MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Bacterial Vaginosis

(UMLS:C0085166)

Definition:: Polymicrobial, nonspecific vaginitis associated with positive cultures of Gardnerella vaginalis and other anaerobic organisms and a decrease in lactobacilli. It remains unclear whether the initial pathogenic event is caused by the growth of anaerobes or a primary decrease in lactobacilli.
UMLS ID:: C0085166
MeSH ID:: D016585

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.954

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.894.906.800

Synonym(s)

Bacterial Vaginosis

AV - Anaerobic vaginosis

BV - Bacterial vaginosis

Bacterial Vaginitis

Bacterial vaginitis

Bacterial vaginosis

NONSPECIFIC VAGINITIS

NSV - Nonspecific vaginitis

10.

Nonspecific bacterial vaginosis

11.

Nonspecific vaginitis

12.

VAGINITIS NON SPECIFIC

13.

VAGINOSIS BACTERIAL

14.

VAGINOSIS NON SPECIFIC

15.

bacterial vaginitis

16.

bacterial vaginoses

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 101 Canada Vigilance: 8	Canada Vigilance US FAERS
2	Copper	FAERS: 46	US FAERS
3	NuvaRing	FAERS: 33 Canada Vigilance: 1	Canada Vigilance US FAERS
4	Estradiol	FAERS: 24	US FAERS
5	etonogestrel	FAERS: 15	US FAERS
6	17 alpha-Hydroxyprogesterone Caproate	FAERS: 9	US FAERS
7	Fingolimod Hydrochloride	FAERS: 8	US FAERS
8	Estrogens, Conjugated (USP)	FAERS: 5	US FAERS
9	Ospemifene	FAERS: 3	US FAERS
10	tofacitinib	FAERS: 3	US FAERS
11	4-Aminopyridine	FAERS: 2	US FAERS
12	Medroxyprogesterone Acetate	FAERS: 2	US FAERS
13	Norethindrone acetate and ethinyl estradiol	FAERS: 2	US FAERS
14	Ondansetron	FAERS: 2	US FAERS
15	Rivaroxaban	FAERS: 2	US FAERS
16	ledipasvir, sofosbuvir drug combination	FAERS: 2	US FAERS
17	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1	US FAERS
18	4-hydroxybutyric acid	FAERS: 1	US FAERS
19	Alendronate	FAERS: 1	US FAERS
20	Bimatoprost	FAERS: 1	US FAERS
21	Canagliflozin	FAERS: 1	US FAERS
22	Chlorzoxazone	FAERS: 1	US FAERS
23	Clindamycin	FAERS: 1	US FAERS
24	Dimethyl Fumarate	FAERS: 1	US FAERS
25	Doxycycline	FAERS: 1	US FAERS
26	Duloxetine Hydrochloride	FAERS: 1	US FAERS
27	Glatiramer Acetate	FAERS: 1	US FAERS
28	Metformin	FAERS: 1	US FAERS
29	Metronidazole	FAERS: 1	US FAERS
30	Ortho Evra	FAERS: 1	US FAERS
31	Qsymia	FAERS: 1	US FAERS
32	Secnidazole	FAERS: 1	US FAERS
33	Thyroxine	FAERS: 1	US FAERS
34	Toremifene	FAERS: 1	US FAERS
35	ambrisentan	FAERS: 1	US FAERS
36	apremilast	FAERS: 1	US FAERS
37	mirabegron	FAERS: 1	US FAERS
38	Amoxicillin-Potassium Clavulanate Combination	Canada Vigilance: 1	Canada Vigilance

Similar ADE(s)

