MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Quinine

(LOUPRKONTZGTKE-WZBLMQSHSA-N)

Structure

SMILES: C=C[C@H]1CN2CC[C@H]1C[C@H]2[C@@H](c1ccnc2c1cc(OC)cc2)O
Type(s): Approved
ATC code(s): M09AA72; P01BC01
Molecular Formula:: C20H24N2O2
Molecular Weight:: 324.417
Log P:: 3.1111
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 45.59
CAS Number(s):: 130-95-0; 1407-83-6

Synonym(s)

Quinine

Biquinate

Legatrim

Myoquin

Quinamm

Quinbisan

Quinbisul

Quindan

Quinimax

10.

Quinine Bisulfate

11.

Quinine Hydrochloride

12.

Quinine Lafran

13.

Quinine Sulfate

14.

Quinine Sulphate

15.

Quinine-Odan

16.

Quinoctal

17.

Quinson

18.

Quinsul

19.

Strema

20.

Surquina

21.

Bisulfate, Quinine

22.

Hydrochloride, Quinine

23.

Sulfate, Quinine

24.

Sulphate, Quinine

External Link(s)

MeSH	D011803
PubChem Compound	3034034
BindingDB	50367247
ChEBI	15854
CHEMBL	CHEMBL170
DrugBank	DB00468
DrugCentral	4523
IUPHAR/BPS Guide to PHARMACOLOGY	2510
KEGG	cpd:C06526
Therapeutic Target Database	D03DDR
ZINC	3831404

