MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Nephritis, Interstitial

(UMLS:C0027707)

Definition:: Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.
UMLS ID:: C0027707
MeSH ID:: D009395

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.570.643

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.570.643

Synonym(s)

Nephritis, Interstitial

IN - Interstitial nephritis

INTERSTITIAL NEPHRITIS

Interstitial Nephritis

Interstitial nephritis

Interstitial nephritis, NOS

Interstitial renal disease or syndrome

NEPHRITIS INTERSTITIAL

Tubulointerstitial Nephritis

10.

disease (or disorder); renal, with interstitial nephritis

11.

disease tubulointerstitial

12.

interstitial nephritis

13.

nephritis interstitial

14.

renal; disease, with interstitial nephritis

15.

tubulointerstitial disease

16.

tubulointerstitial nephropathy

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acetaminophen	View details 2031841 6604293 7100020 9328634 9796356 12832150 16354242 16532256	CTD
2	Acyclovir	2080005 3376977	CTD
3	Adenine	24107419	CTD
4	Alcohols	18468752	CTD
5	Alendronate	16060139	CTD
6	Allopurinol	3822042	CTD
7	Amlodipine	10344374 10940749	CTD
8	Amoxicillin-Potassium Clavulanate Combination	7751590	CTD
9	Amoxicillin	View details 1855326 2128955 7266720 8275607 9761358 10405561 12845278	CTD
10	Amphetamine	6701599	CTD
11	Ampicillin	View details 441462 636917 1128370 2935070 3706419 4137531 4826628 5109877 6604293 6649724 7354769	CTD
12	Aristolochic Acids	21658425	CTD
13	Ascorbic Acid	18042297	CTD
14	Atazanavir Sulfate	16779906	CTD
15	Azathioprine	8427817 16395766	CTD
16	Azithromycin	8395778 15602202 16943303	CTD
17	Bendroflumethiazide	6604293	CTD
18	Bezafibrate	11064678	CTD
19	Caffeine	6683361 10803761	CTD
20	Carbamazepine	View details 1494733 3579484 7229772 9038040 11346062 11431905 12005248 12430739 15229826	CTD
21	Carbenicillin	622610 677983	CTD
22	Carbimazole	12543903	CTD
23	Carboplatin	2003521	CTD
24	Carmustine	7272960	CTD
25	Cefaclor	3713103	CTD
26	Cefdinir	11300142	CTD
27	Cefoperazone	15213314	CTD
28	Cefotaxime	8684569 8856288 10803769	CTD
29	Cefotetan	2399919	CTD
30	Cefoxitin	7283579	CTD
31	Ceftazidime	9033764	CTD
32	Ceftriaxone	7731417 16491410 17896901	CTD
33	Cefuroxime	10657721 11793135 17039330	CTD
34	Celecoxib	12046048	CTD
35	Cephaloridine	1201976	CTD
36	Cephalothin	View details 636917 1246100 4408153 4826627	CTD
37	Cephradine	89922	CTD
38	Cidofovir	10589927	CTD
39	Cimetidine	View details 1294777 3933701 6217424 6294351 6753681 6805823 6838302 7059066 7081178 7234893 7326652 7409394 8352262 8352263 10074607 11219486 16362162	CTD
40	Ciprofloxacin	View details 1481877 1929523 2016981 2222106 2376981 3382112 7645562 8176981 8213803 8700367 9406312 10575299 12911170 13130401 16649401	CTD
41	Clarithromycin	10525003 16627605	CTD
42	Clofibrate	7437867	CTD
43	Clomipramine	17891354	CTD
44	Cloxacillin	View details 1305739 1421648 2016158 2915772	CTD
