MetaADEDB 2.0 @ LMMD
Hyperthyroidism
(UMLS:C0020550)
Definition:
Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.
UMLS ID:
C0020550
MeSH ID:
D006980
Classification:
Name:
Endocrine System Diseases
MeSH Tree Number(s):
C19.874.397
Synonym(s)
1.
Hyperthyroidism
2.
HYPERTHYROID
3.
HYPERTHYROIDISM
4.
Hyperthyroid
5.
Hyperthyroidism, NOS
6.
Overactive Thyroid
7.
Overactive thyroid
8.
hyperthyroid
9.
hyperthyroidism
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1ThyroxineFAERS: 773
Canada Vigilance: 2
Canada Vigilance
US FAERS
2AmiodaroneFAERS: 250
Canada Vigilance: 60

View details

CTD
SIDER
Canada Vigilance
US FAERS
3AmiodaroneFAERS: 235
Canada Vigilance: 21
Canada Vigilance
US FAERS
4ThyroxineFAERS: 114
Canada Vigilance: 6
18219302
18377885
19914224
CTD
SIDER
Canada Vigilance
US FAERS
5SunitinibFAERS: 48
Canada Vigilance: 2
Canada Vigilance
SIDER
US FAERS
6AlendronateFAERS: 40US FAERS
7pazopanibFAERS: 34
Canada Vigilance: 1
Canada Vigilance
US FAERS
8EpoprostenolFAERS: 31US FAERS
9LenalidomideFAERS: 29
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
10NorgestrelFAERS: 27US FAERS
11VareniclineFAERS: 27
Canada Vigilance: 1
Canada Vigilance
US FAERS
12SorafenibFAERS: 21SIDER
US FAERS
13ClozapineFAERS: 20
Canada Vigilance: 3
Canada Vigilance
US FAERS
14TeriparatideFAERS: 20US FAERS
15teriflunomideFAERS: 20US FAERS
16DronedaroneFAERS: 19US FAERS
17IsotretinoinFAERS: 19US FAERS
18rofecoxibFAERS: 19US FAERS
19AtorvastatinFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
20Lithium CarbonateFAERS: 18
Canada Vigilance: 1
Canada Vigilance
US FAERS
21Dimethyl FumarateFAERS: 17US FAERS
22MethylphenidateFAERS: 17US FAERS
23EverolimusFAERS: 16US FAERS
24Imatinib MesylateFAERS: 16US FAERS
25lenvatinibFAERS: 15US FAERS
264-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 14SIDER
US FAERS
27AripiprazoleFAERS: 13SIDER
US FAERS
28Duloxetine HydrochlorideFAERS: 13US FAERS
29NuvaRingFAERS: 13US FAERS
30Atomoxetine HydrochlorideFAERS: 12US FAERS
31LCZ 696FAERS: 12US FAERS
32OctreotideFAERS: 12US FAERS
33pazopanibFAERS: 12US FAERS
34Fingolimod HydrochlorideFAERS: 11
Canada Vigilance: 1
Canada Vigilance
US FAERS
35MethimazoleFAERS: 11

View details

CTD
US FAERS
36MinocyclineFAERS: 1117542873CTD
US FAERS
37Sodium iodide I 131FAERS: 11US FAERS
38LiraglutideFAERS: 10US FAERS
39etonogestrelFAERS: 10US FAERS
40LamotrigineFAERS: 9US FAERS
41SunitinibFAERS: 9US FAERS
42TriiodothyronineFAERS: 91513203
12516873
23391542
CTD
US FAERS
43Zoledronic AcidFAERS: 9
Canada Vigilance: 2
Canada Vigilance
US FAERS
44FinasterideFAERS: 8US FAERS
45Glatiramer AcetateFAERS: 8US FAERS
46LeuprolideFAERS: 8US FAERS
47RisperidoneFAERS: 8US FAERS
48SertralineFAERS: 8US FAERS
49TopiramateFAERS: 8SIDER
US FAERS
50Venlafaxine HydrochlorideFAERS: 8US FAERS
51apremilastFAERS: 8US FAERS
52ledipasvir, sofosbuvir drug combinationFAERS: 8
Canada Vigilance: 1
Canada Vigilance
US FAERS
53Cabozantinib S-malateFAERS: 7US FAERS
54DoxycyclineFAERS: 7US FAERS
55OlanzapineFAERS: 7US FAERS
56OndansetronFAERS: 7US FAERS
57PropylthiouracilFAERS: 7

