MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Uterine Perforation

(UMLS:C0042139)

Definition:: A hole or break through the wall of the UTERUS, usually made by the placement of an instrument or INTRAUTERINE DEVICES.
UMLS ID:: C0042139
MeSH ID:: D014595

Classification 1:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.852.904.500

Classification 2:

Name:

Wounds and Injuries
MeSH Tree Number(s):: C26.761.853.500

Synonym(s)

Uterine Perforation

Perforation Of Uterus

Perforation of uterus

Perforation of uterus, NOS

UTERINE PERFORATION

Uterine perforation

Uterine perforation, NOS

Uterus Perforation

Uterus Wall Perforation

10.

perforation of uterus

11.

perforation uterine

12.

perforation uterus

13.

uterine perforation

14.

uterus perforation

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 5485 Canada Vigilance: 596	Canada Vigilance OFFSIDES SIDER US FAERS
2	Copper	FAERS: 210	US FAERS
3	Misoprostol	FAERS: 3	OFFSIDES US FAERS
4	Dabigatran	FAERS: 2	US FAERS
5	Fingolimod Hydrochloride	FAERS: 2	US FAERS
6	Alendronate	FAERS: 1	US FAERS
7	Ethinyl Estradiol-Norgestrel Combination	FAERS: 1	US FAERS
8	Fluorouracil	FAERS: 1	US FAERS
9	Methotrexate	FAERS: 1	US FAERS
10	NuvaRing	FAERS: 1	US FAERS
11	Raloxifene Hydrochloride	FAERS: 1	US FAERS
12	carbidopa, levodopa drug combination	FAERS: 1	US FAERS
13	Beclomethasone		OFFSIDES
14	Beclomethasone		OFFSIDES
15	Dactinomycin		OFFSIDES
16	Etoposide		OFFSIDES
17	Pramipexole		OFFSIDES
18	Rabeprazole		OFFSIDES
19	Raloxifene Hydrochloride		OFFSIDES
20	Valacyclovir		OFFSIDES
21	valdecoxib		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Endometrial Hyperplasia	24.3%
2	Pyometra	24.3%
3	Endometritis	23.8%
4	Uterine Inversion	20.4%
5	Endometriosis	19.1%
6	Vaginal Diseases	19.1%
7	Vulvar Diseases	19.1%
8	Endometrioma	19.1%
9	Uterine hemorrhage	18.4%
10	Uterine Prolapse	18.2%
11	Vaginal Prolapse	18.2%
12	Uterine Neoplasms	17.5%
13	Uterine Cancer	17.5%
14	Splenic Rupture	16.3%
15	Uterine Cervicitis	16.1%
16	Infertility	14.6%
17	Frostbite	14.1%
18	Uterine Cervical Incompetence	13.3%
19	Metrorrhagia	12.1%
20	Urologic Diseases	11.9%
21	Athletic Injuries	11.7%
22	Hand Injuries	11.7%
23	Soft Tissue Injuries	11.7%
24	Sprain	11.7%
25	Sprains and Strains	11.7%
26	Tendon Injuries	11.7%
27	Laceration	11.7%
28	Wounds, Penetrating	11.7%
29	Heat Cramps	11.7%
30	Endometrial Neoplasms	11.5%
31	Vaginitis	11.4%
32	Vulvitis	11.4%
33	Vaginal Discharge	11.4%
34	Vulvodynia	11.4%
35	Salpingitis	11.2%
36	Vulvovaginitis	11.2%
37	Splenosis	10.5%
38	Crush syndrome	10.2%
39	Femoral Fractures	10.2%
40	Tibial Fractures	10.2%
41	Sexually Transmitted Diseases	10.2%
42	Pregnancy Complications	9.9%
43	Aortic Rupture	9.9%
44	Menorrhagia	9.7%
45	Vaginal Neoplasms	9.7%
46	Vulvar Neoplasms	9.7%
47	Genital Herpes	9.7%
