MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Urethral Stenosis

(UMLS:C0041974)

Definition:: Narrowing of any part of the URETHRA. It is characterized by decreased urinary stream and often other obstructive voiding symptoms.
UMLS ID:: C0041974
MeSH ID:: D014525

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.777.767.700.700

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.968.767.700.700

Synonym(s)

Urethral Stenosis

Narrowing of the urethra

Stenosis;urethral

URETHRA STENOSIS

URETHRAL STENOSIS

Urethral stenosis

ankylurethria

narrowing; urethra

stenosis; urethra

10.

urethra; contracture

11.

urethra; narrowing

12.

urethra; stenosis

13.

urethral stenosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Finasteride	FAERS: 11	US FAERS
2	Ciprofloxacin	FAERS: 7 Canada Vigilance: 1	Canada Vigilance US FAERS
3	rofecoxib	FAERS: 5	OFFSIDES US FAERS
4	4-hydroxybutyric acid	FAERS: 4	US FAERS
5	Alprostadil	FAERS: 4	US FAERS
6	Dabigatran	FAERS: 3	US FAERS
7	Glatiramer Acetate	FAERS: 3	US FAERS
8	Lenalidomide	FAERS: 3	OFFSIDES US FAERS
9	Pamidronate	FAERS: 3	US FAERS
10	Tadalafil	FAERS: 3	US FAERS
11	apixaban	FAERS: 3	US FAERS
12	Abiraterone Acetate	FAERS: 2	US FAERS
13	Acetaminophen	FAERS: 2	US FAERS
14	Amlodipine	FAERS: 2	US FAERS
15	Dutasteride	FAERS: 2	OFFSIDES US FAERS
16	Estradiol	FAERS: 2	US FAERS
17	Lamotrigine	FAERS: 2	US FAERS
18	MDV 3100	FAERS: 2	US FAERS
19	Norgestrel	FAERS: 2	US FAERS
20	acetyl-2-naphthylalanyl-3-chlorophenylalanyl-1-oxohexadecyl-seryl-4-aminophenylalanyl(hydroorotyl)-4-aminophenylalanyl(carbamoyl)-leucyl-ILys-prolyl-alaninamide	FAERS: 2	US FAERS
21	alfuzosin	FAERS: 2	US FAERS
22	carbidopa, levodopa drug combination	FAERS: 2	US FAERS
23	desloratadine	FAERS: 2	US FAERS
24	hydrochlorothiazide-triamterene	FAERS: 2	US FAERS
25	niraparib	FAERS: 2	US FAERS
26	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
27	Adzenys XR-ODT	FAERS: 1	US FAERS
28	Alendronate	FAERS: 1	US FAERS
29	Amlodipine	FAERS: 1	US FAERS
30	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1	OFFSIDES SIDER US FAERS
31	Atomoxetine Hydrochloride	FAERS: 1	US FAERS
32	BMS201038	FAERS: 1	US FAERS
33	Baclofen	FAERS: 1	US FAERS
34	Buprenorphine	FAERS: 1	OFFSIDES US FAERS
35	Clozapine	FAERS: 1	US FAERS
36	Cyclosporine	FAERS: 1	US FAERS
37	Deferasirox	FAERS: 1	US FAERS
38	Diovan Hct	FAERS: 1	US FAERS
39	Doxazosin	FAERS: 1	US FAERS
40	Duloxetine Hydrochloride	FAERS: 1	US FAERS
41	Estrogens, Conjugated (USP)	FAERS: 1	US FAERS
42	Fingolimod Hydrochloride	FAERS: 1	US FAERS
43	Haloperidol	FAERS: 1	US FAERS
44	Hydrocortisone	FAERS: 1	US FAERS
45	Hydroxyurea	FAERS: 1	US FAERS
46	Iophendylate	FAERS: 1	US FAERS
47	Leuprolide	FAERS: 1	US FAERS
48	Methylphenidate	FAERS: 1	US FAERS
49	NuvaRing	FAERS: 1	US FAERS
50	Ondansetron	FAERS: 1	US FAERS
51	Pergolide	FAERS: 1	US FAERS
52	Rosuvastatin Calcium	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
53	Sitagliptin Phosphate	FAERS: 1	US FAERS
