MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Ethambutol

(AEUTYOVWOVBAKS-UWVGGRQHSA-N)

Structure

SMILES: CC[C@H](NCCN[C@H](CO)CC)CO
Type(s): Approved
ATC code(s): J04AK02; J04AM03; J04AM06; J04AM07
Molecular Formula:: C10H24N2O2
Molecular Weight:: 204.310
Log P:: 0.4892
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 4
TPSA:: 64.52
CAS Number(s):: 74-55-5

Synonym(s)

Ethambutol

Dexambutol

EMB-Fatol

EMB-Hefa

Etambutol Llorente

Ethambutol Hydrochloride

Etibi

Miambutol

Myambutol

10.

EMB Fatol

11.

EMB Hefa

12.

Hydrochloride, Ethambutol

13.

Llorente, Etambutol

External Link(s)

MeSH	D004977
PubChem Compound	14052
BindingDB	50448407
ChEBI	4877
CHEMBL	CHEMBL44884
DrugBank	DB00330
DrugCentral	1073
KEGG	dr:D07925 cpd:C06984
ZINC	19364219

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Optic Neuropathy	FAERS: 29		OFFSIDES US FAERS
2	Macular degeneration	FAERS: 26		US FAERS
3	Ocular Toxicity	FAERS: 9		US FAERS
4	Blindness	FAERS: 8	3790421 4059141	CTD SIDER US FAERS
5	Dyschromatopsia	FAERS: 2		US FAERS
6	Overdose	FAERS: 2		US FAERS
7	Scotoma	FAERS: 2	384871	CTD OFFSIDES SIDER US FAERS
8	Toxic Optic Neuropathy	FAERS: 2		US FAERS
9	Toxicity to various agents	FAERS: 2		US FAERS
10	Basal cell carcinoma	FAERS: 1		US FAERS
11	Chromatopsia	FAERS: 1		US FAERS
12	Deafness	FAERS: 1		US FAERS
13	Dizziness	FAERS: 1 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
14	Erythema	FAERS: 1		US FAERS
15	Gluten sensitivity	FAERS: 1		US FAERS
16	Hypersensitivity	FAERS: 1		SIDER US FAERS
17	Hypotension	FAERS: 1		US FAERS
18	Impaired driving ability	FAERS: 1		US FAERS
19	Lip swelling	FAERS: 1		US FAERS
20	Medication Error	FAERS: 1		US FAERS
21	Mental status changes	FAERS: 1		OFFSIDES US FAERS
22	Paranoia	FAERS: 1		US FAERS
23	Thrombocytopenia	FAERS: 1	188103	CTD SIDER US FAERS
24	Vomiting	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
25	Weight decreased	FAERS: 1		US FAERS
26	Wheezing	FAERS: 1		US FAERS
27	Abdominal Pain		15102986	CTD OFFSIDES SIDER
28	Abdominal discomfort			SIDER
29	Abdominal tenderness			OFFSIDES
30	Abscess			OFFSIDES
31	Acid fast bacilli infection			OFFSIDES
32	Acid fast stain positive			OFFSIDES
33	Acidosis			OFFSIDES
34	Acute kidney injury		188103 15102986	CTD
35	Acute psychosis			OFFSIDES
36	Adenitis			OFFSIDES
37	Alanine Aminotransferase Increased			OFFSIDES
38	Alopecia	Canada Vigilance: 1		Canada Vigilance
39	Amblyopia		5314052 5749236	CTD
40	Anaphylactic shock			SIDER
41	Anaphylactoid Reaction			SIDER
42	Anemia, Hemolytic		188103	CTD
43	Anisocoria			OFFSIDES
44	Anorexia			OFFSIDES SIDER
45	Antipsychotic drug level increased			OFFSIDES
46	Anuria		15102986	CTD
47	Anxiety	Canada Vigilance: 1		Canada Vigilance
48	Arterial bypass operation			OFFSIDES
49	Arthralgia	Canada Vigilance: 1		Canada Vigilance SIDER
50	Ascites			OFFSIDES
51	Aseptic Meningitis			OFFSIDES
52	Asterixis			OFFSIDES
53	Ataxia			OFFSIDES
54	Atelectasis			OFFSIDES
55	Atrial tachycardia			OFFSIDES
56	Atypical mycobacterial lymphadenitis			OFFSIDES
57	BK virus infection			OFFSIDES
58	Bacteria stool identified			OFFSIDES
59	Blood albumin decreased			OFFSIDES
