MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Oligospermia

(UMLS:C0028960)

Definition:: A condition of suboptimal concentration of SPERMATOZOA in the ejaculated SEMEN to ensure successful FERTILIZATION of an OVUM. In humans, oligospermia is defined as a sperm count below 20 million per milliliter semen.
UMLS ID:: C0028960
MeSH ID:: D009845

Classification:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.294.365.700.508

Synonym(s)

Oligospermia

Hypospermatogenesis

Low Sperm Count

Low sperm count

Oligoasthenoteratozoospermia

hypospermatogenesis

oligospermia

oligozoospermia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Finasteride	FAERS: 13 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Valproic Acid	FAERS: 2		US FAERS
3	Citalopram	FAERS: 1		US FAERS
4	Clopidogrel	FAERS: 1		US FAERS
5	Everolimus	FAERS: 1		US FAERS
6	Hydroxychloroquine	FAERS: 1		US FAERS
7	Imatinib Mesylate	FAERS: 1		US FAERS
8	Valproic Acid	FAERS: 1		US FAERS
9	haloperidol decanoate	FAERS: 1		US FAERS
10	teriflunomide	FAERS: 1		US FAERS
11	1,2-dibromo-3-chloropropane		73955 12759094	CTD
12	1-bromopropane		17890766 19638432	CTD
13	2-ethoxyethanol		20172899	CTD
14	4-dichlorobenzene		20932873	CTD
15	4-nitro-3-cresol		22467373	CTD
16	4-nonylphenol		27087316	CTD
17	ABVD protocol		17965791	CTD
18	Alcohols		23819932	CTD
19	Ascorbic Acid		View details 8671712 19429265 20305954 29663635 30140404	CTD
20	Atrazine		22372587 22897171	CTD
21	BEP protocol		18987330	CTD
22	Benzo(a)pyrene		22960446 27448386	CTD
23	Bosentan			SIDER
24	Cadmium Chloride		15304303 22828241	CTD
25	Cadmium Compounds		21449042 23193971	CTD
26	Carbamazepine	Canada Vigilance: 1		Canada Vigilance
27	Carboplatin		8776818	CTD
28	Cefuroxime		30797828	CTD
29	Choline		27664006	CTD
30	Cimetidine		435711	CTD
31	Cocaine		31059705	CTD
32	Colchicine			SIDER
33	Colforsin		29283200	CTD
34	Copper Sulfate		27823922	CTD
35	Cyclophosphamide		6788612 9166702 16517039	CTD SIDER
36	Decitabine		21449042	CTD
37	Dexamethasone		29902490	CTD
38	Dibutyl Phthalate		22489061	CTD
39	Dicamba		24420721	CTD
40	Dichlorodiphenyl Dichloroethylene		11856573 19303595	CTD
41	Diclofenac	Canada Vigilance: 1		Canada Vigilance
42	Diethylhexyl Phthalate		View details 25975992 26854921 28082598 29663635	CTD
43	Diethylstilbestrol		12507655 19782717	CTD
44	Doxorubicin		22008532	CTD SIDER
45	Endosulfan		8671712 25077688	CTD
46	Enrofloxacin		27083143	CTD
47	Erythrosine		9299211	CTD
48	Felodipine	Canada Vigilance: 1		Canada Vigilance
49	Fenitrothion		26264430	CTD
50	Fluoxetine		26348076	CTD SIDER
51	Fluoxymesterone			SIDER
52	Flutamide		11856573	CTD
53	Formaldehyde		16909603 24142868	CTD
54	Genistein		19672408	CTD
55	Grape Seed Extract		26854921	CTD
56	Hydroxyurea			SIDER
57	Ifosfamide			SIDER
58	Isoniazid		25683034	CTD
59	Ivermectin		28880400	CTD
60	Ketoconazole			SIDER
61	Linuron		28705778	CTD
62	Lutein		26187899	CTD
63	Lycopene		25682699	CTD
64	Mercaptopurine			SIDER
65	Mercuric Chloride		20820944 24555655 25368988	CTD
66	Mesalamine			SIDER
67	Methotrexate			SIDER
68	Methoxychlor		22348781	CTD
69	Methyltestosterone			SIDER
70	Nandrolone Decanoate		25542992	CTD
71	Nandrolone			SIDER
72	Nicotine		20498001	CTD
73	Nitric Oxide		29983398	CTD
74	Nitrites		29983398	CTD
75	Oxandrolone			SIDER
76	Oxymetholone			SIDER
77	Pectins		23193971	CTD
78	Pentachlorophenol		10434936	CTD
