MetaADEDB 2.0 @ LMMD
anagrelide
(OTBXOEAOVRKTNQ-UHFFFAOYSA-N)
Structure
SMILES
O=C1NC2=Nc3c(CN2C1)c(Cl)c(cc3)Cl
Type(s)
Approved
ATC code(s)
L01XX35
Molecular Formula:
C10H7Cl2N3O
Molecular Weight:
256.088
Log P:
1.6286
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
1
TPSA:
44.7
CAS Number(s):
68475-42-3
Synonym(s)
1.
anagrelide
2.
6,7-dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one hydrochloride
3.
Agrelin
4.
Agrylin
5.
BL 4162A
6.
anagrelide hydrochloride
7.
imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-, monohydrochloride
External Link(s)
MeSHC021139
PubChem Compound135409400
2182
BindingDB50000334
ChEBI142290
CHEMBLCHEMBL760
DrugBankDB00261
DrugCentral209
IUPHAR/BPS Guide to PHARMACOLOGY7114
KEGGdr:D07455
Therapeutic Target DatabaseD0D1HW
ZINC3871541
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1MyelofibrosisFAERS: 15US FAERS
2PalpitationsFAERS: 9SIDER
US FAERS
3Pulmonary HypertensionFAERS: 6OFFSIDES
SIDER
US FAERS
4HeadacheFAERS: 5SIDER
US FAERS
5Myocardial InfarctionFAERS: 5SIDER
US FAERS
6Drug ineffectiveFAERS: 4US FAERS
7FatigueFAERS: 4OFFSIDES
SIDER
US FAERS
8ThrombosisFAERS: 4US FAERS
9Weight decreasedFAERS: 4SIDER
US FAERS
10Adverse eventFAERS: 3US FAERS
11CardiomegalyFAERS: 3SIDER
US FAERS
12Ejection Fraction DecreasedFAERS: 3US FAERS
13MyelocytosisFAERS: 3US FAERS
14Pulmonary arterial hypertensionFAERS: 3US FAERS
15Sudden deathFAERS: 3US FAERS
16SyncopeFAERS: 3SIDER
US FAERS
17ThrombocytopeniaFAERS: 3SIDER
US FAERS
18Acute Coronary SyndromeFAERS: 2SIDER
US FAERS
19Acute kidney injuryFAERS: 2US FAERS
20Acute myocardial infarctionFAERS: 2US FAERS
21Angina PectorisFAERS: 2SIDER
US FAERS
22AstheniaFAERS: 2OFFSIDES
SIDER
US FAERS
23BradycardiaFAERS: 2OFFSIDES
US FAERS
24CardiotoxicityFAERS: 2US FAERS
25Coronary Artery DiseaseFAERS: 2US FAERS
26Gastric ulcerFAERS: 2US FAERS
27Hepatic cancer metastaticFAERS: 2US FAERS
28HypotensionFAERS: 2SIDER
US FAERS
29HypoxiaFAERS: 2US FAERS
30NauseaFAERS: 2OFFSIDES
SIDER
US FAERS
31Night sweatsFAERS: 2US FAERS
32PericarditisFAERS: 2SIDER
US FAERS
33Product use issueFAERS: 2US FAERS
34PruritusFAERS: 2SIDER
US FAERS
35Pulmonary FibrosisFAERS: 2SIDER
US FAERS
36Pyoderma GangrenosumFAERS: 2US FAERS
37Right ventricular failureFAERS: 2US FAERS
38TachycardiaFAERS: 2SIDER
US FAERS
39ThrombocytosisFAERS: 215813844
17137402
20586925		CTD
US FAERS
40Ventricular hypokinesiaFAERS: 2US FAERS
41Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
42Abdominal adhesionsFAERS: 1US FAERS
43AgeusiaFAERS: 1US FAERS
44AlopeciaFAERS: 1SIDER
US FAERS
45ArteriosclerosisFAERS: 1US FAERS
46ArthralgiaFAERS: 1SIDER
US FAERS
47AscitesFAERS: 1US FAERS
48Atrial FibrillationFAERS: 1SIDER
US FAERS
49Atrial FlutterFAERS: 1US FAERS
50Back PainFAERS: 1SIDER
US FAERS
51Blood creatinine increasedFAERS: 1SIDER
US FAERS
52Bone marrow reticulin fibrosisFAERS: 1US FAERS
53BronchopneumopathyFAERS: 1US FAERS
54Burning sensationFAERS: 1OFFSIDES
US FAERS
55Cardiac ArrestFAERS: 1US FAERS
56Cardiac ventricular thrombosisFAERS: 1US FAERS
57Cauda Equina SyndromeFAERS: 1US FAERS
58Cell DeathFAERS: 1US FAERS
59Cerebrovascular accidentFAERS: 1SIDER
US FAERS
60Chest PainFAERS: 1SIDER
US FAERS
61CholestasisFAERS: 1US FAERS