View details

CTD
US FAERS
58DabigatranFAERS: 6US FAERS
59LithiumFAERS: 6

View details

CTD
SIDER
US FAERS
60MetforminFAERS: 6US FAERS
61OmeprazoleFAERS: 6US FAERS
62RivaroxabanFAERS: 6US FAERS
63RosiglitazoneFAERS: 6US FAERS
64Rosuvastatin CalciumFAERS: 6US FAERS
65TacrolimusFAERS: 6US FAERS
66ValsartanFAERS: 6US FAERS
67carbidopa, levodopa drug combinationFAERS: 6US FAERS
68regorafenibFAERS: 6US FAERS
69tofacitinibFAERS: 6US FAERS
70AcitretinFAERS: 5US FAERS
71CyclosporineFAERS: 5US FAERS
72ExenatideFAERS: 5US FAERS
73Fluticasone-Salmeterol Drug CombinationFAERS: 5US FAERS
74HydrocortisoneFAERS: 5US FAERS
75IohexolFAERS: 5SIDER
US FAERS
76LeflunomideFAERS: 5SIDER
US FAERS
77LetrozoleFAERS: 5US FAERS
78Medroxyprogesterone AcetateFAERS: 5US FAERS
79MinocyclineFAERS: 5US FAERS
80MoxifloxacinFAERS: 5US FAERS
81SimvastatinFAERS: 5US FAERS
82aliskirenFAERS: 5US FAERS
832-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chlorideFAERS: 4US FAERS
844-hydroxybutyric acidFAERS: 4US FAERS
85AlbuterolFAERS: 4US FAERS
86AllopurinolFAERS: 4US FAERS
87AxitinibFAERS: 4
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
88CarbamazepineFAERS: 428267586CTD
US FAERS
89DasatinibFAERS: 4US FAERS
90DiclofenacFAERS: 4US FAERS
91EpoprostenolFAERS: 4SIDER
US FAERS
92Erlotinib HydrochlorideFAERS: 4US FAERS
93Estrogens, Conjugated (USP)FAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
94Lisdexamfetamine DimesylateFAERS: 4US FAERS
95Ortho EvraFAERS: 4US FAERS
96PregabalinFAERS: 4SIDER
US FAERS
97RibavirinFAERS: 4
Canada Vigilance: 5
18097301CTD
SIDER
Canada Vigilance
US FAERS
98Ruxolitinib phosphateFAERS: 4US FAERS
99TriiodothyronineFAERS: 4US FAERS
100ambrisentanFAERS: 4US FAERS
101apixabanFAERS: 4
Canada Vigilance: 1
Canada Vigilance
US FAERS
102exemestaneFAERS: 4US FAERS
103glimepirideFAERS: 4US FAERS
104ponatinibFAERS: 4US FAERS
105AlprazolamFAERS: 3US FAERS
106AmitriptylineFAERS: 3US FAERS
107AnastrozoleFAERS: 3US FAERS
108BortezomibFAERS: 3SIDER
US FAERS
109BosentanFAERS: 3US FAERS
110CitalopramFAERS: 3US FAERS
111ClonazepamFAERS: 3US FAERS
112DeferasiroxFAERS: 3US FAERS
113DesogestrelFAERS: 3US FAERS
114EplerenoneFAERS: 3US FAERS
115FluoxetineFAERS: 3SIDER
US FAERS