60	Blood alkaline phosphatase increased			OFFSIDES
61	Blood amylase increased			OFFSIDES
62	Blood creatine increased			OFFSIDES
63	Blood creatine phosphokinase increased			OFFSIDES
64	Blood electrolytes abnormal			OFFSIDES
65	Blood immunoglobulin A increased			OFFSIDES
66	Blood magnesium decreased			OFFSIDES
67	Blood phosphorus decreased			OFFSIDES
68	Blood potassium decreased			OFFSIDES
69	Blood pressure inadequately controlled			OFFSIDES
70	Blood sodium			OFFSIDES
71	Blood triglycerides increased			OFFSIDES
72	Bone Tuberculosis			OFFSIDES
73	Brain Abscess			OFFSIDES
74	Brain stem syndrome			OFFSIDES
75	Breast Cyst			OFFSIDES
76	Bronchiectasis			OFFSIDES
77	CD4 Lymphocytes Decreased			OFFSIDES
78	CD4 lymphocytes increased			OFFSIDES
79	Cardiac Tamponade			OFFSIDES
80	Cataplexy			OFFSIDES
81	Cell Death			OFFSIDES
82	Central nervous system lesion			OFFSIDES
83	Cerebral aspergillosis			OFFSIDES
84	Cerebral atrophy			OFFSIDES
85	Cervical gland tuberculosis			OFFSIDES
86	Chemical and Drug Induced Liver Injury		View details 1079531 2723568 25051504 27933861 28437613	CTD
87	Chemotherapeutic drug level increased			OFFSIDES
88	Cholangiolitis			OFFSIDES
89	Cholecystitis			OFFSIDES
90	Cholestatic liver injury			OFFSIDES
91	Chorioretinitis			OFFSIDES
92	Cirrhosis			OFFSIDES
93	Cluster Headache			OFFSIDES
94	Colitis			OFFSIDES
95	Color blindness			OFFSIDES
96	Complement factor C3 increased			OFFSIDES
97	Complex partial seizures			OFFSIDES
98	Contact Dermatitis			OFFSIDES
99	Creatinine renal clearance decreased			OFFSIDES
100	Culture positive			OFFSIDES
101	Cytolytic hepatitis			OFFSIDES
102	Cytomegalovirus chorioretinitis			OFFSIDES
103	Cytomegalovirus test positive			OFFSIDES
104	Dandy-Walker Syndrome			OFFSIDES
105	Deafness Neurosensory			OFFSIDES
106	Demyelination			OFFSIDES
107	Dermatitis	Canada Vigilance: 1		Canada Vigilance SIDER
108	Discomfort			SIDER
109	Disease recurrence			OFFSIDES
110	Disorientation			SIDER
111	Diverticulum			OFFSIDES
112	Drug Eruptions		7786350	CTD
113	Drug resistance			OFFSIDES
114	Drug toxicity			OFFSIDES
115	Duodenitis			OFFSIDES
116	Edema		9597260	CTD
117	Electrocardiogram repolarisation abnormality			OFFSIDES
118	Encephalitis			OFFSIDES
119	End stage AIDS			OFFSIDES
120	Eosinophilia		18583892	CTD SIDER
121	Eosinophilic Pneumonia			OFFSIDES
122	Erythema Multiforme			SIDER
123	Exanthema		18583892	CTD
124	Extensively Drug-Resistant Tuberculosis		24088636	CTD
125	Eye pain	Canada Vigilance: 1		Canada Vigilance
126	Fanconi Syndrome			OFFSIDES
127	Feeling abnormal			SIDER
128	Fever		9597260	CTD
129	Flushing	Canada Vigilance: 1		Canada Vigilance
130	Gamma-Glutamyltransferase Increased			OFFSIDES
131	Gastrointestinal Pain			SIDER
132	General physical condition			OFFSIDES
133	General physical health deterioration			OFFSIDES
134	Globulinuria			OFFSIDES
135	Glomerulonephritis			OFFSIDES
136	Glycosuria		990786	CTD
137	Gout			SIDER
138	Granulomatous liver disease			OFFSIDES
139	Granuloma			OFFSIDES
140	HIV Wasting Syndrome			OFFSIDES
141	Headache	Canada Vigilance: 1	10847796	CTD SIDER Canada Vigilance
142	Hepatic Encephalopathy		1079531	CTD
143	Hepatic artery thrombosis			OFFSIDES
