MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Nephrosclerosis

(UMLS:C0027719)

Definition:: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
UMLS ID:: C0027719
MeSH ID:: D009400

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.419.610

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.419.610

Synonym(s)

Nephrosclerosis

ARTERIOSCLEROSIS RENAL

Arteriosclerosis of kidney

Chronic arteriosclerotic nephritis

Interstitial arteriosclerotic nephritis

NEPHROSCLEROSIS

Renal Sclerosis

Renal arteriosclerosis

Renal sclerosis

10.

Renal sclerosis, unspecified

11.

Scarring of kidney arteries

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Lansoprazole	FAERS: 40		US FAERS
2	rofecoxib	FAERS: 25 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Mycophenolic Acid	FAERS: 8		US FAERS
4	Tacrolimus	FAERS: 6		SIDER US FAERS
5	Zoledronic Acid	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
6	Alendronate	FAERS: 4		US FAERS
7	Carbamazepine	FAERS: 3		US FAERS
8	Doxorubicin	FAERS: 3	10515446 11798627 28318631	CTD US FAERS
9	Pamidronate	FAERS: 3		US FAERS
10	Sirolimus	FAERS: 3		US FAERS
11	Tramadol	FAERS: 3		US FAERS
12	Amlodipine	FAERS: 2		US FAERS
13	Cyclosporine	FAERS: 2		US FAERS
14	Deferasirox	FAERS: 2		US FAERS
15	Eucreas	FAERS: 2		US FAERS
16	Everolimus	FAERS: 2		SIDER US FAERS
17	Fluoxetine	FAERS: 2		US FAERS
18	NuvaRing	FAERS: 2		US FAERS
19	Rivaroxaban	FAERS: 2		US FAERS
20	Rosiglitazone	FAERS: 2		US FAERS
21	anagrelide	FAERS: 2		US FAERS
22	ponatinib	FAERS: 2		US FAERS
23	4-Aminopyridine	FAERS: 1		US FAERS
24	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
25	Acyclovir	FAERS: 1		US FAERS
26	Allopurinol	FAERS: 1		US FAERS
27	Alprazolam	FAERS: 1		US FAERS
28	Amlodipine	FAERS: 1		US FAERS
29	Atenolol	FAERS: 1		US FAERS
30	Bosentan	FAERS: 1		US FAERS
31	Calcitriol	FAERS: 1		US FAERS
32	Cefuroxime	FAERS: 1		US FAERS
33	Chlorpheniramine	FAERS: 1		US FAERS
34	Citalopram	FAERS: 1		US FAERS
35	Clozapine	FAERS: 1		US FAERS
36	Dabigatran	FAERS: 1		US FAERS
37	Estradiol	FAERS: 1		US FAERS
38	Fentanyl	FAERS: 1		US FAERS
39	Fluoxetine	FAERS: 1		US FAERS
40	Gadolinium	FAERS: 1		US FAERS
41	Gefitinib	FAERS: 1		US FAERS
42	Hydralazine	FAERS: 1		US FAERS
43	Imatinib Mesylate	FAERS: 1		US FAERS
44	Imatinib Mesylate	FAERS: 1		US FAERS
45	Insulin Glargine	FAERS: 1		US FAERS
46	Lithium	FAERS: 1		US FAERS
47	Methotrexate	FAERS: 1		US FAERS
48	Omeprazole	FAERS: 1		US FAERS
49	Phenytoin	FAERS: 1		US FAERS
50	Pioglitazone	FAERS: 1		US FAERS
51	Ruxolitinib phosphate	FAERS: 1		US FAERS
52	Simvastatin	FAERS: 1		US FAERS
53	Sunitinib	FAERS: 1		US FAERS
54	Varenicline	FAERS: 1		US FAERS
55	apixaban	FAERS: 1		US FAERS
56	empagliflozin	FAERS: 1		US FAERS
57	Chloroquine		12673565	CTD