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acute kidney injury	FAERS: 22	12682720 16780456	CTD US FAERS
2	Overdose	FAERS: 16		US FAERS
3	Toxicity to various agents	FAERS: 16		US FAERS
4	Drug abuse	FAERS: 14		US FAERS
5	Blindness	FAERS: 12	View details 1341094 2024217 3800084 3885879 3926054 4671314 5700677 6054919 6530841 7369302 8758098 9517707 10341779 11848734 14676522 15373380	CTD US FAERS
6	Intentional product misuse	FAERS: 10		US FAERS
7	Tinnitus	FAERS: 9	View details 1796238 1896775 1910705 2198912 3800084 9116320 9517707 17114137 20502380	CTD US FAERS
8	Vomiting	FAERS: 9	1796238 3800084 9517707	CTD US FAERS
9	Abdominal Pain	FAERS: 8	3800084	CTD US FAERS
10	Chills	FAERS: 8		US FAERS
11	Unevaluable event	FAERS: 8		US FAERS
12	Optic Atrophy	FAERS: 7	5539279	CTD US FAERS
13	Cerebrovascular accident	FAERS: 6		US FAERS
14	Dizziness	FAERS: 6	1796238 9116320	CTD US FAERS
15	Headache	FAERS: 6 Canada Vigilance: 1	3800084	CTD Canada Vigilance US FAERS
16	Medication Error	FAERS: 6		US FAERS
17	Nausea	FAERS: 6 Canada Vigilance: 1		Canada Vigilance US FAERS
18	Retinal toxicity	FAERS: 6		US FAERS
19	Thrombocytopenia	FAERS: 6 Canada Vigilance: 1	View details 1421383 1898704 8628066 10474732 12682720 14744847	CTD Canada Vigilance US FAERS
20	Disseminated Intravascular Coagulation	FAERS: 5	View details 1979368 2393740 8323089 10474732 12013332 12682720 16780456 18343736	CTD US FAERS
21	Mydriasis	FAERS: 5		US FAERS
22	Retinal Degeneration	FAERS: 4		US FAERS
23	Tremor	FAERS: 4		US FAERS
24	Optic Neuritis	FAERS: 3		US FAERS
25	Retinal Artery Occlusion	FAERS: 3		US FAERS
26	Somnolence	FAERS: 3		US FAERS
27	Stevens-Johnson Syndrome	FAERS: 3 Canada Vigilance: 1	25811541	CTD Canada Vigilance US FAERS
28	Visual Impairment	FAERS: 3		US FAERS
29	Amaurosis	FAERS: 2		US FAERS
30	Asthenia	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
31	Autoimmune thrombocytopenia	FAERS: 2		US FAERS
32	Chest Pain	FAERS: 2	9517707	CTD US FAERS
33	Deafness	FAERS: 2	5700677	CTD US FAERS
34	Delirium	FAERS: 2		US FAERS
35	Dysarthria	FAERS: 2		US FAERS
36	Epistaxis	FAERS: 2		US FAERS
37	Fibrin D dimer increased	FAERS: 2		US FAERS
38	Hypersensitivity	FAERS: 2		US FAERS
39	Hypotension	FAERS: 2	9561594	CTD US FAERS
40	Injection site granuloma	FAERS: 2		US FAERS
41	Malaise	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
42	Mental status changes	FAERS: 2		US FAERS
43	Palpitations	FAERS: 2		US FAERS
44	Pruritus	FAERS: 2		US FAERS
45	Retinal Vascular Disorder	FAERS: 2		US FAERS
46	Retinal depigmentation	FAERS: 2		US FAERS
47	Retinal pigment epitheliopathy	FAERS: 2		US FAERS
48	Retinitis Pigmentosa	FAERS: 2		US FAERS
49	Vertigo	FAERS: 2		US FAERS
50	jaundice	FAERS: 2		US FAERS
51	Abasia	FAERS: 1		US FAERS
52	Accidental overdose	FAERS: 1		US FAERS
53	Administration site calcification	FAERS: 1		US FAERS
54	Agitation	FAERS: 1		US FAERS
55	Amblyopia	FAERS: 1	View details 4671314 5539279 5700677 7369302	CTD US FAERS
56	Angioedema	FAERS: 1		US FAERS
57	Anti-platelet antibody positive	FAERS: 1		US FAERS
58	Anuria	FAERS: 1		US FAERS
59	Aphasia	FAERS: 1		US FAERS
60	Apparent death	FAERS: 1		US FAERS
61	Ataxia	FAERS: 1		US FAERS
62	Blood cholesterol increased	FAERS: 1		US FAERS
63	Bradycardia	FAERS: 1	3800084 8957602	CTD US FAERS
64	Cardiac Arrest	FAERS: 1		US FAERS
65	Cataplexy	FAERS: 1		US FAERS
66	Chromaturia	FAERS: 1		US FAERS
67	Completed Suicide	FAERS: 1		US FAERS
68	Diplopia	FAERS: 1		US FAERS
69	Drug dispensing error	FAERS: 1		US FAERS
70	Drug ineffective	FAERS: 1		US FAERS
71	Drug level increased	FAERS: 1		US FAERS
72	Drug prescribing error	FAERS: 1		US FAERS
73	Ecchymosis	FAERS: 1		US FAERS
74	Eczema	FAERS: 1		US FAERS
75	Eye pain	FAERS: 1		US FAERS
76	Fatigue	FAERS: 1		US FAERS
77	Flushing	FAERS: 1		US FAERS
78	Gastroenteritis	FAERS: 1		US FAERS
79	Gastrointestinal motility disorder	FAERS: 1		US FAERS
80	Granulomatous liver disease	FAERS: 1		US FAERS
81	Head discomfort	FAERS: 1		US FAERS
82	Hepatitis	FAERS: 1	2108777 6402064 8628066	CTD US FAERS
83	Hepatotoxicity	FAERS: 1		US FAERS
84	Hunger	FAERS: 1		US FAERS
85	Hyperacusis	FAERS: 1		US FAERS
86	Immune thrombocytopenic purpura	FAERS: 1		US FAERS
87	Injury asphyxiation	FAERS: 1		US FAERS
88	Intentional product use issue	FAERS: 1		US FAERS
89	Intercepted drug administration error	FAERS: 1		US FAERS
