MetaADEDB 2.0 @ LMMD
adefovir dipivoxil
(WOZSCQDILHKSGG-UHFFFAOYSA-N)
Structure
SMILES
O=C(C(C)(C)C)OCOP(=O)(OCOC(=O)C(C)(C)C)COCCn1cnc2c1ncnc2N
Type(s)
Approved; Investigational
ATC code(s)
J05AF08
Molecular Formula:
C20H32N5O8P
Molecular Weight:
501.471
Log P:
3.2837
Hydrogen Bond Acceptor:
13
Hydrogen Bond Donor:
1
TPSA:
176.79
CAS Number(s):
142340-99-6
Synonym(s)
1.
adefovir dipivoxil
2.
9-(2-((-bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine
3.
GS 840
4.
GS-0840
5.
Hepsera
6.
Preveon
7.
adefovir depivoxil
External Link(s)
MeSHC106812
PubChem Compound60871
BindingDB50248359
50038612
ChEBI31175
CHEMBLCHEMBL922
DrugBankDB00718
DrugCentral88
KEGGdr:D01655
Therapeutic Target DatabaseD0ML1F
ZINC3930376
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1OsteomalaciaFAERS: 23318815461CTD
US FAERS
2OsteoporosisFAERS: 11218815461CTD
OFFSIDES
US FAERS
3Bone painFAERS: 85OFFSIDES
US FAERS
4PainFAERS: 4918815461CTD
US FAERS
5Blood phosphorus decreasedFAERS: 42OFFSIDES
US FAERS
6Alanine Aminotransferase IncreasedFAERS: 41OFFSIDES
US FAERS
7ArthralgiaFAERS: 41US FAERS
8Blood alkaline phosphatase increasedFAERS: 41OFFSIDES
US FAERS
9Fanconi SyndromeFAERS: 34OFFSIDES
US FAERS
10Back PainFAERS: 30US FAERS
11Drug ineffectiveFAERS: 29
Canada Vigilance: 5		Canada Vigilance
OFFSIDES
US FAERS
12Blood creatinine increasedFAERS: 27
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
13Viral load increasedFAERS: 27
Canada Vigilance: 1		Canada Vigilance
US FAERS
14AstheniaFAERS: 23US FAERS
15Bone density decreasedFAERS: 21OFFSIDES
US FAERS
16Viral mutation identifiedFAERS: 19
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
17FatigueFAERS: 18US FAERS
18Renal tubular disorderFAERS: 18OFFSIDES
US FAERS
19Chest PainFAERS: 17US FAERS
20Drug resistanceFAERS: 16
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
21HBV DNA increasedFAERS: 14OFFSIDES
US FAERS
22Hepatitis B DNA increasedFAERS: 14
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
23ProteinuriaFAERS: 14US FAERS
24PregnancyFAERS: 13US FAERS
25Weight decreasedFAERS: 13US FAERS
26Aspartate Aminotransferase IncreasedFAERS: 12US FAERS
27Vitamin D DeficiencyFAERS: 11US FAERS
28Blood creatine phosphokinase increasedFAERS: 10US FAERS
29FractureFAERS: 10US FAERS
30NauseaFAERS: 10US FAERS
31Blood potassium decreasedFAERS: 9OFFSIDES
US FAERS
32Drug exposure during pregnancyFAERS: 9US FAERS
33Gene MutationFAERS: 8US FAERS
34GlycosuriaFAERS: 8US FAERS
35Musculoskeletal chest painFAERS: 8US FAERS
36MyalgiaFAERS: 8US FAERS
37Genotype drug resistance test positiveFAERS: 7OFFSIDES
US FAERS
38Hepatitis BFAERS: 7

View details

10628774
11511568
11551579
12362303
15104374
15142051
15259898
15307884
15388423