116Formoterol FumarateFAERS: 3US FAERS
117GabapentinFAERS: 3SIDER
US FAERS
118GalantamineFAERS: 3US FAERS
119GoserelinFAERS: 3US FAERS
120IopamidolFAERS: 3US FAERS
121LamivudineFAERS: 3
Canada Vigilance: 1
Canada Vigilance
US FAERS
122MetoprololFAERS: 3US FAERS
123MetoprololFAERS: 3US FAERS
124Mycophenolic AcidFAERS: 3US FAERS
125NafarelinFAERS: 3US FAERS
126OrlistatFAERS: 3US FAERS
127Quetiapine FumarateFAERS: 3SIDER
US FAERS
128Raloxifene HydrochlorideFAERS: 3US FAERS
129entecavirFAERS: 3US FAERS
130palbociclibFAERS: 3US FAERS
131pasireotideFAERS: 3US FAERS
132AmlodipineFAERS: 2US FAERS
133BromocriptineFAERS: 2US FAERS
134CID 129626832FAERS: 2US FAERS
135CinacalcetFAERS: 2US FAERS
136DigoxinFAERS: 2US FAERS
137Diovan HctFAERS: 2US FAERS
138EzetimibeFAERS: 2US FAERS
139FluticasoneFAERS: 2US FAERS
140GefitinibFAERS: 2US FAERS
141Ibandronic AcidFAERS: 2US FAERS
142Imatinib MesylateFAERS: 2US FAERS
143IrbesartanFAERS: 2US FAERS
144LevetiracetamFAERS: 2US FAERS
145MDV 3100FAERS: 2US FAERS
146MetforminFAERS: 2US FAERS
147Methylprednisolone AcetateFAERS: 2US FAERS
148NafarelinFAERS: 2US FAERS
149OseltamivirFAERS: 2
Canada Vigilance: 1
Canada Vigilance
US FAERS
150PCI 32765FAERS: 2US FAERS
151Paliperidone PalmitateFAERS: 2US FAERS
152ParoxetineFAERS: 2SIDER
US FAERS
153PioglitazoneFAERS: 2US FAERS
154PrednisoloneFAERS: 28542214CTD
US FAERS
155ProcarbazineFAERS: 2US FAERS
156QlairaFAERS: 2US FAERS
157Quetiapine FumarateFAERS: 2US FAERS
158Sitagliptin PhosphateFAERS: 2US FAERS
159TamoxifenFAERS: 2US FAERS
160TetrabenazineFAERS: 2US FAERS
161VemurafenibFAERS: 2US FAERS
162acetaminophen, aspirin, caffeine drug combinationFAERS: 2US FAERS
163norgestimate, ethinyl estradiol drug combinationFAERS: 2US FAERS
164rizatriptanFAERS: 2US FAERS
165ropiniroleFAERS: 2SIDER
US FAERS
166sofosbuvir-velpatasvir drug combinationFAERS: 2US FAERS
167temsirolimusFAERS: 2US FAERS
16817 alpha-Hydroxyprogesterone CaproateFAERS: 1US FAERS
1692-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triolFAERS: 1US FAERS
1704-AminopyridineFAERS: 1US FAERS
1715-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chlorideFAERS: 1US FAERS
172AmpicillinFAERS: 1US FAERS
173AtenololFAERS: 1US FAERS
174AzacitidineFAERS: 1US FAERS
