MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pelvic Inflammatory Disease

(UMLS:C0242172)

Definition:: A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
UMLS ID:: C0242172
MeSH ID:: D000292

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.539.635.500

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.056.750

Synonym(s)

Pelvic Inflammatory Disease

Disease (PID), Pelvic Inflammatory

Disease;pelvic inflammatory

Female pelvic inflammation

Female pelvic inflammatory disease

Female pelvic inflammatory disease, unspecified

Infection;pelvic inflammatory

Inflammatory Disease (PID), Pelvic

Inflammatory disease of female pelvic organs and tissues, NOS

10.

P.I.D.

11.

PELVIC INFLAMMATION

12.

PELVIC INFLAMMATORY DISEASE

13.

PID

14.

PID - pelvic inflammatory disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Norgestrel	FAERS: 475 Canada Vigilance: 33		Canada Vigilance SIDER US FAERS
2	NuvaRing	FAERS: 35		US FAERS
3	Copper	FAERS: 22		US FAERS
4	etonogestrel	FAERS: 15		US FAERS
5	Isotretinoin	FAERS: 11		US FAERS
6	Ortho Evra	FAERS: 10		US FAERS
7	rofecoxib	FAERS: 4		US FAERS
8	Alendronate	FAERS: 3		US FAERS
9	Clozapine	FAERS: 3		US FAERS
10	Leucovorin	FAERS: 3		US FAERS
11	4-Aminopyridine	FAERS: 2		US FAERS
12	4-hydroxybutyric acid	FAERS: 2		US FAERS
13	Acetaminophen	FAERS: 2		US FAERS
14	Fingolimod Hydrochloride	FAERS: 2		US FAERS
15	Medroxyprogesterone Acetate	FAERS: 2		US FAERS
16	Olanzapine	FAERS: 2		US FAERS
17	Olmesartan Medoxomil	FAERS: 2		US FAERS
18	Sirolimus	FAERS: 2		US FAERS
19	Anastrozole	FAERS: 1		US FAERS
20	Capecitabine	FAERS: 1		US FAERS
21	Ciprofloxacin	FAERS: 1		US FAERS
22	Dacarbazine	FAERS: 1		US FAERS
23	Desogestrel	FAERS: 1		US FAERS
24	Dimethyl Fumarate	FAERS: 1		US FAERS
25	Duloxetine Hydrochloride	FAERS: 1		US FAERS
26	Mycophenolic Acid	FAERS: 1		US FAERS
27	Nicotine	FAERS: 1		US FAERS
28	Ondansetron	FAERS: 1		US FAERS
29	Qlaira	FAERS: 1		US FAERS
30	Sofosbuvir	FAERS: 1		US FAERS
31	Sunitinib	FAERS: 1		US FAERS
32	Tacrolimus	FAERS: 1		US FAERS
33	Temozolomide	FAERS: 1		US FAERS
34	Tenofovir	FAERS: 1		US FAERS
35	Teriparatide	FAERS: 1		US FAERS
36	Varenicline	FAERS: 1		US FAERS
37	ambrisentan	FAERS: 1		US FAERS
38	entecavir	FAERS: 1		US FAERS
39	norgestimate, ethinyl estradiol drug combination	FAERS: 1		US FAERS
40	palbociclib	FAERS: 1		US FAERS
41	tofacitinib	FAERS: 1		US FAERS
42	treprostinil	FAERS: 1		US FAERS
43	Amikacin		1856146	CTD
44	Buspirone			SIDER
45	Cephalothin		1173853	CTD
46	Citalopram			SIDER
47	Dihydroergotamine			SIDER
48	Metronidazole		9247414	CTD
49	Mifepristone			SIDER
