nitisinone
(OUBCNLGXQFSTLU-UHFFFAOYSA-N)
Structure
- SMILES
- O=C1CCCC(=O)C1C(=O)c1ccc(cc1[N+](=O)[O-])C(F)(F)F
- Type(s)
- Approved; Investigational
- ATC code(s)
- A16AX04
- Molecular Formula:
- C14H10F3NO5
- Molecular Weight:
- 329.228
- Log P:
- 3.2578
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 0
- TPSA:
- 97.03
- CAS Number(s):
- 104206-65-7
Synonym(s)
1.
nitisinone
2.
2-(2-nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione
3.
2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione
4.
NTBC cpd
5.
Orfadin
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Amino acid level increased | FAERS: 55 | OFFSIDES US FAERS | |
| 2 | Succinylacetone increased | FAERS: 25 | US FAERS | |
| 3 | Amino acid level decreased | FAERS: 21 | US FAERS | |
| 4 | Drug ineffective | FAERS: 13 | OFFSIDES US FAERS | |
| 5 | Vomiting | FAERS: 13 | US FAERS | |
| 6 | Epilepsy | FAERS: 10 | US FAERS | |
| 7 | Abdominal Pain | FAERS: 8 | US FAERS | |
| 8 | Pain | FAERS: 8 | US FAERS | |
| 9 | Sepsis | FAERS: 8 | US FAERS | |
| 10 | Ascites | FAERS: 7 | OFFSIDES US FAERS | |
| 11 | General physical health deterioration | FAERS: 7 | US FAERS | |
| 12 | Intellectual Disability | FAERS: 7 | US FAERS | |
| 13 | Mental impairment | FAERS: 7 | US FAERS | |
| 14 | Dehydration | FAERS: 6 | US FAERS | |
| 15 | Drug level decreased | FAERS: 6 | US FAERS | |
| 16 | Respiratory distress | FAERS: 6 | US FAERS | |
| 17 | Bronchitis | FAERS: 5 | OFFSIDES US FAERS | |
| 18 | Disease Progression | FAERS: 5 | US FAERS | |
| 19 | Dizziness | FAERS: 5 | US FAERS | |
| 20 | Educational problem | FAERS: 5 | OFFSIDES US FAERS | |
| 21 | Eye pain | FAERS: 5 | OFFSIDES US FAERS | |
| 22 | Hepatic Encephalopathy | FAERS: 5 | US FAERS | |
| 23 | Keratitis | FAERS: 5 | US FAERS | |
| 24 | Pneumonia | FAERS: 5 | US FAERS | |
| 25 | Product supply issue | FAERS: 5 | US FAERS | |
| 26 | Blood creatine phosphokinase increased | FAERS: 4 | US FAERS | |
| 27 | Chest Pain | FAERS: 4 | US FAERS | |
| 28 | Cytolytic hepatitis | FAERS: 4 | OFFSIDES US FAERS | |
| 29 | Hepatomegaly | FAERS: 4 | US FAERS | |
| 30 | Malnutrition | FAERS: 4 | US FAERS | |
| 31 | Memory impairment | FAERS: 4 | US FAERS | |
| 32 | Mental Retardation | FAERS: 4 | OFFSIDES US FAERS | |
| 33 | Portal Hypertension | FAERS: 4 | OFFSIDES US FAERS | |
| 34 | Priapism | FAERS: 4 | US FAERS | |
| 35 | nervous system disorder | FAERS: 4 | US FAERS | |
| 36 | Anxiety | FAERS: 3 | US FAERS | |
| 37 | Appendicitis | FAERS: 3 | OFFSIDES US FAERS | |
| 38 | Aspartate Aminotransferase Increased | FAERS: 3 | US FAERS | |
| 39 | Deafness | FAERS: 3 | US FAERS | |
| 40 | Drug dose omission | FAERS: 3 | US FAERS | |
| 41 | Eczema | FAERS: 3 | US FAERS | |
| 42 | Eye irritation | FAERS: 3 | US FAERS | |