175BaclofenFAERS: 1US FAERS
176BenzphetamineFAERS: 1US FAERS
177Bevespi AerosphereFAERS: 1US FAERS
178BiotinFAERS: 1US FAERS
179Calcium CarbonateFAERS: 1US FAERS
180CanagliflozinFAERS: 1US FAERS
181CarvedilolFAERS: 1US FAERS
182CefazolinFAERS: 1US FAERS
183CelecoxibFAERS: 1US FAERS
184CilostazolFAERS: 1US FAERS
185CitalopramFAERS: 1US FAERS
186ClindamycinFAERS: 1US FAERS
187ClindamycinFAERS: 1SIDER
US FAERS
188CopperFAERS: 1US FAERS
189Desvenlafaxine SuccinateFAERS: 1US FAERS
190DiazepamFAERS: 1US FAERS
191DonepezilFAERS: 1US FAERS
192Duloxetine HydrochlorideFAERS: 1US FAERS
193ErythromycinFAERS: 1US FAERS
194EsomeprazoleFAERS: 1US FAERS
195Ethinyl Estradiol-Norgestrel CombinationFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
196Ethylene GlycolFAERS: 1US FAERS
197FamciclovirFAERS: 1US FAERS
198FenofibrateFAERS: 1US FAERS
199FentanylFAERS: 1US FAERS
200FentanylFAERS: 1US FAERS
201Fexofenadine hydrochloride and pseudoephedrine hydrochlorideFAERS: 1US FAERS
202FluphenazineFAERS: 1US FAERS
203Fluticasone/salmeterolFAERS: 1US FAERS
204Formoterol FumarateFAERS: 1US FAERS
205HydroxyureaFAERS: 1US FAERS
206Ibandronic AcidFAERS: 1US FAERS
207ImiquimodFAERS: 1US FAERS
208Insulin DetemirFAERS: 1US FAERS
209Insulin GlargineFAERS: 1US FAERS
210Insulin degludecFAERS: 1US FAERS
211ItraconazoleFAERS: 1US FAERS
212ItraconazoleFAERS: 1US FAERS
213LapatinibFAERS: 1US FAERS
214LevofloxacinFAERS: 1US FAERS
215LidodermFAERS: 1US FAERS
216LosartanFAERS: 1US FAERS
217MaprotilineFAERS: 1US FAERS
218MefloquineFAERS: 1US FAERS
219Megestrol AcetateFAERS: 1US FAERS
220MercaptopurineFAERS: 1US FAERS
221MethylphenidateFAERS: 1US FAERS
222Methylprednisolone HemisuccinateFAERS: 1US FAERS
223MethylprednisoloneFAERS: 1US FAERS
224MirtazapineFAERS: 1US FAERS
225ModafinilFAERS: 1US FAERS
226NicotineFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
227OctreotideFAERS: 1US FAERS
228OxcarbazepineFAERS: 1US FAERS
229PaclitaxelFAERS: 1US FAERS
230Paliperidone PalmitateFAERS: 1US FAERS
231PantoprazoleFAERS: 1US FAERS
232PerindoprilFAERS: 1US FAERS
233PhentermineFAERS: 1US FAERS
234Povidone-IodineFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
235PramipexoleFAERS: 1SIDER
US FAERS
236PropranololFAERS: 1