15497163
15561234
15564749
15565615
15778544
15866639
15866657
15948869
15964093
15973721
15980671
16240690
16274835
16386596
16481275
16481305
16611191
17112914
17241380
17310821
17321635
17326221
17402992
17516533
17530361
18031370
18184193
18461609
18816503
19043923
19229115
19674281
19758269
 		CTD
OFFSIDES
US FAERS
39MalaiseFAERS: 7US FAERS
40PancreatitisFAERS: 7OFFSIDES
US FAERS
41Product quality issueFAERS: 7OFFSIDES
US FAERS
42Renal tubular acidosisFAERS: 7OFFSIDES
US FAERS
43AnorexiaFAERS: 6OFFSIDES
US FAERS
44Bone lesionFAERS: 6US FAERS
45HyperphosphaturiaFAERS: 6US FAERS
46HypokinesiaFAERS: 6US FAERS
47Metabolic acidosisFAERS: 6US FAERS
48NephrolithiasisFAERS: 6US FAERS
49Pathological fractureFAERS: 6US FAERS
50Protein urine presentFAERS: 6US FAERS
51Unevaluable eventFAERS: 6US FAERS
52Urine phosphorus increasedFAERS: 6US FAERS
53Abdominal PainFAERS: 5US FAERS
54Blood 25-hydroxycholecalciferol decreasedFAERS: 5OFFSIDES
US FAERS
55Blood uric acid decreasedFAERS: 5OFFSIDES
US FAERS
56Creatinine renal clearance decreasedFAERS: 5OFFSIDES
US FAERS
57NocturiaFAERS: 5US FAERS
58OliguriaFAERS: 5US FAERS
59OsteopeniaFAERS: 5US FAERS
60OverdoseFAERS: 5OFFSIDES
US FAERS
61AscitesFAERS: 4OFFSIDES
US FAERS
62Blood cholesterol increasedFAERS: 4US FAERS
63DiscomfortFAERS: 4US FAERS
64DizzinessFAERS: 4US FAERS
65HypotensionFAERS: 4US FAERS
66Joint swellingFAERS: 4US FAERS
67LeukopeniaFAERS: 4US FAERS
68Musculoskeletal PainFAERS: 4US FAERS
69MyopathyFAERS: 4US FAERS
70VomitingFAERS: 4US FAERS
71AbasiaFAERS: 3OFFSIDES
US FAERS
72AcidosisFAERS: 3OFFSIDES
US FAERS
73Acquired aminoaciduriaFAERS: 3US FAERS
74Alpha 1 microglobulin increasedFAERS: 3US FAERS
75Amino acid level increasedFAERS: 3US FAERS
76ArthritisFAERS: 3US FAERS
77Blood 1,25-dihydroxycholecalciferol decreasedFAERS: 3US FAERS
78Bone scan abnormalFAERS: 3OFFSIDES
US FAERS
79DeafnessFAERS: 3US FAERS
80Hepatic EncephalopathyFAERS: 3US FAERS
81HepatitisFAERS: 3OFFSIDES
US FAERS
82HyperplasiaFAERS: 3US FAERS
83OsteosclerosisFAERS: 3US FAERS
84PalpitationsFAERS: 3US FAERS
85Pelvic PainFAERS: 3US FAERS
86Post procedural complicationFAERS: 3US FAERS
87Tension HeadacheFAERS: 3OFFSIDES
US FAERS
88ThrombocytopeniaFAERS: 3US FAERS
89TinnitusFAERS: 3OFFSIDES
US FAERS
90Umbilical herniaFAERS: 3OFFSIDES
US FAERS
91Urine calcium increasedFAERS: 3OFFSIDES
US FAERS
92Urine phosphorus decreasedFAERS: 3US FAERS
93White blood cell count decreasedFAERS: 3US FAERS
94Abdominal tendernessFAERS: 2US FAERS
95Abnormal palmar/plantar creasesFAERS: 2OFFSIDES
US FAERS
96AlopeciaFAERS: 2US FAERS
97Atrial FibrillationFAERS: 2US FAERS
98Bilirubin conjugated increasedFAERS: 2US FAERS
99Blood albumin decreasedFAERS: 2US FAERS