50	Netilmicin		1856146	CTD
51	Ofloxacin		14511503	CTD SIDER
52	Penicillin G		1173853	CTD
53	Probenecid		1173853	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Ovarian Diseases	25%
2	Endometriosis	23.1%
3	Uterine Diseases	23.1%
4	Vaginal Diseases	23.1%
5	Vulvar Diseases	23.1%
6	Endometrioma	23.1%
7	Sexually Transmitted Diseases	22.8%
8	Wound Infection	20.2%
9	Soft Tissue Infection	20.2%
10	Community-Acquired Infections	20.2%
11	Pregnancy Complications, Infectious	19.7%
12	Fallopian Tube Neoplasms	18.4%
13	Urinary tract infection	18.4%
14	Ovarian Hyperstimulation Syndrome	18.4%
15	Salpingitis	18.1%
16	Infertility	17.6%
17	Vulvovaginitis	16.9%
18	Eye Infection	15.9%
19	Respiratory Tract Infections	15.9%
20	Bone Diseases, Infectious	15.4%
21	Skin Diseases, Infectious	15.4%
22	Endometrial Hyperplasia	15.2%
23	Pyometra	15.2%
24	Vaginitis	15.2%
25	Vulvitis	15.2%
26	Vaginal Discharge	15.2%
27	Vulvodynia	15.2%
28	Arthritis, Infectious	15.1%
29	Suppuration	15.1%
30	Cross Infection	15%
31	Septicemia	15%
32	Sepsis	15%
33	Corpus Luteum Cyst	15%
34	Ovarian Cysts	15%
35	Anovulation	14.7%
36	Oophoritis	14.6%
37	Premature Menopause	14.5%
38	Uterine Inversion	13.9%
39	Candidiasis, Vulvovaginal	13.9%
40	Bacterial Vaginosis	13.7%
41	Endotoxemia	13.7%
42	Ulcerative stomatitis	13.5%
43	ovarian neoplasm	13.5%
44	Cellulitis	13.3%
45	Urologic Diseases	13.3%
46	Opportunistic Infections	13.1%
47	Uterine Neoplasms	13%
48	Vaginal Neoplasms	13%
49	Vulvar Neoplasms	13%
50	Uterine Cancer	13%
51	Chlamydia Infections	12.3%
52	Gonorrhea	12.3%
53	Polycystic Ovary Syndrome	12.2%
54	Dermatomycoses	12.1%
55	Skin Diseases, Bacterial	12.1%
56	Syphilis	12%
57	Bacteremia	12%
58	Puerperal Infection	11.9%
59	Bacteriuria	11.8%
60	Pyuria	11.8%
61	Bacterial Infections	11.8%
62	Mycoses	11.8%
63	Hidradenitis Suppurativa	11.7%
64	Genital Herpes	11.7%
65	Pruritus Vulvae	11.5%
66	Uterine hemorrhage	11.5%
67	Vaginal Fistula	11.5%
68	Uterine Prolapse	11.4%
69	Vaginal Prolapse	11.4%
70	Uterine Cervicitis	11.4%
71	Leukorrhea	11.4%
72	Endometritis	11.3%
73	Uterine Rupture	11.3%
74	Carcinoma, Endometrioid	10.8%
75	Urogenital Abnormalities	10.6%
76	Pregnancy Complications	10.6%
77	Fungemia	10.5%
78	Mycetoma	10.3%
79	Bacterial Endocarditis	10.2%
80	Uterine Cervical Incompetence	10.1%
81	Endophthalmitis	10.1%
82	Peritonitis	10.1%
83	Pertussis	10%
84	Lymphogranuloma Venereum	10%
85	Osteomyelitis	9.9%
86	Periostitis	9.9%
87	Surgical Wound Infection	9.9%
88	Abscess	9.8%
89	Empyema	9.8%
90	Psoas Abscess	9.8%
91	Abdominal Abscess	9.8%
92	Endometrial Neoplasms	9.6%
93	granulosa cell tumor	9.4%
