MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperoxaluria

(UMLS:C0020500)

Definition:: Excretion of an excessive amount of OXALATES in the urine.
UMLS ID:: C0020500
MeSH ID:: D006959

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.313

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.313

Synonym(s)

Hyperoxaluria

High urine oxalate levels

Increased level of oxalate in urine

Oxaluria

hyperoxaluria

oxaluria

urine tests nonspecific abnormal findings hyperoxaluria

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Doxycycline	FAERS: 4		US FAERS
2	Amoxicillin	FAERS: 3		US FAERS
3	Orlistat	FAERS: 2		US FAERS
4	Ascorbic Acid	FAERS: 1	54676 54776 18042297	CTD US FAERS
5	Citalopram	FAERS: 1		US FAERS
6	Darunavir	FAERS: 1		US FAERS
7	Dexamethasone	FAERS: 1		US FAERS
8	Levofloxacin	FAERS: 1		US FAERS
9	Naproxen	FAERS: 1		US FAERS
10	Pregabalin	FAERS: 1		US FAERS
11	Topiramate	FAERS: 1		US FAERS
12	Tramadol	FAERS: 1		US FAERS
13	empagliflozin	FAERS: 1		US FAERS
14	palbociclib	FAERS: 1		US FAERS
15	Acetylcysteine		18423961	CTD
16	Azathioprine			OFFSIDES
17	Calcium Oxalate		16284884	CTD
18	Clofibrate		9030817	CTD
19	Ethylene Glycol		View details 16284884 24145091 26526882 27018375 27241030	CTD
20	Methoxyflurane		View details 180940 1259128 5454752 6499021	CTD
21	Mycophenolic Acid		18400815	CTD
22	Octreotide		2298134	CTD
23	Oxalic Acid		22984472	CTD
24	Prednisone acetate			OFFSIDES
25	Ritodrine			OFFSIDES
26	Vitamin A			OFFSIDES
27	Vitamin B 6		8112761	CTD
28	naphthalene		180940	CTD
29	rofecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hydronephrosis	47.5%
2	Kidney Cortex Necrosis	47.5%
3	Kidney Papillary Necrosis	47.5%
4	Nephritis	47.5%
5	Nephrosclerosis	47.5%
6	Nephrosis	47.5%
7	Perinephritis	47.5%
8	Kidney Failure	47.5%
9	Uremia	47.5%
10	Renal Insufficiency	47.5%
11	Anuria	45.9%
12	Nephrolithiasis	45.9%
13	Diabetes Insipidus	38.7%
14	Hepatorenal Syndrome	38.7%
15	Pyelonephritis	38.7%
16	Diabetic Nephropathy	38.2%
17	Renal hypertension	38.2%
18	Renal Artery Obstruction	38.2%
19	Renal Artery Stenosis	38.2%
20	Nephrocalcinosis	37.9%
21	Glomerulonephritis	35.2%
22	Nephritis, Interstitial	35.2%
23	Lipoid nephrosis	35.2%
24	Nephrotic Syndrome	35.2%
25	Pyelitis	35.2%
26	Pyonephrosis	35.2%
27	Nephrogenic Diabetes Insipidus	35.2%
28	Congenital Nephrogenic Diabetes Insipidus	35.2%
29	Acute kidney injury	35.2%
30	Tuberculosis, Renal	34.5%
31	Urinary Bladder Diseases	32.8%
32	Ureteral Diseases	32.8%
33	Urethral Diseases	32.8%
34	Urination Disorders	32.8%
35	Urolithiasis	32.8%
36	Kidney Neoplasm	31.8%
37	Pyelocystitis	29.9%
38	Kidney Calculi	29.5%
39	Balkan Nephropathy	29.2%
40	Focal glomerulosclerosis	29.2%
41	Kidney Failure, Chronic	29.2%
42	Azotemia	28.7%
43	Ureterolithiasis	28.4%
44	Hypertension, Renovascular	28.2%
45	Multicystic Dysplastic Kidney	27.7%
46	AIDS-Associated Nephropathy	27%
47	Urinary tract infection	26.5%
48	Bladder neck obstruction	24.7%
49	Glomerulonephritis, Membranoproliferative	24.5%
50	Polycystic Kidney Diseases	23.7%
