MetaADEDB 2.0 @ LMMD
Clomiphene
(PYTMYKVIJXPNBD-OQKDUQJOSA-N)
Structure
SMILES
OC(=O)C(CC(=O)O)(CC(=O)O)O.CCN(CCOc1ccc(cc1)/C(=C(/c1ccccc1)\Cl)/c1ccccc1)CC
Molecular Formula:
C32H36ClNO8
Molecular Weight:
598.083
Log P:
5.3141
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
4
TPSA:
144.6
CAS Number(s):
50-41-9; 7619-53-6
Synonym(s)
1.
Clomiphene
2.
Chloramiphene
3.
Clomifene
4.
Clomid
5.
Clomide
6.
Clomifen
7.
Clomiphene Citrate
8.
Clomiphene Hydrochloride
9.
Clostilbegit
10.
Dyneric
11.
Gravosan
12.
Klostilbegit
13.
Serophene
14.
Citrate, Clomiphene
15.
Hydrochloride, Clomiphene
External Link(s)
MeSHD002996
PubChem Compound3033832
CHEMBLCHEMBL1213137
KEGGcpd:C08161
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug exposure during pregnancyFAERS: 48OFFSIDES
US FAERS
2Ectopic PregnancyFAERS: 29
Canada Vigilance: 4
Canada Vigilance
US FAERS
3HeadacheFAERS: 21
Canada Vigilance: 1
Canada Vigilance
US FAERS
4NauseaFAERS: 15
Canada Vigilance: 1
Canada Vigilance
US FAERS
5Ovarian Hyperstimulation SyndromeFAERS: 12
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
6Visual ImpairmentFAERS: 11
Canada Vigilance: 3
Canada Vigilance
US FAERS
7VomitingFAERS: 10US FAERS
8Maternal exposure during pregnancyFAERS: 9US FAERS
9PregnancyFAERS: 9US FAERS
10Product use issueFAERS: 8US FAERS
11Drug ineffectiveFAERS: 7OFFSIDES
US FAERS
12Multiple PregnancyFAERS: 7
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
13PainFAERS: 7
Canada Vigilance: 1
Canada Vigilance
US FAERS
14Blood testosterone increasedFAERS: 6US FAERS
15Retinal Vein OcclusionFAERS: 6OFFSIDES
US FAERS
16TremorFAERS: 6
Canada Vigilance: 1
Canada Vigilance
US FAERS
17Visual disturbanceFAERS: 6OFFSIDES
US FAERS
18Deep Vein ThrombosisFAERS: 5US FAERS
19DizzinessFAERS: 5
Canada Vigilance: 2
Canada Vigilance
US FAERS
20FatigueFAERS: 5US FAERS
21Feeling abnormalFAERS: 5US FAERS
22Low birth weight babyFAERS: 5
Canada Vigilance: 2
Canada Vigilance
US FAERS
23Ruptured ectopic pregnancyFAERS: 5OFFSIDES
US FAERS
24Abdominal PainFAERS: 4
Canada Vigilance: 3
Canada Vigilance
US FAERS
25AlopeciaFAERS: 4OFFSIDES
US FAERS
26Chest PainFAERS: 4US FAERS
27Drug exposure before pregnancyFAERS: 4OFFSIDES
US FAERS
28Eye painFAERS: 4OFFSIDES
US FAERS
29IridocyclitisFAERS: 4OFFSIDES
US FAERS
30MalaiseFAERS: 4US FAERS
31Maternal exposure before pregnancyFAERS: 4
Canada Vigilance: 2
Canada Vigilance
US FAERS
32MetrorrhagiaFAERS: 4US FAERS
33Myocardial InfarctionFAERS: 4US FAERS
34No adverse eventFAERS: 4US FAERS
35Ocular icterusFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
36Optic NeuritisFAERS: 4OFFSIDES
US FAERS
37OsteopeniaFAERS: 4US FAERS
38Retinopathy of PrematurityFAERS: 4US FAERS
39Vitreous floatersFAERS: 4US FAERS
40Abdominal discomfortFAERS: 3OFFSIDES
US FAERS
41AgitationFAERS: 3US FAERS
42AnxietyFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
43Breech PresentationFAERS: 3US FAERS
44Cerebrovascular accidentFAERS: 3US FAERS
45Chest discomfortFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
46DeliriumFAERS: 3US FAERS
47Emotional distressFAERS: 3OFFSIDES
US FAERS
48Invasive Ductal Breast CarcinomaFAERS: 3US FAERS
49PalpitationsFAERS: 3US FAERS
50Patent ductus arteriosusFAERS: 3US FAERS
51PhotophobiaFAERS: 3US FAERS
52SepsisFAERS: 3US FAERS