62Chronic gastritisFAERS: 1US FAERS
63ColitisFAERS: 1SIDER
US FAERS
64ConstipationFAERS: 1SIDER
US FAERS
65DeafnessFAERS: 1US FAERS
66Diabetes MellitusFAERS: 1US FAERS
67Diastolic dysfunctionFAERS: 1US FAERS
68Disease ProgressionFAERS: 1US FAERS
69DizzinessFAERS: 1SIDER
US FAERS
70Drug dose omissionFAERS: 1US FAERS
71Enteral NutritionFAERS: 1US FAERS
72Eosinophilic colitisFAERS: 1US FAERS
73EpistaxisFAERS: 1OFFSIDES
SIDER
US FAERS
74ErysipelasFAERS: 1US FAERS
75ErythemaFAERS: 1OFFSIDES
US FAERS
76FibrosisFAERS: 1SIDER
US FAERS
77GlomerulonephritisFAERS: 1US FAERS
78Helicobacter test positiveFAERS: 1US FAERS
79HepatomegalyFAERS: 1US FAERS
80Hypertensive crisisFAERS: 1US FAERS
81HypokinesiaFAERS: 1US FAERS
82HysterectomyFAERS: 1US FAERS
83IleusFAERS: 1US FAERS
84Left Ventricular HypertrophyFAERS: 1US FAERS
85LymphadenopathyFAERS: 1SIDER
US FAERS
86MetrorrhagiaFAERS: 1US FAERS
87Muscle fibrosisFAERS: 1US FAERS
88Musculoskeletal discomfortFAERS: 1SIDER
US FAERS
89MyelitisFAERS: 1US FAERS
90MyocarditisFAERS: 1US FAERS
91NasopharyngitisFAERS: 1US FAERS
92Necrotising granulomatous lymphadenitisFAERS: 1US FAERS
93NeutropeniaFAERS: 1US FAERS
94No adverse eventFAERS: 1US FAERS
95NocturiaFAERS: 1SIDER
US FAERS
96ParaparesisFAERS: 1US FAERS
97Pharmaceutical product complaintFAERS: 1OFFSIDES
US FAERS
98Platelet aggregation abnormalFAERS: 1US FAERS
99PleurisyFAERS: 1US FAERS
100PneumonitisFAERS: 1US FAERS
101PregnancyFAERS: 1US FAERS
102Product difficult to swallowFAERS: 1US FAERS
103Pulmonary EmbolismFAERS: 1US FAERS
104Renal cystFAERS: 1US FAERS
105Respiratory distressFAERS: 1US FAERS
106RhabdomyolysisFAERS: 1US FAERS
107Secretion dischargeFAERS: 1US FAERS
108Skin UlcerFAERS: 1SIDER
US FAERS
109Splenic RuptureFAERS: 1US FAERS
110Therapeutic response unexpectedFAERS: 1US FAERS
111TuberculosisFAERS: 1US FAERS
112Unevaluable eventFAERS: 1US FAERS
113Ventricular FibrillationFAERS: 1OFFSIDES
US FAERS
114VomitingFAERS: 1SIDER
US FAERS
115White blood cell count decreasedFAERS: 1US FAERS
116Abdominal discomfortOFFSIDES
SIDER
117Abnormal visionSIDER
118Acid refluxOFFSIDES
119AgraphiaOFFSIDES
120Alanine Aminotransferase IncreasedOFFSIDES
121AmblyopiaSIDER
122AmnesiaOFFSIDES
SIDER
123Anal FissureOFFSIDES
124AnhedoniaOFFSIDES
125AnorexiaOFFSIDES
SIDER
126AnxietyOFFSIDES
127Aphthous StomatitisSIDER
128AppendectomyOFFSIDES
129AppendicitisOFFSIDES
130ArthritisSIDER
131AsthmaOFFSIDES
SIDER
132AtaxiaOFFSIDES
133AtelectasisOFFSIDES
134Atrial arrhythmiaSIDER
135Blood GlucoseOFFSIDES
136Blood and lymphatic system disordersSIDER
137Blood erythropoietin increasedOFFSIDES
138Blood potassium decreasedOFFSIDES
139Blood potassium increasedOFFSIDES
140Blood thyroid stimulating hormone increasedOFFSIDES
141Bone erosionOFFSIDES
142Bone fragmentationOFFSIDES
143Bone painOFFSIDES
SIDER
144BronchitisSIDER
145BronchopneumoniaOFFSIDES
146BursitisOFFSIDES
147CREST SyndromeOFFSIDES
148Cardiomyopathies11034048
15531464		CTD
149CellulitisOFFSIDES
SIDER
150ChillsSIDER
151Chronic left ventricular failureOFFSIDES
152Chronic ulcerative colitisOFFSIDES
153Congenital tricuspid valve incompetenceOFFSIDES
154ConjunctivitisSIDER
155Cor pulmonaleOFFSIDES
156Cramps of lower extremitiesSIDER
157DehydrationSIDER
158DemyelinationOFFSIDES