94	Carcinoma, Ovarian Epithelial	9.4%
95	Dyspareunia	9.3%
96	Joint Tuberculosis	9.3%
97	Tuberculosis, Osteoarticular	9.3%
98	Bone Tuberculosis	9.3%
99	Candidiasis, Chronic Mucocutaneous	9.3%
100	Cutaneous Candidiasis	9.3%
101	Vesicovaginal Fistula	8.9%
102	Central Nervous System Infection	8.8%
103	Erysipelas	8.7%
104	Staphylococcal Skin Infections	8.7%
105	Trichomonas Vaginitis	8.6%
106	Uterine Perforation	8.6%
107	Metrorrhagia	8.5%
108	Chromoblastomycosis	8.5%
109	Dermatophytosis	8.5%
110	Sporotrichosis	8.5%
111	Tinea	8.5%
112	Tinea Versicolor	8.5%
113	Trichophytosis	8.5%
114	Hyalohyphomycosis	8.5%
115	Erythrasma	8.4%
116	Brain Abscess	8.3%
117	Candidemia	8.3%
118	Superinfection	8.2%
119	Central Nervous System Bacterial Infections	8.2%
120	Tuberculosis, Renal	8.1%
121	Corneal Ulcer	8.1%
122	Spondylitis	7.9%
123	Appendicitis	7.9%
124	Pyomyositis	7.9%
125	Endotoxic shock	7.8%
126	Septic Shock	7.8%
127	Toxic Shock Syndrome	7.8%
128	Urinary Bladder Diseases	7.6%
129	Kidney Diseases	7.6%
130	Ureteral Diseases	7.6%
131	Urethral Diseases	7.6%
132	Urination Disorders	7.6%
133	Urolithiasis	7.6%
134	Panophthalmitis	7.5%
135	Ecthyma	7.5%
136	Subacute Bacterial Endocarditis	7.5%
137	Genital Neoplasms, Female	7.4%
138	Erythema Chronicum Migrans	7.4%
139	Impetigo	7.4%
140	Diverticulitis	7.3%
141	Hordeolum	7.2%
142	Bladder Exstrophy	7.1%
143	Bacterial conjunctivitis	7.1%
144	Epispadias	7.1%
145	Blastomycosis	7%
146	Staphylococcal Scalded Skin Syndrome	7%
147	Menorrhagia	6.8%
148	Fusariosis	6.8%
149	Aspergillosis	6.7%
150	Candidiasis	6.7%
151	Coccidioidomycosis	6.7%
152	Histoplasmosis	6.7%
153	Paracoccidioidomycosis	6.7%
154	Zygomycosis	6.7%
155	Gram-Negative Bacterial Infections	6.7%
156	Gram-Positive Bacterial Infections	6.7%
157	Phaeohyphomycosis	6.7%
158	Pneumocystis Infections	6.7%
159	Borrelia Infections	6.6%
160	Leptospirosis	6.6%
161	Anuria	6.6%
162	Ureterolithiasis	6.6%
163	Nephrolithiasis	6.6%
164	Arthritis, Reactive	6.5%
165	Multicystic Dysplastic Kidney	6.4%
166	Liver Abscess	6.2%
167	carbuncle	6.1%
168	Lung Abscess	6.1%
169	Furunculosis	6.1%
170	furuncle	6.1%
171	Urologic Neoplasms	6%
172	Endometrial Stromal Sarcoma	6%
173	Horseshoe Kidney	6%
174	Tuberculosis, Spinal	6%
175	Diverticulum	6%
176	Diverticulosis	6%
177	Discitis	5.8%
178	Lyme Disease	5.8%
179	Mastoiditis	5.8%
180	Relapsing Fever	5.8%
181	Petrositis	5.8%
182	Rhinoscleroma	5.8%
183	AIDS-Related Opportunistic Infections	5.8%
184	Bladder neck obstruction	5.7%
185	Tinea Capitis	5.7%
186	Onychomycosis	5.7%
187	Polyhydramnios	5.6%
188	Obstetric Labor Complications	5.6%