	Name	Semantic Similarity
1	Vulvovaginitis	31%
2	Borrelia Infections	30.1%
3	Leptospirosis	30.1%
4	Lyme Disease	29.5%
5	Relapsing Fever	29.5%
6	Gram-Negative Bacterial Infections	27.4%
7	Gram-Positive Bacterial Infections	27.4%
8	Lyme Neuroborreliosis	27.2%
9	Trichomonas Vaginitis	25.6%
10	Vaginal Discharge	24.9%
11	Human Ehrlichiosis	24.7%
12	Neurosyphilis	24.5%
13	Syphilis	24.5%
14	Japanese Spotted Fever	23.4%
15	Erythema Chronicum Migrans	23%
16	Candidiasis, Vulvovaginal	22.5%
17	Impetigo	22.2%
18	Central Nervous System Bacterial Infections	22%
19	Rocky Mountain Spotted Fever	21.4%
20	Chlamydia Infections	21%
21	Gonorrhea	21%
22	Erysipelas	20.8%
23	Staphylococcal Skin Infections	20.8%
24	Human anaplasmosis	20.6%
25	Skin Diseases, Bacterial	20.3%
26	Bacteremia	20.1%
27	Actinomycetales Infections	20.1%
28	Bordetella Infections	20.1%
29	Brucellosis	20.1%
30	Campylobacter infection	20.1%
31	Clostridium Infections	20.1%
32	Enterobacteriaceae Infections	20.1%
33	Listeriosis	20.1%
34	Pseudomonas Infections	20.1%
35	Q Fever	20.1%
36	Staphylococcal Infections	20.1%
37	Streptococcal Infections	20.1%
38	Vibrio Infections	20.1%
39	Helicobacter Infections	20.1%
40	Bacillaceae Infections	20.1%
41	Neisseriaceae Infections	20.1%
42	Burkholderia Infections	20.1%
43	Clostridium difficile infection	20.1%
44	Flavobacteriaceae Infections	20.1%
45	Moraxellaceae Infections	20.1%
46	Burkholderia cepacia Infection	20.1%
47	Erythrasma	19.9%
48	Endometriosis	19.6%
49	Uterine Diseases	19.6%
50	Vulvar Diseases	19.6%
51	Endometrioma	19.6%
52	Vaginal Fistula	18.7%
53	Syphilis, Congenital	17.9%
54	Ecthyma	17.9%
55	Subacute Bacterial Endocarditis	17.9%
56	Staphylococcal Scalded Skin Syndrome	17.8%
57	Vaginal Neoplasms	17.7%
58	Lymphogranuloma Venereum	17.6%
59	Mycetoma	17.3%
60	Bacterial Endocarditis	17.1%
61	Acinetobacter Infections	16.6%
62	Actinomycosis	16.6%
63	Bacteroides Infections	16.6%
64	Cholera	16.6%
65	Corynebacterium Infections	16.6%
66	Escherichia coli Infections	16.6%
67	Gas Gangrene	16.6%
68	Haemophilus Infections	16.6%
69	Klebsiella Infections	16.6%
70	Meningococcal Infections	16.6%
71	Mycobacterium Infections	16.6%
72	Mycoplasma Infections	16.6%
73	Nocardia Infections	16.6%
74	Pasteurella Infections	16.6%
75	Pneumococcal Infections	16.6%
76	Proteus Infections	16.6%
77	Rickettsia Infections	16.6%
78	Salmonella infections	16.6%
79	Scarlet Fever	16.6%
80	Scrub Typhus	16.6%
81	Tetanus	16.6%
82	Serratia Infections	16.6%
83	Ureaplasma Infections	16.6%
84	Pulmonary Nocardiosis	16.6%
85	Leukorrhea	16.5%
86	carbuncle	16.4%
87	Meningitis, Listeria	16.3%
88	Pneumonia, Bacterial	16.3%
89	Erysipelothrix infection	15.9%
90	Furunculosis	15.5%
91	furuncle	15.5%
92	Meningitis, Haemophilus	15.4%
93	Meningitis, Pneumococcal	15.4%
94	Sexually Transmitted Diseases	15%
95	Infertility	14.9%
96	Diphtheria	14.8%
97	Leprosy	14.8%
98	Mycobacterium Infections, Nontuberculous	14.8%
99	Psittacosis	14.8%
100	Paratyphoid Fever	14.8%
101	Plague	14.8%
102	Tuberculosis	14.8%
103	Typhoid Fever	14.8%
104	TYPHUS	14.8%
105	Yersinia pseudotuberculosis Infections	14.8%
106	Bubonic Plague	14.8%
107	Mycobacterium abscessus Infection	14.8%
108	Mycoses	14.4%
109	Infection	14.4%
110	Endometritis	14.3%
