MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperparathyroidism, Primary

(UMLS:C0221002)

Definition:: A condition of abnormally elevated output of PARATHYROID HORMONE due to parathyroid HYPERPLASIA or PARATHYROID NEOPLASMS. It is characterized by the combination of HYPERCALCEMIA, phosphaturia, elevated renal 1,25-DIHYDROXYVITAMIN D3 synthesis, and increased BONE RESORPTION.
UMLS ID:: C0221002
MeSH ID:: D049950

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.642.355.239

Synonym(s)

Hyperparathyroidism, Primary

HYPERPARATHYROID PRIMARY

HYPERPARATHYROIDISM PRIMARY

Hyperparathyroidism primary

Hyperparathyroidism, primary

Primary Hyperparathyroidism

Primary hyperparathyroidism

hyperparathyroidism primary

hyperparathyroidism; primary

10.

primary hyperparathyroidism

11.

primary; hyperparathyroidism

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cinacalcet		17472827	CTD
2	Lithium Carbonate		19732204	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperparathyroidism, Secondary	46.7%
2	Hypoparathyroidism	31%
3	Adrenal Gland Diseases	18.5%
4	Gonadal Disorders	18.5%
5	Thyroid Diseases	18.5%
6	Parathyroid Neoplasms	16.4%
7	Bone Diseases, Endocrine	12.2%
8	Endocrine Gland Neoplasms	12.2%
9	Diabetes Mellitus	11.9%
10	Pituitary Diseases	11.8%
11	Adrenal Cortex Diseases	10.3%
12	Adrenal Gland Neoplasms	10.3%
13	Euthyroid Sick Syndromes	10.3%
14	Goiter	10.3%
15	Hyperthyroidism	10.3%
16	Hyperthyroxinemia	10.3%
17	Hypogonadism	10.3%
18	Hypothyroidism	10.3%
19	Delayed Puberty	10.3%
20	Precocious Puberty	10.3%
21	Thyroiditis	10.3%
22	Hypogonadotropic hypogonadism	10.3%
23	Testotoxicosis	10.3%
24	Secondary hypothyroidism	10.3%
25	Primary Hyperthyroidism	10.3%
26	Primary Hypothyroidism	10.3%
27	Dwarfism	8.9%
28	Renal Osteodystrophy	8.5%
29	Renal rickets	8.5%
30	Thyroid Neoplasm	8.2%
31	Thyroid carcinoma	8.2%
32	Testicular Diseases	7%
33	Ovarian Diseases	6.7%
34	Empty Sella Syndrome	6.7%
35	Hyperpituitarism	6.7%
36	Hypopituitarism	6.7%
37	Hypophysitis	6.7%
38	Cushing Syndrome	6.7%
39	Hyperaldosteronism	6.7%
40	Hypoaldosteronism	6.7%
41	Thyrotoxicosis	6.7%
42	Thyroid Hormone Resistance Syndrome	6.7%
43	Congenital Hypothyroidism	5.6%
44	ovarian neoplasm	5.5%
45	Graves Disease	5.4%
46	Thyroid Nodule	5.3%
47	Gestational Diabetes	5.1%
48	Latent Autoimmune Diabetes in Adults	5.1%
49	Diabetes Insipidus	5%
50	Diabetes Mellitus, Experimental	5%
51	Hyperglycemic Hyperosmolar Nonketotic Coma	4.9%
52	Hashimoto Disease	4.9%
53	Adrenocortical carcinoma	4.8%
54	Testicular Neoplasms	4.8%
55	Addison Disease	4.5%
56	Diabetic Angiopathies	4.5%
57	Autoimmune thyroiditis	4.5%
58	Primary Adrenal Insufficiency	4.5%
59	Diabetic Neuropathies	4.4%
60	Myxedema	4.4%
61	Orchitis	4.4%
62	Diabetic Amyotrophy	4.4%
63	Diabetic Autonomic Neuropathy	4.4%
64	Diabetic Cardiomyopathies	4.4%
65	Pituitary Adenoma	4.4%
66	Pituitary Neoplasms	4.4%
67	Ovarian Hyperstimulation Syndrome	4.4%
68	Hyperprolactinemia	4.4%
69	Prolactinoma	4.4%
70	Growth Hormone-Secreting Pituitary Adenoma	4.4%
71	Hermaphroditism	4.1%
72	Disorders of Sex Development	4.1%
73	Pituitary Apoplexy	3.9%
74	Diabetic Foot	3.9%
75	Nelson Syndrome	3.9%
76	Multiple Endocrine Neoplasia	3.4%
77	Pancreatic Neoplasm	3.4%
78	Corpus Luteum Cyst	3.3%
79	Ovarian Cysts	3.3%
80	Gigantism	3.3%
81	Diabetic Nephropathy	3.3%
82	Kallmann Syndrome	3.3%
83	Acromegaly	3.3%
84	Anovulation	3.3%
85	Diabetic Ketoacidosis	3.3%
86	Oophoritis	3.3%
87	granulosa cell tumor	3.2%
88	Carcinoma, Ovarian Epithelial	3.2%
89	Klinefelter Syndrome	2.8%
90	Cryptorchidism	2.7%
91	Gonadal Dysgenesis	2.6%
92	Adrenogenital Syndrome	2.6%
93	Ovotesticular Disorders of Sex Development	2.6%
94	Diabetic Retinopathy	2.5%
95	Polycystic Ovary Syndrome	2.4%
96	Leydig Cell Tumor	2.2%
97	Multiple Endocrine Neoplasia Type 1	2.2%
98	Hyperandrogenism	2.1%
99	Carcinoma, Pancreatic Ductal	1.6%
100	Turner Syndrome	1.4%
101	insulinoma	1.4%
102	Gastrinoma	1.4%
103	Glucagonoma	1.4%
104	Carcinoma, Endometrioid	1.4%
105	Waterhouse-Friderichsen Syndrome	1.3%
106	Vipoma	1.2%
107	Adrenoleukodystrophy	0.8%
108	Denys-Drash Syndrome	0.7%

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