53TachycardiaFAERS: 3US FAERS
54ThrombosisFAERS: 3US FAERS
55jaundiceFAERS: 3US FAERS
56Acute myocardial infarctionFAERS: 2US FAERS
57Adnexa uteri painFAERS: 2US FAERS
58Adverse eventFAERS: 2US FAERS
59Blood human chorionic gonadotropin decreasedFAERS: 2US FAERS
60Breast tendernessFAERS: 2OFFSIDES
US FAERS
61Cerebral PalsyFAERS: 2
Canada Vigilance: 2
Canada Vigilance
OFFSIDES
US FAERS
62Cervix carcinoma stage IFAERS: 2US FAERS
63Congenital brain damageFAERS: 2OFFSIDES
US FAERS
64Congenital vitreous anomalyFAERS: 2OFFSIDES
US FAERS
65CryingFAERS: 2OFFSIDES
US FAERS
66CystFAERS: 2OFFSIDES
US FAERS
67DeafnessFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
68Drug abuseFAERS: 2US FAERS
69DyschromatopsiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
70Emotional disorderFAERS: 2US FAERS
71EndometriosisFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
72ErythemaFAERS: 2US FAERS
73Eye inflammationFAERS: 2OFFSIDES
US FAERS
74HepatomegalyFAERS: 2US FAERS
75HypokinesiaFAERS: 2OFFSIDES
US FAERS
76HypophysitisFAERS: 2US FAERS
77HypothyroidismFAERS: 2US FAERS
78Ideas of referenceFAERS: 2OFFSIDES
US FAERS
79LymphomaFAERS: 2OFFSIDES
US FAERS
80MYELODYSPLASTIC SYNDROMEFAERS: 2US FAERS
81Macular degenerationFAERS: 2US FAERS
82MicrophthalmosFAERS: 2OFFSIDES
US FAERS
83Mood swingsFAERS: 2US FAERS
84Ovarian enlargementFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
85OverdoseFAERS: 2
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
86ParanoiaFAERS: 2OFFSIDES
US FAERS
87Precocious PubertyFAERS: 2US FAERS
88Pulmonary EmbolismFAERS: 2US FAERS
89Rectal abscessFAERS: 2US FAERS
90Retinal Artery OcclusionFAERS: 2OFFSIDES
US FAERS
91Retinal exudatesFAERS: 2OFFSIDES
US FAERS
92SomnolenceFAERS: 2US FAERS
93VertigoFAERS: 2US FAERS
94AbasiaFAERS: 1US FAERS
95Abdominal rigidityFAERS: 1US FAERS
96Abdominal tendernessFAERS: 1US FAERS
97Abortion earlyFAERS: 1US FAERS
98Abortion of ectopic pregnancyFAERS: 1US FAERS
99Adnexa uteri massFAERS: 1US FAERS
100Alanine Aminotransferase IncreasedFAERS: 1OFFSIDES
US FAERS
101Amaurosis FugaxFAERS: 1US FAERS
102AnencephalyFAERS: 1US FAERS
103AngerFAERS: 1US FAERS
104ApathyFAERS: 1US FAERS
105ArthralgiaFAERS: 1US FAERS
106ArthropathyFAERS: 1US FAERS
107AscitesFAERS: 1OFFSIDES
US FAERS
108Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
109AsthmaFAERS: 1US FAERS
110Atrioventricular Septal DefectFAERS: 1US FAERS
111Autoimmune hepatitisFAERS: 1US FAERS
112Back PainFAERS: 1US FAERS
113Bicuspid aortic valveFAERS: 1US FAERS
114Bilirubin conjugated increasedFAERS: 1US FAERS
115BlindnessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
116Blood cholesterol increasedFAERS: 1US FAERS
117Blood follicle stimulating hormone increasedFAERS: 1US FAERS
118Blood testosterone abnormalFAERS: 1US FAERS
119Blood testosterone decreasedFAERS: 1US FAERS
120Breast cancer stage IIIFAERS: 1US FAERS
121Burning sensationFAERS: 1US FAERS
122CalcinosisFAERS: 1US FAERS
123Cerebellar infarctionFAERS: 1US FAERS
124Cerebral ThrombosisFAERS: 1US FAERS
125CholecystitisFAERS: 1OFFSIDES
US FAERS
126CholelithiasisFAERS: 1US FAERS
127ChromaturiaFAERS: 1US FAERS
128ClubbingFAERS: 1US FAERS
129Completed SuicideFAERS: 1OFFSIDES
US FAERS
130Complications of maternal exposure to therapeutic drugsFAERS: 1OFFSIDES
