence	2.6%
197	Diabetic Ketoacidosis	2.6%
198	Renal Osteodystrophy	2.5%
199	Renal rickets	2.5%
200	Glomerulonephritis	2.4%
201	Nephritis, Interstitial	2.4%
202	Lipoid nephrosis	2.4%
203	Nephrotic Syndrome	2.4%
204	Pyelitis	2.4%
205	Pyonephrosis	2.4%
206	Urethral Stenosis	2.4%
207	Nephrogenic Diabetes Insipidus	2.4%
208	Congenital Nephrogenic Diabetes Insipidus	2.4%
209	Acute kidney injury	2.4%
210	Urethral stricture	2.4%
211	Mesoblastic Nephroma	2.4%
212	Renal Cell Carcinoma	2.4%
213	Papillary Renal Cell Carcinoma	2.4%
214	Enuresis	2.2%
215	Glycosuria, Renal	2.2%
216	Balkan Nephropathy	2%
217	Focal glomerulosclerosis	2%
218	Kidney Failure, Chronic	2%
219	Diabetic Retinopathy	2%
220	Azotemia	2%
221	Nephroblastoma	2%
222	Albuminuria	2%
223	Hemoglobinuria	2%
224	Hypertension, Renovascular	2%
225	Urge Incontinence	1.9%
226	Multiple Endocrine Neoplasia Type 1	1.9%
227	AIDS-Associated Nephropathy	1.9%
228	Glomerulonephritis, Membranoproliferative	1.7%
229	Polycystic Kidney Diseases	1.6%
230	Diurnal Enuresis	1.6%
231	Renal Aminoacidurias	1.6%
232	Fanconi Syndrome	1.6%
233	Pseudohypoaldosteronism	1.6%
234	Liddle Syndrome	1.6%
235	Hemolytic-Uremic Syndrome	1.6%
236	Carcinoma, Pancreatic Ductal	1.5%
237	Renal tubular acidosis	1.4%
238	Anti-Glomerular Basement Membrane Disease	1.4%
239	Lupus Nephritis	1.4%
240	Polycystic Kidney, Autosomal Dominant	1.3%
241	Cystinuria	1.3%
242	Atypical Hemolytic Uremic Syndrome	1.3%
243	insulinoma	1.2%
244	Gastrinoma	1.2%
245	Glucagonoma	1.2%
246	Waterhouse-Friderichsen Syndrome	1.2%
247	Zellweger Syndrome	1.1%
248	Hyperphosphaturia	1.1%
249	Vipoma	1.1%
250	Adrenoleukodystrophy	0.7%
251	Familial Hypophosphatemic Rickets	0.6%

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