90	Macular dystrophy congenital	FAERS: 1		US FAERS
91	Meningitis	FAERS: 1		US FAERS
92	Metabolic acidosis	FAERS: 1		US FAERS
93	Migraine with Aura	FAERS: 1		US FAERS
94	Muscle tightness	FAERS: 1		US FAERS
95	Myalgia	FAERS: 1		US FAERS
96	Narcolepsy	FAERS: 1		US FAERS
97	Neutropenia	FAERS: 1	1421383	CTD US FAERS
98	Pain	FAERS: 1	7352543	CTD US FAERS
99	Pallor	FAERS: 1		US FAERS
100	Pancytopenia	FAERS: 1	8323089	CTD US FAERS
101	Petechiae	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
102	Pharmaceutical product complaint	FAERS: 1		US FAERS
103	Photophobia	FAERS: 1		US FAERS
104	Pre-existing condition improved	FAERS: 1		US FAERS
105	Product preparation issue	FAERS: 1		US FAERS
106	Product use in unapproved indication	FAERS: 1		US FAERS
107	Pupillary light reflex tests abnormal	FAERS: 1		US FAERS
108	Purpura	FAERS: 1		US FAERS
109	Reduced facial expression	FAERS: 1		US FAERS
110	Retinal pallor	FAERS: 1		US FAERS
111	Sepsis	FAERS: 1		US FAERS
112	Sleep Paralysis	FAERS: 1		US FAERS
113	Status Epilepticus	FAERS: 1		US FAERS
114	Sunburn	FAERS: 1		US FAERS
115	Syncope	FAERS: 1	9604078	CTD US FAERS
116	Tachycardia	FAERS: 1	3800084 9561594	CTD US FAERS
117	Thrombosis	FAERS: 1		US FAERS
118	Unresponsive to stimuli	FAERS: 1		US FAERS
119	Weight decreased	FAERS: 1		US FAERS
120	nervous system disorder	FAERS: 1		US FAERS
121	Abnormalities, Drug-Induced		5973659	CTD
122	Agranulocytosis		1611088	CTD
123	Anemia, Hemolytic		17381629 18343736	CTD
124	Anorexia		6582023	CTD
125	Anxiety Disorders		1506013	CTD
126	Atrioventricular Block		3800084	CTD
127	Benign neoplasm of skin	Canada Vigilance: 1		Canada Vigilance
128	Chemical and Drug Induced Liver Injury		View details 15047046 19362101 22166485 23152190	CTD
129	Ciliophora Infections		12113305	CTD
130	Confusion		3800084 14676522 14765563	CTD
131	Dermatitis		4229630	CTD
132	Drug Eruptions		1998811	CTD
133	Drug Overdose		9517707	CTD
134	Dyspnea		9517707	CTD
135	Dystonia		14697088	CTD
136	Dysuria	Canada Vigilance: 1		Canada Vigilance
137	Fetal Diseases		5973659	CTD
138	Fever		8138671 15107507	CTD
139	Fish Diseases		12113305	CTD
140	Gait inability	Canada Vigilance: 1		Canada Vigilance
141	Granuloma		6402064 8628066 15047046	CTD
142	Hearing Loss		View details 2049249 2198912 2406680 3800084 7855666 8143397 8471402 9039480 9134134 9517707 20502380	CTD
143	Heart Diseases		3926054 22166485	CTD
144	Hemolytic-Uremic Syndrome		View details 1415380 1611088 1898704 7679450 7977300 8160939 9202872 10923967 11604563 11747383 12013332 12432194 12682720 12759685 14671503 16388419 16780456 20799358	CTD
145	Hemorrhage		1998811	CTD
146	Hypokalemia		9517707	CTD
147	Hypotension, Orthostatic		8513843 9518913	CTD
148	Kidney Cortex Necrosis		18343736	CTD
149	Long QT Syndrome		9517707 16178046	CTD
150	Malaria, Cerebral		8644976	CTD
151	Malaria, Falciparum		View details 1101464 4885738 6340187 8202114 8513843 9561594 9604078 15215119 17297207	CTD
152	Malaria		View details 1796238 1896775 2406680 8116811 8619448 8957602 15107507 18717145 18807436	CTD
153	Movement Disorders		21494842	CTD
154	Muscle Cramp		View details 1457303 1457907 1979368 12074203 14744847 18343736 19260037	CTD
155	Myotonia Congenita		1896199	CTD
156	Necrosis		12432194	CTD
157	Nephritis, Interstitial		8048427	CTD
158	Neuromuscular Diseases		16568672	CTD
159	Parasitemia		1896775 8138671 15107507	CTD
160	Photosensitivity Disorders		1998811	CTD
161	Poisoning		View details 3800084 3926054 3983356 14676522	CTD
162	Psychotic Disorders		5338485	CTD
163	Purpura, Thrombotic Thrombocytopenic		View details 8323089 11604563 11747383 12432194 14671503 16388419 20799358	CTD
164	Renal Insufficiency		View details 1421383 1898704 2393740 5426771 8048427 8323089 19260037 22166485	CTD
165	Retinal Diseases		8543087	CTD
166	Rhabdomyolysis		16780456	CTD
167	Seizures		1322322 14765563	CTD
168	Thrombotic Microangiopathies		19260037	CTD
169	Tonic Pupil		7369302	CTD
170	Torsades de Pointes		9272545 16178046	CTD
171	Urinary tract infection	Canada Vigilance: 1		Canada Vigilance
172	Vasculitis		View details 1457303 1998811 2108777 4238534	CTD
173	Ventricular Fibrillation		18717145 18807436	CTD
174	Vision Disorders		View details 3983356 6482803 7198212 17967270	CTD

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234