MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperglycemic Hyperosmolar Nonketotic Coma

(UMLS:C0020457)

Definition:: A serious complication of TYPE 2 DIABETES MELLITUS. It is characterized by extreme HYPERGLYCEMIA; DEHYDRATION; serum hyperosmolarity; and depressed consciousness leading to COMA in the absence of KETOSIS and ACIDOSIS.
UMLS ID:: C0020457
MeSH ID:: D006944

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.246.099.750.490

Synonym(s)

Hyperglycemic Hyperosmolar Nonketotic Coma

DIABETIC NONKETOTIC HYPEROSMOLAR COMA

Diabetes with hyperosmolar coma

Diabetic hyperosmolar coma

HYPEROSMOLAR COMA

Hyperosmolar coma

Hyperosmolar nonketotic coma in diabetes

coma hyperosmolar

coma; hyperosmolar

10.

diabetes mellitus with hyperglycemic hyperosmolar nonketotic state with coma

11.

diabetic hyperosmolar coma

12.

diabetic hyperosmolar nonketotic state with coma

13.

hhnc

14.

hyperosmolar coma

15.

hyperosmolar non-ketotic coma

16.

hyperosmolar nonketotic coma

17.

hyperosmolar; coma

18.

nkhhc

19.

nonketotic hyperosmolar coma

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Diazoxide	5544160	CTD
2	Lithium	9538487 10210013	CTD
3	Methadone	16997682	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Diabetic Angiopathies	23.6%
2	Diabetic Neuropathies	23.1%
3	Diabetic Amyotrophy	23.1%
4	Diabetic Autonomic Neuropathy	23.1%
5	Diabetic Cardiomyopathies	23.1%
6	Diabetic Foot	18.1%
7	Diabetic Nephropathy	17.2%
8	Diabetic Ketoacidosis	17%
9	Adrenal Gland Diseases	16.4%
10	Gonadal Disorders	16.4%
11	Parathyroid Diseases	16.4%
12	Thyroid Diseases	16.4%
13	Gestational Diabetes	12.7%
14	Latent Autoimmune Diabetes in Adults	12.7%
15	Diabetes Mellitus, Experimental	12.5%
16	Diabetic Retinopathy	11.7%
17	Bone Diseases, Endocrine	10.8%
18	Endocrine Gland Neoplasms	10.8%
19	Pituitary Diseases	10.5%
20	Adrenal Gland Neoplasms	8.5%
21	Adrenal Cortex Diseases	8.5%
22	Euthyroid Sick Syndromes	8.5%
23	Goiter	8.5%
24	Hyperparathyroidism	8.5%
25	Hyperthyroidism	8.5%
26	Hyperthyroxinemia	8.5%
27	Hypogonadism	8.5%
28	Hypoparathyroidism	8.5%
29	Hypothyroidism	8.5%
30	Delayed Puberty	8.5%
31	Precocious Puberty	8.5%
32	Thyroiditis	8.5%
33	Hypogonadotropic hypogonadism	8.5%
34	Testotoxicosis	8.5%
35	Secondary hypothyroidism	8.5%
36	Primary Hyperthyroidism	8.5%
37	Primary Hypothyroidism	8.5%
38	Dwarfism	8%
39	Parathyroid Neoplasms	6.8%
40	Thyroid Neoplasm	6.8%
41	Thyroid carcinoma	6.8%
42	Testicular Diseases	5.7%
43	Ovarian Diseases	5.6%
44	Empty Sella Syndrome	5.5%
45	Hyperpituitarism	5.5%
46	Hypopituitarism	5.5%
47	Hypophysitis	5.5%
48	Cushing Syndrome	4.9%
49	Hyperaldosteronism	4.9%
50	Hyperparathyroidism, Secondary	4.9%
51	Hypoaldosteronism	4.9%
52	Thyrotoxicosis	4.9%
53	Hyperparathyroidism, Primary	4.9%
54	Thyroid Hormone Resistance Syndrome	4.9%
55	Congenital Hypothyroidism	4.4%
56	ovarian neoplasm	4.4%
57	Diabetes Insipidus	4.2%
58	Graves Disease	4%
59	Thyroid Nodule	3.9%
60	Testicular Neoplasms	3.8%
61	Pituitary Adenoma	3.6%
62	Pituitary Neoplasms	3.6%
63	Hermaphroditism	3.4%
64	Disorders of Sex Development	3.4%
65	Addison Disease	3.4%
66	Autoimmune thyroiditis	3.4%
67	Primary Adrenal Insufficiency	3.4%
68	Myxedema	3.3%
69	Orchitis	3.3%
70	Pituitary Apoplexy	3.3%
71	Prolactinoma	3.2%
72	Growth Hormone-Secreting Pituitary Adenoma	3.2%
73	Ovarian Hyperstimulation Syndrome	3.2%
74	Hyperprolactinemia	3.2%
75	Hashimoto Disease	3.2%
76	Adrenocortical carcinoma	3.2%
77	Multiple Endocrine Neoplasia	2.9%
78	Pancreatic Neoplasm	2.9%
79	Nelson Syndrome	2.6%
80	Corpus Luteum Cyst	2.5%
81	Ovarian Cysts	2.5%
82	Gigantism	2.5%
83	Acromegaly	2.4%
84	Anovulation	2.4%
85	Oophoritis	2.4%
86	Kallmann Syndrome	2.3%
87	granulosa cell tumor	2.3%
88	Carcinoma, Ovarian Epithelial	2.3%
89	Cryptorchidism	2%
90	Klinefelter Syndrome	2%
91	Gonadal Dysgenesis	2%
92	Adrenogenital Syndrome	2%
93	Ovotesticular Disorders of Sex Development	2%
94	Multiple Endocrine Neoplasia Type 1	1.6%
95	Polycystic Ovary Syndrome	1.6%
96	Hyperandrogenism	1.4%
97	Leydig Cell Tumor	1.4%
98	Carcinoma, Pancreatic Ductal	1.2%
99	Waterhouse-Friderichsen Syndrome	1%
100	Turner Syndrome	0.9%
101	insulinoma	0.9%
102	Gastrinoma	0.9%
103	Glucagonoma	0.9%
104	Carcinoma, Endometrioid	0.9%
105	Renal Osteodystrophy	0.8%
106	Renal rickets	0.8%
107	Vipoma	0.8%
108	Adrenoleukodystrophy	0.6%
109	Denys-Drash Syndrome	0.5%

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