58	Desoxycorticosterone Acetate		30290168	CTD
59	Dibutyl Phthalate		28919491	CTD
60	Enalapril		18812665	CTD
61	Hydrochlorothiazide		8818920	CTD
62	Hydrocortisone		9471316	CTD
63	Ibuprofen		7579049	CTD
64	Lasofoxifene			SIDER
65	Leukotriene B4		30818366	CTD
66	Losartan		8382237 11883791	CTD
67	Metformin		27551045 30290168	CTD
68	Naproxen			SIDER
69	Niclosamide		28318631	CTD
70	Nitrendipine		1639466	CTD
71	Streptozocin		9523171 23611540 27542954	CTD
72	Valsartan		9523171 10760100	CTD
73	benazepril		View details 9523171 10515446 10760100 11883791	CTD
74	fluindione		16221711	CTD
75	honokiol		21265825	CTD
76	hydrochlorothiazide-triamterene		7579049	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hydronephrosis	47.5%
2	Hyperoxaluria	47.5%
3	Kidney Cortex Necrosis	47.5%
4	Kidney Papillary Necrosis	47.5%
5	Nephritis	47.5%
6	Nephrosis	47.5%
7	Perinephritis	47.5%
8	Kidney Failure	47.5%
9	Uremia	47.5%
10	Oxalosis	47.5%
11	Renal Insufficiency	47.5%
12	Anuria	45.9%
13	Nephrolithiasis	45.9%
14	Diabetes Insipidus	38.7%
15	Hepatorenal Syndrome	38.7%
16	Pyelonephritis	38.7%
17	Diabetic Nephropathy	38.2%
18	Renal hypertension	38.2%
19	Renal Artery Obstruction	38.2%
20	Renal Artery Stenosis	38.2%
21	Nephrocalcinosis	37.9%
22	Glomerulonephritis	35.2%
23	Nephritis, Interstitial	35.2%
24	Lipoid nephrosis	35.2%
25	Nephrotic Syndrome	35.2%
26	Pyelitis	35.2%
27	Pyonephrosis	35.2%
28	Nephrogenic Diabetes Insipidus	35.2%
29	Congenital Nephrogenic Diabetes Insipidus	35.2%
30	Acute kidney injury	35.2%
31	Tuberculosis, Renal	34.5%
32	Urinary Bladder Diseases	32.8%
33	Ureteral Diseases	32.8%
34	Urethral Diseases	32.8%
35	Urination Disorders	32.8%
36	Urolithiasis	32.8%
37	Kidney Neoplasm	31.8%
38	Pyelocystitis	29.9%
39	Kidney Calculi	29.5%
40	Balkan Nephropathy	29.2%
41	Focal glomerulosclerosis	29.2%
42	Kidney Failure, Chronic	29.2%
43	Azotemia	28.7%
44	Ureterolithiasis	28.4%
45	Hypertension, Renovascular	28.2%
46	Multicystic Dysplastic Kidney	27.7%
47	AIDS-Associated Nephropathy	27%
48	Urinary tract infection	26.5%
49	Bladder neck obstruction	24.7%
50	Glomerulonephritis, Membranoproliferative	24.5%
51	Polycystic Kidney Diseases	23.7%
52	Renal Aminoacidurias	23.5%
53	Fanconi Syndrome	23.5%
54	Pseudohypoaldosteronism	23.5%
55	Liddle Syndrome	23.5%
56	Hemolytic-Uremic Syndrome	23.4%
57	Glycosuria, Renal	22.6%
58	Cystitis	21.3%
59	Ureteral obstruction	21.3%
60	Ureterocele	21.3%
61	Urethral Obstruction	21.3%
62	Urethritis	21.3%
63	Vesico-Ureteral Reflux	21.3%
64	Urinary Retention	21.3%
65	Ureteral Calculi	20.9%
66	Renal Osteodystrophy	20.9%
67	Renal rickets	20.9%
68	Mesoblastic Nephroma	20.6%
69	Renal Cell Carcinoma	20.5%
70	Papillary Renal Cell Carcinoma	20.5%
71	Renal tubular acidosis	20.1%