45	Clozapine	View details 10513719 10939762 12123128 15285988 20126316	CTD
46	Cocaine	10344374 17338430 18468752	CTD
47	Creatine	10075534	CTD
48	Creatinine	View details 8671848 9823562 11205659 12073628 15007714 17014549 19174096 19212915	CTD
49	Cyclosporine	16114793	CTD
50	Cytarabine	11096300	CTD
51	Dermazin	4843201	CTD
52	Dextropropoxyphene	7100020	CTD
53	Diazepam	3827435	CTD
54	Diclofenac	View details 10444806 15651168 16943303 18274699	CTD
55	Dicloxacillin	622610	CTD
56	Diflunisal	6444363 7100020	CTD
57	Disulfiram	16943303	CTD
58	Ergotamine	11071983	CTD
59	Famotidine	9794575	CTD
60	Fenoprofen	View details 503131 6339355 6375363 6602549 6977270 7290034 7354644	CTD
61	Floxacillin	7624012 16943303	CTD
62	Flurbiprofen	1951476 3626164	CTD
63	Folic Acid	15013062	CTD
64	Foscarnet	2560634	CTD
65	Furosemide	View details 946513 3701771 3822042 6339355 10344374	CTD
66	GW 501516	21966476	CTD
67	Gentamicins	View details 185707 445001 6604293 7354245 7413550 8444569 12495276 15627798 16751989 16943303	CTD
68	Glyburide	16943303	CTD
69	Griseofulvin	2237566	CTD
70	Hydrochlorothiazide	946513 3360558 6339355	CTD
71	Hydroxychloroquine	15751825	CTD
72	Hydroxyurea	9221195	CTD
73	Ibuprofen	View details 1561566 3670248 6375363 7914617 7932183 8134235 8820499 9481750 10791141 14627791 17879100 18468752	CTD
74	Ifosfamide	9569955 10968388	CTD
75	Indapamide	2369678	CTD
76	Indinavir	View details 9337438 9681107 10739809 11126974 11362124 11545487 11915002	CTD
77	Indoles	6840011	CTD
78	Indomethacin	View details 3071148 3975749 3980192 10534532 16943303	CTD
79	Irbesartan	16943303	CTD
80	Ketoprofen	3071148	CTD
81	Lansoprazole	15004262 19204634 19682153	CTD
82	Leflunomide	15102985	CTD
83	Lincomycin	7413550	CTD
84	Linezolid	18044266 19733945	CTD
85	Lisinopril	10344374	CTD
86	Lithium Carbonate	7207556	CTD
87	Lithium	View details 6172717 6455457 6516842 7254275 9784708 9789472 10513719 10549692 11022396 12846754 20344995	CTD
88	Lomustine	7272960	CTD
89	Loratadine	14558336	CTD
90	Magnesium Sulfate	9617735 9617736	CTD
91	Mefenamic Acid	View details 2739843 3126948 3140090 4081705 6106853 6694957 6784867 7811132 15651168	CTD
92	Menthol	3556044	CTD
93	Mercuric Chloride	View details 12834626 14620542 16005714 17250768 27720909	CTD
94	Mercury Compounds	10820171	CTD
95	Mesalamine	View details 2224669 7830805 8671848 9243128 9306372 9582560 9673750 9740571 9823562 9823565 10393373 10791141 11205659 11431204 12003743 12073628 12187103 12235076 12500420 15007714 15877665 16830305 17404867 19174096 19212915 20178728 20699041	CTD
96	Methicillin	View details 25018 27331 185707 445303 707534 879956 897744 907335 1128566 1266666 3450212 3618353 4176988 4211170 4531900 4826627 7282631 7312349 7380775 11473672	CTD
97	Methylprednisolone	View details 8671830 11388597 12372954 15877665 19212915	CTD
98	Mezlocillin	4015267	CTD
99	Minocycline	View details 435818 444868 2780454 8671830 11728996	CTD
100	Moxifloxacin	20731847	CTD
101	Nabumetone	8570441	CTD