100Blood bilirubin abnormalFAERS: 2US FAERS
101Blood creatinine decreasedFAERS: 2US FAERS
102Blood glucose fluctuationFAERS: 2US FAERS
103Blood glucose increasedFAERS: 2US FAERS
104Blood phosphorus abnormalFAERS: 2US FAERS
105BronchospasmFAERS: 2US FAERS
106CataractFAERS: 2US FAERS
107Chest discomfortFAERS: 2US FAERS
108ConstipationFAERS: 2US FAERS
109DemyelinationFAERS: 2US FAERS
110DysgeusiaFAERS: 2US FAERS
111EosinophiliaFAERS: 2US FAERS
112Eosinophilic PneumoniaFAERS: 2OFFSIDES
US FAERS
113Erythema MultiformeFAERS: 2US FAERS
114Feeling abnormalFAERS: 2US FAERS
115Food cravingFAERS: 2OFFSIDES
US FAERS
116HeadacheFAERS: 2US FAERS
117Hepatic cancer metastaticFAERS: 2US FAERS
118Hepatitis B DNA assay positiveFAERS: 2OFFSIDES
US FAERS
119HepatomegalyFAERS: 2US FAERS
120HypermetabolismFAERS: 2US FAERS
121HypospermiaFAERS: 2US FAERS
122HypoxiaFAERS: 2US FAERS
123Intervertebral Disc DegenerationFAERS: 2US FAERS
124Joint Range of Motion DecreasedFAERS: 2US FAERS
125LymphomaFAERS: 2US FAERS
126Memory impairmentFAERS: 2US FAERS
127Meniscus injuryFAERS: 2US FAERS
128Muscle strainFAERS: 2OFFSIDES
US FAERS
129Muscle tightnessFAERS: 2OFFSIDES
US FAERS
130Musculoskeletal stiffnessFAERS: 2US FAERS
131NasopharyngitisFAERS: 2US FAERS
132NeutropeniaFAERS: 2US FAERS
133Pancreatic CystFAERS: 2US FAERS
134ParanoiaFAERS: 2US FAERS
135Portal Vein ThrombosisFAERS: 2US FAERS
136Psychiatric symptomFAERS: 2OFFSIDES
US FAERS
137Rebound effectFAERS: 2OFFSIDES
US FAERS
138Renal painFAERS: 2US FAERS
139RhabdomyolysisFAERS: 2OFFSIDES
US FAERS
140ScreamingFAERS: 2OFFSIDES
US FAERS
141SepsisFAERS: 214647053CTD
US FAERS
142SwellingFAERS: 2US FAERS
143TremorFAERS: 2US FAERS
144Urinary sediment presentFAERS: 2US FAERS
145Urine output increasedFAERS: 2OFFSIDES
US FAERS
146Urine potassium increasedFAERS: 2US FAERS
147UrticariaFAERS: 2US FAERS
148VasculitisFAERS: 2US FAERS
149Virologic failureFAERS: 2US FAERS
150jaundiceFAERS: 211511568CTD
US FAERS
151prostatitisFAERS: 2US FAERS
152Abdominal symptomFAERS: 1US FAERS
153AcneFAERS: 1US FAERS
154Activities of daily living impairedFAERS: 1US FAERS
155AgeusiaFAERS: 1US FAERS
156AlbuminuriaFAERS: 1US FAERS
157Alpha 2 globulin decreasedFAERS: 1US FAERS
158AminoaciduriaFAERS: 1OFFSIDES
US FAERS
159Ankle FractureFAERS: 1US FAERS
160AnxietyFAERS: 1US FAERS
161ArthropathyFAERS: 1US FAERS
162AtaxiaFAERS: 1OFFSIDES
US FAERS
163Beta 2 microglobulin increasedFAERS: 1US FAERS
164Beta 2 microglobulin urine increasedFAERS: 1OFFSIDES
US FAERS
165Beta-N-acetyl-D-glucosaminidase increasedFAERS: 1US FAERS
166Blood bilirubin decreasedFAERS: 1US FAERS
167Blood chloride increasedFAERS: 1OFFSIDES
US FAERS
168Blood creatine increasedFAERS: 1US FAERS