72	Anti-Glomerular Basement Membrane Disease	19.9%
73	Lupus Nephritis	19.7%
74	Bladder Exstrophy	19.5%
75	Epispadias	19.5%
76	Polycystic Kidney, Autosomal Dominant	19.5%
77	Cystinuria	19.4%
78	Atypical Hemolytic Uremic Syndrome	19.3%
79	Urogenital Abnormalities	17.7%
80	Bacteriuria	17.1%
81	Glycosuria	17.1%
82	Hematuria	17.1%
83	Oliguria	17.1%
84	Polyuria	17.1%
85	Proteinuria	17.1%
86	Pyuria	17.1%
87	Urinary Calculi	17.1%
88	Cystocele	17%
89	Urinary Incontinence	17%
90	Urinary Bladder Fistula	16.8%
91	Bladder Neoplasm	16.8%
92	Ureteral Neoplasms	16.8%
93	Urethral Neoplasms	16.8%
94	Nephroblastoma	16.7%
95	Zellweger Syndrome	15.8%
96	Urethral Stenosis	15.8%
97	Urethral stricture	15.8%
98	Hyperphosphaturia	15.6%
99	Enuresis	14.4%
100	Albuminuria	12.6%
101	Hemoglobinuria	12.6%
102	Infertility	12.6%
103	Urge Incontinence	12.6%
104	Genital Diseases, Male	11.8%
105	Denys-Drash Syndrome	11.5%
106	Hypospadias	10.6%
107	Pregnancy Complications	10.6%
108	Diurnal Enuresis	10.6%
109	Urologic Neoplasms	10.1%
110	Horseshoe Kidney	10.1%
111	Endometriosis	9.9%
112	Uterine Diseases	9.9%
113	Vaginal Diseases	9.9%
114	Vulvar Diseases	9.9%
115	Endometrioma	9.9%
116	Vesicovaginal Fistula	8.9%
117	Sexually Transmitted Diseases	8.8%
118	Endometritis	8.5%
119	Hermaphroditism	8.5%
120	Disorders of Sex Development	8.5%
121	Genital Herpes	8.3%
122	Familial Hypophosphatemic Rickets	8.2%
123	Genital Neoplasms, Male	8.2%
124	Uterine Neoplasms	7.8%
125	Vaginal Neoplasms	7.8%
126	Vulvar Neoplasms	7.8%
127	Uterine Cancer	7.8%
128	Genital Neoplasms, Female	7.4%
129	Uterine Inversion	7.4%
130	Salpingitis	7.3%
131	Vulvovaginitis	7.3%
132	Fallopian Tube Neoplasms	6.8%
133	Epididymitis	6.7%
134	Penile Diseases	6.7%
135	Prostatic Diseases	6.7%
136	Spermatic Cord Torsion	6.7%
137	Hemospermia	6.7%
138	Testicular Hydrocele	6.7%
139	Dyspareunia	6.7%
140	Penile Neoplasms	6.6%
141	Prostatic Neoplasms	6.6%
142	Endometrial Hyperplasia	6.5%
143	Pyometra	6.5%
144	Vaginitis	6.5%
145	Vulvitis	6.5%
146	Vaginal Discharge	6.5%
147	Vulvodynia	6.5%
148	Uterine Rupture	6%
149	Oophoritis	5.8%
150	Endometrial Neoplasms	5.8%
151	Polyhydramnios	5.6%
152	Obstetric Labor Complications	5.6%
153	Ectopic Pregnancy	5.6%
154	Pregnancy, Prolonged	5.6%
155	Puerperal Disorders	5.6%
156	Oligohydramnios	5.6%
157	Prenatal Injuries	5.6%
158	Cryptorchidism	5.6%
159	Gonadal Dysgenesis	5.5%
160	Adrenogenital Syndrome	5.5%
161	Ovotesticular Disorders of Sex Development	5.5%
162	Uterine Cervical Incompetence	5.3%
163	Testicular Diseases	5.1%
164	Varicocele	5.1%
165	Spermatocele	5%
166	Ovarian Diseases	5%
167	ovarian neoplasm	5%
168	Abruptio Placentae	5%
169	Placenta Accreta	5%
170	Adnexitis	4.9%
171	Pruritus Vulvae	4.9%
172	Uterine hemorrhage	4.9%
173	Vaginal Fistula	4.9%