102	Nafcillin	View details 622610 7431606 8439691 17653125 20959502	CTD
103	Naproxen	View details 503131 1855326 2128955 2179759 3358393 3684403 3823799 3975749 7115444 10356706 11388597 12774222	CTD
104	Nicergoline	12372954	CTD
105	Nifedipine	10718277	CTD
106	Nitrofurantoin	View details 7970102 8888204 19214031 19828642	CTD
107	Norfloxacin	9406312 11015000 18045047	CTD
108	Ofloxacin	View details 11076114 11793135 11989200 12552523	CTD
109	Omeprazole	View details 1341422 7802778 7934394 8356994 8529303 9044464 9412948 9627043 9882866 10222687 10566755 10924942 10978407 11774962 11803011 12601409 15004262 15219071 16630752 19682153 20573087	CTD
110	Oxacillin	7436655	CTD
111	Oxcarbazepine	14634926	CTD
112	Pamidronate	12637657 14964460	CTD
113	Pantoprazole	View details 15372423 16482642 16630752 19682153 20067906	CTD
114	Penicillamine	3823508	CTD
115	Penicillin G	View details 37350 636917 4604688 6225083 16943303	CTD
116	Pentazocine	1316215	CTD
117	Phenindione	27331 139882 5061531	CTD
118	Phenobarbital	1530819	CTD
119	Phentermine	9799071	CTD
120	Phenylbutazone	View details 147510 647258 2934808 6781669	CTD
121	Phenylpropanolamine	87921 7109141	CTD
122	Phenytoin	View details 465192 660357 894414 1614700 3156084 6693586 7280771 19112234	CTD
123	Piperacillin, Tazobactam Drug Combination	9017778 16649401	CTD
124	Piperacillin	View details 2755033 8413777 9447761 11793135 11967611	CTD
125	Piromidic Acid	6840011	CTD
126	Piroxicam	3993703 6691775 8298379	CTD
127	Polymyxin B	4292201	CTD
128	Prednisolone	View details 6106853 6604293 7934394 8671830 9740571 10525003 11300142 12073628 12601409 15213314 18709970 20731847	CTD
129	Prednisone	View details 707534 4081705 9017778 10549692 11205659 12500420 12774222 15705174 18417438	CTD
130	Promethazine	19814645	CTD
131	Propranolol	6948214	CTD
132	Propylthiouracil	View details 7942812 9550661 10344375 11014318 16354242 17985400	CTD
133	Puromycin Aminonucleoside	View details 3258389 8635280 10718277 10803761	CTD
134	Quinapril	8305170	CTD
135	Quinine	8048427	CTD
136	Rabeprazole	15705174 16630752 19682153	CTD
137	Ranitidine	View details 8285978 8352262 8352263 11431197	CTD
138	Rifampin	View details 27331 879592 946666 2773924 3476051 3663501 3706419 3746041 3769771 4086833 4123591 6487531 6517118 6518324 6597267 6627764 6727485 6837651 10213665 10493554 10599213 11209029 11471316 11473672 11798598 11837753 11977498 12324902 16236685 16537068 16943303 18445910 18709970 19224484 19376565 19764465 19861876 20497752	CTD
139	Saridon	847456 3489155	CTD
140	Silver	27417253	CTD
141	Simvastatin	11064678	CTD
142	Streptozocin	186169	CTD
143	Sulfasalazine	View details 1353741 10791141 16512452 19509026	CTD
144	Sulfinpyrazone	3157154 6234742 7258104	CTD
145	Sulindac	3208459 6585720 6842802	CTD
146	Suprofen	3565984	CTD
147	Tacrolimus	14620542	CTD
148	Testosterone	18073317	CTD
149	Tetracycline	9884423	CTD
150	Ticlopidine	7771492	CTD
151	Ticrynafen	7004678	CTD