| 43 | Headache | FAERS: 3 | US FAERS | |
| 44 | Hepatoblastoma | FAERS: 3 | OFFSIDES US FAERS | |
| 45 | Malaise | FAERS: 3 | US FAERS | |
| 46 | Malignant neoplasm progression | FAERS: 3 | US FAERS | |
| 47 | Maternal exposure during pregnancy | FAERS: 3 | US FAERS | |
| 48 | Metabolic acidosis | FAERS: 3 | US FAERS | |
| 49 | Microcephaly | FAERS: 3 | OFFSIDES US FAERS | |
| 50 | Opisthotonus | FAERS: 3 | OFFSIDES US FAERS | |
| 51 | Photophobia | FAERS: 3 | US FAERS | |
| 52 | Pregnancy | FAERS: 3 | US FAERS | |
| 53 | Psychomotor skills impaired | FAERS: 3 | US FAERS | |
| 54 | Quadriparesis | FAERS: 3 | OFFSIDES US FAERS | |
| 55 | Suicide attempt | FAERS: 3 | US FAERS | |
| 56 | Thrombocytopenia | FAERS: 3 | US FAERS | |
| 57 | Urine delta aminolevulinate increased | FAERS: 3 | OFFSIDES US FAERS | |
| 58 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 59 | Anger | FAERS: 2 | OFFSIDES US FAERS | |
| 60 | Asthenia | FAERS: 2 | US FAERS | |
| 61 | Bronchiolitis | FAERS: 2 | US FAERS | |
| 62 | Cardiac Arrest | FAERS: 2 | US FAERS | |
| 63 | Cholestasis | FAERS: 2 | US FAERS | |
| 64 | Constipation | FAERS: 2 | US FAERS | |
| 65 | Corneal lesion | FAERS: 2 | US FAERS | |
| 66 | Cyanosis | FAERS: 2 | OFFSIDES US FAERS | |
| 67 | Deposit eye | FAERS: 2 | US FAERS | |
| 68 | Drug toxicity | FAERS: 2 | OFFSIDES US FAERS | |
| 69 | Eclampsia | FAERS: 2 | US FAERS | |
| 70 | Economic problem | FAERS: 2 | US FAERS | |
| 71 | Eye Redness | FAERS: 2 | OFFSIDES US FAERS | |
| 72 | Eye inflammation | FAERS: 2 | US FAERS | |
| 73 | Failure to Thrive | FAERS: 2 | US FAERS | |
| 74 | Fatigue | FAERS: 2 | US FAERS | |
| 75 | Feeling abnormal | FAERS: 2 | US FAERS | |
| 76 | Glioblastoma Multiforme | FAERS: 2 | US FAERS | |
| 77 | Guillain-Barre Syndrome | FAERS: 2 | US FAERS | |
| 78 | Hepatitis | FAERS: 2 | US FAERS | |
| 79 | Hepatosplenomegaly | FAERS: 2 | OFFSIDES US FAERS | |
| 80 | Infection | FAERS: 2 | US FAERS | |
| 81 | Influenza | FAERS: 2 | US FAERS | |
| 82 | Lymphoma | FAERS: 2 | OFFSIDES US FAERS | |
| 83 | Metastases to adrenals | FAERS: 2 | US FAERS | |
| 84 | Mutism | FAERS: 2 | US FAERS | |
| 85 | Myoclonus | FAERS: 2 | US FAERS | |
| 86 | Nausea | FAERS: 2 | US FAERS | |
| 87 | Nephrolithiasis | FAERS: 2 | US FAERS | |
| 88 | Obesity | FAERS: 2 | US FAERS | |
| 89 | Polyneuropathy | FAERS: 2 | OFFSIDES US FAERS | |
| 90 | Protein total decreased | FAERS: 2 | OFFSIDES US FAERS | |
| 91 | Protein total increased | FAERS: 2 | US FAERS | |
| 92 | Pruritus | FAERS: 2 | US FAERS | |
| 93 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 94 | Syncope | FAERS: 2 | US FAERS | |
| 95 | Tachycardia | FAERS: 2 | US FAERS | |
| 96 | Urinary tract infection | FAERS: 2 | US FAERS | |
| 97 | Urine delta aminolevulinate | FAERS: 2 | US FAERS | |
