MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thyroid Hormone Resistance Syndrome

(UMLS:C2940786)

Definition:: An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.
UMLS ID:: C2940786
MeSH ID:: D018382

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.874.410.500

Synonym(s)

Thyroid Hormone Resistance Syndrome

Refetoff syndrome

Resistance to thyroid stimulating hormone

Resistance to thyrotropin

TSH resistance

Thyroid Hormone Resistance

Thyroid hormone resistance

Thyroid hormone resistance syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Atenolol		9349583	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Euthyroid Sick Syndromes	31%
2	Goiter	31%
3	Hyperthyroidism	31%
4	Hypothyroidism	31%
5	Thyroiditis	31%
6	Secondary hypothyroidism	31%
7	Primary Hyperthyroidism	31%
8	Primary Hypothyroidism	31%
9	Thyrotoxicosis	20%
10	Adrenal Gland Diseases	18.5%
11	Gonadal Disorders	18.5%
12	Parathyroid Diseases	18.5%
13	Thyroid Neoplasm	16.4%
14	Thyroid carcinoma	16.4%
15	Graves Disease	16.2%
16	Hashimoto Disease	14.8%
17	Autoimmune thyroiditis	13.6%
18	Myxedema	13.3%
19	Bone Diseases, Endocrine	12.2%
20	Endocrine Gland Neoplasms	12.2%
21	Diabetes Mellitus	11.9%
22	Pituitary Diseases	11.8%
23	Thyroid Nodule	10.5%
24	Adrenal Cortex Diseases	10.3%
25	Adrenal Gland Neoplasms	10.3%
26	Hyperparathyroidism	10.3%
27	Hypogonadism	10.3%
28	Hypoparathyroidism	10.3%
29	Delayed Puberty	10.3%
30	Precocious Puberty	10.3%
31	Hypogonadotropic hypogonadism	10.3%
32	Testotoxicosis	10.3%
33	Congenital Hypothyroidism	10.1%
34	Dwarfism	8.9%
35	Parathyroid Neoplasms	8.2%
36	Testicular Diseases	7%
37	Ovarian Diseases	6.7%
38	Empty Sella Syndrome	6.7%
39	Hyperpituitarism	6.7%
40	Hypopituitarism	6.7%
41	Hypophysitis	6.7%
42	Cushing Syndrome	6.7%
43	Hyperaldosteronism	6.7%
44	Hyperparathyroidism, Secondary	6.7%
45	Hypoaldosteronism	6.7%
46	Hyperparathyroidism, Primary	6.7%
47	ovarian neoplasm	5.5%
48	Gestational Diabetes	5.1%
49	Latent Autoimmune Diabetes in Adults	5.1%
50	Diabetes Insipidus	5%
51	Diabetes Mellitus, Experimental	5%
52	Hyperglycemic Hyperosmolar Nonketotic Coma	4.9%
53	Adrenocortical carcinoma	4.8%
54	Testicular Neoplasms	4.8%
55	Addison Disease	4.5%
56	Diabetic Angiopathies	4.5%
57	Primary Adrenal Insufficiency	4.5%
58	Diabetic Neuropathies	4.4%
59	Orchitis	4.4%
60	Diabetic Amyotrophy	4.4%
61	Diabetic Autonomic Neuropathy	4.4%
62	Diabetic Cardiomyopathies	4.4%
63	Pituitary Adenoma	4.4%
64	Pituitary Neoplasms	4.4%
65	Ovarian Hyperstimulation Syndrome	4.4%
66	Hyperprolactinemia	4.4%
67	Prolactinoma	4.4%
68	Growth Hormone-Secreting Pituitary Adenoma	4.4%
69	Hermaphroditism	4.1%
70	Disorders of Sex Development	4.1%
71	Pituitary Apoplexy	3.9%
72	Diabetic Foot	3.9%
73	Nelson Syndrome	3.9%
74	Multiple Endocrine Neoplasia	3.4%
75	Pancreatic Neoplasm	3.4%
76	Corpus Luteum Cyst	3.3%
77	Ovarian Cysts	3.3%
78	Gigantism	3.3%
79	Diabetic Nephropathy	3.3%
80	Kallmann Syndrome	3.3%
81	Acromegaly	3.3%
82	Anovulation	3.3%
83	Diabetic Ketoacidosis	3.3%
84	Oophoritis	3.3%
85	granulosa cell tumor	3.2%
86	Carcinoma, Ovarian Epithelial	3.2%
87	Klinefelter Syndrome	2.8%
88	Cryptorchidism	2.7%
89	Gonadal Dysgenesis	2.6%
90	Adrenogenital Syndrome	2.6%
91	Ovotesticular Disorders of Sex Development	2.6%
92	Diabetic Retinopathy	2.5%
93	Polycystic Ovary Syndrome	2.4%
94	Leydig Cell Tumor	2.2%
95	Multiple Endocrine Neoplasia Type 1	2.2%
96	Hyperandrogenism	2.1%
97	Carcinoma, Pancreatic Ductal	1.6%
98	Turner Syndrome	1.4%
99	insulinoma	1.4%
100	Gastrinoma	1.4%
101	Glucagonoma	1.4%
102	Carcinoma, Endometrioid	1.4%
103	Waterhouse-Friderichsen Syndrome	1.3%
104	Renal Osteodystrophy	1.2%
105	Renal rickets	1.2%
106	Vipoma	1.2%
107	Adrenoleukodystrophy	0.8%
108	Denys-Drash Syndrome	0.7%

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