MetaADEDB 2.0 @ LMMD
obeticholic acid
(ZXERDUOLZKYMJM-ZWECCWDJSA-N)
Structure
SMILES
CC[C@H]1[C@@H](O)[C@H]2[C@@H]3CC[C@@H]([C@@]3(C)CC[C@@H]2[C@@]2([C@H]1C[C@H](O)CC2)C)[C@@H](CCC(=O)O)C
Type(s)
Approved
ATC code(s)
A05AA04
Molecular Formula:
C26H44O4
Molecular Weight:
420.625
Log P:
5.1140
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
3
TPSA:
77.76
CAS Number(s):
459789-99-2
Synonym(s)
1.
obeticholic acid
2.
6-ECDCA
3.
6-ethyl chenodeoxycholic acid
4.
6-ethyl-3,7-dihydroxycholan-24-oic acid
5.
6-ethylchenodeoxycholic acid
6.
6ECDCA
7.
6alpha-ethyl-3alpha,7alpha-dihydroxy-5beta-cholan-24-oic acid
8.
6alpha-ethyl-chenodeoxycholic acid
9.
DSP-1747
10.
DSP1747
11.
INT 747
12.
INT-747
13.
INT747
14.
Ocaliva
15.
cholan-24-oic acid, 6-ethyl-3,7-dihydroxy-, (3alpha,5beta,6alpha,7alpha)-
External Link(s)
MeSHC464660
PubChem Compound447715
BindingDB21675
ChEBI43602
CHEMBLCHEMBL566315
DrugBankDB05990
DrugCentral5155
IUPHAR/BPS Guide to PHARMACOLOGY3435
KEGGcpd:C15636
dr:D09360
Therapeutic Target DatabaseD0M4WA
ZINC14164617
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PruritusFAERS: 936
Canada Vigilance: 3
Canada Vigilance
US FAERS
2FatigueFAERS: 308
Canada Vigilance: 1
Canada Vigilance
US FAERS
3Drug ineffectiveFAERS: 112
Canada Vigilance: 1
Canada Vigilance
US FAERS
4ArthralgiaFAERS: 108US FAERS
5NauseaFAERS: 98
Canada Vigilance: 2
Canada Vigilance
US FAERS
6ConstipationFAERS: 97
Canada Vigilance: 1
Canada Vigilance
US FAERS
7Drug dose omissionFAERS: 88US FAERS
8DizzinessFAERS: 78US FAERS
9Blood alkaline phosphatase increasedFAERS: 63
Canada Vigilance: 1
Canada Vigilance
US FAERS
10MalaiseFAERS: 61
Canada Vigilance: 1
Canada Vigilance
US FAERS
11HeadacheFAERS: 45
Canada Vigilance: 1
Canada Vigilance
US FAERS
12AstheniaFAERS: 40US FAERS
13Abdominal PainFAERS: 38US FAERS
14VomitingFAERS: 38US FAERS
15Product dose omissionFAERS: 37US FAERS
16Peripheral swellingFAERS: 34
Canada Vigilance: 1
Canada Vigilance
US FAERS
17Abdominal discomfortFAERS: 32US FAERS
18AlopeciaFAERS: 31US FAERS
19PainFAERS: 30US FAERS
20Dry skinFAERS: 29US FAERS
21Back PainFAERS: 28US FAERS
22HypersensitivityFAERS: 28US FAERS
23SomnolenceFAERS: 28US FAERS
24Weight decreasedFAERS: 28
Canada Vigilance: 1
Canada Vigilance
US FAERS
25Feeling abnormalFAERS: 23US FAERS
26InfluenzaFAERS: 23US FAERS
27UrticariaFAERS: 21US FAERS
28Oropharyngeal painFAERS: 20US FAERS
29MyalgiaFAERS: 19US FAERS
30PneumoniaFAERS: 18US FAERS
31Blood cholesterol increasedFAERS: 17US FAERS
32Memory impairmentFAERS: 17US FAERS
33AscitesFAERS: 16US FAERS
34SwellingFAERS: 16US FAERS
35PalpitationsFAERS: 15US FAERS
36Therapy cessationFAERS: 15US FAERS
37jaundiceFAERS: 15US FAERS
38Disease ProgressionFAERS: 14US FAERS
39Urinary tract infectionFAERS: 14US FAERS
40Joint swellingFAERS: 13US FAERS
41NasopharyngitisFAERS: 13US FAERS