48	Urogenital Abnormalities	9.5%
49	Hip Fractures	9.4%
50	Trauma, Nervous System	9.1%
51	Oophoritis	9.1%
52	Bites and Stings	8.8%
53	Extravasation of Diagnostic and Therapeutic Materials	8.8%
54	Vascular System Injuries	8.8%
55	Tympanic Membrane Perforation	8.8%
56	Tooth Injuries	8.8%
57	Ovarian Diseases	8.7%
58	Asphyxia	8.7%
59	Esophageal Perforation	8.7%
60	Shock, Traumatic	8.7%
61	Self Mutilation	8.6%
62	Adnexitis	8.6%
63	Pruritus Vulvae	8.6%
64	Vaginal Fistula	8.6%
65	Pelvic Inflammatory Disease	8.6%
66	Chilblains	8.4%
67	Spinal Fractures	8.4%
68	Hip Dislocation	8.1%
69	Shoulder Dislocation	8.1%
70	Hip Dysplasia	8.1%
71	Leukorrhea	7.5%
72	Parametritis	7.5%
73	Fallopian Tube Neoplasms	7.4%
74	Dyspareunia	7%
75	Spinal Cord Injuries	7%
76	Drowning	6.9%
77	Candidiasis, Vulvovaginal	6.8%
78	Human Bite	6.7%
79	Contusions	6.7%
80	Decompression Sickness	6.7%
81	Finger Injuries	6.7%
82	Flail Chest	6.7%
83	Fractures, Closed	6.7%
84	Pathological fracture	6.7%
85	Heart Injuries	6.7%
86	Heat Exhaustion	6.7%
87	Heat Stroke	6.7%
88	Knee Injuries	6.7%
89	Foot Injuries	6.7%
90	Decapitation	6.7%
91	Ankle Fracture	6.7%
92	Avulsion fracture	6.7%
93	Compression fracture	6.7%
94	Osteoporotic Fractures	6.7%
95	Iliotibial Band Syndrome	6.6%
96	Urinary Bladder Diseases	6.3%
97	Kidney Diseases	6.3%
98	Ureteral Diseases	6.3%
99	Urethral Diseases	6.3%
100	Urination Disorders	6.3%
101	Urolithiasis	6.3%
102	Genital Neoplasms, Female	6.2%
103	Endometrial Stromal Sarcoma	6%
104	Vesicovaginal Fistula	5.9%
105	Bacterial Vaginosis	5.8%
106	Bladder Exstrophy	5.7%
107	Epispadias	5.7%
108	Trichomonas Vaginitis	5.7%
109	Ovarian Hyperstimulation Syndrome	5.7%
110	Tuberculosis, Renal	5.7%
111	Radiation injury	5.6%
112	Eye Burns	5.6%
113	ovarian neoplasm	5.4%
114	Craniocerebral Trauma	5.1%
115	Tendinitis	5.1%
116	Lung Injury	5.1%
117	Tendinopathy	5.1%
118	Urinary tract infection	5.1%
119	Polyhydramnios	5%
120	Obstetric Labor Complications	5%
121	Ectopic Pregnancy	5%
122	Pregnancy, Prolonged	5%
123	Puerperal Disorders	5%
124	Oligohydramnios	5%
125	Prenatal Injuries	5%
126	Foreign-Body Reaction	5%
127	Insect Bites and Stings	5%
128	Paralysis, Obstetric	5%
129	Sunburn	5%
130	Tooth Avulsion	5%
131	Conus Medullaris Syndrome	5%
132	Urologic Neoplasms	5%
133	Horseshoe Kidney	5%
134	Near Drowning	5%
135	Osteoradionecrosis	5%
136	Multicystic Dysplastic Kidney	5%
137	Anuria	4.9%
138	Ureterolithiasis	4.9%
139	Nephrolithiasis	4.9%
140	Corpus Luteum Cyst	4.6%
141	Ovarian Cysts	4.6%
142	Anovulation	4.5%
143	Premature Menopause	4.5%
144	Pseudarthrosis	4.4%
145	Smoke Inhalation Injury	4.4%
146	Hermaphroditism	4.2%
147	Disorders of Sex Development	4.2%
148	Urinary Bladder Fistula	4.2%
149	Bladder Neoplasm	4.2%
150	Kidney Neoplasm	4.2%
151	Ureteral Neoplasms	4.2%
152	Urethral Neoplasms	4.2%
