MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Addison Disease

(UMLS:C0001403)

Definition:: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
UMLS ID:: C0001403
MeSH ID:: D000224

Classification 1:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.053.500.263

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.163

Synonym(s)

Addison Disease

ADDISON DISEASE

ADRENAL INSUFFICIENCY (ADDISON'S DISEASE)

ADRENOCORTICAL INSUFFICIENCY, PRIMARY FAILURE

Addison disease

Addison's Disease

Addison's disease

Addison's disease, NOS

Addison; disease or syndrome

10.

Addisons Disease

11.

Chronic Primary Adrenal Insufficiency

12.

Disease;Addisons

13.

Hypocortisolism

14.

Primary Hypoadrenalism

15.

Primary adrenal deficiency

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fludrocortisone		9816363	CTD
2	Hydrocortisone		16682841	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hypoaldosteronism	31.8%
2	Antiphospholipid Syndrome	27.9%
3	Autoimmune thyroiditis	24.1%
4	Lupus Erythematosus, Systemic	21.1%
5	Overlap syndrome	21.1%
6	Adrenal Cortex Diseases	20.9%
7	Pemphigus	20.7%
8	Latent Autoimmune Diabetes in Adults	20.7%
9	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	20.5%
10	Autoimmune hepatitis	20.5%
11	Graves Disease	18.2%
12	Autoimmune Lymphoproliferative Syndrome	17.2%
13	Adrenal Gland Neoplasms	16.7%
14	Dermatitis Herpetiformis	16.4%
15	Hypersensitivity	14.6%
16	Immunologic Deficiency Syndromes	14.6%
17	Immunoproliferative Disorders	14.6%
18	Immune reconstitution syndrome	14.6%
19	Immune Reconstitution Inflammatory Syndrome	14.6%
20	Rheumatoid Arthritis	13.8%
21	Juvenile arthritis	13.8%
22	Cushing Syndrome	13.6%
23	Hyperaldosteronism	13.6%
24	Anti-Glomerular Basement Membrane Disease	13.4%
25	Myasthenia Gravis, Autoimmune, Experimental	12.4%
26	Myasthenia Gravis	12.3%
27	Uveomeningoencephalitic Syndrome	12.3%
28	Gonadal Disorders	12.2%
29	Parathyroid Diseases	12.2%
30	Thyroid Diseases	12.2%
31	Granulomatosis with polyangiitis	12%
32	Autoimmune thrombocytopenia	11.8%
33	Immune thrombocytopenic purpura	11.8%
34	Transfusion Reaction	10.9%
35	Hypotensive Transfusion Reaction	10.9%
36	Stiff-Person Syndrome	10.3%
37	Polyradiculoneuropathy	10.3%
38	Polyradiculoneuritis	10.3%
39	Multiple Sclerosis	10.1%
40	Felty Syndrome	10%
41	Lupus Nephritis	9.9%
42	Adrenocortical carcinoma	9.8%
43	Neuromyelitis Optica	9.4%
44	Leukoencephalitis, Acute Hemorrhagic	9.3%
45	Immune Complex Diseases	9.3%
46	Latex allergy	9.3%
47	Bone Diseases, Endocrine	9.1%
48	Endocrine Gland Neoplasms	9.1%
49	Diabetes Mellitus	8.9%
50	Multiple Sclerosis, Chronic Progressive	8.9%
51	Multiple Sclerosis, Relapsing-Remitting	8.9%
52	Pituitary Diseases	8.8%
53	Vasculitis, Central Nervous System	8.7%
54	Rheumatoid Vasculitis	8.5%
55	Encephalomyelitis, Acute Disseminated	8.3%
56	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.3%
57	Lupus Vasculitis, Central Nervous System	8.3%
58	Waterhouse-Friderichsen Syndrome	8.3%