42TremorFAERS: 13US FAERS
43ChromaturiaFAERS: 12US FAERS
44AnxietyFAERS: 11US FAERS
45Bone painFAERS: 11US FAERS
46SinusitisFAERS: 11US FAERS
47Blood alkaline phosphatase abnormalFAERS: 10US FAERS
48DysgeusiaFAERS: 10US FAERS
49Product prescribing errorFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
50EczemaFAERS: 9US FAERS
51ErythemaFAERS: 9US FAERS
52Night sweatsFAERS: 9US FAERS
53Adverse eventFAERS: 8US FAERS
54Chest PainFAERS: 8US FAERS
55Hepatic EncephalopathyFAERS: 8US FAERS
56DehydrationFAERS: 7US FAERS
57EpistaxisFAERS: 7US FAERS
58Ocular icterusFAERS: 7US FAERS
59ArthritisFAERS: 6US FAERS
60ChillsFAERS: 6US FAERS
61Depressed moodFAERS: 6US FAERS
62DyspepsiaFAERS: 6US FAERS
63FlatulenceFAERS: 6US FAERS
64InfectionFAERS: 6US FAERS
65NervousnessFAERS: 6US FAERS
66Portal HypertensionFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
67Product use in unapproved indicationFAERS: 6US FAERS
68Therapy non-responderFAERS: 6US FAERS
69Atrial FibrillationFAERS: 5US FAERS
70Cerebrovascular accidentFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
71Drug prescribing errorFAERS: 5US FAERS
72Flank PainFAERS: 5US FAERS
73General physical health deteriorationFAERS: 5US FAERS
74HypotensionFAERS: 5US FAERS
75Loss of personal independence in daily activitiesFAERS: 5US FAERS
76Medication ErrorFAERS: 5US FAERS
77Meniscus injuryFAERS: 5US FAERS
78Mood swingsFAERS: 5US FAERS
79Myocardial InfarctionFAERS: 5US FAERS
80ScabFAERS: 5US FAERS
81Throat irritationFAERS: 5US FAERS
82Blood glucose increasedFAERS: 4US FAERS
83Burning sensationFAERS: 4US FAERS
84Chest discomfortFAERS: 4US FAERS
85CystFAERS: 4US FAERS
86Feeling jitteryFAERS: 4US FAERS
87Fluid overloadFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
88Inappropriate schedule of drug administrationFAERS: 4US FAERS
89Irritable Bowel SyndromeFAERS: 4US FAERS
90Limb injuryFAERS: 4US FAERS
91Pain of skinFAERS: 4US FAERS
92Product use issueFAERS: 4US FAERS
93Skin UlcerFAERS: 4US FAERS
94Wrong technique in product usage processFAERS: 4US FAERS
95AcneFAERS: 3US FAERS
96Ammonia increasedFAERS: 3US FAERS
97Bladder painFAERS: 3US FAERS
98Blood iron decreasedFAERS: 3US FAERS
99Bowel movement irregularityFAERS: 3US FAERS
100BronchitisFAERS: 3US FAERS
101Cardiac ArrestFAERS: 3US FAERS
102Concomitant disease progressionFAERS: 3US FAERS
103DysphoniaFAERS: 3US FAERS
104Hepatorenal SyndromeFAERS: 3US FAERS
105Incorrect dose administeredFAERS: 3US FAERS
106Intentional product misuseFAERS: 3US FAERS
107LethargyFAERS: 3US FAERS
108Low density lipoprotein increasedFAERS: 3US FAERS
109Model for end stage liver disease score increasedFAERS: 3US FAERS
110Neck PainFAERS: 3US FAERS
111OnychoclasisFAERS: 3US FAERS
112PresyncopeFAERS: 3US FAERS
113Salt cravingFAERS: 3US FAERS
114SepsisFAERS: 3US FAERS
115SplenomegalyFAERS: 3US FAERS