169Blood creatine phosphokinase decreasedFAERS: 1OFFSIDES
US FAERS
170Blood creatinine abnormalFAERS: 1US FAERS
171Blood glucose decreasedFAERS: 1US FAERS
172Blood immunoglobulin G increasedFAERS: 1US FAERS
173Blood magnesium increasedFAERS: 1US FAERS
174Blood potassium increasedFAERS: 1US FAERS
175Blood sodium increasedFAERS: 1OFFSIDES
US FAERS
176Blood urea abnormalFAERS: 1US FAERS
177Blood urea increasedFAERS: 1US FAERS
178Bone density abnormalFAERS: 1US FAERS
179Calcium deficiencyFAERS: 1US FAERS
180Carbon dioxide decreasedFAERS: 1US FAERS
181ChemotherapyFAERS: 1US FAERS
182CholecystitisFAERS: 1US FAERS
183ChorioamnionitisFAERS: 1US FAERS
184Complications of maternal exposure to therapeutic drugsFAERS: 1US FAERS
185Compression fractureFAERS: 1US FAERS
186Coronary Artery DiseaseFAERS: 1US FAERS
187Counterfeit product administeredFAERS: 1US FAERS
188Cystatin C increasedFAERS: 1US FAERS
189CystFAERS: 1US FAERS
190Delusional disorder, persecutory typeFAERS: 1US FAERS
191Developmental Coordination DisorderFAERS: 1US FAERS
192DextrocardiaFAERS: 1US FAERS
193Diabetes MellitusFAERS: 1US FAERS
194Diabetic NephropathyFAERS: 1US FAERS
195DiplopiaFAERS: 1US FAERS
196DisabilityFAERS: 1US FAERS
197Disease recurrenceFAERS: 1US FAERS
198DisorientationFAERS: 1US FAERS
199Double Outlet Right VentricleFAERS: 1US FAERS
200Drug dispensing errorFAERS: 1US FAERS
201Drug exposure before pregnancyFAERS: 1OFFSIDES
US FAERS
202Drug level increasedFAERS: 1US FAERS
203EcchymosisFAERS: 1US FAERS
204EpilepsyFAERS: 1US FAERS
205ErythropeniaFAERS: 1US FAERS
206FlatulenceFAERS: 1US FAERS
207GangreneFAERS: 1US FAERS
208Gastric ulcerFAERS: 1US FAERS
209Gastrointestinal motility disorderFAERS: 1US FAERS
210Glomerular vascular disorderFAERS: 1US FAERS
211GoutFAERS: 1US FAERS
212Hepatitis B DNA assayFAERS: 1US FAERS
213Hepatitis B surface antigen positiveFAERS: 1US FAERS
214Hyaluronic acid increasedFAERS: 1US FAERS
215HyperparathyroidismFAERS: 1OFFSIDES
US FAERS
216HyperreflexiaFAERS: 1US FAERS
217Hypertrophic CardiomyopathyFAERS: 1US FAERS
218HyperventilationFAERS: 1US FAERS
219HypoparathyroidismFAERS: 1US FAERS
220Immune thrombocytopenic purpuraFAERS: 1US FAERS
221Inappropriate schedule of drug administrationFAERS: 1US FAERS
222Inhibin B decreasedFAERS: 1US FAERS
223Initial insomniaFAERS: 1US FAERS
224Intentional product misuseFAERS: 1US FAERS
225Intercostal neuralgiaFAERS: 1US FAERS
226Intermittent ClaudicationFAERS: 1US FAERS
227Intervertebral disc compressionFAERS: 1US FAERS
228Intervertebral disc disorderFAERS: 1US FAERS
229Limb discomfortFAERS: 1US FAERS
230Lipase increasedFAERS: 1US FAERS
231Lower respiratory tract inflammationFAERS: 1US FAERS
232Mental impairmentFAERS: 1US FAERS