59	Neuritis, Autoimmune, Experimental	8.3%
60	Glomerulonephritis, Membranoproliferative	8.3%
61	Lambert-Eaton Myasthenic Syndrome	7.6%
62	Sicca Syndrome	7.5%
63	Sjogren's Syndrome	7.5%
64	Environmental Illness	7.3%
65	Dwarfism	7.1%
66	Guillain-Barre Syndrome	7.1%
67	Lymphoproliferative Disorders	7%
68	Euthyroid Sick Syndromes	7%
69	Goiter	7%
70	Hyperparathyroidism	7%
71	Hyperthyroidism	7%
72	Hyperthyroxinemia	7%
73	Hypogonadism	7%
74	Hypoparathyroidism	7%
75	Hypothyroidism	7%
76	Delayed Puberty	7%
77	Precocious Puberty	7%
78	Thyroiditis	7%
79	Hypogonadotropic hypogonadism	7%
80	Testotoxicosis	7%
81	Secondary hypothyroidism	7%
82	Primary Hyperthyroidism	7%
83	Primary Hypothyroidism	7%
84	Paraproteinemias	6.9%
85	Parathyroid Neoplasms	6.9%
86	Thyroid Neoplasm	6.9%
87	Thyroid carcinoma	6.9%
88	Lymphopenia	6.8%
89	anaphylaxis	6.8%
90	Food Allergy	6.8%
91	Anaphylactic shock	6.8%
92	Primary amyloidosis	6.7%
93	Monoclonal Gammopathy of Undetermined Significance	6.7%
94	Serum Sickness	6.1%
95	Thrombocytopenic purpura	5.8%
96	Asthma, Aspirin-Induced	5.8%
97	Milk Allergy	5.6%
98	Schnitzler Syndrome	5.6%
99	Wheat Hypersensitivity	5.6%
100	Hypergammaglobulinemia	5.6%
101	Giant Cell Arteritis	5.5%
102	Temporal Arteritis	5.5%
103	Agammaglobulinemia	5.5%
104	Kounis Syndrome	5.5%
105	HIV Infections	5.4%
106	Transfusion-Related Acute Lung Injury	5.4%
107	Respiratory Hypersensitivity	5.4%
108	Testicular Diseases	5.3%
109	Sick Building Syndrome	5.2%
110	Multiple Chemical Sensitivity	5.2%
111	Ovarian Diseases	5.1%
112	Empty Sella Syndrome	5.1%
113	Hyperpituitarism	5.1%
114	Hypopituitarism	5.1%
115	Hypophysitis	5.1%
116	Plasmacytoma	5.1%
117	Tumor Lysis Syndrome	5.1%
118	Urticaria	5.1%
119	Vasculitis, Leukocytoclastic, Cutaneous	5.1%
120	HTLV-I Infections	5%
121	Job Syndrome	5%
122	Adrenoleukodystrophy	5%
123	Multiple Myeloma	5%
124	Myelitis, Transverse	5%
125	Congenital Hypothyroidism	4.8%
126	ovarian neoplasm	4.8%
127	Sezary Syndrome	4.7%
128	Hyperparathyroidism, Secondary	4.5%
129	Thyrotoxicosis	4.5%
130	Hyperparathyroidism, Primary	4.5%
131	Thyroid Hormone Resistance Syndrome	4.5%
132	Miller Fisher Syndrome	4.5%
133	Thyroid Nodule	4.4%
134	Testicular Neoplasms	4.2%
135	Mastocytosis, Systemic	4.1%
136	Gestational Diabetes	4.1%
137	Lymphoma	4.1%
138	Diabetes Insipidus	4.1%
139	Diabetes Mellitus, Experimental	4.1%
140	Mastocytosis	4.1%
141	Drug Eruptions	4.1%
142	Chronic granulomatous disease	4%
143	Heavy Chain Disease	4%
144	Dermatitis, Allergic Contact	4%
145	HIV Seropositivity	4%
146	Pituitary Adenoma	4%
147	Pituitary Neoplasms	4%
148	Prolactinoma	3.8%
149	Growth Hormone-Secreting Pituitary Adenoma	3.8%
150	Diabetic Angiopathies	3.4%
151	Hermaphroditism	3.4%
152	Disorders of Sex Development	3.4%
153	Diabetic Neuropathies	3.4%
154	Myxedema	3.4%
155	Orchitis	3.4%
156	Diabetic Amyotrophy	3.4%
157	Diabetic Autonomic Neuropathy	3.4%
158	Diabetic Cardiomyopathies	3.4%
159	Angioedema	3.4%
160	Kernicterus	3.4%
161	Hyperglycemic Hyperosmolar Nonketotic Coma	3.4%
