MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Polyhydramnios

(UMLS:C0020224)

Definition:: A condition of abnormally high AMNIOTIC FLUID volume, such as greater than 2,000 ml in the LAST TRIMESTER and usually diagnosed by ultrasonographic criteria (AMNIOTIC FLUID INDEX). It is associated with maternal DIABETES MELLITUS; MULTIPLE PREGNANCY; CHROMOSOMAL DISORDERS; and congenital abnormalities.
UMLS ID:: C0020224
MeSH ID:: D006831

Classification:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.703.610

Synonym(s)

Polyhydramnios

Excessive liquor

HYDRAMNIOS

High levels of amniotic fluid

Hydramnios

Hydrops amnion

Hydrops of amnion

POLYHYDRAMNIOS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Metformin	FAERS: 16		US FAERS
2	Paroxetine	FAERS: 11 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Sertraline	FAERS: 9		US FAERS
4	Metformin	FAERS: 7		US FAERS
5	Thyroxine	FAERS: 6		US FAERS
6	Valproic Acid	FAERS: 6		US FAERS
7	Lithium Carbonate	FAERS: 5		US FAERS
8	Insulin Glargine	FAERS: 4		US FAERS
9	Isotretinoin	FAERS: 4		US FAERS
10	Lamotrigine	FAERS: 4		OFFSIDES US FAERS
11	Norgestrel	FAERS: 4		US FAERS
12	Ondansetron	FAERS: 4		US FAERS
13	17 alpha-Hydroxyprogesterone Caproate	FAERS: 3		US FAERS
14	Fluoxetine	FAERS: 3		US FAERS
15	Hydroxyurea	FAERS: 3		US FAERS
16	Lopinavir	FAERS: 3		US FAERS
17	Warfarin	FAERS: 3		US FAERS
18	Amlodipine	FAERS: 2		US FAERS
19	Bisoprolol	FAERS: 2		US FAERS
20	Citalopram	FAERS: 2		US FAERS
21	Citalopram	FAERS: 2		US FAERS
22	Dexamethasone	FAERS: 2		US FAERS
23	Ergotamine	FAERS: 2		US FAERS
24	Fingolimod Hydrochloride	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
25	Lacosamide	FAERS: 2		OFFSIDES US FAERS
26	Levetiracetam	FAERS: 2		US FAERS
27	Propylthiouracil	FAERS: 2		US FAERS
28	Tacrolimus	FAERS: 2		US FAERS
29	cefuroxime axetil	FAERS: 2		OFFSIDES US FAERS
30	pimecrolimus	FAERS: 2		OFFSIDES US FAERS
31	reviparin	FAERS: 2		US FAERS
32	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
33	Acetaminophen	FAERS: 1		US FAERS
34	Acyclovir	FAERS: 1		US FAERS
35	Albendazole	FAERS: 1		OFFSIDES US FAERS
36	Ambenonium Chloride	FAERS: 1		US FAERS
37	Betamethasone	FAERS: 1		US FAERS
38	Bromocriptine	FAERS: 1		US FAERS
39	Carbamazepine	FAERS: 1		US FAERS
40	Citalopram	FAERS: 1		US FAERS
41	Copper	FAERS: 1		US FAERS
42	Cyclosporine	FAERS: 1		US FAERS
43	Cysteamine	FAERS: 1		US FAERS
44	Diclofenac	FAERS: 1		US FAERS
45	Digoxin	FAERS: 1		US FAERS
46	Duloxetine Hydrochloride	FAERS: 1		US FAERS
47	Dutasteride	FAERS: 1		OFFSIDES US FAERS
48	Flurbiprofen	FAERS: 1		US FAERS
49	Furosemide	FAERS: 1		US FAERS
50	Glatiramer Acetate	FAERS: 1		US FAERS
51	Imatinib Mesylate	FAERS: 1		US FAERS
