MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Testotoxicosis

(UMLS:C1504412)

Definition:: Familial precocious puberty in boys usually presents by age 4 with rapid VIRILIZATION and is also characterized by gonadotropin-independent testosterone secretion, low secretion of LUTEINIZING HORMONE, and advanced SPERMATOGENESIS in the testis. Mutations in the LHCGR gene have been identified. OMIM: 176410
UMLS ID:: C1504412
MeSH ID:: D011629

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.693

Synonym(s)

Testotoxicosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cabergoline	FAERS: 6		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Hypogonadism	42.9%
2	Delayed Puberty	42.9%
3	Hypogonadotropic hypogonadism	42.9%
4	Testicular Diseases	28.6%
5	Ovarian Diseases	27.6%
6	Adrenal Gland Diseases	23.1%
7	Parathyroid Diseases	23.1%
8	Thyroid Diseases	23.1%
9	Orchitis	20.5%
10	Ovarian Hyperstimulation Syndrome	20.1%
11	Hermaphroditism	16.7%
12	Disorders of Sex Development	16.7%
13	Kallmann Syndrome	15.6%
14	Corpus Luteum Cyst	15.3%
15	Ovarian Cysts	15.3%
16	Bone Diseases, Endocrine	15%
17	Endocrine Gland Neoplasms	15%
18	Anovulation	14.9%
19	Oophoritis	14.9%
20	Diabetes Mellitus	14.6%
21	ovarian neoplasm	14.6%
22	Pituitary Diseases	14.5%
23	Adrenal Cortex Diseases	14.3%
24	Euthyroid Sick Syndromes	14.3%
25	Goiter	14.3%
26	Hyperparathyroidism	14.3%
27	Hyperthyroidism	14.3%
28	Hyperthyroxinemia	14.3%
29	Hypoparathyroidism	14.3%
30	Hypothyroidism	14.3%
31	Thyroiditis	14.3%
32	Secondary hypothyroidism	14.3%
33	Primary Hyperthyroidism	14.3%
34	Primary Hypothyroidism	14.3%
35	Adrenal Gland Neoplasms	14%
36	Klinefelter Syndrome	13.4%
37	Testicular Neoplasms	12.6%
38	Polycystic Ovary Syndrome	12.4%
39	Cryptorchidism	12.3%
40	Gonadal Dysgenesis	12%
41	Adrenogenital Syndrome	12%
42	Ovotesticular Disorders of Sex Development	12%
43	Parathyroid Neoplasms	11.1%
44	Thyroid Neoplasm	11.1%
45	Thyroid carcinoma	11.1%
46	Dwarfism	10.9%
47	Hyperandrogenism	10.8%
48	Cushing Syndrome	10.3%
49	Hyperaldosteronism	10.3%
50	Hyperparathyroidism, Secondary	10.3%
51	Hypoaldosteronism	10.3%
52	Thyrotoxicosis	10.3%
53	Hyperparathyroidism, Primary	10.3%
54	Thyroid Hormone Resistance Syndrome	10.3%
55	granulosa cell tumor	9.8%
56	Carcinoma, Ovarian Epithelial	9.8%
57	Empty Sella Syndrome	9.1%
58	Hyperpituitarism	9.1%
59	Hypopituitarism	9.1%
60	Hypophysitis	9.1%
61	Hyperglycemic Hyperosmolar Nonketotic Coma	8.5%
62	Hashimoto Disease	8.5%
63	Graves Disease	8.2%
64	Adrenocortical carcinoma	8.2%
65	Thyroid Nodule	8%
66	Congenital Hypothyroidism	7.9%
67	Leydig Cell Tumor	7.5%
68	Addison Disease	7%
69	Diabetic Angiopathies	7%
70	Autoimmune thyroiditis	7%
71	Primary Adrenal Insufficiency	7%
72	Gestational Diabetes	7%
73	Latent Autoimmune Diabetes in Adults	7%
74	Turner Syndrome	6.9%
75	Carcinoma, Endometrioid	6.9%
76	Diabetes Insipidus	6.8%
77	Diabetes Mellitus, Experimental	6.8%
78	Diabetic Neuropathies	6.8%
79	Myxedema	6.8%
80	Diabetic Amyotrophy	6.8%
81	Diabetic Autonomic Neuropathy	6.8%
82	Diabetic Cardiomyopathies	6.8%
83	Hyperprolactinemia	6.7%
84	Prolactinoma	6.6%
85	Growth Hormone-Secreting Pituitary Adenoma	6.6%
86	Diabetic Foot	6.6%
87	Nelson Syndrome	6.5%
88	Pituitary Adenoma	5.9%
89	Pituitary Neoplasms	5.9%
90	Pituitary Apoplexy	5.3%
91	Gigantism	5.1%
92	Diabetic Nephropathy	5%
93	Acromegaly	5%
94	Diabetic Ketoacidosis	5%
95	Multiple Endocrine Neoplasia	4.7%
96	Pancreatic Neoplasm	4.7%
97	Diabetic Retinopathy	4.3%
98	Denys-Drash Syndrome	3.7%
99	Multiple Endocrine Neoplasia Type 1	3.3%
100	Carcinoma, Pancreatic Ductal	2.5%
101	insulinoma	2.3%
102	Gastrinoma	2.3%
103	Glucagonoma	2.3%
104	Renal Osteodystrophy	2%
105	Renal rickets	2%
106	Vipoma	2%
107	Waterhouse-Friderichsen Syndrome	2%
108	Adrenoleukodystrophy	1.1%

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