153	Carcinoma, Endometrioid	4.2%
154	Hypospadias	4.2%
155	Neoplasms, Radiation-Induced	4.2%
156	Abruptio Placentae	4.1%
157	Placenta Accreta	4.1%
158	Peripheral Nerve Injuries	4.1%
159	Medial Tibial Stress Syndrome	4.1%
160	Bladder neck obstruction	4.1%
161	Central Cord Syndrome	4%
162	Fetal Diseases	4%
163	Pregnancy Complications, Cardiovascular	4%
164	Pregnancy Complications, Neoplastic	4%
165	Brain Concussion	3.8%
166	Pregnancy Complications, Hematologic	3.8%
167	Pregnancy Complications, Infectious	3.8%
168	Fetal Death	3.8%
169	Perinatal death	3.8%
170	Morning Sickness	3.7%
171	Cystitis	3.7%
172	Hydronephrosis	3.7%
173	Hyperoxaluria	3.7%
174	Kidney Cortex Necrosis	3.7%
175	Kidney Papillary Necrosis	3.7%
176	Nephritis	3.7%
177	Nephrosclerosis	3.7%
178	Nephrosis	3.7%
179	Perinephritis	3.7%
180	Kidney Failure	3.7%
181	Uremia	3.7%
182	Ureteral obstruction	3.7%
183	Ureterocele	3.7%
184	Urethral Obstruction	3.7%
185	Urethritis	3.7%
186	Vesico-Ureteral Reflux	3.7%
187	Urinary Retention	3.7%
188	Oxalosis	3.7%
189	Renal Insufficiency	3.7%
190	Chorioamnionitis	3.6%
191	Brain Contusion	3.5%
192	Polycystic Ovary Syndrome	3.4%
193	Cardiotoxicity	3.4%
194	Leukemia, Radiation-Induced	3.4%
195	granulosa cell tumor	3.3%
196	Carcinoma, Ovarian Epithelial	3.3%
197	Radiation Pneumonitis	3.3%
198	Radiation Fibrosis	3.3%
199	Puerperal Infection	3.3%
200	Facial Injuries	3.3%
201	Granuloma, Foreign-Body	3.3%
202	Enthesopathy	3.3%
203	Postpartum Hemorrhage	3.3%
204	Chlamydia Infections	3.2%
205	Gonorrhea	3.2%
206	Kidney Calculi	3.2%
207	Ureteral Calculi	3.2%
208	Gestational Diabetes	3%
209	Diabetes Insipidus	3%
210	Hepatorenal Syndrome	3%
211	Bacteriuria	3%
212	Diabetic Nephropathy	3%
213	Glycosuria	3%
214	Hematuria	3%
215	Renal hypertension	3%
216	Oliguria	3%
217	Polyuria	3%
218	Proteinuria	3%
219	Pyuria	3%
220	Renal Artery Obstruction	3%
221	Renal Artery Stenosis	3%
222	Urinary Calculi	3%
223	Cystocele	2.9%
224	Nephrocalcinosis	2.9%
225	Urinary Incontinence	2.9%
226	Syphilis	2.8%
227	Abnormalities, Radiation-Induced	2.8%
228	Radiation Injuries, Experimental	2.8%
229	Pyelocystitis	2.8%
230	Abortion, Habitual	2.7%
231	Dystocia	2.7%
232	Eclampsia	2.7%
233	Fetal Membranes, Premature Rupture	2.7%
234	Placental Insufficiency	2.7%
235	Pre-Eclampsia	2.7%
236	Prenatal Exposure Delayed Effects	2.7%
237	HELLP Syndrome	2.7%
238	Placenta, Retained	2.7%
239	Brain Injuries	2.6%
240	Coma, Post-Head Injury	2.6%
241	Carpal Tunnel Syndrome	2.6%
242	Enuresis	2.5%
243	Gonadal Dysgenesis	2.5%
244	Adrenogenital Syndrome	2.5%
245	Ovotesticular Disorders of Sex Development	2.5%
246	Glomerulonephritis	2.4%
247	Nephritis, Interstitial	2.4%
248	Lipoid nephrosis	2.4%
249	Nephrotic Syndrome	2.4%
250	Pyelitis	2.4%
251	Pyonephrosis	2.4%
252	Urethral Stenosis	2.4%
253	Nephrogenic Diabetes Insipidus	2.4%