51	Renal Aminoacidurias	23.5%
52	Fanconi Syndrome	23.5%
53	Pseudohypoaldosteronism	23.5%
54	Liddle Syndrome	23.5%
55	Hemolytic-Uremic Syndrome	23.4%
56	Glycosuria, Renal	22.6%
57	Cystitis	21.3%
58	Ureteral obstruction	21.3%
59	Ureterocele	21.3%
60	Urethral Obstruction	21.3%
61	Urethritis	21.3%
62	Vesico-Ureteral Reflux	21.3%
63	Urinary Retention	21.3%
64	Ureteral Calculi	20.9%
65	Renal Osteodystrophy	20.9%
66	Renal rickets	20.9%
67	Mesoblastic Nephroma	20.6%
68	Renal Cell Carcinoma	20.5%
69	Papillary Renal Cell Carcinoma	20.5%
70	Renal tubular acidosis	20.1%
71	Anti-Glomerular Basement Membrane Disease	19.9%
72	Lupus Nephritis	19.7%
73	Bladder Exstrophy	19.5%
74	Epispadias	19.5%
75	Polycystic Kidney, Autosomal Dominant	19.5%
76	Cystinuria	19.4%
77	Atypical Hemolytic Uremic Syndrome	19.3%
78	Urogenital Abnormalities	17.7%
79	Bacteriuria	17.1%
80	Glycosuria	17.1%
81	Hematuria	17.1%
82	Oliguria	17.1%
83	Polyuria	17.1%
84	Proteinuria	17.1%
85	Pyuria	17.1%
86	Urinary Calculi	17.1%
87	Cystocele	17%
88	Urinary Incontinence	17%
89	Urinary Bladder Fistula	16.8%
90	Bladder Neoplasm	16.8%
91	Ureteral Neoplasms	16.8%
92	Urethral Neoplasms	16.8%
93	Nephroblastoma	16.7%
94	Zellweger Syndrome	15.8%
95	Urethral Stenosis	15.8%
96	Urethral stricture	15.8%
97	Hyperphosphaturia	15.6%
98	Enuresis	14.4%
99	Albuminuria	12.6%
100	Hemoglobinuria	12.6%
101	Infertility	12.6%
102	Urge Incontinence	12.6%
103	Genital Diseases, Male	11.8%
104	Denys-Drash Syndrome	11.5%
105	Hypospadias	10.6%
106	Pregnancy Complications	10.6%
107	Diurnal Enuresis	10.6%
108	Urologic Neoplasms	10.1%
109	Horseshoe Kidney	10.1%
110	Endometriosis	9.9%
111	Uterine Diseases	9.9%
112	Vaginal Diseases	9.9%
113	Vulvar Diseases	9.9%
114	Endometrioma	9.9%
115	Vesicovaginal Fistula	8.9%
116	Sexually Transmitted Diseases	8.8%
117	Endometritis	8.5%
118	Hermaphroditism	8.5%
119	Disorders of Sex Development	8.5%
120	Genital Herpes	8.3%
121	Familial Hypophosphatemic Rickets	8.2%
122	Genital Neoplasms, Male	8.2%
123	Uterine Neoplasms	7.8%
124	Vaginal Neoplasms	7.8%
125	Vulvar Neoplasms	7.8%
126	Uterine Cancer	7.8%
127	Genital Neoplasms, Female	7.4%
128	Uterine Inversion	7.4%
129	Salpingitis	7.3%
130	Vulvovaginitis	7.3%
131	Fallopian Tube Neoplasms	6.8%
132	Epididymitis	6.7%
133	Penile Diseases	6.7%
134	Prostatic Diseases	6.7%
135	Spermatic Cord Torsion	6.7%
136	Hemospermia	6.7%
137	Testicular Hydrocele	6.7%
138	Dyspareunia	6.7%
139	Penile Neoplasms	6.6%
140	Prostatic Neoplasms	6.6%
141	Endometrial Hyperplasia	6.5%
142	Pyometra	6.5%
143	Vaginitis	6.5%
144	Vulvitis	6.5%
145	Vaginal Discharge	6.5%
146	Vulvodynia	6.5%
147	Uterine Rupture	6%
148	Oophoritis	5.8%
149	Endometrial Neoplasms	5.8%
150	Polyhydramnios	5.6%
151	Obstetric Labor Complications	5.6%
152	Ectopic Pregnancy	5.6%
153	Pregnancy, Prolonged	5.6%
154	Puerperal Disorders	5.6%
155	Oligohydramnios	5.6%
156	Prenatal Injuries	5.6%
157	Cryptorchidism	5.6%
158	Gonadal Dysgenesis	5.5%
159	Adrenogenital Syndrome	5.5%
160	Ovotesticular Disorders of Sex Development	5.5%