116StomatitisFAERS: 3US FAERS
117Unevaluable eventFAERS: 3US FAERS
118White blood cell count decreasedFAERS: 3US FAERS
119skin abrasionFAERS: 3US FAERS
120Alanine Aminotransferase IncreasedFAERS: 2US FAERS
121AmnesiaFAERS: 2US FAERS
122AneurysmFAERS: 2US FAERS
123Anorectal discomfortFAERS: 2US FAERS
124AphasiaFAERS: 2US FAERS
125ArthropathyFAERS: 2US FAERS
126Bile Duct StenosisFAERS: 2US FAERS
127Bladder discomfortFAERS: 2US FAERS
128Blood albumin decreasedFAERS: 2US FAERS
129Blood cholesterol abnormalFAERS: 2US FAERS
130Blood thyroid stimulating hormone decreasedFAERS: 2US FAERS
131Blood urine presentFAERS: 2US FAERS
132Breast cancer recurrentFAERS: 2US FAERS
133CholelithiasisFAERS: 2US FAERS
134Clostridium difficile infectionFAERS: 2US FAERS
135Cold sweatFAERS: 2US FAERS
136ColitisFAERS: 221242261CTD
US FAERS
137Deep Vein ThrombosisFAERS: 2US FAERS
138Dental cariesFAERS: 2US FAERS
139DiscomfortFAERS: 2US FAERS
140Drug ineffective for unapproved indicationFAERS: 2US FAERS
141Ear discomfortFAERS: 2US FAERS
142Emergency CareFAERS: 2US FAERS
143Emotional disorderFAERS: 2US FAERS
144FibromyalgiaFAERS: 2US FAERS
145GastritisFAERS: 2US FAERS
146Gastrointestinal sounds abnormalFAERS: 2US FAERS
147Genital HerpesFAERS: 2US FAERS
148Head discomfortFAERS: 2US FAERS
149HepatitisFAERS: 2US FAERS
150HypothyroidismFAERS: 2US FAERS
151HysterectomyFAERS: 2US FAERS
152Immunosuppressant drug level increasedFAERS: 2US FAERS
153Impaired work abilityFAERS: 2US FAERS
154Initial insomniaFAERS: 2US FAERS
155Intervertebral disc disorderFAERS: 2US FAERS
156Intestinal ObstructionFAERS: 2US FAERS
157Intra-abdominal fluid collectionFAERS: 2US FAERS
158Lip swellingFAERS: 2US FAERS
159Liver transplant rejectionFAERS: 2US FAERS
160Lyme DiseaseFAERS: 2US FAERS
161Macular degenerationFAERS: 2US FAERS
162Musculoskeletal PainFAERS: 2US FAERS
163NephrolithiasisFAERS: 2US FAERS
164ObstructionFAERS: 2US FAERS
165Oral mucosal eruptionFAERS: 2US FAERS
166Oral painFAERS: 2US FAERS
167OverdoseFAERS: 2US FAERS
168Productive CoughFAERS: 2US FAERS
169PsoriasisFAERS: 2US FAERS
170Pulmonary EmbolismFAERS: 2US FAERS
171Pulmonary congestionFAERS: 2US FAERS
172Rash erythematousFAERS: 2US FAERS
173RetchingFAERS: 2US FAERS
174Rheumatoid ArthritisFAERS: 2US FAERS
175Septic ShockFAERS: 2US FAERS
176Skin reactionFAERS: 2US FAERS
177SneezingFAERS: 2US FAERS
178StressFAERS: 2US FAERS
179SunburnFAERS: 2US FAERS
180SyncopeFAERS: 2US FAERS
181Tongue discomfortFAERS: 2US FAERS
182Trigeminal NeuralgiaFAERS: 2US FAERS
183Urinary RetentionFAERS: 2US FAERS
184VertigoFAERS: 2US FAERS
185Vulvovaginal burning sensationFAERS: 2US FAERS
186Vulvovaginal pruritusFAERS: 2US FAERS
187WheezingFAERS: 2US FAERS
188muscle injuryFAERS: 2US FAERS
189Abdominal Compartment SyndromeFAERS: 1US FAERS
190Abdominal rigidityFAERS: 1US FAERS
191Abdominal tendernessFAERS: 1US FAERS
