MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypoaldosteronism

(UMLS:C0020595)

Definition:: A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.
UMLS ID:: C0020595
MeSH ID:: D006994

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.053.500.480

Synonym(s)

Hypoaldosteronism

Aldosterone Deficiency

Aldosterone deficiency

Aldosterone deficiency syndrome

Aldosterone deficiency, NOS

HYPOALDOSTERONISM

Hypoaldosteronemia

Mineralocorticoid Deficiency

Unspecified adrenocortical insufficiency

10.

aldosterone deficiency

11.

hypoadrenalism

12.

hypoaldosteronism

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Carbamazepine	FAERS: 6		US FAERS
2	reviparin	FAERS: 4	10726030	CTD US FAERS
3	Furosemide	FAERS: 3		US FAERS
4	Dexamethasone	FAERS: 2		US FAERS
5	Itraconazole	FAERS: 2		US FAERS
6	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 2		US FAERS
7	Budesonide	FAERS: 1		US FAERS
8	Celecoxib	FAERS: 1		US FAERS
9	Cyclosporine	FAERS: 1		US FAERS
10	Diclofenac	FAERS: 1		US FAERS
11	Etodolac	FAERS: 1		US FAERS
12	Linezolid	FAERS: 1		US FAERS
13	Lisinopril	FAERS: 1		US FAERS
14	Methylphenidate	FAERS: 1		US FAERS
15	pimecrolimus	FAERS: 1		US FAERS
16	Benzbromarone			OFFSIDES
17	Glycyrrhizic Acid			OFFSIDES
18	Indomethacin		3375885 6814155	CTD
19	Mitomycin		8061399	CTD
20	Naproxen		3375885	CTD
21	sarpogrelate			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Addison Disease	31.8%
2	Primary Adrenal Insufficiency	31.8%
3	Adrenal Cortex Diseases	31%
4	Adrenal Gland Neoplasms	20.7%
5	Cushing Syndrome	20%
6	Hyperaldosteronism	20%
7	Gonadal Disorders	18.5%
8	Parathyroid Diseases	18.5%
9	Thyroid Diseases	18.5%
10	Bone Diseases, Endocrine	12.2%
11	Endocrine Gland Neoplasms	12.2%
12	Diabetes Mellitus	11.9%
13	Pituitary Diseases	11.8%
14	Adrenocortical carcinoma	11.3%
15	Euthyroid Sick Syndromes	10.3%
16	Goiter	10.3%
17	Hyperparathyroidism	10.3%
18	Hyperthyroidism	10.3%
19	Hyperthyroxinemia	10.3%
20	Hypogonadism	10.3%
21	Hypoparathyroidism	10.3%
22	Hypothyroidism	10.3%
23	Delayed Puberty	10.3%
24	Precocious Puberty	10.3%
25	Thyroiditis	10.3%
26	Hypogonadotropic hypogonadism	10.3%
27	Testotoxicosis	10.3%
28	Secondary hypothyroidism	10.3%
29	Primary Hyperthyroidism	10.3%
30	Primary Hypothyroidism	10.3%
31	Waterhouse-Friderichsen Syndrome	9%
32	Dwarfism	8.9%
33	Parathyroid Neoplasms	8.2%
34	Thyroid Neoplasm	8.2%
35	Thyroid carcinoma	8.2%
36	Testicular Diseases	7%
37	Ovarian Diseases	6.7%
38	Empty Sella Syndrome	6.7%
39	Hyperpituitarism	6.7%
40	Hypopituitarism	6.7%
41	Hypophysitis	6.7%
42	Hyperparathyroidism, Secondary	6.7%
43	Thyrotoxicosis	6.7%
44	Hyperparathyroidism, Primary	6.7%
45	Thyroid Hormone Resistance Syndrome	6.7%
46	Congenital Hypothyroidism	5.6%
47	ovarian neoplasm	5.5%
48	Graves Disease	5.4%
49	Adrenoleukodystrophy	5.3%
50	Thyroid Nodule	5.3%
51	Gestational Diabetes	5.1%
52	Latent Autoimmune Diabetes in Adults	5.1%
53	Diabetes Insipidus	5%
54	Diabetes Mellitus, Experimental	5%
55	Hyperglycemic Hyperosmolar Nonketotic Coma	4.9%
56	Hashimoto Disease	4.9%
57	Testicular Neoplasms	4.8%
58	Diabetic Angiopathies	4.5%
59	Autoimmune thyroiditis	4.5%
60	Diabetic Neuropathies	4.4%
61	Myxedema	4.4%
62	Orchitis	4.4%
63	Diabetic Amyotrophy	4.4%
64	Diabetic Autonomic Neuropathy	4.4%
65	Diabetic Cardiomyopathies	4.4%
66	Pituitary Adenoma	4.4%
67	Pituitary Neoplasms	4.4%
68	Ovarian Hyperstimulation Syndrome	4.4%
69	Hyperprolactinemia	4.4%
70	Prolactinoma	4.4%
71	Growth Hormone-Secreting Pituitary Adenoma	4.4%
72	Hermaphroditism	4.1%
73	Disorders of Sex Development	4.1%
74	Pituitary Apoplexy	3.9%
75	Diabetic Foot	3.9%
76	Nelson Syndrome	3.9%
77	Multiple Endocrine Neoplasia	3.4%
78	Pancreatic Neoplasm	3.4%
79	Corpus Luteum Cyst	3.3%
80	Ovarian Cysts	3.3%
81	Gigantism	3.3%
82	Diabetic Nephropathy	3.3%
83	Kallmann Syndrome	3.3%
84	Acromegaly	3.3%
85	Anovulation	3.3%
86	Diabetic Ketoacidosis	3.3%
87	Oophoritis	3.3%
88	granulosa cell tumor	3.2%
89	Carcinoma, Ovarian Epithelial	3.2%
90	Klinefelter Syndrome	2.8%
91	Cryptorchidism	2.7%
92	Gonadal Dysgenesis	2.6%
93	Adrenogenital Syndrome	2.6%
94	Ovotesticular Disorders of Sex Development	2.6%
95	Diabetic Retinopathy	2.5%
96	Polycystic Ovary Syndrome	2.4%
97	Leydig Cell Tumor	2.2%
98	Multiple Endocrine Neoplasia Type 1	2.2%
99	Hyperandrogenism	2.1%
100	Carcinoma, Pancreatic Ductal	1.6%
101	Turner Syndrome	1.4%
102	insulinoma	1.4%
103	Gastrinoma	1.4%
104	Glucagonoma	1.4%
105	Carcinoma, Endometrioid	1.4%
106	Renal Osteodystrophy	1.2%
107	Renal rickets	1.2%
108	Vipoma	1.2%
109	Denys-Drash Syndrome	0.7%

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