MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Urethral Obstruction

(UMLS:C0041972)

Definition:: Partial or complete blockage in any part of the URETHRA that can lead to difficulty or inability to empty the URINARY BLADDER. It is characterized by an enlarged, often damaged, bladder with frequent urges to void.
UMLS ID:: C0041972
MeSH ID:: D014524

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.767.700

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.767.700

Synonym(s)

Urethral Obstruction

Obstruction of urethra

Obstruction of urethra, NOS

Urethral obstruction

Urethral obstruction, NOS

obstruction of urethra

obstruction; urethra

occlusion; urethra

urethra obstruction

10.

urethra; obstruction

11.

urethra; occlusion

12.

urethral obstruction

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	MDV 3100	FAERS: 5		US FAERS
2	Sorafenib	FAERS: 5		US FAERS
3	Octreotide	FAERS: 3		US FAERS
4	Aspirin	FAERS: 2		US FAERS
5	Clopidogrel	FAERS: 2		US FAERS
6	Clozapine	FAERS: 2		OFFSIDES US FAERS
7	Finasteride	FAERS: 2		US FAERS
8	Glatiramer Acetate	FAERS: 2		OFFSIDES US FAERS
9	Lamotrigine	FAERS: 2		US FAERS
10	NuvaRing	FAERS: 2		OFFSIDES US FAERS
11	Solifenacin Succinate	FAERS: 2		OFFSIDES US FAERS
12	Zoledronic Acid	FAERS: 2		OFFSIDES US FAERS
13	4-Aminopyridine	FAERS: 1		US FAERS
14	Abiraterone Acetate	FAERS: 1		US FAERS
15	Axitinib	FAERS: 1		US FAERS
16	Capecitabine	FAERS: 1		US FAERS
17	Carbamazepine	FAERS: 1		US FAERS
18	Dabigatran	FAERS: 1		US FAERS
19	Dimethyl Fumarate	FAERS: 1		US FAERS
20	Diovan Hct	FAERS: 1		US FAERS
21	Dutasteride	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
22	Fexofenadine hydrochloride and pseudoephedrine hydrochloride	FAERS: 1		US FAERS
23	Fingolimod Hydrochloride	FAERS: 1		US FAERS
24	Imatinib Mesylate	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
25	LCZ 696	FAERS: 1		US FAERS
26	Leuprolide	FAERS: 1		US FAERS
27	Levetiracetam	FAERS: 1		US FAERS
28	Morphine	FAERS: 1		US FAERS
29	Mupirocin	FAERS: 1		US FAERS
30	Norgestrel	FAERS: 1		US FAERS
31	Paroxetine	FAERS: 1		US FAERS
32	Prasugrel Hydrochloride	FAERS: 1		US FAERS
33	Pregabalin	FAERS: 1		US FAERS
34	Rivaroxaban	FAERS: 1		US FAERS
35	Rivastigmine	FAERS: 1		US FAERS
36	Sunitinib	FAERS: 1		US FAERS
37	Tacrolimus	FAERS: 1		US FAERS
38	Tamsulosin	FAERS: 1		US FAERS
39	Teriparatide	FAERS: 1		US FAERS
40	alogliptin	FAERS: 1		US FAERS
41	esmolol	FAERS: 1		US FAERS
42	gemcitabine	FAERS: 1		US FAERS
43	niraparib	FAERS: 1		US FAERS
44	pazopanib	FAERS: 1		US FAERS
45	Amiloride			OFFSIDES
46	Chlorhexidine			OFFSIDES
47	Cyclophosphamide			OFFSIDES
48	Doxorubicin			SIDER