79	Permethrin		18455858	CTD
80	Phosphamidon		8671712	CTD
81	Potassium Dichromate		20079796	CTD
82	Quercetin		View details 22372587 22467373 25046308 26264430 27111109 28040552	CTD
83	Resveratrol		26348076 26499206 28606469	CTD
84	Rifampin		20305954	CTD
85	Risperidone		15960571	CTD
86	Selenium		19367646	CTD
87	Sirolimus		17845575	CTD
88	Sodium Fluoride		23707774 27237588 27664006	CTD
89	Sodium Selenite		22828241	CTD
90	Streptozocin		8417201 26499206	CTD
91	Sulfasalazine			SIDER
92	Sulfur Dioxide		27237588 30195209	CTD
93	Taurine		19429265 20498001 25542992	CTD
94	Testosterone Propionate		25077688	CTD
95	Testosterone			SIDER
96	Thioctic Acid		28880400 29214690	CTD
97	Vitamin E		View details 15304303 20079796 20305954 25046308 27823922 28395332 29663635	CTD
98	Zearalenone		24412631 25682699	CTD
99	Zinc Oxide		27111109	CTD
100	acetamiprid		28395332	CTD
101	beta Carotene		15304303	CTD
102	bioallethrin		28181402	CTD
103	bis(tri-n-butyltin)oxide		17451821	CTD
104	bisphenol A		View details 19782717 23528252 23554804 24085620 25461564 27296223 30275377	CTD
105	cadmium sulfate		26105546	CTD
106	chlorpyrifos-ethyl		23364943	CTD
107	chromium hexavalent ion		20079796 20360146	CTD
108	cypermethrin		20131380	CTD
109	decabromobiphenyl ether		View details 21901812 23038006 26602377 30300726	CTD
110	ethyl tert-butyl ether		24448831	CTD
111	fenvalerate		19683566 20063364 20138952	CTD
112	gemcitabine			SIDER
113	glyphosate		29908847	CTD
114	mancozeb		8671712 29283200	CTD
115	methyl cellosolve		2763296 3987992	CTD
116	morin		28844848	CTD
117	perfluorooctane sulfonic acid		19590684	CTD
118	perfluorooctanoic acid		19590684	CTD
119	phenylhydrazine		30140404	CTD
120	prolinedithiocarbamate		31059705	CTD
121	propylene dichloride		2744274	CTD
122	quinalphos		24581381	CTD
123	sabeluzole		8417201	CTD
124	sodium arsenite		View details 16483355 19429265 29214690 30189373 30195209 30278210 30291770	CTD
125	testosterone enanthate		21729141	CTD
126	thiacloprid		28692354	CTD
127	titanium dioxide		28844848	CTD
128	trestolone acetate		14602755	CTD
129	tri-o-cresyl phosphate		22450445	CTD
130	triphenyltin hydroxide		16806747	CTD
131	triptolide		26219505 30836114	CTD
132	turmeric extract		20182699	CTD
133	vendex		16806747	CTD
134	vinclozolin		11856573 19672408	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Azoospermia	48.4%
2	Asthenozoospermia	48.4%
3	Teratozoospermia	48.4%
4	Aspermia	48.4%
5	Epididymitis	25.4%
6	Penile Diseases	25.4%
7	Prostatic Diseases	25.4%
8	Spermatic Cord Torsion	25.4%
9	Hemospermia	25.4%
10	Testicular Hydrocele	25.4%
11	Testicular Diseases	17.2%
12	Varicocele	17.2%
13	Genital Neoplasms, Male	17.1%
14	Spermatocele	16.9%
15	Balanitis	14.8%
16	Benign prostatic hypertrophy	14.8%
17	Phimosis	14.8%
18	Priapism	14.8%
19	prostatitis	14.8%
20	Prostatic Adenoma	14.8%
21	Benign Prostatic Hyperplasia	14.8%
22	Prostatic Hypertrophy	14.8%
23	Prostatic Hyperplasia	14.8%
24	Penile Neoplasms	13.8%
25	Prostatic Neoplasms	13.8%
26	Urologic Diseases	10.8%
27	Sexually Transmitted Diseases	10.6%
28	Premature Ejaculation	10.1%
29	Erectile dysfunction	10.1%
30	Genital Herpes	10%
31	Orchitis	9.9%
32	Impotence, Vasculogenic	9.7%
33	Cryptorchidism	9.4%
34	Hypospadias	9.4%
35	Prostatic Neoplasms, Castration-Resistant	9%
36	Urogenital Abnormalities	8.1%
37	Dyspareunia	7.5%
38	Testicular Neoplasms	5.7%
39	Urinary Bladder Diseases	5.6%