54	Solifenacin Succinate	FAERS: 1	US FAERS
55	Tacrolimus	FAERS: 1	US FAERS
56	Tamsulosin	FAERS: 1	US FAERS
57	Teriparatide	FAERS: 1	US FAERS
58	Valproic Acid	FAERS: 1	US FAERS
59	empagliflozin	FAERS: 1	US FAERS
60	fesoterodine	FAERS: 1	US FAERS
61	fexofenadine	FAERS: 1	US FAERS
62	valrubicin	FAERS: 1	US FAERS
63	Amisulpride		OFFSIDES
64	Atomoxetine Hydrochloride		OFFSIDES
65	Bezafibrate		OFFSIDES
66	Bisacodyl		OFFSIDES
67	Chloroquine		OFFSIDES
68	Chlorpromazine		OFFSIDES
69	Clopidogrel		OFFSIDES
70	Cloxacillin		OFFSIDES
71	Diosmin		OFFSIDES
72	Doxycycline		OFFSIDES
73	Famotidine		OFFSIDES
74	Flupenthixol		OFFSIDES
75	Flurazepam		OFFSIDES
76	Fondaparinux		OFFSIDES
77	Fulvestrant		OFFSIDES
78	Goserelin		OFFSIDES
79	Hydromorphone		OFFSIDES SIDER
80	Hydron;carbonate		OFFSIDES
81	Irbesartan		OFFSIDES
82	Loxapine		OFFSIDES
83	Megestrol		OFFSIDES
84	Megestrol Acetate		OFFSIDES
85	Meperidine		OFFSIDES
86	Methocarbamol		OFFSIDES
87	Methotrexate		OFFSIDES
88	Morphine		SIDER
89	Mupirocin		OFFSIDES
90	Nitrofurantoin		OFFSIDES
91	Oxcarbazepine		OFFSIDES
92	Pamidronate		OFFSIDES
93	Penicillin V		OFFSIDES
94	Perphenazine		OFFSIDES
95	Ramipril		OFFSIDES
96	Telmisartan		OFFSIDES
97	Tiotropium Bromide		OFFSIDES
98	Triamterene		OFFSIDES
99	Trifluoperazine		OFFSIDES
100	Warfarin		OFFSIDES
101	alfuzosin		OFFSIDES
102	azelastine		OFFSIDES
103	calcipotriene		OFFSIDES
104	calcium acetate		OFFSIDES
105	cefuroxime axetil		OFFSIDES
106	cevimeline		OFFSIDES
107	dolasetron		OFFSIDES
108	trandolapril		OFFSIDES
109	valdecoxib		OFFSIDES
110	ziprasidone		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Bladder neck obstruction	43.3%
2	Urethritis	35.2%
3	Urinary Bladder Diseases	27%
4	Kidney Diseases	27%
5	Ureteral Diseases	27%
6	Urination Disorders	27%
7	Urolithiasis	27%
8	Epispadias	26.5%
9	Urethral Neoplasms	23.7%
10	Urinary tract infection	21.9%
11	Anuria	21.1%
12	Ureterolithiasis	21.1%
13	Nephrolithiasis	21.1%
14	Cystitis	15.8%
15	Hydronephrosis	15.8%
16	Hyperoxaluria	15.8%
17	Kidney Cortex Necrosis	15.8%
18	Kidney Papillary Necrosis	15.8%
19	Nephritis	15.8%
20	Nephrosclerosis	15.8%
21	Nephrosis	15.8%
22	Perinephritis	15.8%
23	Kidney Failure	15.8%
24	Uremia	15.8%
25	Ureteral obstruction	15.8%
26	Ureterocele	15.8%
27	Urogenital Abnormalities	15.8%
28	Vesico-Ureteral Reflux	15.8%
29	Urinary Retention	15.8%
30	Oxalosis	15.8%
31	Renal Insufficiency	15.8%
32	Bladder Exstrophy	15.1%
33	Tuberculosis, Renal	15%
34	Kidney Calculi	13.9%
35	Ureteral Calculi	13.9%
36	Diabetes Insipidus	12.9%
37	Hepatorenal Syndrome	12.9%
38	Bacteriuria	12.7%
39	Diabetic Nephropathy	12.7%
40	Glycosuria	12.7%
41	Hematuria	12.7%
42	Renal hypertension	12.7%
43	Oliguria	12.7%
44	Polyuria	12.7%
45	Proteinuria	12.7%
46	Pyuria	12.7%
47	Renal Artery Obstruction	12.7%
48	Renal Artery Stenosis	12.7%
49	Urinary Calculi	12.7%
50	Cystocele	12.6%
51	Nephrocalcinosis	12.6%
52	Urinary Incontinence	12.6%
53	Urinary Bladder Fistula	12.5%
54	Bladder Neoplasm	12.5%
55	Kidney Neoplasm	12.5%
56	Ureteral Neoplasms	12.5%