254	Mesoblastic Nephroma	2.4%
255	Congenital Nephrogenic Diabetes Insipidus	2.4%
256	Acute kidney injury	2.4%
257	Urethral stricture	2.4%
258	Renal Cell Carcinoma	2.4%
259	Papillary Renal Cell Carcinoma	2.4%
260	Lymphogranuloma Venereum	2.4%
261	Pyelonephritis	2.4%
262	Abortion, Veterinary	2.2%
263	Pregnancy Complications, Parasitic	2.2%
264	Glycosuria, Renal	2.1%
265	Brain Hemorrhage, Traumatic	2.1%
266	AIDS-Associated Nephropathy	2.1%
267	Lactation Disorder	2.1%
268	Mastitis	2.1%
269	Depression, Postpartum	2.1%
270	Embryo Loss	2.1%
271	Fetal Resorption	2%
272	Eye Injuries	2%
273	Hyperemesis Gravidarum	2%
274	Azotemia	2%
275	Nephroblastoma	2%
276	Brain Injuries, Diffuse	1.9%
277	Traumatic Brain Injury	1.9%
278	Albuminuria	1.9%
279	Hemoglobinuria	1.9%
280	Hypertension, Renovascular	1.9%
281	Urge Incontinence	1.9%
282	Cubital Tunnel Syndrome	1.9%
283	Hyperandrogenism	1.9%
284	Vertebral Artery Dissection	1.9%
285	Balkan Nephropathy	1.8%
286	Focal glomerulosclerosis	1.8%
287	Kidney Failure, Chronic	1.8%
288	Denys-Drash Syndrome	1.7%
289	Fetal Growth Retardation	1.7%
290	Trophoblastic Neoplasms	1.7%
291	Embolism, Amniotic Fluid	1.7%
292	Uterine Rupture	1.7%
293	Fetal Hypoxia	1.7%
294	Fetal Alcohol Spectrum Disorders	1.7%
295	Pneumocephalus	1.6%
296	Olfactory Nerve Injuries	1.6%
297	Breech Presentation	1.6%
298	Polycystic Kidney Diseases	1.6%
299	Cerebrospinal Fluid Otorrhea	1.6%
300	Cerebrospinal Fluid Rhinorrhea	1.6%
301	Stillbirth	1.6%
302	Carotid Artery Injuries	1.6%
303	Premature Birth	1.6%
304	Diurnal Enuresis	1.6%
305	Epilepsy, Post-Traumatic	1.6%
306	Renal Osteodystrophy	1.6%
307	Renal rickets	1.6%
308	Renal Aminoacidurias	1.6%
309	Fanconi Syndrome	1.6%
310	Pseudohypoaldosteronism	1.6%
311	Liddle Syndrome	1.6%
312	Hemolytic-Uremic Syndrome	1.6%
313	Diffuse Axonal Injury	1.6%
314	Glomerulonephritis, Membranoproliferative	1.5%
315	Facial Nerve Injuries	1.4%
316	Corneal Scar	1.4%
317	Renal tubular acidosis	1.4%
318	Turner Syndrome	1.3%
319	Anti-Glomerular Basement Membrane Disease	1.2%
320	Kallmann Syndrome	1.2%
321	Zellweger Syndrome	1.2%
322	Lupus Nephritis	1.2%
323	Meconium Aspiration Syndrome	1.2%
324	Corneal Perforation	1.2%
325	Galactorrhea	1.2%
326	Hematoma, Subdural	1.2%
327	Hematoma, Epidural, Cranial	1.2%
328	Polycystic Kidney, Autosomal Dominant	1.2%
329	Cystinuria	1.2%
330	Atypical Hemolytic Uremic Syndrome	1.2%
331	Hyperphosphaturia	1.1%
332	Klinefelter Syndrome	1.1%
333	Subarachnoid Hemorrhage, Traumatic	1.1%
334	Carotid Artery, Internal, Dissection	1.1%
335	Hematoma, Subdural, Intracranial	1%
336	Hematoma, Subdural, Chronic	1%
337	Hematoma, Subdural, Acute	1%
338	Choriocarcinoma	0.8%
339	Hydatidiform Mole	0.6%
340	Hydrops Fetalis	0.5%
341	Familial Hypophosphatemic Rickets	0.5%

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