159Dental abscessOFFSIDES
160Dental cariesOFFSIDES
161DermatitisSIDER
162Device FailureOFFSIDES
163DiabetesOFFSIDES
164DiarrheaOFFSIDES
165DiplopiaSIDER
166DiscomfortSIDER
167Distress gastrointestinalSIDER
168DiverticulumOFFSIDES
169Drug toxicityOFFSIDES
170Dry skinSIDER
171Duodenal UlcerSIDER
172DysarthriaSIDER
173DyslexiaOFFSIDES
174DyspepsiaSIDER
175DysuriaSIDER
176Ear and labyrinth disordersSIDER
177EcchymosisSIDER
178Economic problemOFFSIDES
179Emotional distressOFFSIDES
180EndocarditisOFFSIDES
181Endodontic procedureOFFSIDES
182EnteritisOFFSIDES
183Enterococcal infectionOFFSIDES
184Eosinophilic PneumoniaSIDER
185Erectile dysfunctionOFFSIDES
SIDER
186EructationSIDER
187Escherichia infectionOFFSIDES
188Eye laser surgeryOFFSIDES
189Facial NeuralgiaOFFSIDES
190Failure to ThriveOFFSIDES
191Feeling abnormalSIDER
192Flat affectOFFSIDES
193FlatulenceSIDER
194Flu symptomsSIDER
195Fluid overloadOFFSIDES
196GastritisSIDER
197GastroduodenitisOFFSIDES
198Gastrointestinal PainSIDER
199General physical health deteriorationOFFSIDES
200GranulomaOFFSIDES
201Headache occurringSIDER
202Heart failure11034048CTD
203Hemorrhage16398570
16484586		CTD
204HepatitisSIDER
205HepatotoxicityOFFSIDES
SIDER
206IncontinenceSIDER
207InfectionSIDER
208Influenza-like symptomsSIDER
209InfluenzaSIDER
210Infusion site mobility decreasedOFFSIDES
211Joint Range of Motion DecreasedOFFSIDES
212Joint sprainOFFSIDES
213Joint stiffnessOFFSIDES
214Kidney FailureOFFSIDES
215LymphedemaOFFSIDES
216MalaiseSIDER
217Mallory-Weiss SyndromeOFFSIDES
218MalnutritionSIDER
219MalocclusionOFFSIDES
220Metastatic NeoplasmOFFSIDES
221Mixed Connective Tissue DiseaseOFFSIDES
222Multiple SclerosisOFFSIDES
223Musculoskeletal stiffnessOFFSIDES
224MyalgiaSIDER
225Neck PainSIDER
226NervousnessSIDER
227OliguriaOFFSIDES
228Optic NeuritisOFFSIDES
229Osteitis DeformansOFFSIDES
230OsteolysisOFFSIDES
231OsteomyelitisOFFSIDES
232OsteopeniaOFFSIDES
233OsteoporosisOFFSIDES
234PainOFFSIDES
SIDER
235PancreatitisSIDER
236PancytopeniaSIDER
237Pericardial effusionSIDER
238PeriodontitisOFFSIDES
239PharyngitisSIDER
240PneumoniaSIDER
241Polycythemia Vera11034048
15531464		CTD
242Poor dental conditionOFFSIDES
243Post inflammatory pigmentation changeOFFSIDES
244Reticulocyte count decreasedOFFSIDES
245RhinitisSIDER
246SacroiliitisOFFSIDES
247ScabOFFSIDES
248Scan bone marrow abnormalOFFSIDES
249SclerodermaOFFSIDES
250ShockSIDER
251SinusitisOFFSIDES
SIDER
252Sjogren's SyndromeOFFSIDES
253Skin IndurationOFFSIDES
254Skin hypertrophyOFFSIDES
255Skin tightnessOFFSIDES
256SomnolenceSIDER
257Supraventricular tachycardiaOFFSIDES
SIDER
258SweatingSIDER
259TensionSIDER
260Thrombocythemia, Essential

View details

12924084
15531464
16398570
17137402
 		CTD
261Thromboembolism16896569
19636672		CTD
262TinnitusSIDER
263Tooth ExtractionOFFSIDES
264Urinary IncontinenceSIDER
265Urinary tract infectionSIDER
266UrticariaSIDER
267VIIth nerve paralysisOFFSIDES
268Venous Thrombosis16398570
16484586		CTD
269Visual ImpairmentSIDER
270Vitreous DetachmentOFFSIDES
271Wound infection staphylococcalOFFSIDES
272Wrong drug administeredOFFSIDES
273bone marrow fibrosisOFFSIDES
274nervous system disorderSIDER
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