233Mitral Valve StenosisFAERS: 1US FAERS
234Multiple MyelomaFAERS: 1US FAERS
235Musculoskeletal discomfortFAERS: 1US FAERS
236Myocardial fibrosisFAERS: 1US FAERS
237MyositisFAERS: 1US FAERS
238Nasal mucosal disorderFAERS: 1US FAERS
239NecrosisFAERS: 111486172CTD
US FAERS
240Nephritic syndromeFAERS: 1US FAERS
241Nerve injuryFAERS: 1US FAERS
242NeuritisFAERS: 1US FAERS
243No adverse eventFAERS: 1US FAERS
244NoduleFAERS: 1US FAERS
245Obsessive-Compulsive DisorderFAERS: 1US FAERS
246Oropharyngeal painFAERS: 1US FAERS
247OsteitisFAERS: 1US FAERS
248OsteodystrophyFAERS: 1US FAERS
249Patellofemoral Pain SyndromeFAERS: 1US FAERS
250Perihepatic discomfortFAERS: 1US FAERS
251Peripheral swellingFAERS: 1US FAERS
252PeritonitisFAERS: 1US FAERS
253Pharmaceutical product complaintFAERS: 1US FAERS
254Pharmaceutical product counterfeitFAERS: 1US FAERS
255Pharyngolaryngeal PainFAERS: 1US FAERS
256Pleuritic painFAERS: 1US FAERS
257Poor quality drug administeredFAERS: 1US FAERS
258Poor quality sleepFAERS: 1US FAERS
259Positron emission tomogram abnormalFAERS: 1US FAERS
260Postoperative infectionFAERS: 1US FAERS
261Prealbumin decreasedFAERS: 1US FAERS
262Prescribed overdoseFAERS: 1OFFSIDES
US FAERS
263Product counterfeitFAERS: 1US FAERS
264Product solubility abnormalFAERS: 1US FAERS
265Product substitution issueFAERS: 1US FAERS
266Product taste abnormalFAERS: 1US FAERS
267Prostatic calcificationFAERS: 1US FAERS
268Protein total decreasedFAERS: 1US FAERS
269Protein urine absentFAERS: 1US FAERS
270PruritusFAERS: 1US FAERS
271Pulmonary Valve StenosisFAERS: 1US FAERS
272Pulmonary malformationFAERS: 1US FAERS
273Renal Artery StenosisFAERS: 1US FAERS
274Renal Cell CarcinomaFAERS: 1US FAERS
275Renal hypertensionFAERS: 1US FAERS
276Renal massFAERS: 1US FAERS
277Renal scan abnormalFAERS: 1US FAERS
278Renal tubular necrosisFAERS: 1OFFSIDES
US FAERS
279Rheumatic disorderFAERS: 1US FAERS
280RhinalgiaFAERS: 1US FAERS
281RhinitisFAERS: 1US FAERS
282SacroiliitisFAERS: 1US FAERS
283Serum procollagen type I N-terminal propeptide increasedFAERS: 1US FAERS
284ShockFAERS: 1US FAERS
285Spinal column stenosisFAERS: 1US FAERS
286SpondylolisthesisFAERS: 1US FAERS
287Spontaneous penile erectionFAERS: 1OFFSIDES
US FAERS
288ThrombosisFAERS: 1US FAERS
289Thyroid NeoplasmFAERS: 1US FAERS
290Transaminases increasedFAERS: 1US FAERS
291UlcerFAERS: 1OFFSIDES
US FAERS
292UnderweightFAERS: 1US FAERS
293Urinary RetentionFAERS: 1US FAERS
294Urinary tract infectionFAERS: 1US FAERS
295Urine calcium decreasedFAERS: 1US FAERS
296Urine sodium decreasedFAERS: 1US FAERS
297Viral load decreasedFAERS: 1US FAERS
298Wheelchair userFAERS: 1US FAERS
299kyphosisFAERS: 1US FAERS
300pH urine increasedFAERS: 1US FAERS