162	Hashimoto Disease	3.4%
163	Acquired Immunodeficiency Syndrome	3.4%
164	AIDS related complex	3.4%
165	Infectious Mononucleosis	3.4%
166	Ovarian Hyperstimulation Syndrome	3.3%
167	Hyperprolactinemia	3.3%
168	Cryoglobulinemia	3.3%
169	Hodgkin Disease	3.3%
170	Leukemia, Plasma Cell	3.3%
171	Lymphoma, Non-Hodgkin	3.3%
172	Pituitary Apoplexy	3.3%
173	POEMS Syndrome	3.3%
174	Leukemia, T-Cell	3.3%
175	Acute Generalized Exanthematous Pustulosis	3.3%
176	Leukemia, B-Cell	3.3%
177	Diabetic Foot	3.3%
178	Nelson Syndrome	3.3%
179	Ataxia Telangiectasia	3%
180	Asthma, Exercise-Induced	3%
181	Status Asthmaticus	3%
182	Multiple Endocrine Neoplasia	3%
183	Pancreatic Neoplasm	3%
184	Hydrops Fetalis	3%
185	Lymphoma, Follicular	3%
186	T-Cell Lymphoma	3%
187	Mantle cell lymphoma	3%
188	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3%
189	Leukemia, Large Granular Lymphocytic	3%
190	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3%
191	AIDS-Related Opportunistic Infections	2.9%
192	Kallmann Syndrome	2.9%
193	Dermatitis, Atopic	2.9%
194	granulosa cell tumor	2.9%
195	Carcinoma, Ovarian Epithelial	2.9%
196	Asthma	2.9%
197	HIV Wasting Syndrome	2.9%
198	AIDS Dementia Complex	2.8%
199	AIDS-Associated Nephropathy	2.8%
200	Hereditary Angioedema Type III	2.8%
201	Hereditary Angioedema Types I and II	2.8%
202	Lymphoma, T-Cell, Cutaneous	2.8%
203	Lymphoma, AIDS-Related	2.8%
204	Enteropathy-Associated T-Cell Lymphoma	2.8%
205	Composite Lymphoma	2.8%
206	Primary Effusion Lymphoma	2.8%
207	Erythema Nodosum	2.8%
208	Dermatitis, Photoallergic	2.7%
209	Lymphangioleiomyomatosis	2.7%
210	Corpus Luteum Cyst	2.7%
211	Ovarian Cysts	2.7%
212	Gigantism	2.7%
213	Mycosis Fungoides	2.7%
214	Lymphomatoid Papulosis	2.7%
215	Plasmablastic lymphoma	2.7%
216	Diabetic Nephropathy	2.7%
217	Acromegaly	2.7%
218	Anovulation	2.7%
219	Diabetic Ketoacidosis	2.7%
220	Oophoritis	2.6%
221	Asthma, Occupational	2.6%
222	Klinefelter Syndrome	2.5%
223	Farmer's Lung	2.5%
224	Angioedemas, Hereditary	2.5%
225	Waldenstrom Macroglobulinemia	2.5%
226	Wiskott-Aldrich Syndrome	2.5%
227	Hay fever	2.5%
228	Rhinitis, Allergic, Perennial	2.5%
229	HIV-Associated Lipodystrophy Syndrome	2.5%
230	Aspergillosis, Allergic Bronchopulmonary	2.4%
231	Lymphomatoid Granulomatosis	2.3%
232	Cryptorchidism	2.3%
233	Gonadal Dysgenesis	2.2%
234	Adrenogenital Syndrome	2.2%
235	Ovotesticular Disorders of Sex Development	2.2%
236	Toxic Epidermal Necrolysis	2.1%
237	Stevens-Johnson Syndrome	2.1%
238	Diabetic Retinopathy	2%
239	Polycystic Ovary Syndrome	2%
240	Burkitt Lymphoma	2%
241	Leydig Cell Tumor	2%
242	Hyperandrogenism	1.9%
243	Multiple Endocrine Neoplasia Type 1	1.9%
244	Carcinoma, Pancreatic Ductal	1.5%
245	Turner Syndrome	1.3%
246	insulinoma	1.2%
247	Gastrinoma	1.2%
248	Glucagonoma	1.2%
249	Carcinoma, Endometrioid	1.2%
250	Renal Osteodystrophy	1.1%
251	Renal rickets	1.1%
252	Vipoma	1.1%
253	Denys-Drash Syndrome	0.7%

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