192Anal infectionFAERS: 1US FAERS
193ApathyFAERS: 1US FAERS
194Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
195AsthenopiaFAERS: 1US FAERS
196AsthmaFAERS: 1US FAERS
197AstigmatismFAERS: 1US FAERS
198AuraFAERS: 1US FAERS
199Autoimmune hepatitisFAERS: 1US FAERS
200Bacterial test positiveFAERS: 1US FAERS
201BedriddenFAERS: 1US FAERS
202Biliary ColicFAERS: 1US FAERS
203BiopsyFAERS: 1US FAERS
204Blood creatinine increasedFAERS: 1US FAERS
205Blood parathyroid hormone abnormalFAERS: 1US FAERS
206Blood phosphorus increasedFAERS: 1US FAERS
207Blood potassium decreasedFAERS: 1US FAERS
208Blood thyroid stimulating hormone increasedFAERS: 1US FAERS
209CREST SyndromeFAERS: 1US FAERS
210CachexiaFAERS: 1US FAERS
211Cardiac FlutterFAERS: 1US FAERS
212CataractFAERS: 1US FAERS
213Child-Pugh-Turcotte score increasedFAERS: 1US FAERS
214Compression fractureFAERS: 1US FAERS
215Corneal erosionFAERS: 1US FAERS
216Coronary Artery DiseaseFAERS: 1US FAERS
217CryingFAERS: 1US FAERS
218CystitisFAERS: 1US FAERS
219DeafnessFAERS: 1US FAERS
220Diabetes MellitusFAERS: 1US FAERS
221Diabetic KetoacidosisFAERS: 1US FAERS
222DisorientationFAERS: 1US FAERS
223DiverticulitisFAERS: 1US FAERS
224Drug administration errorFAERS: 1US FAERS
225Drug dispensing errorFAERS: 1US FAERS
226DysarthriaFAERS: 1US FAERS
227EcchymosisFAERS: 1US FAERS
228Electrolyte imbalanceFAERS: 1US FAERS
229EosinophiliaFAERS: 1US FAERS
230Epigastric discomfortFAERS: 1US FAERS
231EructationFAERS: 1US FAERS
232Exfoliative rashFAERS: 1US FAERS
233Eye InfectionFAERS: 1US FAERS
234Feeling ColdFAERS: 1US FAERS
235Food PoisoningFAERS: 1US FAERS
236FormicationFAERS: 1US FAERS
237Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
238Gamma-glutamyltransferase abnormalFAERS: 1US FAERS
239Gastric ulcerFAERS: 1US FAERS
240Gastroenteritis norovirusFAERS: 1US FAERS
241GlossitisFAERS: 1US FAERS
242Hair injuryFAERS: 1US FAERS
243Head titubationFAERS: 1US FAERS
244Hepatic fibrosis marker increasedFAERS: 1US FAERS
245HerniaFAERS: 1US FAERS
246Hip surgeryFAERS: 1US FAERS
247HordeolumFAERS: 1US FAERS
248Hormone level abnormalFAERS: 1US FAERS
249Hospice CareFAERS: 1US FAERS
250HungerFAERS: 1US FAERS
251HyperchlorhydriaFAERS: 1US FAERS
252HypersomniaFAERS: 1US FAERS
253HyperthyroidismFAERS: 1US FAERS
254Hypo HDL cholesterolaemiaFAERS: 1US FAERS
255HypoxiaFAERS: 1US FAERS
256Inappropriate schedule of product administrationFAERS: 1US FAERS
257Incorrect drug administration rateFAERS: 1US FAERS
258InflammationFAERS: 129660435CTD
US FAERS
259Insurance issueFAERS: 1US FAERS
260Joint Range of Motion DecreasedFAERS: 1US FAERS
261Joint injuryFAERS: 1US FAERS
262Joint stiffnessFAERS: 1US FAERS
263LacerationFAERS: 1US FAERS
264Lipids abnormalFAERS: 1US FAERS
265LymphadenitisFAERS: 1US FAERS
266LymphadenopathyFAERS: 1US FAERS
267LymphomaFAERS: 1US FAERS