111	Ulcerative stomatitis	14.3%
112	Pertussis	14.1%
113	Mycobacterium avium-intracellulare Infection	14%
114	Lymph Node Tuberculosis	14%
115	Tuberculosis, Miliary	14%
116	Tuberculosis, Multidrug-Resistant	14%
117	Leprosy, Multibacillary	14%
118	Latent Tuberculosis	14%
119	Adnexitis	13.7%
120	Pelvic Inflammatory Disease	13.7%
121	Rhinoscleroma	13.7%
122	Hidradenitis Suppurativa	13.6%
123	Ophthalmia Neonatorum	13.6%
124	Trachoma	13.6%
125	Borderline leprosy	13.5%
126	Leprosy, Lepromatous	13.5%
127	Tuberculoid leprosy	13.5%
128	Extensively Drug-Resistant Tuberculosis	13.5%
129	Hordeolum	12.9%
130	Bacterial conjunctivitis	12.7%
131	Tuberculosis, Meningeal	12.7%
132	Joint Tuberculosis	12.4%
133	Tuberculosis, Osteoarticular	12.4%
134	Bone Tuberculosis	12.4%
135	Urologic Diseases	12.1%
136	Meningitis, Bacterial	12%
137	Salmonella Infections, Animal	11.7%
138	Endometrial Hyperplasia	11.6%
139	Pyometra	11.6%
140	Vulvitis	11.6%
141	Vulvodynia	11.6%
142	Tuberculosis, Renal	11.6%
143	Erythema Induratum	11.6%
144	Salpingitis	11.4%
145	Rheumatic Heart Disease	11.3%
146	Salmonella food poisoning	11.2%
147	Pregnancy Complications, Infectious	10.8%
148	Uterine Inversion	10.8%
149	Central Nervous System Infection	10.8%
150	Tuberculosis, Gastrointestinal	10.7%
151	Urinary tract infection	10.7%
152	Panophthalmitis	10.5%
153	Tuberculosis, Central Nervous System	10.4%
154	Pregnancy Complications	10.2%
155	Rheumatic Fever	10.1%
156	Enterocolitis, Pseudomembranous	9.8%
157	Uterine Neoplasms	9.8%
158	Vulvar Neoplasms	9.8%
159	Uterine Cancer	9.8%
160	pseudomembranous colitis	9.8%
161	Dysentery, Bacillary	9.8%
162	Genital Herpes	9.8%
163	Vesicovaginal Fistula	9.7%
164	Urogenital Abnormalities	9.7%
165	Dermatomycoses	9.5%
166	Tuberculosis, Spinal	9.4%
167	Candidiasis, Chronic Mucocutaneous	9.4%
168	Cutaneous Candidiasis	9.4%
169	Candidemia	9.3%
170	Oophoritis	9.2%
171	Aspergillosis	9.1%
172	Candidiasis	9.1%
173	Coccidioidomycosis	9.1%
174	Histoplasmosis	9.1%
175	Paracoccidioidomycosis	9.1%
176	Pelvic Infection	9.1%
177	Wound Infection	9.1%
178	Zygomycosis	9.1%
179	Soft Tissue Infection	9.1%
180	Community-Acquired Infections	9.1%
181	Phaeohyphomycosis	9.1%
182	Pneumocystis Infections	9.1%
183	Ovarian Diseases	8.9%
184	Uterine Rupture	8.8%
185	Pruritus Vulvae	8.7%
186	Uterine hemorrhage	8.7%
187	Tuberculosis, Pulmonary	8.7%
188	Uterine Prolapse	8.6%
189	Vaginal Prolapse	8.6%
190	Botulism	8.4%
191	Neuroaspergillosis	8%
192	Fungemia	7.9%
193	Waterhouse-Friderichsen Syndrome	7.7%
194	Uterine Cervicitis	7.7%
195	Parametritis	7.7%
196	Fallopian Tube Neoplasms	7.5%
197	Puerperal Infection	7.4%
198	Brain Abscess	7.3%
199	Chromoblastomycosis	7.3%
200	Dermatophytosis	7.3%
201	Sporotrichosis	7.3%
202	Tinea	7.3%
203	Tinea Versicolor	7.3%
204	Trichophytosis	7.3%
205	Invasive Pulmonary Aspergillosis	7.3%
206	Hyalohyphomycosis	7.3%
207	Endotoxemia	7.2%
208	Eye Infection	7.2%
209	Respiratory Tract Infections	7.2%
210	Dyspareunia	7.1%
211	Blastomycosis	7%
212	Bacteriuria	7%
213	Pyuria	7%
214	Uterine Cervical Incompetence	7%
215	Bone Diseases, Infectious	6.9%
216	Otomycosis	6.9%
217	Skin Diseases, Infectious	6.9%
218	Arthritis, Infectious	6.8%
219	Piedra	6.8%
220	Central Nervous System Fungal Infections	6.8%