152	Tolmetin	3738663 3975749 6375363	CTD
153	Tretinoin	11604554	CTD
154	Triamterene	6119586 6339355	CTD
155	Trimethoprim, Sulfamethoxazole Drug Combination	View details 85078 85859 445001 3265285 3879246 6604293 6993701 7149348 19863874	CTD
156	Valproic Acid	View details 3124010 8684554 11891102 15785938 17069740	CTD
157	Vancomycin	View details 2596477 3178372 3348258 7294568 8975151 9825081 11601669 16114793 16943303 17896901 18030187	CTD
158	Venlafaxine Hydrochloride	10513719	CTD
159	Verapamil	10718277	CTD
160	Warfarin	2500616 18380703	CTD
161	amiloride, hydrochlorothiazide drug combination	7618655	CTD
162	chlorazanil	6840011	CTD
163	cinitapride	18028853	CTD
164	erdosteine	16532256	CTD
165	fluindione	View details 1754986 16221711 17176918 18417438 19357010	CTD
166	hexachlorobutadiene	11280606	CTD
167	hydrochlorothiazide-triamterene	6339355 7446559	CTD
168	magnapen	6604293	CTD
169	methyl salicylate	3556044	CTD
170	methylmercuric chloride	27720909	CTD
171	norcantharidin	18176075	CTD
172	phendimetrazine	9799071	CTD
173	pirprofen	3809790	CTD
174	pyrrolidine dithiocarbamic acid	15627798	CTD
175	rofecoxib	12613001 15892770	CTD
176	sarpogrelate	24107419	CTD
177	telithromycin	15264209	CTD
178	ticarcillin-clavulanic acid	11793135	CTD
179	trandolapril	27428043	CTD
180	zomepirac	View details 3975749 6375363 6723230 7114649	CTD
181	zopiclone	12778435	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Glomerulonephritis	48.8%
2	Pyelitis	48.8%
3	Focal glomerulosclerosis	36.4%
4	Hydronephrosis	35.2%
5	Hyperoxaluria	35.2%
6	Kidney Cortex Necrosis	35.2%
7	Kidney Papillary Necrosis	35.2%
8	Nephrosclerosis	35.2%
9	Nephrosis	35.2%
10	Perinephritis	35.2%
11	Kidney Failure	35.2%
12	Uremia	35.2%
13	Oxalosis	35.2%
14	Renal Insufficiency	35.2%
15	Anuria	34.1%
16	Nephrolithiasis	34.1%
17	Pyelocystitis	31.2%
18	Glomerulonephritis, Membranoproliferative	30.6%
19	Diabetes Insipidus	28.7%
20	Hepatorenal Syndrome	28.7%
21	Diabetic Nephropathy	28.3%
22	Renal hypertension	28.3%
23	Renal Artery Obstruction	28.3%
24	Renal Artery Stenosis	28.3%
25	Nephrocalcinosis	28.2%
26	Urinary Bladder Diseases	27%
27	Ureteral Diseases	27%
28	Urethral Diseases	27%
29	Urination Disorders	27%
30	Urolithiasis	27%
31	Tuberculosis, Renal	26.2%
32	Anti-Glomerular Basement Membrane Disease	24.9%
33	Lupus Nephritis	24.6%
34	Pyelonephritis	24.2%
35	Kidney Neoplasm	23.7%
36	Lipoid nephrosis	23.2%
37	Nephrotic Syndrome	23.2%
38	Pyonephrosis	23.2%
39	Nephrogenic Diabetes Insipidus	23.2%
40	Congenital Nephrogenic Diabetes Insipidus	23.2%
41	Acute kidney injury	23.2%
42	Urinary tract infection	21.9%
43	Ureterolithiasis	21.1%
44	AIDS-Associated Nephropathy	20.1%
45	Kidney Calculi	19.6%
46	Multicystic Dysplastic Kidney	19.5%
47	Azotemia	19%
48	Hypertension, Renovascular	18.6%
49	Bladder neck obstruction	17.5%
50	Kidney Failure, Chronic	17.3%
51	Cystitis	15.8%
52	Ureteral obstruction	15.8%
53	Ureterocele	15.8%
54	Urethral Obstruction	15.8%