| 98 | jaundice | FAERS: 2 | US FAERS | |
| 99 | Abasia | FAERS: 1 | OFFSIDES US FAERS | |
| 100 | Accidental death | FAERS: 1 | US FAERS | |
| 101 | Acidosis | FAERS: 1 | US FAERS | |
| 102 | Acrodermatitis enteropathica | FAERS: 1 | US FAERS | |
| 103 | Acute kidney injury | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 104 | Adenoidectomy | FAERS: 1 | US FAERS | |
| 105 | Aneurysm | FAERS: 1 | US FAERS | |
| 106 | Back Pain | FAERS: 1 | US FAERS | |
| 107 | Blepharitis | FAERS: 1 | US FAERS | |
| 108 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 109 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 110 | Body height below normal | FAERS: 1 | US FAERS | |
| 111 | Bronchopulmonary Dysplasia | FAERS: 1 | US FAERS | |
| 112 | Burning sensation | FAERS: 1 | US FAERS | |
| 113 | Cell Death | FAERS: 1 | US FAERS | |
| 114 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 115 | Coagulation test abnormal | FAERS: 1 | US FAERS | |
| 116 | Conjunctivitis | FAERS: 1 | US FAERS | |
| 117 | Corneal Opacity | FAERS: 1 | US FAERS | |
| 118 | Corneal erosion | FAERS: 1 | US FAERS | |
| 119 | Death of relative | FAERS: 1 | US FAERS | |
| 120 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 121 | Device related sepsis | FAERS: 1 | US FAERS | |
| 122 | Disseminated Intravascular Coagulation | FAERS: 1 | US FAERS | |
| 123 | Drowning | FAERS: 1 | US FAERS | |
| 124 | Dry skin | FAERS: 1 | OFFSIDES US FAERS | |
| 125 | Dysphonia | FAERS: 1 | US FAERS | |
| 126 | Ear tube insertion | FAERS: 1 | US FAERS | |
| 127 | Electroencephalogram abnormal | FAERS: 1 | US FAERS | |
| 128 | Erythema | FAERS: 1 | US FAERS | |
| 129 | Facial Pain | FAERS: 1 | US FAERS | |
| 130 | Gastritis | FAERS: 1 | US FAERS | |
| 131 | Gastroenteritis | FAERS: 1 | OFFSIDES US FAERS | |
| 132 | General physical condition abnormal | FAERS: 1 | US FAERS | |
| 133 | Genital erythema | FAERS: 1 | US FAERS | |
| 134 | Glaucoma | FAERS: 1 | US FAERS | |
| 135 | Hepatic dysplasia | FAERS: 1 | OFFSIDES US FAERS | |
| 136 | Hyperphagia | FAERS: 1 | US FAERS | |
| 137 | Hypersensitivity | FAERS: 1 | US FAERS | |
| 138 | Hypophagia | FAERS: 1 | US FAERS | |
| 139 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 140 | Ileus | FAERS: 1 | US FAERS | |
| 141 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 142 | Infantile spitting up | FAERS: 1 | US FAERS | |
| 143 | Inflammation | FAERS: 1 | US FAERS | |
| 144 | Intelligence test abnormal | FAERS: 1 | US FAERS | |
| 145 | Intestinal Obstruction | FAERS: 1 | OFFSIDES US FAERS | |
| 146 | Lethargy | FAERS: 1 | US FAERS | |
| 147 | Liver transplant rejection | FAERS: 1 | US FAERS | |
| 148 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 149 | Malignant transformation | FAERS: 1 | US FAERS | |
