MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cushing Syndrome

(UMLS:C0010481)

Definition:: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.
UMLS ID:: C0010481
MeSH ID:: D003480

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.053.800.367

Synonym(s)

Cushing Syndrome

CUSHING

CUSHING SYNDROME

CUSHING'S SYNDROME

CUSHINGS SYNDROME

Cortisol Excess

Cushing syndrome

Cushing's Syndrome

Cushing's basophilism

10.

Cushing's syndrome

11.

Cushing's syndrome III

Associated Drug(s)

	Name	Reference(s)	Data Source
1	18-hydroxydeoxycorticosterone	11993792	CTD
2	Azathioprine	12488716	CTD
3	Bromocriptine	1332855	CTD
4	Cisapride	12519861	CTD
5	Corticosterone	9881897 11993792	CTD
6	Cyproheptadine	69087 6327962 7915698	CTD
7	Desoxycorticosterone	9881897	CTD
8	Dexamethasone	1619017 3596646 10463118	CTD
9	Hydrocortisone	7792821	CTD
10	Ketoconazole	2632720 11308052 20529775	CTD
11	Medroxyprogesterone Acetate	8522428	CTD
12	Megestrol Acetate	8522428	CTD
13	Methylprednisolone Acetate	11004305	CTD
14	Metyrapone	11308052	CTD
15	Mifepristone	19289534	CTD
16	Mitotane	2963295 19153526	CTD
17	Octreotide	20529775	CTD
18	Prednisolone	12488716 17199845 17951084	CTD
19	Prednisone	4700331 5764773	CTD
20	Triamcinolone	7788158	CTD
21	prednisolone acetate	11004305	CTD
22	trilostane	19153526	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperaldosteronism	46.7%
2	Adrenal Cortex Diseases	31%
3	Adrenal Gland Neoplasms	20.7%
4	Hypoaldosteronism	20%
5	Gonadal Disorders	18.5%
6	Parathyroid Diseases	18.5%
7	Thyroid Diseases	18.5%
8	Addison Disease	13.6%
9	Primary Adrenal Insufficiency	13.6%
10	Bone Diseases, Endocrine	12.2%
11	Endocrine Gland Neoplasms	12.2%
12	Diabetes Mellitus	11.9%
13	Pituitary Diseases	11.8%
14	Adrenocortical carcinoma	11.3%
15	Euthyroid Sick Syndromes	10.3%
16	Goiter	10.3%
17	Hyperparathyroidism	10.3%
18	Hyperthyroidism	10.3%
19	Hyperthyroxinemia	10.3%
20	Hypogonadism	10.3%
21	Hypoparathyroidism	10.3%
22	Hypothyroidism	10.3%
23	Delayed Puberty	10.3%
24	Precocious Puberty	10.3%
25	Thyroiditis	10.3%
26	Hypogonadotropic hypogonadism	10.3%
27	Testotoxicosis	10.3%
28	Secondary hypothyroidism	10.3%
29	Primary Hyperthyroidism	10.3%
30	Primary Hypothyroidism	10.3%
31	Dwarfism	8.9%
32	Parathyroid Neoplasms	8.2%
33	Thyroid Neoplasm	8.2%
34	Thyroid carcinoma	8.2%
35	Testicular Diseases	7%
36	Ovarian Diseases	6.7%
37	Empty Sella Syndrome	6.7%
38	Hyperpituitarism	6.7%
39	Hypopituitarism	6.7%
40	Hypophysitis	6.7%
41	Hyperparathyroidism, Secondary	6.7%
42	Thyrotoxicosis	6.7%
43	Hyperparathyroidism, Primary	6.7%
44	Thyroid Hormone Resistance Syndrome	6.7%
45	Congenital Hypothyroidism	5.6%
46	ovarian neoplasm	5.5%
47	Graves Disease	5.4%
48	Thyroid Nodule	5.3%
49	Gestational Diabetes	5.1%
50	Latent Autoimmune Diabetes in Adults	5.1%
51	Diabetes Insipidus	5%
52	Diabetes Mellitus, Experimental	5%
53	Hyperglycemic Hyperosmolar Nonketotic Coma	4.9%
54	Hashimoto Disease	4.9%
55	Testicular Neoplasms	4.8%
56	Diabetic Angiopathies	4.5%
57	Autoimmune thyroiditis	4.5%
58	Diabetic Neuropathies	4.4%
59	Myxedema	4.4%
60	Orchitis	4.4%
61	Diabetic Amyotrophy	4.4%
62	Diabetic Autonomic Neuropathy	4.4%
63	Diabetic Cardiomyopathies	4.4%
64	Pituitary Adenoma	4.4%
65	Pituitary Neoplasms	4.4%
66	Ovarian Hyperstimulation Syndrome	4.4%
67	Hyperprolactinemia	4.4%
68	Prolactinoma	4.4%
69	Growth Hormone-Secreting Pituitary Adenoma	4.4%
70	Hermaphroditism	4.1%
71	Disorders of Sex Development	4.1%
72	Pituitary Apoplexy	3.9%
73	Diabetic Foot	3.9%
74	Waterhouse-Friderichsen Syndrome	3.9%
75	Nelson Syndrome	3.9%
76	Multiple Endocrine Neoplasia	3.4%
77	Pancreatic Neoplasm	3.4%
78	Corpus Luteum Cyst	3.3%
79	Ovarian Cysts	3.3%
80	Gigantism	3.3%
81	Diabetic Nephropathy	3.3%
82	Kallmann Syndrome	3.3%
83	Acromegaly	3.3%
84	Anovulation	3.3%
85	Diabetic Ketoacidosis	3.3%
86	Oophoritis	3.3%
87	granulosa cell tumor	3.2%
88	Carcinoma, Ovarian Epithelial	3.2%
89	Klinefelter Syndrome	2.8%
90	Cryptorchidism	2.7%
91	Gonadal Dysgenesis	2.6%
92	Adrenogenital Syndrome	2.6%
93	Ovotesticular Disorders of Sex Development	2.6%
94	Diabetic Retinopathy	2.5%
95	Polycystic Ovary Syndrome	2.4%
96	Adrenoleukodystrophy	2.3%
97	Leydig Cell Tumor	2.2%
98	Multiple Endocrine Neoplasia Type 1	2.2%
99	Hyperandrogenism	2.1%
100	Carcinoma, Pancreatic Ductal	1.6%
101	Turner Syndrome	1.4%
102	insulinoma	1.4%
103	Gastrinoma	1.4%
104	Glucagonoma	1.4%
105	Carcinoma, Endometrioid	1.4%
106	Renal Osteodystrophy	1.2%
107	Renal rickets	1.2%
108	Vipoma	1.2%
109	Denys-Drash Syndrome	0.7%

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