189	Ectopic Pregnancy	5.6%
190	Pregnancy, Prolonged	5.6%
191	Puerperal Disorders	5.6%
192	Oligohydramnios	5.6%
193	Prenatal Injuries	5.6%
194	Urinary Bladder Fistula	5.6%
195	Bladder Neoplasm	5.6%
196	Kidney Neoplasm	5.6%
197	Ureteral Neoplasms	5.6%
198	Urethral Neoplasms	5.6%
199	Lyme Neuroborreliosis	5.3%
200	Ophthalmia Neonatorum	5.3%
201	Trachoma	5.3%
202	Neuroaspergillosis	5.3%
203	Otomycosis	5.1%
204	Hermaphroditism	5.1%
205	Disorders of Sex Development	5.1%
206	Piedra	5%
207	Central Nervous System Fungal Infections	5%
208	Hypospadias	5%
209	Abruptio Placentae	5%
210	Placenta Accreta	5%
211	Retropharyngeal Abscess	4.9%
212	Cystitis	4.9%
213	Hydronephrosis	4.9%
214	Hyperoxaluria	4.9%
215	Kidney Cortex Necrosis	4.9%
216	Kidney Papillary Necrosis	4.9%
217	Nephritis	4.9%
218	Nephrosclerosis	4.9%
219	Nephrosis	4.9%
220	Perinephritis	4.9%
221	Kidney Failure	4.9%
222	Uremia	4.9%
223	Ureteral obstruction	4.9%
224	Ureterocele	4.9%
225	Urethral Obstruction	4.9%
226	Urethritis	4.9%
227	Vesico-Ureteral Reflux	4.9%
228	Urinary Retention	4.9%
229	Epidural Abscess	4.9%
230	Oxalosis	4.9%
231	Renal Insufficiency	4.9%
232	Human Ehrlichiosis	4.9%
233	Neurosyphilis	4.9%
234	Peritonsillar Abscess	4.9%
235	Tinea Pedis	4.8%
236	Kidney Calculi	4.8%
237	Ureteral Calculi	4.8%
238	Invasive Pulmonary Aspergillosis	4.6%
239	Erythema Induratum	4.6%
240	Japanese Spotted Fever	4.5%
241	Chorioamnionitis	4.4%
242	Fetal Diseases	4.4%
243	Pregnancy Complications, Cardiovascular	4.4%
244	Pregnancy Complications, Neoplastic	4.4%
245	Pyelocystitis	4.4%
246	Actinomycetales Infections	4.4%
247	Bordetella Infections	4.4%
248	Brucellosis	4.4%
249	Campylobacter infection	4.4%
250	Clostridium Infections	4.4%
251	Enterobacteriaceae Infections	4.4%
252	Listeriosis	4.4%
253	Mucormycosis	4.4%
254	Pseudomonas Infections	4.4%
255	Q Fever	4.4%
256	Staphylococcal Infections	4.4%
257	Streptococcal Infections	4.4%
258	Vibrio Infections	4.4%
259	Helicobacter Infections	4.4%
260	Bacillaceae Infections	4.4%
261	Neisseriaceae Infections	4.4%
262	Burkholderia Infections	4.4%
263	Clostridium difficile infection	4.4%
264	Flavobacteriaceae Infections	4.4%
265	Moraxellaceae Infections	4.4%
266	Burkholderia cepacia Infection	4.4%
267	Pregnancy Complications, Hematologic	4.3%
268	Fetal Death	4.2%
269	Perinatal death	4.2%
270	Morning Sickness	4.2%
271	Toxoplasmosis, Cerebral	4.2%
272	Lung Diseases, Fungal	4.1%
273	Human anaplasmosis	4.1%
274	Pneumonia, Bacterial	4%
275	Diabetes Insipidus	4%
276	Hepatorenal Syndrome	4%
277	Pyelonephritis	4%
278	Diabetic Nephropathy	3.9%
279	Glycosuria	3.9%
280	Hematuria	3.9%