52	Indomethacin	FAERS: 1	View details 1748938 2405319 8163032 8379817 8498410 8843476 9507041 11677312	CTD OFFSIDES US FAERS
53	Lamivudine	FAERS: 1		US FAERS
54	Methimazole	FAERS: 1		US FAERS
55	Modafinil	FAERS: 1		US FAERS
56	Nicotine	FAERS: 1		US FAERS
57	Paroxetine	FAERS: 1		US FAERS
58	Pregabalin	FAERS: 1		US FAERS
59	Procysbi	FAERS: 1		US FAERS
60	Progesterone	FAERS: 1		US FAERS
61	Rosuvastatin Calcium	FAERS: 1		US FAERS
62	Sertraline	FAERS: 1		US FAERS
63	Sulindac	FAERS: 1		US FAERS
64	Tenofovir	FAERS: 1		US FAERS
65	Thyroxine	FAERS: 1		US FAERS
66	Varenicline	FAERS: 1		US FAERS
67	montelukast	FAERS: 1		US FAERS
68	Aripiprazole			OFFSIDES
69	Azathioprine			OFFSIDES
70	Bromocriptine			OFFSIDES
71	Buprenorphine			OFFSIDES
72	Bupropion			OFFSIDES
73	Cabergoline			OFFSIDES
74	Clomiphene			OFFSIDES
75	Clomipramine			OFFSIDES
76	Clorazepate Dipotassium			OFFSIDES
77	Dapsone			OFFSIDES
78	Darunavir			OFFSIDES
79	Hydroxyzine			OFFSIDES
80	Isradipine			OFFSIDES
81	Lactulose			OFFSIDES
82	Lithium	Canada Vigilance: 1	2199873	CTD Canada Vigilance
83	Lofepramine			OFFSIDES
84	Mannitol			OFFSIDES
85	Medroxyprogesterone			SIDER
86	Mefenamic Acid		1930046	CTD
87	Methyldopa			OFFSIDES
88	Mycophenolic Acid			OFFSIDES
89	Olopatadine Hydrochloride			OFFSIDES
90	Penicillin G			OFFSIDES
91	Potassium Iodide			OFFSIDES
92	Prazepam			OFFSIDES
93	Saquinavir			OFFSIDES
94	Sulfate			OFFSIDES
95	Tenofovir			OFFSIDES
96	Terbutaline			OFFSIDES
97	cyamemazine			OFFSIDES
98	etravirine			OFFSIDES
99	lamivudine, zidovudine drug combination			OFFSIDES
100	tetrazepam			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Obstetric Labor Complications	42.9%
2	Ectopic Pregnancy	42.9%
3	Pregnancy, Prolonged	42.9%
4	Puerperal Disorders	42.9%
5	Oligohydramnios	42.9%
6	Prenatal Injuries	42.9%
7	Abruptio Placentae	40.9%
8	Placenta Accreta	40.9%
9	Chorioamnionitis	34.7%
10	Abortion, Habitual	31%
11	Dystocia	31%
12	Eclampsia	31%
13	Fetal Membranes, Premature Rupture	31%
14	Placental Insufficiency	31%
15	Pre-Eclampsia	31%
16	Prenatal Exposure Delayed Effects	31%
17	HELLP Syndrome	31%
18	Placenta, Retained	31%
19	Puerperal Infection	30.5%
20	Postpartum Hemorrhage	30.3%
21	Fetal Diseases	30%
22	Pregnancy Complications, Cardiovascular	30%
23	Pregnancy Complications, Neoplastic	30%
24	Pregnancy Complications, Hematologic	28.6%
25	Pregnancy Complications, Infectious	28.6%
26	Fetal Death	27.9%
27	Perinatal death	27.9%
28	Morning Sickness	27.6%
29	Uterine Inversion	25.8%
30	Premature Birth	25.4%
31	Female Urogenital Diseases	23.1%
32	Abortion, Veterinary	22%
33	Pregnancy Complications, Parasitic	22%
34	Uterine Cervical Incompetence	21.5%
35	Gestational Diabetes	20.9%
36	Lactation Disorder	20.5%
37	Mastitis	20.5%