US FAERS
131Congenital anomaly in offspringFAERS: 1US FAERS
132Congenital hydronephrosisFAERS: 1US FAERS
133ConstipationFAERS: 1US FAERS
134Contraindicated drug administeredFAERS: 1US FAERS
135CraniorachischisisFAERS: 1US FAERS
136Creutzfeldt-Jakob diseaseFAERS: 1US FAERS
137Death of relativeFAERS: 1US FAERS
138Depressed moodFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
139Double ureterFAERS: 1US FAERS
140Drug dispensing errorFAERS: 1US FAERS
141Drug prescribing errorFAERS: 1US FAERS
142Drug screen false positiveFAERS: 1US FAERS
143Drug toxicityFAERS: 1OFFSIDES
US FAERS
144Dry skinFAERS: 1US FAERS
145DuodenitisFAERS: 1US FAERS
146Dural Arteriovenous FistulaFAERS: 1US FAERS
147DwarfismFAERS: 1US FAERS
148DysplasiaFAERS: 1US FAERS
149Ectopia CordisFAERS: 1US FAERS
150Euphoric moodFAERS: 1US FAERS
151Exposure via fatherFAERS: 1US FAERS
152Gamma-Glutamyltransferase IncreasedFAERS: 1US FAERS
153Gastrointestinal hypermotilityFAERS: 1US FAERS
154GastroschisisFAERS: 1US FAERS
155Gestational DiabetesFAERS: 1OFFSIDES
US FAERS
156GlaucomaFAERS: 1US FAERS
157Head deformityFAERS: 1US FAERS
158HepatosplenomegalyFAERS: 1US FAERS
159HerniaFAERS: 1US FAERS
160HoloprosencephalyFAERS: 1US FAERS
161HydronephrosisFAERS: 1US FAERS
162HypersensitivityFAERS: 1US FAERS
163Hypoplastic Left Heart SyndromeFAERS: 1US FAERS
164HypotensionFAERS: 1US FAERS
165Impaired driving abilityFAERS: 1US FAERS
166Impaired work abilityFAERS: 1US FAERS
167Inappropriate schedule of drug administrationFAERS: 1US FAERS
168Incorrect drug administration durationFAERS: 1US FAERS
169Intracranial meningioma malignantFAERS: 1US FAERS
170Joint stiffnessFAERS: 1US FAERS
171LymphadenitisFAERS: 1US FAERS
172LymphadenopathyFAERS: 1US FAERS
173LymphangioleiomyomatosisFAERS: 1US FAERS
174Malignant ovarian cystFAERS: 1US FAERS
175MedulloblastomaFAERS: 1US FAERS
176MeningitisFAERS: 1US FAERS
177MetastasisFAERS: 1US FAERS
178Migraine with AuraFAERS: 1US FAERS
179Murphy's sign positiveFAERS: 1US FAERS
180Musculoskeletal PainFAERS: 1US FAERS
181Musculoskeletal stiffnessFAERS: 1US FAERS
182MyalgiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
183MydriasisFAERS: 1US FAERS
184Neonatal pneumoniaFAERS: 1US FAERS
185Nerve injuryFAERS: 1US FAERS
186NoduleFAERS: 1US FAERS
187Obsessive-Compulsive DisorderFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
188Occult blood positiveFAERS: 1US FAERS
189OligohydramniosFAERS: 1US FAERS
190Optic AtrophyFAERS: 1US FAERS
191PancreatitisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
192PancytopeniaFAERS: 1US FAERS
193Panic DisorderFAERS: 1US FAERS
194Paradoxical drug reactionFAERS: 1US FAERS
195Pelvic PainFAERS: 1US FAERS
196Pelvic abscessFAERS: 1US FAERS
197Personality ChangeFAERS: 1US FAERS
198Pharyngolaryngeal PainFAERS: 1US FAERS
199Pityriasis RoseaFAERS: 1US FAERS
200Placenta AccretaFAERS: 1US FAERS
201PneumoniaFAERS: 1US FAERS
202PneumothoraxFAERS: 1US FAERS
203Post procedural complicationFAERS: 1US FAERS
204Pregnancy test negativeFAERS: 1US FAERS
205Product complaintFAERS: 1US FAERS
206Product contamination physicalFAERS: 1US FAERS
207Product dispensing errorFAERS: 1US FAERS
208Protein urine presentFAERS: 1US FAERS
209PruritusFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