49	Ipratropium		2480586	CTD
50	Lovastatin			OFFSIDES
51	Methocarbamol			OFFSIDES
52	Metolazone			OFFSIDES
53	Octreotide	Canada Vigilance: 1		Canada Vigilance OFFSIDES
54	Oxymorphone		17138599	CTD
55	Pamidronate			OFFSIDES
56	Prazosin		1975868	CTD
57	Primidone			OFFSIDES
58	Tamoxifen			OFFSIDES
59	Triptorelin Pamoate			SIDER
60	Ubiquinone			OFFSIDES
61	brinzolamide			OFFSIDES
62	chlorhexidine gluconate			OFFSIDES
63	samarium Sm-153 lexidronam			OFFSIDES
64	testosterone 17 beta-cypionate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Urethritis	47.5%
2	Epispadias	34.8%
3	Urinary Bladder Diseases	32.8%
4	Kidney Diseases	32.8%
5	Ureteral Diseases	32.8%
6	Urination Disorders	32.8%
7	Urolithiasis	32.8%
8	Urethral Neoplasms	31.8%
9	Anuria	28.4%
10	Ureterolithiasis	28.4%
11	Nephrolithiasis	28.4%
12	Urinary tract infection	26.5%
13	Cystitis	21.3%
14	Hydronephrosis	21.3%
15	Hyperoxaluria	21.3%
16	Kidney Cortex Necrosis	21.3%
17	Kidney Papillary Necrosis	21.3%
18	Nephritis	21.3%
19	Nephrosclerosis	21.3%
20	Nephrosis	21.3%
21	Perinephritis	21.3%
22	Kidney Failure	21.3%
23	Uremia	21.3%
24	Ureteral obstruction	21.3%
25	Ureterocele	21.3%
26	Vesico-Ureteral Reflux	21.3%
27	Urinary Retention	21.3%
28	Oxalosis	21.3%
29	Renal Insufficiency	21.3%
30	Kidney Calculi	20.9%
31	Ureteral Calculi	20.9%
32	Bladder Exstrophy	19.5%
33	Tuberculosis, Renal	19.4%
34	Pyelocystitis	19.1%
35	Urogenital Abnormalities	17.7%
36	Diabetes Insipidus	17.3%
37	Hepatorenal Syndrome	17.3%
38	Pyelonephritis	17.3%
39	Bacteriuria	17.1%
40	Diabetic Nephropathy	17.1%
41	Glycosuria	17.1%
42	Hematuria	17.1%
43	Renal hypertension	17.1%
44	Oliguria	17.1%
45	Polyuria	17.1%
46	Proteinuria	17.1%
47	Pyuria	17.1%
48	Renal Artery Obstruction	17.1%
49	Renal Artery Stenosis	17.1%
50	Urinary Calculi	17.1%
51	Cystocele	17%
52	Nephrocalcinosis	17%
53	Urinary Incontinence	17%
54	Urinary Bladder Fistula	16.8%
55	Bladder Neoplasm	16.8%
56	Kidney Neoplasm	16.8%
57	Ureteral Neoplasms	16.8%
58	Multicystic Dysplastic Kidney	16.3%
59	Glomerulonephritis	15.8%
60	Nephritis, Interstitial	15.8%
61	Lipoid nephrosis	15.8%
62	Nephrotic Syndrome	15.8%
63	Pyelitis	15.8%
64	Pyonephrosis	15.8%
65	Nephrogenic Diabetes Insipidus	15.8%
66	Congenital Nephrogenic Diabetes Insipidus	15.8%
67	Acute kidney injury	15.8%
68	Enuresis	14.4%
69	Bladder neck obstruction	14.1%
70	Glycosuria, Renal	14%
71	Balkan Nephropathy	13.1%
72	Focal glomerulosclerosis	13.1%
73	Kidney Failure, Chronic	13.1%
74	Azotemia	12.9%
75	Albuminuria	12.6%
76	Hemoglobinuria	12.6%
77	Hypertension, Renovascular	12.6%
78	Infertility	12.6%
79	Urge Incontinence	12.6%
80	AIDS-Associated Nephropathy	12.1%
81	Genital Diseases, Male	11.8%
