Deferiprone
(TZXKOCQBRNJULO-UHFFFAOYSA-N)
Structure
- SMILES
- Cn1ccc(=O)c(c1C)O
- Type(s)
- Approved
- ATC code(s)
- V03AC02
- Molecular Formula:
- C7H9NO2
- Molecular Weight:
- 139.152
- Log P:
- 0.3993
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 1
- TPSA:
- 42.23
- CAS Number(s):
- 30652-11-0
Synonym(s)
1.
Deferiprone
2.
1,2-Dimethyl-3-hydroxy-4-pyridinone
3.
1,2-Dimethyl-3-hydroxypyrid-4-one
4.
1,2-Dimethyl-3-hydroxypyridin-4-one
5.
3-Hydroxy-1,2-dimethyl-4-pyridinone
6.
DMOHPO
7.
Ferriprox
8.
HDMPP
9.
1,2 Dimethyl 3 hydroxy 4 pyridinone
10.
1,2 Dimethyl 3 hydroxypyrid 4 one
11.
1,2 Dimethyl 3 hydroxypyridin 4 one
12.
3 Hydroxy 1,2 dimethyl 4 pyridinone
External Link(s)
| MeSH | D000077543 |
| PubChem Compound | 2972 |
| ChEBI | 68554 |
| CHEMBL | CHEMBL70927 |
| DrugBank | DB08826 |
| DrugCentral | 4188 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 7456 |
| KEGG | dr:D07416 |
| Therapeutic Target Database | D0N0OU |
| ZINC | 6226 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Agranulocytosis | FAERS: 40 Canada Vigilance: 5 | Canada Vigilance SIDER US FAERS | |
| 2 | Neutropenia | FAERS: 21 Canada Vigilance: 6 | Canada Vigilance SIDER US FAERS | |
| 3 | Nausea | FAERS: 14 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 4 | Arthralgia | FAERS: 11 | SIDER US FAERS | |
| 5 | Vomiting | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 6 | Fatigue | FAERS: 8 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 7 | Pneumonia | FAERS: 8 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 8 | White blood cell count decreased | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 9 | Infection | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 10 | Leukopenia | FAERS: 6 | US FAERS | |
| 11 | Myalgia | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 12 | Sepsis | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 13 | Febrile Neutropenia | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 14 | Pain | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance SIDER US FAERS | |
| 15 | Thrombocytopenia | FAERS: 5 | US FAERS | |
| 16 | Arthritis | FAERS: 4 | SIDER US FAERS | |
| 17 | Asthenia | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 18 | Back Pain | FAERS: 4 | SIDER US FAERS | |
| 19 | Chills | FAERS: 4 | SIDER US FAERS | |
| 20 | Dizziness | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 21 | Hypotension | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 22 | Malaise | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 23 | Neutrophil count decreased | FAERS: 4 | SIDER US FAERS | |
| 24 | Somnolence | FAERS: 4 | SIDER US FAERS | |
| 25 | Abdominal discomfort | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 26 | Cerebrovascular accident | FAERS: 3 | US FAERS | |
| 27 | Hypertransaminasaemia | FAERS: 3 | US FAERS | |
| 28 | Mastectomy | FAERS: 3 | US FAERS | |
| 29 | Pharyngitis | FAERS: 3 | SIDER US FAERS | |
| 30 | Urticaria | FAERS: 3 | SIDER US FAERS | |
| 31 | Agitation | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 32 | Back disorder | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 33 | Hyperpyrexia | FAERS: 2 | US FAERS | |
| 34 | Miliaria | FAERS: 2 | US FAERS | |
| 35 | Oropharyngeal pain | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 36 | Persistent depressive disorder | FAERS: 2 | US FAERS | |
| 37 | School refusal | FAERS: 2 | US FAERS | |
| 38 | Separation Anxiety Disorder | FAERS: 2 | US FAERS | |
| 39 | Sinusitis | FAERS: 2 | US FAERS | |
| 40 | Tachycardia | FAERS: 2 | US FAERS | |
| 41 | Toxicity to various agents | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 42 | Unevaluable event | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 43 | Abscess | FAERS: 1 | US FAERS | |
| 44 | Alanine Aminotransferase Increased | FAERS: 1 | SIDER US FAERS | |
| 45 | Anal Fistula | FAERS: 1 | US FAERS | |
| 46 | Ankle Fracture | FAERS: 1 | US FAERS | |
| 47 | Aspartate Aminotransferase Increased | FAERS: 1 | SIDER US FAERS | |
| 48 | Asthma | FAERS: 1 | US FAERS | |
| 49 | Atrial Fibrillation | FAERS: 1 | SIDER US FAERS | |
| 50 | Babesiosis | FAERS: 1 | US FAERS | |
| 51 | Bone pain | FAERS: 1 | US FAERS | |
| 52 | Breech Presentation | FAERS: 1 | US FAERS | |
| 53 | Bronchitis | FAERS: 1 | US FAERS | |
| 54 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 55 | Catheter site infection | FAERS: 1 | US FAERS | |
| 56 | Cellulitis | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 57 | Chest Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 58 | Cholestasis | FAERS: 1 | US FAERS | |
| 59 | Clostridium difficile colitis | FAERS: 1 | US FAERS | |