144	Hepatitis B surface antigen positive			OFFSIDES
145	Hepatitis B			OFFSIDES
146	Hepatitis		3098151 4131429	CTD OFFSIDES SIDER
147	Hepatomegaly		28108177	CTD
148	Hepatosplenomegaly			OFFSIDES
149	Hepatotoxicity			OFFSIDES
150	Histiocytosis haematophagic			OFFSIDES
151	Hospice Care			OFFSIDES
152	Hydrocephalus			OFFSIDES
153	Hypersensitive syndrome			SIDER
154	Hypertensive heart disease			OFFSIDES
155	Immune reconstitution syndrome			OFFSIDES
156	Impaired gastric emptying			OFFSIDES
157	Intraocular inflammation			OFFSIDES
158	Iridocele			OFFSIDES
159	Iridocyclitis			OFFSIDES
160	Jaundice, Obstructive		3083914	CTD
161	Kidney Failure			OFFSIDES
162	Klebsiella sepsis			OFFSIDES
163	Laparotomy			OFFSIDES
164	Large intestine perforation			OFFSIDES
165	Legionella			OFFSIDES
166	Leukopenia neonatal			OFFSIDES
167	Leukopenia			SIDER
168	Limb discomfort			OFFSIDES
169	Liver diseases		188103 10599213	CTD
170	Lower respiratory tract infection bacterial			OFFSIDES
171	Lymph Node Tuberculosis			OFFSIDES
172	Lymphadenopathy			SIDER
173	Lymphatic Diseases		9597260	CTD
174	Lymphocyte percentage decreased			OFFSIDES
175	Lymphocyte stimulation test positive			OFFSIDES
176	Lymphoma			OFFSIDES
177	Malaise	Canada Vigilance: 1		Canada Vigilance SIDER
178	Malaria			OFFSIDES
179	Markedly reduced dietary intake			OFFSIDES
180	Mental Retardation			OFFSIDES
181	Metabolic acidosis			OFFSIDES
182	Mitochondrial toxicity			OFFSIDES
183	Mixed liver injury			OFFSIDES
184	Mononeuritis			OFFSIDES
185	Muscle abscess			OFFSIDES
186	Muscle necrosis			OFFSIDES
187	Musculoskeletal discomfort			SIDER
188	Mycobacterium Infections, Nontuberculous		1949931	CTD
189	Mycobacterium Infections		View details 3165976 9665308 10063276 19205626	CTD
190	Mycobacterium abscessus Infection			OFFSIDES
191	Mycobacterium avium complex immune restoration disease			OFFSIDES
192	Myelitis		4473301 4530778	CTD
193	Myocarditis			SIDER
194	Nausea	Canada Vigilance: 2		Canada Vigilance SIDER
195	Necrotising granulomatous lymphadenitis			OFFSIDES
196	Nephritis			SIDER
197	Nephrotic Syndrome			OFFSIDES
198	Nerve Degeneration		6265603	CTD
199	Neuritis			SIDER
200	Neutropenia			SIDER
201	Numbness			SIDER
202	Nutritional condition abnormal			OFFSIDES
203	Ocular icterus	Canada Vigilance: 1		Canada Vigilance OFFSIDES
204	Oliguria		15102986	CTD
205	Optic Atrophy, Hereditary, Leber		16767386	CTD
206	Optic Atrophy		6248440 8501256	CTD OFFSIDES
207	Optic Neuritis	Canada Vigilance: 1	View details 424915 500179 589757 617934 693342 727719 1030352 1031407 1153172 1757046 1848398 3451844 4423899 4432030 4760682 4794562 4845425 5159029 5562251 5760394 6243261 7222808 7342904 11775861 15287205 16108516	CTD OFFSIDES SIDER Canada Vigilance
208	Orthopnea			OFFSIDES
209	Ototoxicity			OFFSIDES
210	Pain		9597260	CTD
211	Pallor			OFFSIDES
212	Paradoxical drug reaction			OFFSIDES
213	Paraparesis			OFFSIDES
214	Parapharyngeal abscess			OFFSIDES
215	Paresthesia		24897009	CTD
216	Pericardial effusion			OFFSIDES
217	Pericarditis			SIDER
218	Peripheral Nervous System Diseases		View details 4346665 6243261 6248440 6248441 6265603 7449477	CTD
219	Phlebitis			OFFSIDES
220	Pneumocystis jiroveci pneumonia			OFFSIDES