82	Glomerulonephritis, Membranoproliferative	11%
83	Mesoblastic Nephroma	10.9%
84	Renal Cell Carcinoma	10.8%
85	Papillary Renal Cell Carcinoma	10.8%
86	Polycystic Kidney Diseases	10.6%
87	Hypospadias	10.6%
88	Pregnancy Complications	10.6%
89	Diurnal Enuresis	10.6%
90	Renal Aminoacidurias	10.5%
91	Fanconi Syndrome	10.5%
92	Pseudohypoaldosteronism	10.5%
93	Liddle Syndrome	10.5%
94	Hemolytic-Uremic Syndrome	10.5%
95	Urologic Neoplasms	10.1%
96	Horseshoe Kidney	10.1%
97	Endometriosis	9.9%
98	Uterine Diseases	9.9%
99	Vaginal Diseases	9.9%
100	Vulvar Diseases	9.9%
101	Endometrioma	9.9%
102	Renal Osteodystrophy	9.4%
103	Renal rickets	9.4%
104	Renal tubular acidosis	9%
105	Vesicovaginal Fistula	8.9%
106	Anti-Glomerular Basement Membrane Disease	8.9%
107	Nephroblastoma	8.8%
108	Lupus Nephritis	8.8%
109	Sexually Transmitted Diseases	8.8%
110	Polycystic Kidney, Autosomal Dominant	8.7%
111	Cystinuria	8.7%
112	Atypical Hemolytic Uremic Syndrome	8.7%
113	Endometritis	8.5%
114	Hermaphroditism	8.5%
115	Disorders of Sex Development	8.5%
116	Genital Herpes	8.3%
117	Genital Neoplasms, Male	8.2%
118	Uterine Neoplasms	7.8%
119	Vaginal Neoplasms	7.8%
120	Vulvar Neoplasms	7.8%
121	Uterine Cancer	7.8%
122	Genital Neoplasms, Female	7.4%
123	Uterine Inversion	7.4%
124	Salpingitis	7.3%
125	Vulvovaginitis	7.3%
126	Zellweger Syndrome	7.1%
127	Hyperphosphaturia	7%
128	Denys-Drash Syndrome	6.9%
129	Fallopian Tube Neoplasms	6.8%
130	Epididymitis	6.7%
131	Penile Diseases	6.7%
132	Prostatic Diseases	6.7%
133	Spermatic Cord Torsion	6.7%
134	Hemospermia	6.7%
135	Testicular Hydrocele	6.7%
136	Dyspareunia	6.7%
137	Penile Neoplasms	6.6%
138	Prostatic Neoplasms	6.6%
139	Endometrial Hyperplasia	6.5%
140	Pyometra	6.5%
141	Vaginitis	6.5%
142	Vulvitis	6.5%
143	Vaginal Discharge	6.5%
144	Vulvodynia	6.5%
145	Uterine Rupture	6%
146	Oophoritis	5.8%
147	Endometrial Neoplasms	5.8%
148	Polyhydramnios	5.6%
149	Obstetric Labor Complications	5.6%
150	Ectopic Pregnancy	5.6%
151	Pregnancy, Prolonged	5.6%
152	Puerperal Disorders	5.6%
153	Oligohydramnios	5.6%
154	Prenatal Injuries	5.6%
155	Cryptorchidism	5.6%
156	Gonadal Dysgenesis	5.5%
157	Adrenogenital Syndrome	5.5%
158	Ovotesticular Disorders of Sex Development	5.5%
159	Uterine Cervical Incompetence	5.3%
160	Testicular Diseases	5.1%
161	Varicocele	5.1%
162	Spermatocele	5%
163	Ovarian Diseases	5%
164	ovarian neoplasm	5%
165	Abruptio Placentae	5%
166	Placenta Accreta	5%
167	Adnexitis	4.9%
168	Pruritus Vulvae	4.9%
169	Uterine hemorrhage	4.9%
170	Vaginal Fistula	4.9%
171	Pelvic Inflammatory Disease	4.9%
172	Uterine Prolapse	4.9%
173	Vaginal Prolapse	4.9%
174	Uterine Cervicitis	4.9%