221	Suppuration	6.8%
222	Cross Infection	6.8%
223	Septicemia	6.8%
224	Sepsis	6.8%
225	Cellulitis	6.7%
226	Mucormycosis	6.7%
227	Endometrial Neoplasms	6.5%
228	Urinary Bladder Diseases	6.4%
229	Kidney Diseases	6.4%
230	Ureteral Diseases	6.4%
231	Urethral Diseases	6.4%
232	Urination Disorders	6.4%
233	Urolithiasis	6.4%
234	Genital Neoplasms, Female	6.3%
235	Fusariosis	6.2%
236	Meningitis, Cryptococcal	6%
237	Opportunistic Infections	5.9%
238	Uterine Perforation	5.8%
239	Ovarian Hyperstimulation Syndrome	5.8%
240	Bladder Exstrophy	5.8%
241	Epispadias	5.8%
242	Metrorrhagia	5.7%
243	Lemierre Syndrome	5.6%
244	Lung Diseases, Fungal	5.6%
245	Psoas Abscess	5.5%
246	Abdominal Abscess	5.5%
247	ovarian neoplasm	5.5%
248	Tinea Capitis	5.2%
249	Onychomycosis	5.2%
250	Polyhydramnios	5.1%
251	Obstetric Labor Complications	5.1%
252	Ectopic Pregnancy	5.1%
253	Pregnancy, Prolonged	5.1%
254	Puerperal Disorders	5.1%
255	Oligohydramnios	5.1%
256	Prenatal Injuries	5.1%
257	Oral candidiasis	5.1%
258	Endophthalmitis	5.1%
259	Peritonitis	5.1%
260	Urologic Neoplasms	5.1%
261	Horseshoe Kidney	5.1%
262	Osteomyelitis	5%
263	Periostitis	5%
264	Surgical Wound Infection	5%
265	Pulmonary Aspergillosis	5%
266	Bronchopulmonary Aspergillosis	5%
267	Multicystic Dysplastic Kidney	5%
268	Abscess	5%
269	Empyema	5%
270	Anuria	5%
271	Ureterolithiasis	5%
272	Nephrolithiasis	5%
273	Corpus Luteum Cyst	4.7%
274	Ovarian Cysts	4.7%
275	Anovulation	4.6%
276	Menorrhagia	4.6%
277	Premature Menopause	4.6%
278	Tinea Pedis	4.4%
279	Hermaphroditism	4.3%
280	Disorders of Sex Development	4.3%
281	Urinary Bladder Fistula	4.2%
282	Bladder Neoplasm	4.2%
283	Kidney Neoplasm	4.2%
284	Ureteral Neoplasms	4.2%
285	Urethral Neoplasms	4.2%
286	Hypospadias	4.2%
287	Carcinoma, Endometrioid	4.2%
288	Abruptio Placentae	4.2%
289	Placenta Accreta	4.2%
290	Superinfection	4.1%
291	Diverticulitis	4.1%
292	Bladder neck obstruction	4.1%
293	Corneal Ulcer	4.1%
294	Fetal Diseases	4%
295	Pregnancy Complications, Cardiovascular	4%
296	Pregnancy Complications, Neoplastic	4%
297	Spondylitis	4%
298	Appendicitis	4%
299	Meningitis, Fungal	4%
300	Pyomyositis	4%
301	Endotoxic shock	3.9%
302	Septic Shock	3.9%
303	Toxic Shock Syndrome	3.9%
304	Pregnancy Complications, Hematologic	3.9%
305	Fetal Death	3.8%
306	Perinatal death	3.8%
307	Toxoplasmosis, Cerebral	3.8%
308	Morning Sickness	3.8%
309	Liver Abscess	3.8%
310	Cystitis	3.7%
311	Hydronephrosis	3.7%
312	Hyperoxaluria	3.7%
313	Kidney Cortex Necrosis	3.7%
314	Kidney Papillary Necrosis	3.7%
315	Nephritis	3.7%
316	Nephrosclerosis	3.7%
317	Nephrosis	3.7%
318	Perinephritis	3.7%
319	Kidney Failure	3.7%
320	Uremia	3.7%
321	Ureteral obstruction	3.7%
322	Ureterocele	3.7%
323	Urethral Obstruction	3.7%
324	Urethritis	3.7%
325	Vesico-Ureteral Reflux	3.7%
326	Urinary Retention	3.7%
327	Oxalosis	3.7%
328	Renal Insufficiency	3.7%
329	Chorioamnionitis	3.6%
330	Polycystic Ovary Syndrome	3.4%
331	Lung Abscess	3.4%
332	Endometrial Stromal Sarcoma	3.4%
333	granulosa cell tumor	3.4%
334	Carcinoma, Ovarian Epithelial	3.4%
335	Diverticulum	3.3%
336	Diverticulosis	3.3%
337	Postpartum Hemorrhage	3.3%
338	Discitis	3.3%
339	Mastoiditis	3.3%
340	Petrositis	3.3%
341	Arthritis, Reactive	3.3%
342	Kidney Calculi	3.2%