210Pulmonary FibrosisFAERS: 1US FAERS
211Pulmonary Valve StenosisFAERS: 1US FAERS
212Pulmonary arterial hypertensionFAERS: 1US FAERS
213PyelocaliectasisFAERS: 1US FAERS
214PyelonephritisFAERS: 1US FAERS
215Respiratory FailureFAERS: 1US FAERS
216Retinal pigment epitheliopathyFAERS: 1US FAERS
217ScotomaFAERS: 1US FAERS
218SeminomaFAERS: 1US FAERS
219ShockFAERS: 1US FAERS
220Spina BifidaFAERS: 1OFFSIDES
US FAERS
221StillbirthFAERS: 1US FAERS
222Suicide attemptFAERS: 1US FAERS
223SwellingFAERS: 1US FAERS
224SyncopeFAERS: 1US FAERS
225TachyphreniaFAERS: 1US FAERS
226TalipesFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
227TenosynovitisFAERS: 1US FAERS
228Throat irritationFAERS: 1US FAERS
229Thyroid NeoplasmFAERS: 1US FAERS
230TinnitusFAERS: 1US FAERS
231Toxic Shock SyndromeFAERS: 1US FAERS
232Transaminases increasedFAERS: 1US FAERS
233Tubal ruptureFAERS: 1US FAERS
234Tumour haemorrhageFAERS: 1US FAERS
235Urinary RetentionFAERS: 1US FAERS
236Urinary tract infectionFAERS: 1US FAERS
237UrticariaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
238Wrong technique in product usage processFAERS: 1US FAERS
239hypertensive nephropathyFAERS: 1US FAERS
240Abnormal visionOFFSIDES
241AdenocarcinomaOFFSIDES
242Alanine aminotransferase abnormalCanada Vigilance: 1Canada Vigilance
243AlveolitisOFFSIDES
244AmenorrheaOFFSIDES
245AngioedemaCanada Vigilance: 1Canada Vigilance
246Anticholinergic SyndromeOFFSIDES
247Blighted ovumOFFSIDES
248Blood cholesterolOFFSIDES
249Blood follicle stimulating hormone decreasedOFFSIDES
250Blood growth hormone increasedOFFSIDES
251Blood prolactin increasedOFFSIDES
252Blurred visionOFFSIDES
253BronchitisOFFSIDES
254CataractCanada Vigilance: 3Canada Vigilance
255ChillsCanada Vigilance: 1Canada Vigilance
256Circumstance or information capable of leading to medication errorOFFSIDES
257ClaustrophobiaOFFSIDES
258Cleft PalateOFFSIDES
259CraniosynostosisOFFSIDES
260DermatofibrosarcomaOFFSIDES
261Device FailureOFFSIDES
262Device related infectionOFFSIDES
263DysmorphismOFFSIDES
264Dysthymic DisorderOFFSIDES
265Economic problemOFFSIDES
266Electrocardiogram ST-T changeOFFSIDES
267Electrocardiogram repolarisation abnormalityOFFSIDES
268EncephalitisCanada Vigilance: 1Canada Vigilance
269Endometrial HyperplasiaOFFSIDES
270Epstein-Barr virus antibody positiveOFFSIDES
271Flank PainOFFSIDES
272Gait inabilityCanada Vigilance: 1Canada Vigilance
273GalactorrheaOFFSIDES
274GamblingOFFSIDES
275GangreneOFFSIDES
276General physical health deteriorationOFFSIDES
277HaemoconcentrationOFFSIDES
278Hyperemesis GravidarumOFFSIDES
279InfertilityOFFSIDES
280Intention tremorOFFSIDES
281Kidney FailureOFFSIDES
282MediastinitisOFFSIDES
283NystagmusCanada Vigilance: 1Canada Vigilance
284Optic Disc EdemaOFFSIDES
285OrthopneaOFFSIDES
286Ovarian cyst torsionOFFSIDES
287Pericardial effusionOFFSIDES
288PlagiocephalyOFFSIDES
289PolyhydramniosOFFSIDES
290Progesterone decreasedOFFSIDES
291Pulmonary congestionOFFSIDES
292PurpuraCanada Vigilance: 1Canada Vigilance
293SinusitisOFFSIDES
294Supraventricular tachycardiaOFFSIDES
295SyndactylyCanada Vigilance: 1Canada Vigilance
OFFSIDES
296Trisomy 21Canada Vigilance: 1Canada Vigilance
297Uterine CancerOFFSIDES
298Wound InfectionOFFSIDES
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