281	Renal hypertension	3.9%
282	Oliguria	3.9%
283	Polyuria	3.9%
284	Postpartum Hemorrhage	3.9%
285	Proteinuria	3.9%
286	Renal Artery Obstruction	3.9%
287	Renal Artery Stenosis	3.9%
288	Urinary Calculi	3.9%
289	Cystocele	3.9%
290	Nephrocalcinosis	3.9%
291	Urinary Incontinence	3.9%
292	Rocky Mountain Spotted Fever	3.8%
293	Meningitis, Cryptococcal	3.8%
294	Glomerulonephritis	3.6%
295	Nephritis, Interstitial	3.6%
296	Lipoid nephrosis	3.6%
297	Nephrotic Syndrome	3.6%
298	Pyelitis	3.6%
299	Pyonephrosis	3.6%
300	Urethral Stenosis	3.6%
301	Nephrogenic Diabetes Insipidus	3.6%
302	Congenital Nephrogenic Diabetes Insipidus	3.6%
303	Acute kidney injury	3.6%
304	Urethral stricture	3.6%
305	Mesoblastic Nephroma	3.6%
306	Renal Cell Carcinoma	3.6%
307	Papillary Renal Cell Carcinoma	3.6%
308	Erysipelothrix infection	3.5%
309	Gestational Diabetes	3.4%
310	Oral candidiasis	3.4%
311	Enuresis	3.3%
312	Pulmonary Aspergillosis	3.3%
313	Bronchopulmonary Aspergillosis	3.3%
314	Abortion, Habitual	3.3%
315	Dystocia	3.3%
316	Eclampsia	3.3%
317	Fetal Membranes, Premature Rupture	3.3%
318	Placental Insufficiency	3.3%
319	Pre-Eclampsia	3.3%
320	Prenatal Exposure Delayed Effects	3.3%
321	HELLP Syndrome	3.3%
322	Placenta, Retained	3.3%
323	Syphilis, Congenital	3.3%
324	Gonadal Dysgenesis	3.3%
325	Adrenogenital Syndrome	3.3%
326	Ovotesticular Disorders of Sex Development	3.3%
327	Acinetobacter Infections	3.3%
328	Actinomycosis	3.3%
329	Bacteroides Infections	3.3%
330	Cholera	3.3%
331	Corynebacterium Infections	3.3%
332	Escherichia coli Infections	3.3%
333	Gas Gangrene	3.3%
334	Haemophilus Infections	3.3%
335	Klebsiella Infections	3.3%
336	Meningococcal Infections	3.3%
337	Mycobacterium Infections	3.3%
338	Mycoplasma Infections	3.3%
339	Nocardia Infections	3.3%
340	Pasteurella Infections	3.3%
341	Pneumococcal Infections	3.3%
342	Proteus Infections	3.3%
343	Rickettsia Infections	3.3%
344	Salmonella infections	3.3%
345	Scarlet Fever	3.3%
346	Scrub Typhus	3.3%
347	Tetanus	3.3%
348	Serratia Infections	3.3%
349	Ureaplasma Infections	3.3%
350	Pulmonary Nocardiosis	3.3%
351	Meningitis, Listeria	3.2%
352	Glycosuria, Renal	3.2%
353	Liver Abscess, Amebic	3.2%
354	Balkan Nephropathy	3%
355	Focal glomerulosclerosis	3%
356	Kidney Failure, Chronic	3%
357	Azotemia	3%
358	Meningitis, Haemophilus	3%
359	Meningitis, Pneumococcal	3%
360	Nephroblastoma	2.9%
361	Albuminuria	2.9%
362	Hemoglobinuria	2.9%
363	Hypertension, Renovascular	2.9%
364	Urge Incontinence	2.9%
365	Hyperandrogenism	2.9%
366	AIDS-Associated Nephropathy	2.8%
367	Denys-Drash Syndrome	2.8%
368	Diphtheria	2.7%
369	Leprosy	2.7%