343	Ureteral Calculi	3.2%
344	Gestational Diabetes	3.1%
345	Diabetes Insipidus	3%
346	Hepatorenal Syndrome	3%
347	Diabetic Nephropathy	3%
348	Glycosuria	3%
349	Hematuria	3%
350	Renal hypertension	3%
351	Oliguria	3%
352	Polyuria	3%
353	Proteinuria	3%
354	Renal Artery Obstruction	3%
355	Renal Artery Stenosis	3%
356	Urinary Calculi	3%
357	Cystocele	3%
358	Nephrocalcinosis	3%
359	Urinary Incontinence	3%
360	AIDS-Related Opportunistic Infections	2.9%
361	Pyelocystitis	2.8%
362	Abortion, Habitual	2.8%
363	Dystocia	2.8%
364	Eclampsia	2.8%
365	Fetal Membranes, Premature Rupture	2.8%
366	Placental Insufficiency	2.8%
367	Pre-Eclampsia	2.8%
368	Prenatal Exposure Delayed Effects	2.8%
369	HELLP Syndrome	2.8%
370	Placenta, Retained	2.8%
371	Retropharyngeal Abscess	2.8%
372	Epidural Abscess	2.8%
373	Peritonsillar Abscess	2.7%
374	Enuresis	2.5%
375	Gonadal Dysgenesis	2.5%
376	Adrenogenital Syndrome	2.5%
377	Ovotesticular Disorders of Sex Development	2.5%
378	Glomerulonephritis	2.5%
379	Nephritis, Interstitial	2.5%
380	Lipoid nephrosis	2.5%
381	Nephrotic Syndrome	2.5%
382	Pyelitis	2.5%
383	Pyonephrosis	2.5%
384	Urethral Stenosis	2.5%
385	Nephrogenic Diabetes Insipidus	2.5%
386	Congenital Nephrogenic Diabetes Insipidus	2.5%
387	Acute kidney injury	2.5%
388	Urethral stricture	2.5%
389	Mesoblastic Nephroma	2.4%
390	Renal Cell Carcinoma	2.4%
391	Papillary Renal Cell Carcinoma	2.4%
392	Pyelonephritis	2.4%
393	Aspergillosis, Allergic Bronchopulmonary	2.4%
394	Abortion, Veterinary	2.2%
395	Pregnancy Complications, Parasitic	2.2%
396	Glycosuria, Renal	2.2%
397	AIDS-Associated Nephropathy	2.1%
398	Lactation Disorder	2.1%
399	Mastitis	2.1%
400	Depression, Postpartum	2.1%
401	Embryo Loss	2.1%
402	Fetal Resorption	2.1%
403	Hyperemesis Gravidarum	2.1%
404	Liver Abscess, Amebic	2%
405	Azotemia	2%
406	Nephroblastoma	2%
407	Albuminuria	2%
408	Hemoglobinuria	2%
409	Hypertension, Renovascular	2%
410	Urge Incontinence	2%
411	Hyperandrogenism	1.9%
412	Balkan Nephropathy	1.8%
413	Focal glomerulosclerosis	1.8%
414	Kidney Failure, Chronic	1.8%
415	Denys-Drash Syndrome	1.7%
416	Fetal Growth Retardation	1.7%
417	Trophoblastic Neoplasms	1.7%
418	Embolism, Amniotic Fluid	1.7%
419	Fetal Hypoxia	1.7%
420	Fetal Alcohol Spectrum Disorders	1.7%
421	Premature Birth	1.7%
422	Breech Presentation	1.7%
423	Polycystic Kidney Diseases	1.6%
424	Stillbirth	1.6%
425	Diurnal Enuresis	1.6%
426	Renal Aminoacidurias	1.6%
427	Fanconi Syndrome	1.6%
428	Pseudohypoaldosteronism	1.6%
429	Liddle Syndrome	1.6%
430	Renal Osteodystrophy	1.6%
431	Renal rickets	1.6%
432	Hemolytic-Uremic Syndrome	1.6%
433	Glomerulonephritis, Membranoproliferative	1.5%
434	Renal tubular acidosis	1.4%
435	Turner Syndrome	1.3%
436	Anti-Glomerular Basement Membrane Disease	1.2%
437	Kallmann Syndrome	1.2%
438	Galactorrhea	1.2%
439	Zellweger Syndrome	1.2%
440	Lupus Nephritis	1.2%
441	Meconium Aspiration Syndrome	1.2%
442	Polycystic Kidney, Autosomal Dominant	1.2%
443	Cystinuria	1.2%
444	Atypical Hemolytic Uremic Syndrome	1.2%
445	Hyperphosphaturia	1.1%
446	Klinefelter Syndrome	1.1%
447	Choriocarcinoma	0.8%
448	Hydatidiform Mole	0.7%
449	Hydrops Fetalis	0.6%
450	Familial Hypophosphatemic Rickets	0.5%

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