| 60 | Constipation | FAERS: 1 | US FAERS | |
| 61 | Cyst | FAERS: 1 | US FAERS | |
| 62 | Cytomegalovirus test positive | FAERS: 1 | US FAERS | |
| 63 | Diplopia | FAERS: 1 | SIDER US FAERS | |
| 64 | Disease Progression | FAERS: 1 | US FAERS | |
| 65 | Epilepsy | FAERS: 1 | US FAERS | |
| 66 | Epistaxis | FAERS: 1 | SIDER US FAERS | |
| 67 | Erythema | FAERS: 1 | US FAERS | |
| 68 | Euphoric mood | FAERS: 1 | US FAERS | |
| 69 | Feeling abnormal | FAERS: 1 | US FAERS | |
| 70 | Gastritis | FAERS: 1 | US FAERS | |
| 71 | General physical health deterioration | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 72 | Gingival Hypertrophy | FAERS: 1 | US FAERS | |
| 73 | Hospice Care | FAERS: 1 | US FAERS | |
| 74 | Hypersplenism | FAERS: 1 | SIDER US FAERS | |
| 75 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 76 | Inflammation | FAERS: 1 | US FAERS | |
| 77 | Injection site infection | FAERS: 1 | US FAERS | |
| 78 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 79 | Iron Overload | FAERS: 1 | 31542421 | CTD US FAERS |
| 80 | Leptotrichia infection | FAERS: 1 | US FAERS | |
| 81 | Lymphadenitis | FAERS: 1 | US FAERS | |
| 82 | Lymphoma | FAERS: 1 | US FAERS | |
| 83 | Lymphopenia | FAERS: 1 | US FAERS | |
| 84 | MYELODYSPLASTIC SYNDROME | FAERS: 1 | US FAERS | |
| 85 | Malignant neoplasm progression | FAERS: 1 | US FAERS | |
| 86 | Malnutrition | FAERS: 1 | SIDER US FAERS | |
| 87 | Medical device change | FAERS: 1 | US FAERS | |
| 88 | Myoclonus | FAERS: 1 | US FAERS | |
| 89 | Nasopharyngitis | FAERS: 1 | US FAERS | |
| 90 | Nephroptosis | FAERS: 1 | US FAERS | |
| 91 | Noninfective gingivitis | FAERS: 1 | US FAERS | |
| 92 | Oral infection | FAERS: 1 | US FAERS | |
| 93 | Overdose | FAERS: 1 | US FAERS | |
| 94 | Pancytopenia | FAERS: 1 | SIDER US FAERS | |
| 95 | Polyarthritis | FAERS: 1 | US FAERS | |
| 96 | Pre-existing condition improved | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 97 | Procedural complication | FAERS: 1 | US FAERS | |
| 98 | Pruritus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 99 | Pulmonary Embolism | FAERS: 1 | SIDER US FAERS | |
| 100 | Rhinovirus infection | FAERS: 1 | US FAERS | |
| 101 | Soft Tissue Infection | FAERS: 1 | US FAERS | |
| 102 | Systemic Inflammatory Response Syndrome | FAERS: 1 | US FAERS | |
| 103 | Thrombosis | FAERS: 1 | US FAERS | |
| 104 | Tooth Infection | FAERS: 1 | US FAERS | |
| 105 | Transaminases increased | FAERS: 1 | US FAERS | |
| 106 | Urethral fistula | FAERS: 1 | US FAERS | |
| 107 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 108 | Visual Impairment | FAERS: 1 | US FAERS | |
| 109 | Weight decreased | FAERS: 1 | US FAERS | |
| 110 | Abdominal Pain | SIDER | ||
| 111 | Anaphylactic shock | SIDER | ||
| 112 | Arthropathy | SIDER | ||
| 113 | Blood and lymphatic system disorders | SIDER | ||
| 114 | Bruxism | SIDER | ||
| 115 | Cardiomyopathies | 18298856 | CTD | |
| 116 | Cardiovascular Diseases | 16339662 | CTD | |
| 117 | Chromaturia | SIDER | ||
| 118 | Cryptococcal cutaneous infection | SIDER | ||
| 119 | Dehydration | SIDER | ||
| 120 | Dermatitis | SIDER | ||
| 121 | Disability | SIDER | ||
| 122 | Discomfort | SIDER | ||
| 123 | Drug ineffective | Canada Vigilance: 3 | Canada Vigilance | |
| 124 | Dyspepsia | SIDER | ||
| 125 | Encephalitis | SIDER | ||
| 126 | Enterocolitis | SIDER | ||
| 127 | Fibrosis | SIDER | ||
| 128 | Friedreich Ataxia | 23418481 | CTD | |
| 129 | Gastric ulcer | SIDER | ||
| 130 | Gastrointestinal Pain | SIDER | ||
| 131 | Glycosuria | SIDER | ||
| 132 | Headache | SIDER | ||
| 133 | Hepatitis C | SIDER | ||
| 134 | Hepatitis | SIDER | ||
| 135 | Hepatomegaly | SIDER | ||
| 136 | Hypersensitivity | SIDER | ||
| 137 | Infestation | SIDER | ||
| 138 | Metabolic acidosis | SIDER | ||
| 139 | Muscle Spasticity | Canada Vigilance: 1 | Canada Vigilance | |
| 140 | Muscle relaxant therapy | SIDER | ||
| 141 | Musculoskeletal discomfort | SIDER | ||
| 142 | Myositis | SIDER | ||
| 143 | Nystagmus | SIDER | ||
| 144 | Obsessive-Compulsive Disorder | SIDER | ||
| 145 | Optic Neuritis | SIDER | ||
| 146 | Pancreatitis | SIDER | ||
| 147 | Psychomotor skills impaired | SIDER | ||
| 148 | Retinal toxicity | SIDER | ||
| 149 | Subcutaneous Abscess | SIDER | ||
| 150 | Thrombocytosis | SIDER | ||
| 151 | Trismus | SIDER | ||
| 152 | Ventricular Dysfunction, Left | 16798648 18298856 31542421 | CTD | |
| 153 | effusion | SIDER | ||
| 154 | furuncle | SIDER | ||
| 155 | jaundice | SIDER | ||
| 156 | nervous system disorder | SIDER |
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