175	Leukorrhea	4.9%
176	Parametritis	4.9%
177	Candidiasis, Vulvovaginal	4.9%
178	Prostatic Neoplasms, Castration-Resistant	4.9%
179	Hyperandrogenism	4.8%
180	Carcinoma, Endometrioid	4.8%
181	Chorioamnionitis	4.4%
182	Fetal Diseases	4.4%
183	Pregnancy Complications, Cardiovascular	4.4%
184	Pregnancy Complications, Neoplastic	4.4%
185	Balanitis	4.4%
186	Benign prostatic hypertrophy	4.4%
187	Phimosis	4.4%
188	Priapism	4.4%
189	prostatitis	4.4%
190	Prostatic Adenoma	4.4%
191	Benign Prostatic Hyperplasia	4.4%
192	Prostatic Hypertrophy	4.4%
193	Prostatic Hyperplasia	4.4%
194	Pregnancy Complications, Hematologic	4.3%
195	Pregnancy Complications, Infectious	4.3%
196	Fetal Death	4.2%
197	Perinatal death	4.2%
198	Morning Sickness	4.2%
199	Puerperal Infection	4%
200	Postpartum Hemorrhage	3.9%
201	Bacterial Vaginosis	3.7%
202	Familial Hypophosphatemic Rickets	3.7%
203	Trichomonas Vaginitis	3.7%
204	Uterine Perforation	3.7%
205	Ovarian Hyperstimulation Syndrome	3.7%
206	Metrorrhagia	3.6%
207	Endometrial Stromal Sarcoma	3.6%
208	Chlamydia Infections	3.5%
209	Gonorrhea	3.5%
210	Gestational Diabetes	3.4%
211	Premature Ejaculation	3.4%
212	Erectile dysfunction	3.4%
213	granulosa cell tumor	3.3%
214	Carcinoma, Ovarian Epithelial	3.3%
215	Testicular Neoplasms	3.3%
216	Orchitis	3.3%
217	Abortion, Habitual	3.3%
218	Dystocia	3.3%
219	Eclampsia	3.3%
220	Fetal Membranes, Premature Rupture	3.3%
221	Placental Insufficiency	3.3%
222	Pre-Eclampsia	3.3%
223	Prenatal Exposure Delayed Effects	3.3%
224	HELLP Syndrome	3.3%
225	Placenta, Retained	3.3%
226	Azoospermia	3.3%
227	Oligospermia	3.3%
228	Impotence, Vasculogenic	3.3%
229	Asthenozoospermia	3.3%
230	Teratozoospermia	3.3%
231	Aspermia	3.3%
232	Turner Syndrome	3.2%
233	Kallmann Syndrome	3.1%
234	Syphilis	3%
235	Corpus Luteum Cyst	3%
236	Ovarian Cysts	3%
237	Anovulation	2.9%
238	Menorrhagia	2.9%
239	Premature Menopause	2.9%
240	Lymphogranuloma Venereum	2.9%
241	Klinefelter Syndrome	2.7%
242	Abortion, Veterinary	2.6%
243	Pregnancy Complications, Parasitic	2.6%
244	Lactation Disorder	2.5%
245	Mastitis	2.5%
246	Depression, Postpartum	2.5%
247	Embryo Loss	2.5%
248	Fetal Resorption	2.5%
249	Hyperemesis Gravidarum	2.4%
250	Polycystic Ovary Syndrome	2.4%
251	Premature Birth	2.2%
252	Fetal Growth Retardation	2%
253	Trophoblastic Neoplasms	2%
254	Embolism, Amniotic Fluid	2%
255	Fetal Hypoxia	2%
256	Fetal Alcohol Spectrum Disorders	2%
257	Breech Presentation	2%
258	Stillbirth	2%
259	Leydig Cell Tumor	1.8%
260	Galactorrhea	1.6%
261	Meconium Aspiration Syndrome	1.5%
262	Choriocarcinoma	1.1%
263	Hydatidiform Mole	1%
264	Hydrops Fetalis	0.7%

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