268MaculeFAERS: 1US FAERS
269MalnutritionFAERS: 1US FAERS
270Mental impairmentFAERS: 1US FAERS
271Metabolic acidosisFAERS: 1US FAERS
272Middle insomniaFAERS: 1US FAERS
273MonoplegiaFAERS: 1US FAERS
274Mouth swellingFAERS: 1US FAERS
275Muscle FatigueFAERS: 1US FAERS
276Musculoskeletal discomfortFAERS: 1US FAERS
277Musculoskeletal stiffnessFAERS: 1US FAERS
278Nail bed disorderFAERS: 1US FAERS
279NeuralgiaFAERS: 1US FAERS
280OliguriaFAERS: 1US FAERS
281Overlap syndromeFAERS: 1US FAERS
282Oxygen saturation abnormalFAERS: 1US FAERS
283PancreatitisFAERS: 1US FAERS
284Pelvic discomfortFAERS: 1US FAERS
285Peptic UlcerFAERS: 1US FAERS
286Perioral DermatitisFAERS: 1US FAERS
287Platelet count abnormalFAERS: 1US FAERS
288Poor quality sleepFAERS: 1US FAERS
289Post procedural complicationFAERS: 1US FAERS
290Post procedural infectionFAERS: 1US FAERS
291Primary Biliary CholangitisFAERS: 1US FAERS
292Product administration errorFAERS: 1US FAERS
293Product communication issueFAERS: 1US FAERS
294Reaction to excipientFAERS: 1US FAERS
295Rectal ProlapseFAERS: 1US FAERS
296Retinal DetachmentFAERS: 1US FAERS
297Rotator cuff syndromeFAERS: 1US FAERS
298SciaticaFAERS: 1US FAERS
299Sinus headacheFAERS: 1US FAERS
300Sjogren's SyndromeFAERS: 1US FAERS
301Skin discomfortFAERS: 1US FAERS
302Skin lesionFAERS: 1US FAERS
303SluggishnessFAERS: 1US FAERS
304Solar lentigoFAERS: 1US FAERS
305SpondylitisFAERS: 1US FAERS
306Strangulated herniaFAERS: 1US FAERS
307Subacute hepatic failureFAERS: 1US FAERS
308Sudden onset of sleepFAERS: 1US FAERS
309Temperature regulation disorderFAERS: 1US FAERS
310Therapy changeFAERS: 1US FAERS
311ThirstFAERS: 1US FAERS
312ThrombosisFAERS: 1US FAERS
313ToothacheFAERS: 1US FAERS
314Transaminases increasedFAERS: 1US FAERS
315TransplantFAERS: 1US FAERS
316Unresponsive to stimuliFAERS: 1US FAERS
317Upper-airway cough syndromeFAERS: 1US FAERS
318Urticarial vasculitisFAERS: 1US FAERS
319Visual ImpairmentFAERS: 1US FAERS
320Vocal Cord ParalysisFAERS: 1US FAERS
321Vulvovaginal discomfortFAERS: 1US FAERS
322Vulvovaginal drynessFAERS: 1US FAERS
323Wrong doseFAERS: 1US FAERS
324colonoscopyFAERS: 1US FAERS
325furuncleFAERS: 1US FAERS
326Albuminuria26655953CTD
327Chemical and Drug Induced Liver Injury29660435
30745416
CTD
328Cholangitis31299240CTD
329Cholestasis29660435CTD
330Fatty Liver26655953CTD
331Fibrosis26655953CTD
332Hemorrhage21242261CTD
333Hepatitis, Animal30745416CTD
334Hepatomegaly27865854CTD
335Liver Cirrhosis, Experimental15860571
15980055
CTD
336Liver Cirrhosis30745416CTD
337Massive Hepatic Necrosis29660435CTD
338Necrosis27865854CTD
339Non-alcoholic Fatty Liver Disease30745416CTD
340Renal Insufficiency26655953CTD
341Ulcer21242261CTD
342Weight Gain26655953
30745416
CTD
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120238

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.