View details

CTD
US FAERS
237QVA149FAERS: 1US FAERS
238QuinaprilFAERS: 1US FAERS
239RestasisFAERS: 1US FAERS
240Risedronic AcidFAERS: 1US FAERS
241RivastigmineFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
242RocuroniumFAERS: 1US FAERS
243RoflumilastFAERS: 1US FAERS
244SertralineFAERS: 1US FAERS
245Sildenafil CitrateFAERS: 1SIDER
US FAERS
246Sodium ChlorideFAERS: 1US FAERS
247SotalolFAERS: 1US FAERS
248SovriadFAERS: 1US FAERS
249SulfamethoxazoleFAERS: 1US FAERS
250SumatriptanFAERS: 1US FAERS
251TadalafilFAERS: 1US FAERS
252TamoxifenFAERS: 1US FAERS
253TenofovirFAERS: 1US FAERS
254ThalidomideFAERS: 1US FAERS
255TicagrelorFAERS: 1US FAERS
256TimololFAERS: 1US FAERS
257TramadolFAERS: 1US FAERS
258TretinoinFAERS: 1US FAERS
259Triamcinolone AcetonideFAERS: 1US FAERS
260Trimethoprim, Sulfamethoxazole Drug CombinationFAERS: 1US FAERS
261TriumeqFAERS: 1US FAERS
262Umeclidinium bromideFAERS: 1US FAERS
263Valproic AcidFAERS: 1US FAERS
264VerapamilFAERS: 1US FAERS
265VortioxetineFAERS: 1US FAERS
266WarfarinFAERS: 1US FAERS
267ZanamivirFAERS: 1US FAERS
268ZidovudineFAERS: 1US FAERS
269abacavir, lamivudine drug combinationFAERS: 1US FAERS
270cabozantinibFAERS: 1US FAERS
271carfilzomibFAERS: 1US FAERS
272ceritinibFAERS: 1US FAERS
273dabrafenibFAERS: 1US FAERS
274dofetilideFAERS: 1US FAERS
275dorzolamideFAERS: 1US FAERS
276fexofenadineFAERS: 1US FAERS
277gemcitabineFAERS: 1US FAERS
278haloperidol decanoateFAERS: 1US FAERS
279iodixanolFAERS: 1US FAERS
280iopromideFAERS: 1SIDER
US FAERS
281isoniazid, pyrazinamide, rifampin drug combinationFAERS: 1US FAERS
282lorcaserinFAERS: 1US FAERS
283midostaurinFAERS: 1US FAERS
284niraparibFAERS: 1US FAERS
285norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combinationFAERS: 1US FAERS
286obeticholic acidFAERS: 1US FAERS
287pomalidomideFAERS: 1US FAERS
288riociguatFAERS: 1US FAERS
289sapropterinFAERS: 1US FAERS
290selexipagFAERS: 1US FAERS
291sibutramineFAERS: 1US FAERS
292tegaserodFAERS: 1US FAERS
293telithromycinFAERS: 1US FAERS
294valdecoxibFAERS: 1US FAERS
295ziprasidoneFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
2962,2',4,4'-tetrahydroxybenzophenone29660579CTD
297BetaxololSIDER
298BexaroteneSIDER
299Bromocriptine8691994CTD
300Carbimazole