40	Kidney Diseases	5.6%
41	Ureteral Diseases	5.6%
42	Urethral Diseases	5.6%
43	Urination Disorders	5.6%
44	Urolithiasis	5.6%
45	Bladder Exstrophy	4.4%
46	Epispadias	4.4%
47	Tuberculosis, Renal	4.4%
48	Urinary tract infection	4.3%
49	Urologic Neoplasms	4.2%
50	Horseshoe Kidney	4.2%
51	Anuria	3.9%
52	Ureterolithiasis	3.9%
53	Nephrolithiasis	3.9%
54	Multicystic Dysplastic Kidney	3.9%
55	Hermaphroditism	3.4%
56	Disorders of Sex Development	3.4%
57	Urinary Bladder Fistula	3.3%
58	Bladder Neoplasm	3.3%
59	Cystitis	3.3%
60	Hydronephrosis	3.3%
61	Hyperoxaluria	3.3%
62	Kidney Cortex Necrosis	3.3%
63	Kidney Neoplasm	3.3%
64	Kidney Papillary Necrosis	3.3%
65	Nephritis	3.3%
66	Nephrosclerosis	3.3%
67	Nephrosis	3.3%
68	Perinephritis	3.3%
69	Kidney Failure	3.3%
70	Uremia	3.3%
71	Ureteral Neoplasms	3.3%
72	Ureteral obstruction	3.3%
73	Ureterocele	3.3%
74	Urethral Neoplasms	3.3%
75	Urethral Obstruction	3.3%
76	Urethritis	3.3%
77	Vesico-Ureteral Reflux	3.3%
78	Urinary Retention	3.3%
79	Oxalosis	3.3%
80	Renal Insufficiency	3.3%
81	Bladder neck obstruction	3.2%
82	Chlamydia Infections	3.2%
83	Gonorrhea	3.2%
84	Syphilis	2.8%
85	Diabetes Insipidus	2.5%
86	Hepatorenal Syndrome	2.5%
87	Bacteriuria	2.5%
88	Diabetic Nephropathy	2.5%
89	Glycosuria	2.5%
90	Hematuria	2.5%
91	Renal hypertension	2.5%
92	Oliguria	2.5%
93	Polyuria	2.5%
94	Proteinuria	2.5%
95	Pyuria	2.5%
96	Renal Artery Obstruction	2.5%
97	Renal Artery Stenosis	2.5%
98	Urinary Calculi	2.5%
99	Cystocele	2.4%
100	Nephrocalcinosis	2.4%
101	Urinary Incontinence	2.4%
102	Kidney Calculi	2.4%
103	Ureteral Calculi	2.4%
104	Lymphogranuloma Venereum	2.4%
105	Leydig Cell Tumor	2.4%
106	Pyelocystitis	2.2%
107	Glomerulonephritis	2.1%
108	Nephritis, Interstitial	2.1%
109	Lipoid nephrosis	2.1%
110	Nephrotic Syndrome	2.1%
111	Pyelitis	2.1%
112	Pyonephrosis	2.1%
113	Urethral Stenosis	2.1%
114	Nephrogenic Diabetes Insipidus	2.1%
115	Congenital Nephrogenic Diabetes Insipidus	2.1%
116	Acute kidney injury	2.1%
117	Urethral stricture	2.1%
118	Enuresis	2%
119	Gonadal Dysgenesis	2%
120	Adrenogenital Syndrome	2%
121	Ovotesticular Disorders of Sex Development	2%
122	Pyelonephritis	1.9%
123	Mesoblastic Nephroma	1.8%
124	Renal Cell Carcinoma	1.8%
125	Papillary Renal Cell Carcinoma	1.8%
126	Azotemia	1.6%
127	AIDS-Associated Nephropathy	1.6%
128	Albuminuria	1.6%
129	Glycosuria, Renal	1.6%
130	Hemoglobinuria	1.6%
131	Hypertension, Renovascular	1.6%
132	Urge Incontinence	1.6%
133	Balkan Nephropathy	1.6%
134	Focal glomerulosclerosis	1.6%
135	Kidney Failure, Chronic	1.6%
136	Nephroblastoma	1.5%
137	Hyperandrogenism	1.4%
138	Polycystic Kidney Diseases	1.3%
139	Diurnal Enuresis	1.3%
140	Renal Aminoacidurias	1.3%
141	Fanconi Syndrome	1.3%
142	Pseudohypoaldosteronism	1.3%
143	Liddle Syndrome	1.3%
144	Hemolytic-Uremic Syndrome	1.3%
145	Glomerulonephritis, Membranoproliferative	1.3%
146	Denys-Drash Syndrome	1.2%
147	Renal Osteodystrophy	1.2%
148	Renal rickets	1.2%
149	Renal tubular acidosis	1.1%
150	Anti-Glomerular Basement Membrane Disease	1%
151	Lupus Nephritis	1%
152	Polycystic Kidney, Autosomal Dominant	1%
153	Cystinuria	1%
154	Atypical Hemolytic Uremic Syndrome	1%
155	Kallmann Syndrome	0.9%
156	Turner Syndrome	0.9%
157	Zellweger Syndrome	0.9%
158	Hyperphosphaturia	0.8%
159	Klinefelter Syndrome	0.8%
160	Familial Hypophosphatemic Rickets	0.4%

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