| 150 | Medication Error | FAERS: 1 | US FAERS | |
| 151 | Mental status changes | FAERS: 1 | US FAERS | |
| 152 | Metastases to muscle | FAERS: 1 | US FAERS | |
| 153 | Myoclonic Epilepsy | FAERS: 1 | US FAERS | |
| 154 | Myopathy | FAERS: 1 | US FAERS | |
| 155 | Neonatal disorder | FAERS: 1 | US FAERS | |
| 156 | Neuroblastoma | FAERS: 1 | US FAERS | |
| 157 | Nutritional condition abnormal | FAERS: 1 | US FAERS | |
| 158 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 159 | Overweight | FAERS: 1 | US FAERS | |
| 160 | Paresis | FAERS: 1 | US FAERS | |
| 161 | Peritonitis | FAERS: 1 | US FAERS | |
| 162 | Piloerection | FAERS: 1 | US FAERS | |
| 163 | Pinguecula | FAERS: 1 | US FAERS | |
| 164 | Pneumococcal sepsis | FAERS: 1 | US FAERS | |
| 165 | Posterior reversible encephalopathy syndrome | FAERS: 1 | US FAERS | |
| 166 | Protein total abnormal | FAERS: 1 | US FAERS | |
| 167 | Prothrombin level decreased | FAERS: 1 | US FAERS | |
| 168 | Prothrombin time ratio decreased | FAERS: 1 | US FAERS | |
| 169 | Pseudoporphyria | FAERS: 1 | US FAERS | |
| 170 | Rash erythematous | FAERS: 1 | US FAERS | |
| 171 | Renal tubular disorder | FAERS: 1 | US FAERS | |
| 172 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 173 | Respiratory muscle weakness | FAERS: 1 | US FAERS | |
| 174 | Respiratory tract congestion | FAERS: 1 | US FAERS | |
| 175 | Rickets | FAERS: 1 | US FAERS | |
| 176 | Selective Mutism | FAERS: 1 | US FAERS | |
| 177 | Sensory level abnormal | FAERS: 1 | US FAERS | |
| 178 | Septic Shock | FAERS: 1 | US FAERS | |
| 179 | Speech rehabilitation | FAERS: 1 | US FAERS | |
| 180 | Subcutaneous Abscess | FAERS: 1 | US FAERS | |
| 181 | Tenosynovitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 182 | Therapy cessation | FAERS: 1 | US FAERS | |
| 183 | Therapy non-responder | FAERS: 1 | US FAERS | |
| 184 | Tonsillectomy | FAERS: 1 | US FAERS | |
| 185 | Transaminases increased | FAERS: 1 | US FAERS | |
| 186 | Ultrasound liver abnormal | FAERS: 1 | US FAERS | |
| 187 | Visual Impairment | FAERS: 1 | US FAERS | |
| 188 | Weight decreased | FAERS: 1 | US FAERS | |
| 189 | Zinc deficiency | FAERS: 1 | US FAERS | |
| 190 | treatment failure | FAERS: 1 | US FAERS | |
| 191 | Acute polyneuropathy | OFFSIDES | ||
| 192 | Amnesia | OFFSIDES | ||
| 193 | Apnea | OFFSIDES | ||
| 194 | Bulbar palsy | OFFSIDES | ||
| 195 | Cardioactive drug level | OFFSIDES | ||
| 196 | Cirrhosis | OFFSIDES | ||
| 197 | Conjunctival deposit | OFFSIDES | ||
| 198 | Diarrhea | OFFSIDES | ||
| 199 | Fluid overload | OFFSIDES | ||
| 200 | Hyporeflexia | OFFSIDES | ||
| 201 | Neonatal hypotension | OFFSIDES | ||
| 202 | Neonatal respiratory failure | OFFSIDES | ||
| 203 | Tyrosinemias | 11488774 12899938 | CTD |
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