View details

CTD
301CeliprololSIDER
302CetirizineCanada Vigilance: 1Canada Vigilance
303Chlorpheniramine19534646CTD
304CitalopramSIDER
305ClomipramineSIDER
306FluoxetineCanada Vigilance: 1Canada Vigilance
307Glutathione19914224CTD
308Iodine8223196
9247777
CTD
309LabetalolSIDER
310LovastatinCanada Vigilance: 1Canada Vigilance
311Maneb20061368CTD
312MedroxyprogesteroneSIDER
313MemantineSIDER
314N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamideSIDER
315Nadolol3544631CTD
316OvosistonCanada Vigilance: 1Canada Vigilance
317OxyphenbutazoneCanada Vigilance: 1Canada Vigilance
318Polychlorinated Dibenzodioxins15822908CTD
319PrednisoneSIDER
320RabeprazoleSIDER
321Reserpine4589407CTD
322Resveratrol23391542CTD
323Rifampin16236685CTD
324Sotalol83509CTD
325Ursodeoxycholic Acid19534646CTD
326Venlafaxine HydrochlorideSIDER
327Vitamin E19914224CTD
328VoriconazoleSIDER
329decabromobiphenyl ether20686340CTD
330entacaponeSIDER
331mancozeb20061368CTD
332potassium perchlorate18334037CTD
333sibutramineSIDER
334turmeric extract19914224CTD
335zolmitriptanSIDER
Similar ADE(s)
NameSemantic Similarity
1Euthyroid Sick Syndromes42.9%
2Goiter42.9%
3Hyperthyroxinemia42.9%
4Hypothyroidism42.9%
5Thyroiditis42.9%
6Secondary hypothyroidism42.9%
7Primary Hypothyroidism42.9%
8Thyroid Hormone Resistance Syndrome31%
9Hashimoto Disease25.4%
10Adrenal Gland Diseases23.1%
11Gonadal Disorders23.1%
12Parathyroid Diseases23.1%
13Thyroid Neoplasm22.2%
14Thyroid carcinoma22.2%
15Autoimmune thyroiditis20.9%
16Myxedema20.5%
17Thyroid Nodule16%
18Bone Diseases, Endocrine15%
19Endocrine Gland Neoplasms15%
20Congenital Hypothyroidism14.7%
21Diabetes Mellitus14.6%
22Pituitary Diseases14.5%
23Adrenal Cortex Diseases14.3%
24Hyperparathyroidism14.3%
25Hypogonadism14.3%
26Hypoparathyroidism14.3%
27Delayed Puberty14.3%
28Precocious Puberty14.3%
29Hypogonadotropic hypogonadism14.3%
30Testotoxicosis14.3%
31Adrenal Gland Neoplasms14%
32Graves Disease12.3%
33Parathyroid Neoplasms11.1%
34Dwarfism10.9%
35Cushing Syndrome10.3%
36Hyperaldosteronism10.3%
37Hyperparathyroidism, Secondary10.3%
38Hypoaldosteronism10.3%
39Hyperparathyroidism, Primary10.3%
40Testicular Diseases9.5%
41Ovarian Diseases9.2%
42Empty Sella Syndrome9.1%
43Hyperpituitarism9.1%
44Hypopituitarism9.1%
45Hypophysitis9.1%
46Hyperglycemic Hyperosmolar Nonketotic Coma8.5%
47Adrenocortical carcinoma8.2%
48ovarian neoplasm7.8%
49Addison Disease7%
50Diabetic Angiopathies7%
51Primary Adrenal Insufficiency7%
52Gestational Diabetes7%
53Latent Autoimmune Diabetes in Adults7%
54Diabetes Insipidus6.8%
55Diabetes Mellitus, Experimental6.8%
56Diabetic Neuropathies6.8%
57Orchitis6.8%
58Diabetic Amyotrophy6.8%
59Diabetic Autonomic Neuropathy6.8%
60Diabetic Cardiomyopathies6.8%
61Testicular Neoplasms6.8%
62Ovarian Hyperstimulation Syndrome6.7%
63Hyperprolactinemia6.7%
64Prolactinoma6.6%
65Growth Hormone-Secreting Pituitary Adenoma6.6%
66Diabetic Foot6.6%
67Nelson Syndrome6.5%
68Pituitary Adenoma5.9%
69Pituitary Neoplasms5.9%
70Hermaphroditism5.6%
71Disorders of Sex Development5.6%
72Pituitary Apoplexy5.3%
73Kallmann Syndrome5.2%
74granulosa cell tumor5.1%
75Carcinoma, Ovarian Epithelial5.1%
76Corpus Luteum Cyst5.1%
77Ovarian Cysts5.1%
78Gigantism5.1%
79Diabetic Nephropathy5%
80Acromegaly5%
81Anovulation5%
82Diabetic Ketoacidosis5%
83Oophoritis5%
84Multiple Endocrine Neoplasia4.7%
85Pancreatic Neoplasm4.7%
86Klinefelter Syndrome4.5%
87Diabetic Retinopathy4.3%
88Polycystic Ovary Syndrome4.1%
89Cryptorchidism4.1%
90Gonadal Dysgenesis4%
91Adrenogenital Syndrome4%
92Ovotesticular Disorders of Sex Development4%
93Leydig Cell Tumor3.8%
94Hyperandrogenism3.6%
95Multiple Endocrine Neoplasia Type 13.3%
96Carcinoma, Pancreatic Ductal2.5%
97insulinoma2.3%
98Gastrinoma2.3%
99Glucagonoma2.3%
100Turner Syndrome2.3%
101Carcinoma, Endometrioid2.3%
102Renal Osteodystrophy2%
103Renal rickets2%
104Vipoma2%
105Waterhouse-Friderichsen Syndrome2%
106Denys-Drash Syndrome1.2%
107Adrenoleukodystrophy1.1%
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.