57	Pyelocystitis	12.1%
58	Multicystic Dysplastic Kidney	12%
59	Enuresis	10.7%
60	Genital Diseases, Male	10.4%
61	Glomerulonephritis	10.4%
62	Nephritis, Interstitial	10.4%
63	Lipoid nephrosis	10.4%
64	Nephrotic Syndrome	10.4%
65	Pyelitis	10.4%
66	Pyonephrosis	10.4%
67	Nephrogenic Diabetes Insipidus	10.4%
68	Congenital Nephrogenic Diabetes Insipidus	10.4%
69	Acute kidney injury	10.4%
70	Infertility	10.4%
71	Pyelonephritis	10.3%
72	Pregnancy Complications	9.8%
73	Glycosuria, Renal	9.3%
74	AIDS-Associated Nephropathy	9%
75	Hypospadias	8.6%
76	Azotemia	8.5%
77	Albuminuria	8.3%
78	Hemoglobinuria	8.3%
79	Hypertension, Renovascular	8.3%
80	Urge Incontinence	8.3%
81	Urologic Neoplasms	8.3%
82	Horseshoe Kidney	8.3%
83	Endometriosis	8.1%
84	Uterine Diseases	8.1%
85	Vaginal Diseases	8.1%
86	Vulvar Diseases	8.1%
87	Endometrioma	8.1%
88	Balkan Nephropathy	7.8%
89	Focal glomerulosclerosis	7.8%
90	Kidney Failure, Chronic	7.8%
91	Sexually Transmitted Diseases	7.2%
92	Mesoblastic Nephroma	7.2%
93	Renal Cell Carcinoma	7.2%
94	Papillary Renal Cell Carcinoma	7.2%
95	Polycystic Kidney Diseases	7%
96	Hermaphroditism	7%
97	Disorders of Sex Development	7%
98	Diurnal Enuresis	7%
99	Renal Osteodystrophy	7%
100	Renal rickets	7%
101	Renal Aminoacidurias	7%
102	Fanconi Syndrome	7%
103	Pseudohypoaldosteronism	7%
104	Liddle Syndrome	7%
105	Hemolytic-Uremic Syndrome	6.9%
106	Genital Herpes	6.9%
107	Genital Neoplasms, Male	6.7%
108	Glomerulonephritis, Membranoproliferative	6.5%
109	Genital Neoplasms, Female	6.1%
110	Endometritis	6%
111	Renal tubular acidosis	6%
112	Vesicovaginal Fistula	5.9%
113	Nephroblastoma	5.9%
114	Uterine Neoplasms	5.8%
115	Vaginal Neoplasms	5.8%
116	Vulvar Neoplasms	5.8%
117	Uterine Cancer	5.8%
118	Uterine Inversion	5.7%
119	Epididymitis	5.5%
120	Penile Diseases	5.5%
121	Prostatic Diseases	5.5%
122	Spermatic Cord Torsion	5.5%
123	Hemospermia	5.5%
124	Testicular Hydrocele	5.5%
125	Anti-Glomerular Basement Membrane Disease	5.3%
126	Zellweger Syndrome	5.3%
127	Lupus Nephritis	5.2%
128	Polycystic Kidney, Autosomal Dominant	5.2%
129	Cystinuria	5.2%
130	Atypical Hemolytic Uremic Syndrome	5.2%
131	Polyhydramnios	5%
132	Obstetric Labor Complications	5%
133	Ectopic Pregnancy	5%
134	Pregnancy, Prolonged	5%
135	Puerperal Disorders	5%
136	Oligohydramnios	5%
137	Prenatal Injuries	5%
138	Dyspareunia	5%
139	Penile Neoplasms	4.9%
140	Prostatic Neoplasms	4.9%
141	Endometrial Hyperplasia	4.8%
142	Pyometra	4.8%
143	Vaginitis	4.8%
144	Vulvitis	4.8%
145	Vaginal Discharge	4.8%
146	Vulvodynia	4.8%
147	Fallopian Tube Neoplasms	4.8%
148	Salpingitis	4.8%
149	Vulvovaginitis	4.8%
150	Hyperphosphaturia	4.6%
151	Uterine Rupture	4.6%
152	Cryptorchidism	4.4%
153	Denys-Drash Syndrome	4.2%
154	Testicular Diseases	4.2%
155	Varicocele	4.2%
156	Spermatocele	4.1%
157	Abruptio Placentae	4.1%
158	Placenta Accreta	4.1%
159	Gonadal Dysgenesis	4.1%
160	Adrenogenital Syndrome	4.1%
161	Ovotesticular Disorders of Sex Development	4.1%
162	Fetal Diseases	3.9%