55	Urethritis	15.8%
56	Urogenital Abnormalities	15.8%
57	Vesico-Ureteral Reflux	15.8%
58	Urinary Retention	15.8%
59	Polycystic Kidney Diseases	15.7%
60	Renal Osteodystrophy	15.6%
61	Renal rickets	15.6%
62	Renal Aminoacidurias	15.5%
63	Fanconi Syndrome	15.5%
64	Pseudohypoaldosteronism	15.5%
65	Liddle Syndrome	15.5%
66	Hemolytic-Uremic Syndrome	15.5%
67	Bladder Exstrophy	15.1%
68	Epispadias	15.1%
69	Glycosuria, Renal	15%
70	Ureteral Calculi	13.9%
71	Mesoblastic Nephroma	13.7%
72	Renal Cell Carcinoma	13.6%
73	Papillary Renal Cell Carcinoma	13.6%
74	Renal tubular acidosis	13.3%
75	Bacteriuria	12.7%
76	Glycosuria	12.7%
77	Hematuria	12.7%
78	Oliguria	12.7%
79	Polyuria	12.7%
80	Proteinuria	12.7%
81	Pyuria	12.7%
82	Urinary Calculi	12.7%
83	Cystocele	12.6%
84	Urinary Incontinence	12.6%
85	Urinary Bladder Fistula	12.5%
86	Bladder Neoplasm	12.5%
87	Ureteral Neoplasms	12.5%
88	Urethral Neoplasms	12.5%
89	Zellweger Syndrome	11.8%
90	Polycystic Kidney, Autosomal Dominant	11.6%
91	Cystinuria	11.5%
92	Atypical Hemolytic Uremic Syndrome	11.5%
93	Nephroblastoma	11.1%
94	Enuresis	10.7%
95	Genital Diseases, Male	10.4%
96	Urethral Stenosis	10.4%
97	Urethral stricture	10.4%
98	Infertility	10.4%
99	Hyperphosphaturia	10.4%
100	Pregnancy Complications	9.8%
101	Hypospadias	8.6%
102	Albuminuria	8.3%
103	Hemoglobinuria	8.3%
104	Urge Incontinence	8.3%
105	Urologic Neoplasms	8.3%
106	Horseshoe Kidney	8.3%
107	Endometriosis	8.1%
108	Uterine Diseases	8.1%
109	Vaginal Diseases	8.1%
110	Vulvar Diseases	8.1%
111	Endometrioma	8.1%
112	Sexually Transmitted Diseases	7.2%
113	Hermaphroditism	7%
114	Disorders of Sex Development	7%
115	Diurnal Enuresis	7%
116	Denys-Drash Syndrome	7%
117	Genital Herpes	6.9%
118	Genital Neoplasms, Male	6.7%
119	Genital Neoplasms, Female	6.1%
120	Endometritis	6%
121	Vesicovaginal Fistula	5.9%
122	Uterine Neoplasms	5.8%
123	Vaginal Neoplasms	5.8%
124	Vulvar Neoplasms	5.8%
125	Uterine Cancer	5.8%
126	Uterine Inversion	5.7%
127	Epididymitis	5.5%
128	Penile Diseases	5.5%
129	Prostatic Diseases	5.5%
130	Spermatic Cord Torsion	5.5%
131	Hemospermia	5.5%
132	Testicular Hydrocele	5.5%
133	Polyhydramnios	5%
134	Obstetric Labor Complications	5%
135	Ectopic Pregnancy	5%
136	Pregnancy, Prolonged	5%
137	Puerperal Disorders	5%
138	Oligohydramnios	5%
139	Prenatal Injuries	5%
140	Dyspareunia	5%
141	Familial Hypophosphatemic Rickets	4.9%
142	Penile Neoplasms	4.9%
143	Prostatic Neoplasms	4.9%
144	Endometrial Hyperplasia	4.8%
145	Pyometra	4.8%
146	Vaginitis	4.8%
147	Vulvitis	4.8%
148	Vaginal Discharge	4.8%
149	Vulvodynia	4.8%
150	Fallopian Tube Neoplasms	4.8%
151	Salpingitis	4.8%
152	Vulvovaginitis	4.8%
153	Uterine Rupture	4.6%
154	Cryptorchidism	4.4%
155	Testicular Diseases	4.2%
156	Varicocele	4.2%
157	Spermatocele	4.1%
158	Abruptio Placentae	4.1%
159	Placenta Accreta	4.1%
160	Gonadal Dysgenesis	4.1%
161	Adrenogenital Syndrome	4.1%
162	Ovotesticular Disorders of Sex Development	4.1%
163	Fetal Diseases	3.9%