38	Depression, Postpartum	20.5%
39	Embryo Loss	20.5%
40	Fetal Resorption	20.2%
41	Hyperemesis Gravidarum	20.1%
42	Uterine Rupture	19.7%
43	Galactorrhea	16.7%
44	Fetal Growth Retardation	15.5%
45	Trophoblastic Neoplasms	15.5%
46	Embolism, Amniotic Fluid	15.4%
47	Fetal Hypoxia	15.4%
48	Fetal Alcohol Spectrum Disorders	15.4%
49	Breech Presentation	15%
50	Stillbirth	14.9%
51	Hydatidiform Mole	11.1%
52	Endometritis	10.5%
53	Meconium Aspiration Syndrome	10.5%
54	Endometriosis	10.3%
55	Uterine Diseases	10.3%
56	Vaginal Diseases	10.3%
57	Vulvar Diseases	10.3%
58	Endometrioma	10.3%
59	Urologic Diseases	10%
60	Choriocarcinoma	9.9%
61	Salpingitis	9.9%
62	Vulvovaginitis	9.9%
63	Endometrial Hyperplasia	8.5%
64	Pyometra	8.5%
65	Vaginitis	8.5%
66	Vulvitis	8.5%
67	Vaginal Discharge	8.5%
68	Vulvodynia	8.5%
69	Uterine Neoplasms	8.3%
70	Vaginal Neoplasms	8.3%
71	Vulvar Neoplasms	8.3%
72	Uterine Cancer	8.3%
73	Fallopian Tube Neoplasms	7.8%
74	Uterine Cervicitis	7.6%
75	Leukorrhea	7.6%
76	Parametritis	7.6%
77	Oophoritis	7.4%
78	Urogenital Abnormalities	7.4%
79	Endometrial Neoplasms	7.3%
80	Vesicovaginal Fistula	7.3%
81	Candidiasis, Vulvovaginal	7%
82	Urinary Bladder Diseases	7%
83	Infertility	7%
84	Kidney Diseases	7%
85	Ureteral Diseases	7%
86	Urethral Diseases	7%
87	Urination Disorders	7%
88	Urolithiasis	7%
89	Genital Neoplasms, Female	6.8%
90	Anuria	6.7%
91	Ureterolithiasis	6.7%
92	Nephrolithiasis	6.7%
93	Bladder neck obstruction	6.3%
94	Hydrops Fetalis	6.2%
95	Bladder Exstrophy	6.2%
96	Epispadias	6.2%
97	Tuberculosis, Renal	6.1%
98	Carcinoma, Endometrioid	6%
99	Multicystic Dysplastic Kidney	5.9%
100	Ovarian Diseases	5.7%
101	Pyelocystitis	5.7%
102	Adnexitis	5.6%
103	Cystitis	5.6%
104	Hydronephrosis	5.6%
105	Hyperoxaluria	5.6%
106	Kidney Cortex Necrosis	5.6%
107	Kidney Papillary Necrosis	5.6%
108	Nephritis	5.6%
109	Nephrosclerosis	5.6%
110	Nephrosis	5.6%
111	Perinephritis	5.6%
112	Pruritus Vulvae	5.6%
113	Kidney Failure	5.6%
114	Uremia	5.6%
115	Ureteral obstruction	5.6%
116	Ureterocele	5.6%
117	Urethral Obstruction	5.6%
118	Urethritis	5.6%
119	Uterine hemorrhage	5.6%
120	Vaginal Fistula	5.6%
121	Vesico-Ureteral Reflux	5.6%
122	Urinary Retention	5.6%
123	Pelvic Inflammatory Disease	5.6%
124	Oxalosis	5.6%
125	Renal Insufficiency	5.6%
126	Uterine Prolapse	5.6%
127	Vaginal Prolapse	5.6%
128	Urinary Bladder Fistula	5.5%
129	Bladder Neoplasm	5.5%
130	Kidney Neoplasm	5.5%
131	Ureteral Neoplasms	5.5%
132	Urethral Neoplasms	5.5%
133	Pyelonephritis	5.5%
134	Kidney Calculi	5.5%
135	Ureteral Calculi	5.5%
136	Endometrial Stromal Sarcoma	5.4%
137	ovarian neoplasm	5.3%
138	Urinary tract infection	5.3%
139	Urologic Neoplasms	5.2%
140	Horseshoe Kidney	5.2%
141	Bacterial Vaginosis	5.1%