163	Pregnancy Complications, Cardiovascular	3.9%
164	Pregnancy Complications, Neoplastic	3.9%
165	Oophoritis	3.9%
166	Endometrial Neoplasms	3.8%
167	Pregnancy Complications, Hematologic	3.8%
168	Pregnancy Complications, Infectious	3.8%
169	Fetal Death	3.7%
170	Perinatal death	3.7%
171	Ovarian Diseases	3.7%
172	Morning Sickness	3.7%
173	Adnexitis	3.6%
174	Pruritus Vulvae	3.6%
175	Uterine hemorrhage	3.6%
176	Vaginal Fistula	3.6%
177	Pelvic Inflammatory Disease	3.6%
178	Uterine Prolapse	3.6%
179	Vaginal Prolapse	3.6%
180	Uterine Cervical Incompetence	3.6%
181	Chorioamnionitis	3.6%
182	ovarian neoplasm	3.5%
183	Puerperal Infection	3.3%
184	Postpartum Hemorrhage	3.3%
185	Balanitis	3.2%
186	Benign prostatic hypertrophy	3.2%
187	Phimosis	3.2%
188	Priapism	3.2%
189	prostatitis	3.2%
190	Prostatic Adenoma	3.2%
191	Benign Prostatic Hyperplasia	3.2%
192	Prostatic Hypertrophy	3.2%
193	Prostatic Hyperplasia	3.2%
194	Prostatic Neoplasms, Castration-Resistant	3.2%
195	Hyperandrogenism	3.2%
196	Uterine Cervicitis	3.2%
197	Leukorrhea	3.2%
198	Parametritis	3.2%
199	Gestational Diabetes	3%
200	Carcinoma, Endometrioid	3%
201	Candidiasis, Vulvovaginal	2.9%
202	Abortion, Habitual	2.7%
203	Dystocia	2.7%
204	Eclampsia	2.7%
205	Fetal Membranes, Premature Rupture	2.7%
206	Placental Insufficiency	2.7%
207	Pre-Eclampsia	2.7%
208	Prenatal Exposure Delayed Effects	2.7%
209	HELLP Syndrome	2.7%
210	Placenta, Retained	2.7%
211	Premature Ejaculation	2.5%
212	Erectile dysfunction	2.5%
213	Testicular Neoplasms	2.5%
214	Bacterial Vaginosis	2.5%
215	Orchitis	2.4%
216	Trichomonas Vaginitis	2.4%
217	Uterine Perforation	2.4%
218	Ovarian Hyperstimulation Syndrome	2.4%
219	Metrorrhagia	2.4%
220	Chlamydia Infections	2.3%
221	Gonorrhea	2.3%
222	Familial Hypophosphatemic Rickets	2.2%
223	Abortion, Veterinary	2.1%
224	Pregnancy Complications, Parasitic	2.1%
225	Turner Syndrome	2.1%
226	Azoospermia	2.1%
227	Oligospermia	2.1%
228	Impotence, Vasculogenic	2.1%
229	Asthenozoospermia	2.1%
230	Teratozoospermia	2.1%
231	Aspermia	2.1%
232	granulosa cell tumor	2.1%
233	Carcinoma, Ovarian Epithelial	2.1%
234	Lactation Disorder	2%
235	Mastitis	2%
236	Depression, Postpartum	2%
237	Embryo Loss	2%
238	Kallmann Syndrome	2%
239	Fetal Resorption	2%
240	Hyperemesis Gravidarum	2%
241	Syphilis	2%
242	Endometrial Stromal Sarcoma	2%
243	Corpus Luteum Cyst	2%
244	Ovarian Cysts	2%
245	Anovulation	1.9%
246	Menorrhagia	1.9%
247	Premature Menopause	1.9%
248	Klinefelter Syndrome	1.8%
249	Lymphogranuloma Venereum	1.7%
250	Fetal Growth Retardation	1.7%
251	Trophoblastic Neoplasms	1.7%
252	Embolism, Amniotic Fluid	1.7%
253	Fetal Hypoxia	1.7%
254	Fetal Alcohol Spectrum Disorders	1.7%
255	Breech Presentation	1.6%
256	Stillbirth	1.6%
257	Premature Birth	1.6%
258	Polycystic Ovary Syndrome	1.4%
259	Meconium Aspiration Syndrome	1.2%
260	Galactorrhea	1.2%
261	Leydig Cell Tumor	1.1%
262	Choriocarcinoma	0.8%
263	Hydatidiform Mole	0.6%
264	Hydrops Fetalis	0.5%

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