164	Pregnancy Complications, Cardiovascular	3.9%
165	Pregnancy Complications, Neoplastic	3.9%
166	Oophoritis	3.9%
167	Endometrial Neoplasms	3.8%
168	Pregnancy Complications, Hematologic	3.8%
169	Pregnancy Complications, Infectious	3.8%
170	Fetal Death	3.7%
171	Perinatal death	3.7%
172	Ovarian Diseases	3.7%
173	Morning Sickness	3.7%
174	Adnexitis	3.6%
175	Pruritus Vulvae	3.6%
176	Uterine hemorrhage	3.6%
177	Vaginal Fistula	3.6%
178	Pelvic Inflammatory Disease	3.6%
179	Uterine Prolapse	3.6%
180	Vaginal Prolapse	3.6%
181	Uterine Cervical Incompetence	3.6%
182	Chorioamnionitis	3.6%
183	ovarian neoplasm	3.5%
184	Puerperal Infection	3.3%
185	Postpartum Hemorrhage	3.3%
186	Balanitis	3.2%
187	Benign prostatic hypertrophy	3.2%
188	Phimosis	3.2%
189	Priapism	3.2%
190	prostatitis	3.2%
191	Prostatic Adenoma	3.2%
192	Benign Prostatic Hyperplasia	3.2%
193	Prostatic Hypertrophy	3.2%
194	Prostatic Hyperplasia	3.2%
195	Prostatic Neoplasms, Castration-Resistant	3.2%
196	Hyperandrogenism	3.2%
197	Uterine Cervicitis	3.2%
198	Leukorrhea	3.2%
199	Parametritis	3.2%
200	Gestational Diabetes	3%
201	Carcinoma, Endometrioid	3%
202	Candidiasis, Vulvovaginal	2.9%
203	Abortion, Habitual	2.7%
204	Dystocia	2.7%
205	Eclampsia	2.7%
206	Fetal Membranes, Premature Rupture	2.7%
207	Placental Insufficiency	2.7%
208	Pre-Eclampsia	2.7%
209	Prenatal Exposure Delayed Effects	2.7%
210	HELLP Syndrome	2.7%
211	Placenta, Retained	2.7%
212	Premature Ejaculation	2.5%
213	Erectile dysfunction	2.5%
214	Testicular Neoplasms	2.5%
215	Bacterial Vaginosis	2.5%
216	Orchitis	2.4%
217	Trichomonas Vaginitis	2.4%
218	Uterine Perforation	2.4%
219	Ovarian Hyperstimulation Syndrome	2.4%
220	Metrorrhagia	2.4%
221	Chlamydia Infections	2.3%
222	Gonorrhea	2.3%
223	Abortion, Veterinary	2.1%
224	Pregnancy Complications, Parasitic	2.1%
225	Turner Syndrome	2.1%
226	Azoospermia	2.1%
227	Oligospermia	2.1%
228	Impotence, Vasculogenic	2.1%
229	Asthenozoospermia	2.1%
230	Teratozoospermia	2.1%
231	Aspermia	2.1%
232	granulosa cell tumor	2.1%
233	Carcinoma, Ovarian Epithelial	2.1%
234	Lactation Disorder	2%
235	Mastitis	2%
236	Depression, Postpartum	2%
237	Embryo Loss	2%
238	Kallmann Syndrome	2%
239	Fetal Resorption	2%
240	Hyperemesis Gravidarum	2%
241	Syphilis	2%
242	Endometrial Stromal Sarcoma	2%
243	Corpus Luteum Cyst	2%
244	Ovarian Cysts	2%
245	Anovulation	1.9%
246	Menorrhagia	1.9%
247	Premature Menopause	1.9%
248	Klinefelter Syndrome	1.8%
249	Lymphogranuloma Venereum	1.7%
250	Fetal Growth Retardation	1.7%
251	Trophoblastic Neoplasms	1.7%
252	Embolism, Amniotic Fluid	1.7%
253	Fetal Hypoxia	1.7%
254	Fetal Alcohol Spectrum Disorders	1.7%
255	Breech Presentation	1.6%
256	Stillbirth	1.6%
257	Premature Birth	1.6%
258	Polycystic Ovary Syndrome	1.4%
259	Meconium Aspiration Syndrome	1.2%
260	Galactorrhea	1.2%
261	Leydig Cell Tumor	1.1%
262	Choriocarcinoma	0.8%
263	Hydatidiform Mole	0.6%
264	Hydrops Fetalis	0.5%

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