301Acute kidney injury14647053CTD
302AgraphiaOFFSIDES
303Anion gap normalOFFSIDES
304Anti-platelet antibody positiveOFFSIDES
305Aortic AneurysmOFFSIDES
306ApathyOFFSIDES
307Apnea14647053CTD
308Blood amylase increasedOFFSIDES
309Blood cholesterolOFFSIDES
310Blood immunoglobulin EOFFSIDES
311Blood parathyroid hormone increasedOFFSIDES
312Bone fissureOFFSIDES
313BradycardiaOFFSIDES
314Brain Diseases14647053CTD
315Bronchoalveolar lavage abnormalOFFSIDES
316Chemotherapeutic drug level increasedOFFSIDES
317Chronic respiratory failureOFFSIDES
318ContractureOFFSIDES
319Cytolytic hepatitisOFFSIDES
320Diarrhea14647053CTD
321Drug administration errorOFFSIDES
322Drug exposure via breast milkOFFSIDES
323Duodenal fistulaOFFSIDES
324Enterocolitis viralOFFSIDES
325Fatty LiverOFFSIDES
326Fluid overloadOFFSIDES
327Food aversionOFFSIDES
328Gamma-Glutamyltransferase IncreasedOFFSIDES
329Gastrointestinal Hemorrhage14647053CTD
330Gastrointestinal inflammationOFFSIDES
331General physical conditionOFFSIDES
332GlobulinuriaOFFSIDES
333HIV Infections11365545
11486172		CTD
334HemiparesisOFFSIDES
335Hepatitis B, Chronic

View details

10869300
12143057
12962817
14647053
14699491
14756274
14997399
15125374
15655050
15740536
15915463
16224157
16278590
16386595
16699864
16729316
16842441
17087951
17196132
17256746
17400303
17431777
17561304
17637268
17683493
17713159
17898551
17983801
17988233
18279995
18433925
18572751
18971179
19119245
19222742
19302908
19346785
19387534
19602924
19669266
19704174
19780875
19818142
19912686
20386079
20498322
20558919
 		CTD
336Hepatorenal Syndrome14647053CTD
337HepatosplenomegalyOFFSIDES
338Hip swellingOFFSIDES
339Hormone level abnormalOFFSIDES
340Hypophosphatemia18815461CTD
341Kidney FailureOFFSIDES
342Liver Cirrhosis16611191
17087951
19912686		CTD
343Liver Failure14647053
14997399
15104374		CTD
344Lymphocyte count abnormalOFFSIDES
345Lymphocytic infiltrationOFFSIDES
346MarasmusOFFSIDES
347Metastases to abdominal cavityOFFSIDES
348Murphy's sign positiveOFFSIDES
349Muscle WeaknessOFFSIDES
350OsteolysisOFFSIDES
351Pathogen resistanceOFFSIDES
352Peripheral arterial occlusive diseaseOFFSIDES
353Plantar erythemaOFFSIDES
354Pneumocystis jiroveci pneumoniaOFFSIDES
355Pregnancy of partnerOFFSIDES
356Pulmonary sepsisOFFSIDES
357Renal Insufficiency11486172CTD
358Renal cystOFFSIDES
359Renal tubular atrophyOFFSIDES
360Therapy non-responderOFFSIDES
361ToxoplasmosisOFFSIDES
362Transmission of drug via semenOFFSIDES
363Troponin increasedOFFSIDES
364Viremia12962817
18461609		CTD
365Vitamin A DeficiencyOFFSIDES
366Waist circumference increasedOFFSIDES
367White blood cell count abnormalOFFSIDES
368muscle injuryOFFSIDES
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