MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Delayed Puberty

(UMLS:C0034012)

Definition:: The lack of development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations above the mean age at onset of PUBERTY in a population. Delayed puberty can be classified by defects in the hypothalamic LHRH pulse generator, the PITUITARY GLAND, or the GONADS. These patients will undergo spontaneous but delayed puberty whereas patients with SEXUAL INFANTILISM will not.
UMLS ID:: C0034012
MeSH ID:: D011628

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.690

Synonym(s)

Delayed Puberty

Constitutional Growth Delay

DELAYED PUBERTY

Delay in sexual development AND/OR puberty

Delayed pubertal development

Delayed pubertal growth

Delayed puberty

Delayed sexual development

Delayed;puberty

10.

PUBERTY DELAYED

11.

Pubertal Delay

12.

Pubertal delay

13.

Puberty, delayed

14.

Sexual development retarded

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Risperidone	FAERS: 16	US FAERS
2	histrelin	FAERS: 13	US FAERS
3	Methylphenidate	FAERS: 12	US FAERS
4	Atomoxetine Hydrochloride	FAERS: 5	US FAERS
5	Aripiprazole	FAERS: 4	US FAERS
6	Testosterone	FAERS: 3	US FAERS
7	Carbamazepine	FAERS: 2	US FAERS
8	Deferasirox	FAERS: 2	US FAERS
9	Betaine	FAERS: 1	US FAERS
10	Cyclosporine	FAERS: 1	US FAERS
11	Dextroamphetamine	FAERS: 1	US FAERS
12	Everolimus	FAERS: 1	US FAERS
13	Haloperidol	FAERS: 1	US FAERS
14	Oxcarbazepine	FAERS: 1	US FAERS
15	Paroxetine	FAERS: 1	US FAERS
16	Phenytoin	FAERS: 1	US FAERS
17	Topiramate	FAERS: 1	US FAERS
18	Valproic Acid	FAERS: 1	US FAERS
19	ziprasidone	FAERS: 1	US FAERS
20	Busulfan		OFFSIDES SIDER
21	Cytarabine		OFFSIDES
22	Etoposide		OFFSIDES
23	Mercaptopurine		OFFSIDES
24	Mitoxantrone		OFFSIDES
25	Vigabatrin		OFFSIDES SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Hypogonadism	42.9%
2	Precocious Puberty	42.9%
3	Hypogonadotropic hypogonadism	42.9%
4	Testotoxicosis	42.9%
5	Testicular Diseases	28.6%
6	Ovarian Diseases	27.6%
7	Adrenal Gland Diseases	23.1%
8	Parathyroid Diseases	23.1%
9	Thyroid Diseases	23.1%
10	Orchitis	20.5%
11	Ovarian Hyperstimulation Syndrome	20.1%
12	Hermaphroditism	16.7%
13	Disorders of Sex Development	16.7%
14	Kallmann Syndrome	15.6%
15	Corpus Luteum Cyst	15.3%
16	Ovarian Cysts	15.3%
17	Bone Diseases, Endocrine	15%
18	Endocrine Gland Neoplasms	15%
19	Anovulation	14.9%
20	Oophoritis	14.9%
21	Diabetes Mellitus	14.6%
22	ovarian neoplasm	14.6%
23	Pituitary Diseases	14.5%
24	Adrenal Cortex Diseases	14.3%
25	Euthyroid Sick Syndromes	14.3%
26	Goiter	14.3%
27	Hyperparathyroidism	14.3%
28	Hyperthyroidism	14.3%
29	Hyperthyroxinemia	14.3%
30	Hypoparathyroidism	14.3%
31	Hypothyroidism	14.3%
32	Thyroiditis	14.3%
33	Secondary hypothyroidism	14.3%
34	Primary Hyperthyroidism	14.3%
35	Primary Hypothyroidism	14.3%
36	Adrenal Gland Neoplasms	14%
37	Klinefelter Syndrome	13.4%
38	Testicular Neoplasms	12.6%
39	Polycystic Ovary Syndrome	12.4%
40	Cryptorchidism	12.3%
41	Gonadal Dysgenesis	12%
42	Adrenogenital Syndrome	12%
43	Ovotesticular Disorders of Sex Development	12%
44	Parathyroid Neoplasms	11.1%
45	Thyroid Neoplasm	11.1%
46	Thyroid carcinoma	11.1%
47	Dwarfism	10.9%
48	Hyperandrogenism	10.8%
49	Cushing Syndrome	10.3%
50	Hyperaldosteronism	10.3%
51	Hyperparathyroidism, Secondary	10.3%
52	Hypoaldosteronism	10.3%
53	Thyrotoxicosis	10.3%
54	Hyperparathyroidism, Primary	10.3%
55	Thyroid Hormone Resistance Syndrome	10.3%
56	granulosa cell tumor	9.8%
57	Carcinoma, Ovarian Epithelial	9.8%
58	Empty Sella Syndrome	9.1%
59	Hyperpituitarism	9.1%
60	Hypopituitarism	9.1%
61	Hypophysitis	9.1%
62	Hyperglycemic Hyperosmolar Nonketotic Coma	8.5%
63	Hashimoto Disease	8.5%
64	Graves Disease	8.2%
65	Adrenocortical carcinoma	8.2%
66	Thyroid Nodule	8%
67	Congenital Hypothyroidism	7.9%
68	Leydig Cell Tumor	7.5%
69	Addison Disease	7%
70	Diabetic Angiopathies	7%
71	Autoimmune thyroiditis	7%
72	Primary Adrenal Insufficiency	7%
73	Gestational Diabetes	7%
74	Latent Autoimmune Diabetes in Adults	7%
75	Turner Syndrome	6.9%
76	Carcinoma, Endometrioid	6.9%
77	Diabetes Insipidus	6.8%
78	Diabetes Mellitus, Experimental	6.8%
79	Diabetic Neuropathies	6.8%
80	Myxedema	6.8%
81	Diabetic Amyotrophy	6.8%
82	Diabetic Autonomic Neuropathy	6.8%
83	Diabetic Cardiomyopathies	6.8%
84	Hyperprolactinemia	6.7%
85	Prolactinoma	6.6%
86	Growth Hormone-Secreting Pituitary Adenoma	6.6%
87	Diabetic Foot	6.6%
88	Nelson Syndrome	6.5%
89	Pituitary Adenoma	5.9%
90	Pituitary Neoplasms	5.9%
91	Pituitary Apoplexy	5.3%
92	Gigantism	5.1%
93	Diabetic Nephropathy	5%
94	Acromegaly	5%
95	Diabetic Ketoacidosis	5%
96	Multiple Endocrine Neoplasia	4.7%
97	Pancreatic Neoplasm	4.7%
98	Diabetic Retinopathy	4.3%
99	Denys-Drash Syndrome	3.7%
100	Multiple Endocrine Neoplasia Type 1	3.3%
101	Carcinoma, Pancreatic Ductal	2.5%
102	insulinoma	2.3%
103	Gastrinoma	2.3%
104	Glucagonoma	2.3%
105	Renal Osteodystrophy	2%
106	Renal rickets	2%
107	Vipoma	2%
108	Waterhouse-Friderichsen Syndrome	2%
109	Adrenoleukodystrophy	1.1%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120262