161	Uterine Cervical Incompetence	5.3%
162	Testicular Diseases	5.1%
163	Varicocele	5.1%
164	Spermatocele	5%
165	Ovarian Diseases	5%
166	ovarian neoplasm	5%
167	Abruptio Placentae	5%
168	Placenta Accreta	5%
169	Adnexitis	4.9%
170	Pruritus Vulvae	4.9%
171	Uterine hemorrhage	4.9%
172	Vaginal Fistula	4.9%
173	Pelvic Inflammatory Disease	4.9%
174	Uterine Prolapse	4.9%
175	Vaginal Prolapse	4.9%
176	Uterine Cervicitis	4.9%
177	Leukorrhea	4.9%
178	Parametritis	4.9%
179	Candidiasis, Vulvovaginal	4.9%
180	Prostatic Neoplasms, Castration-Resistant	4.9%
181	Hyperandrogenism	4.8%
182	Carcinoma, Endometrioid	4.8%
183	Chorioamnionitis	4.4%
184	Fetal Diseases	4.4%
185	Pregnancy Complications, Cardiovascular	4.4%
186	Pregnancy Complications, Neoplastic	4.4%
187	Balanitis	4.4%
188	Benign prostatic hypertrophy	4.4%
189	Phimosis	4.4%
190	Priapism	4.4%
191	prostatitis	4.4%
192	Prostatic Adenoma	4.4%
193	Benign Prostatic Hyperplasia	4.4%
194	Prostatic Hypertrophy	4.4%
195	Prostatic Hyperplasia	4.4%
196	Pregnancy Complications, Hematologic	4.3%
197	Pregnancy Complications, Infectious	4.3%
198	Fetal Death	4.2%
199	Perinatal death	4.2%
200	Morning Sickness	4.2%
201	Puerperal Infection	4%
202	Postpartum Hemorrhage	3.9%
203	Bacterial Vaginosis	3.7%
204	Trichomonas Vaginitis	3.7%
205	Uterine Perforation	3.7%
206	Ovarian Hyperstimulation Syndrome	3.7%
207	Metrorrhagia	3.6%
208	Endometrial Stromal Sarcoma	3.6%
209	Chlamydia Infections	3.5%
210	Gonorrhea	3.5%
211	Gestational Diabetes	3.4%
212	Premature Ejaculation	3.4%
213	Erectile dysfunction	3.4%
214	granulosa cell tumor	3.3%
215	Carcinoma, Ovarian Epithelial	3.3%
216	Testicular Neoplasms	3.3%
217	Orchitis	3.3%
218	Abortion, Habitual	3.3%
219	Dystocia	3.3%
220	Eclampsia	3.3%
221	Fetal Membranes, Premature Rupture	3.3%
222	Placental Insufficiency	3.3%
223	Pre-Eclampsia	3.3%
224	Prenatal Exposure Delayed Effects	3.3%
225	HELLP Syndrome	3.3%
226	Placenta, Retained	3.3%
227	Azoospermia	3.3%
228	Oligospermia	3.3%
229	Impotence, Vasculogenic	3.3%
230	Asthenozoospermia	3.3%
231	Teratozoospermia	3.3%
232	Aspermia	3.3%
233	Turner Syndrome	3.2%
234	Kallmann Syndrome	3.1%
235	Syphilis	3%
236	Corpus Luteum Cyst	3%
237	Ovarian Cysts	3%
238	Anovulation	2.9%
239	Menorrhagia	2.9%
240	Premature Menopause	2.9%
241	Lymphogranuloma Venereum	2.9%
242	Klinefelter Syndrome	2.7%
243	Abortion, Veterinary	2.6%
244	Pregnancy Complications, Parasitic	2.6%
245	Lactation Disorder	2.5%
246	Mastitis	2.5%
247	Depression, Postpartum	2.5%
248	Embryo Loss	2.5%
249	Fetal Resorption	2.5%
250	Hyperemesis Gravidarum	2.4%
251	Polycystic Ovary Syndrome	2.4%
252	Premature Birth	2.2%
253	Fetal Growth Retardation	2%
254	Trophoblastic Neoplasms	2%
255	Embolism, Amniotic Fluid	2%
256	Fetal Hypoxia	2%
257	Fetal Alcohol Spectrum Disorders	2%
258	Breech Presentation	2%
259	Stillbirth	2%
260	Leydig Cell Tumor	1.8%
261	Galactorrhea	1.6%
262	Meconium Aspiration Syndrome	1.5%
263	Choriocarcinoma	1.1%
264	Hydatidiform Mole	1%
265	Hydrops Fetalis	0.7%

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