142	Trichomonas Vaginitis	5%
143	Uterine Perforation	5%
144	Ovarian Hyperstimulation Syndrome	5%
145	Glomerulonephritis	5%
146	Metrorrhagia	5%
147	Nephritis, Interstitial	5%
148	Lipoid nephrosis	5%
149	Nephrotic Syndrome	5%
150	Pyelitis	5%
151	Pyonephrosis	5%
152	Urethral Stenosis	5%
153	Nephrogenic Diabetes Insipidus	5%
154	Congenital Nephrogenic Diabetes Insipidus	5%
155	Acute kidney injury	5%
156	Urethral stricture	5%
157	Balkan Nephropathy	4.7%
158	Focal glomerulosclerosis	4.7%
159	Kidney Failure, Chronic	4.7%
160	Sexually Transmitted Diseases	4.3%
161	Diabetes Insipidus	4.3%
162	Hepatorenal Syndrome	4.3%
163	Dyspareunia	4.3%
164	Bacteriuria	4.2%
165	Diabetic Nephropathy	4.2%
166	Glycosuria	4.2%
167	Hematuria	4.2%
168	Renal hypertension	4.2%
169	Oliguria	4.2%
170	Polyuria	4.2%
171	Proteinuria	4.2%
172	Pyuria	4.2%
173	Renal Artery Obstruction	4.2%
174	Renal Artery Stenosis	4.2%
175	Urinary Calculi	4.2%
176	Mesoblastic Nephroma	4.2%
177	Renal Cell Carcinoma	4.2%
178	Cystocele	4.2%
179	Hermaphroditism	4.2%
180	Nephrocalcinosis	4.2%
181	Disorders of Sex Development	4.2%
182	Urinary Incontinence	4.2%
183	Papillary Renal Cell Carcinoma	4.2%
184	Hypospadias	4.1%
185	granulosa cell tumor	4.1%
186	Carcinoma, Ovarian Epithelial	4.1%
187	Genital Herpes	4.1%
188	Corpus Luteum Cyst	3.8%
189	Ovarian Cysts	3.8%
190	Azotemia	3.8%
191	Anovulation	3.7%
192	Menorrhagia	3.7%
193	Albuminuria	3.7%
194	Hemoglobinuria	3.7%
195	Hypertension, Renovascular	3.7%
196	Premature Menopause	3.7%
197	Urge Incontinence	3.7%
198	Glomerulonephritis, Membranoproliferative	3.7%
199	Glycosuria, Renal	3.7%
200	Polycystic Ovary Syndrome	3.5%
201	Enuresis	3.4%
202	Gonadal Dysgenesis	3.3%
203	Adrenogenital Syndrome	3.3%
204	Ovotesticular Disorders of Sex Development	3.3%
205	Nephroblastoma	3.3%
206	Hyperandrogenism	3.2%
207	Denys-Drash Syndrome	3.2%
208	Polycystic Kidney Diseases	3%
209	Diurnal Enuresis	3%
210	Renal Aminoacidurias	3%
211	Fanconi Syndrome	3%
212	Pseudohypoaldosteronism	3%
213	Liddle Syndrome	3%
214	Hemolytic-Uremic Syndrome	2.9%
215	Anti-Glomerular Basement Membrane Disease	2.8%
216	Lupus Nephritis	2.8%
217	Polycystic Kidney, Autosomal Dominant	2.8%
218	Cystinuria	2.8%
219	AIDS-Associated Nephropathy	2.8%
220	Atypical Hemolytic Uremic Syndrome	2.8%
221	Chlamydia Infections	2.5%
222	Gonorrhea	2.5%
223	Renal tubular acidosis	2.5%
224	Lymphogranuloma Venereum	2.3%
225	Kallmann Syndrome	2.1%
226	Syphilis	2.1%
227	Turner Syndrome	2.1%
228	Renal Osteodystrophy	2%
229	Renal rickets	2%
230	Hyperphosphaturia	1.8%
231	Klinefelter Syndrome	1.8%
232	Zellweger Syndrome	1.5%
233	Familial Hypophosphatemic Rickets	1%

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