174	Pelvic Inflammatory Disease	4.9%
175	Uterine Prolapse	4.9%
176	Vaginal Prolapse	4.9%
177	Uterine Cervicitis	4.9%
178	Leukorrhea	4.9%
179	Parametritis	4.9%
180	Candidiasis, Vulvovaginal	4.9%
181	Prostatic Neoplasms, Castration-Resistant	4.9%
182	Hyperandrogenism	4.8%
183	Carcinoma, Endometrioid	4.8%
184	Chorioamnionitis	4.4%
185	Fetal Diseases	4.4%
186	Pregnancy Complications, Cardiovascular	4.4%
187	Pregnancy Complications, Neoplastic	4.4%
188	Balanitis	4.4%
189	Benign prostatic hypertrophy	4.4%
190	Phimosis	4.4%
191	Priapism	4.4%
192	prostatitis	4.4%
193	Prostatic Adenoma	4.4%
194	Benign Prostatic Hyperplasia	4.4%
195	Prostatic Hypertrophy	4.4%
196	Prostatic Hyperplasia	4.4%
197	Pregnancy Complications, Hematologic	4.3%
198	Pregnancy Complications, Infectious	4.3%
199	Fetal Death	4.2%
200	Perinatal death	4.2%
201	Morning Sickness	4.2%
202	Puerperal Infection	4%
203	Postpartum Hemorrhage	3.9%
204	Bacterial Vaginosis	3.7%
205	Trichomonas Vaginitis	3.7%
206	Uterine Perforation	3.7%
207	Ovarian Hyperstimulation Syndrome	3.7%
208	Metrorrhagia	3.6%
209	Endometrial Stromal Sarcoma	3.6%
210	Chlamydia Infections	3.5%
211	Gonorrhea	3.5%
212	Gestational Diabetes	3.4%
213	Premature Ejaculation	3.4%
214	Erectile dysfunction	3.4%
215	granulosa cell tumor	3.3%
216	Carcinoma, Ovarian Epithelial	3.3%
217	Testicular Neoplasms	3.3%
218	Orchitis	3.3%
219	Abortion, Habitual	3.3%
220	Dystocia	3.3%
221	Eclampsia	3.3%
222	Fetal Membranes, Premature Rupture	3.3%
223	Placental Insufficiency	3.3%
224	Pre-Eclampsia	3.3%
225	Prenatal Exposure Delayed Effects	3.3%
226	HELLP Syndrome	3.3%
227	Placenta, Retained	3.3%
228	Azoospermia	3.3%
229	Oligospermia	3.3%
230	Impotence, Vasculogenic	3.3%
231	Asthenozoospermia	3.3%
232	Teratozoospermia	3.3%
233	Aspermia	3.3%
234	Turner Syndrome	3.2%
235	Kallmann Syndrome	3.1%
236	Syphilis	3%
237	Corpus Luteum Cyst	3%
238	Ovarian Cysts	3%
239	Anovulation	2.9%
240	Menorrhagia	2.9%
241	Premature Menopause	2.9%
242	Lymphogranuloma Venereum	2.9%
243	Klinefelter Syndrome	2.7%
244	Abortion, Veterinary	2.6%
245	Pregnancy Complications, Parasitic	2.6%
246	Lactation Disorder	2.5%
247	Mastitis	2.5%
248	Depression, Postpartum	2.5%
249	Embryo Loss	2.5%
250	Fetal Resorption	2.5%
251	Hyperemesis Gravidarum	2.4%
252	Polycystic Ovary Syndrome	2.4%
253	Premature Birth	2.2%
254	Fetal Growth Retardation	2%
255	Trophoblastic Neoplasms	2%
256	Embolism, Amniotic Fluid	2%
257	Fetal Hypoxia	2%
258	Fetal Alcohol Spectrum Disorders	2%
259	Breech Presentation	2%
260	Stillbirth	2%
261	Leydig Cell Tumor	1.8%
262	Galactorrhea	1.6%
263	Meconium Aspiration Syndrome	1.5%
264	Choriocarcinoma	1.1%
265	Hydatidiform Mole	1%
266	Hydrops Fetalis	0.7%

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