221	Pneumonia			SIDER
222	Polymyalgia Rheumatica			OFFSIDES
223	Polymyositis		18583892	CTD
224	Prealbumin decreased			OFFSIDES
225	Pregnancy on oral contraceptive			OFFSIDES
226	Productive Cough			OFFSIDES
227	Protein total increased			OFFSIDES
228	Proteinuria		990786 15102986	CTD
229	Pruritus	Canada Vigilance: 1		Canada Vigilance SIDER
230	Psychoses, Substance-Induced		10533303	CTD
231	Pubic pain			OFFSIDES
232	Pulmonary Hypertension			OFFSIDES
233	Pulmonary thrombosis			OFFSIDES
234	Purulence			OFFSIDES
235	Pyopneumothorax			OFFSIDES
236	Rash erythematous	Canada Vigilance: 1		Canada Vigilance
237	Renal Insufficiency		990786 1949931	CTD
238	Renal tubular acidosis			OFFSIDES
239	Renal tubular disorder			OFFSIDES
240	Renal tubular necrosis			OFFSIDES
241	Respiratory Tract Infections		1949931	CTD
242	Retinal Diseases		View details 3454316 15923521 17182409 19525243	CTD
243	Retinal pigment epitheliopathy			OFFSIDES
244	Retinitis		4068570	CTD
245	Septic Shock			OFFSIDES
246	Skin discomfort			OFFSIDES
247	Skin lesion			OFFSIDES
248	Sputum culture positive			OFFSIDES
249	Status Epilepticus		1152365	CTD
250	Stevens-Johnson Syndrome			OFFSIDES SIDER
251	Subileus			OFFSIDES
252	Sudden death			OFFSIDES
253	Thrombosis in device			OFFSIDES
254	Tingling of extremity			SIDER
255	Tinnitus	Canada Vigilance: 1		Canada Vigilance
256	Tonsillectomy			OFFSIDES
257	Tonsillitis			OFFSIDES
258	Toxic Epidermal Necrolysis			SIDER
259	Toxoplasmosis			OFFSIDES
260	Transaminases increased			OFFSIDES
261	Transmission of drug via semen			OFFSIDES
262	Tuberculoid leprosy			OFFSIDES
263	Tuberculoma of central nervous system			OFFSIDES
264	Tuberculosis, Central Nervous System		6709824	CTD
265	Tuberculosis, Miliary		18709970	CTD
266	Tuberculosis, Multidrug-Resistant		1096388 16178466	CTD
267	Tuberculosis, Osteoarticular		19764465 20111890	CTD
268	Tuberculosis, Pulmonary		View details 188103 500179 522432 1031407 3345472 3828274 4059141 4203159 4784034 4906375 5083435 5677157 6243261 6789927 7786350 8918638 10599213 11209029 11596792 11744817 12948256 15058748 15923521 16848215	CTD
269	Tuberculosis, Spinal		1913897 16212643	CTD
270	Tuberculosis		View details 824103 1124382 1800342 2723568 2770528 3607664 4131429 5042531 5354403 5815541 6440306 6615272 7098379 7187065 8898542 9326729 9531761 9661830 11775861 12109797 12161991 14601701 14677899 14755385 15287205 15565293 15909750 16710500 16767386 16933231 17240918 17289435 18647459 19063910 19900585 20879012 27933861	CTD
271	Ultrasound abdomen abnormal			OFFSIDES
272	Vertigo	Canada Vigilance: 1		Canada Vigilance
273	Vision Disorders		View details 672129 690537 865003 1913897 2449333 2956288 3345472 3604618 3607664 3828274 5416949 5815541 6118620 6248440 8071504 8501256 8590273 9510653 10172409 11775861 15565293 15909750 16024847 16710500 17182409 17510481 19063910 19145123 19525243 20111890 24897009	CTD
274	Visual Impairment	Canada Vigilance: 8		Canada Vigilance SIDER
275	Visual disturbance			OFFSIDES
276	Xanthopsia			OFFSIDES
277	anaphylaxis		8643939	CTD
278	jaundice		15102986	CTD
279	kyphosis			OFFSIDES

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