370	Mycobacterium Infections, Nontuberculous	2.7%
371	Psittacosis	2.7%
372	Paratyphoid Fever	2.7%
373	Plague	2.7%
374	Tuberculosis	2.7%
375	Typhoid Fever	2.7%
376	TYPHUS	2.7%
377	Yersinia pseudotuberculosis Infections	2.7%
378	Bubonic Plague	2.7%
379	Mycobacterium abscessus Infection	2.7%
380	Meningitis, Bacterial	2.6%
381	Meningitis, Fungal	2.6%
382	Abortion, Veterinary	2.6%
383	Pregnancy Complications, Parasitic	2.6%
384	Glomerulonephritis, Membranoproliferative	2.5%
385	Lactation Disorder	2.5%
386	Mastitis	2.5%
387	Depression, Postpartum	2.5%
388	Embryo Loss	2.5%
389	Fetal Resorption	2.5%
390	Polycystic Kidney Diseases	2.5%
391	Hyperemesis Gravidarum	2.4%
392	Diurnal Enuresis	2.4%
393	Renal Aminoacidurias	2.4%
394	Fanconi Syndrome	2.4%
395	Mycobacterium avium-intracellulare Infection	2.4%
396	Pseudohypoaldosteronism	2.4%
397	Lymph Node Tuberculosis	2.4%
398	Tuberculosis, Miliary	2.4%
399	Tuberculosis, Multidrug-Resistant	2.4%
400	Liddle Syndrome	2.4%
401	Leprosy, Multibacillary	2.4%
402	Latent Tuberculosis	2.4%
403	Hemolytic-Uremic Syndrome	2.4%
404	Tuberculosis, Meningeal	2.4%
405	Borderline leprosy	2.3%
406	Leprosy, Lepromatous	2.3%
407	Tuberculoid leprosy	2.3%
408	Extensively Drug-Resistant Tuberculosis	2.3%
409	Premature Birth	2.2%
410	Renal Osteodystrophy	2.2%
411	Renal rickets	2.2%
412	Salmonella Infections, Animal	2.1%
413	Renal tubular acidosis	2.1%
414	Rheumatic Heart Disease	2.1%
415	Anti-Glomerular Basement Membrane Disease	2.1%
416	Salmonella food poisoning	2%
417	Lupus Nephritis	2%
418	Fetal Growth Retardation	2%
419	Trophoblastic Neoplasms	2%
420	Polycystic Kidney, Autosomal Dominant	2%
421	Cystinuria	2%
422	Embolism, Amniotic Fluid	2%
423	Rheumatic Fever	2%
424	Fetal Hypoxia	2%
425	Atypical Hemolytic Uremic Syndrome	2%
426	Fetal Alcohol Spectrum Disorders	2%
427	Breech Presentation	2%
428	Stillbirth	2%
429	Enterocolitis, Pseudomembranous	1.9%
430	pseudomembranous colitis	1.9%
431	Dysentery, Bacillary	1.9%
432	Turner Syndrome	1.9%
433	Tuberculosis, Gastrointestinal	1.9%
434	Kallmann Syndrome	1.8%
435	Tuberculosis, Central Nervous System	1.8%
436	Botulism	1.7%
437	Zellweger Syndrome	1.6%
438	Galactorrhea	1.6%
439	Hyperphosphaturia	1.6%
440	Klinefelter Syndrome	1.6%
441	Tuberculosis, Pulmonary	1.5%
442	Meconium Aspiration Syndrome	1.5%
443	Aspergillosis, Allergic Bronchopulmonary	1.4%
444	Waterhouse-Friderichsen Syndrome	1.4%
445	Choriocarcinoma	1.1%
446	Lemierre Syndrome	1%
447	Hydatidiform Mole	1%
448	Familial Hypophosphatemic Rickets	0.9%
449	Hydrops Fetalis	0.7%

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