MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Graves Disease

(UMLS:C0018213)

Definition:: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).
UMLS ID:: C0018213
MeSH ID:: D006111

Classification 1:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.675.349.500

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.874.283.605|C19.874.397.370

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.555

Synonym(s)

Graves Disease

BASEDOW DISEASE

Basedow

Basedow Disease

Basedow disease

Basedow's disease

Disease;Basedows

Disease;Graves

EXOPHTHALMIC GOITER

10.

Exophthalmic goiter

11.

Exophthalmic goitre

12.

FLAJANI DISEASE

13.

Flajani

14.

GOITER, EXOPHTHALMIC

15.

GRAVE DISEASE

16.

GRAVES DISEASE

17.

GRAVES' DISEASE

18.

Graves

19.

Graves disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Carbimazole	View details 1681385 7950664 9450891 12201214 16018796 19263707	CTD
2	Methimazole	View details 434980 1642096 7714072 8956314 9245107 9322804 9777751 11038449 12467281 15072706 18788922	CTD
3	Potassium Iodide	3840600	CTD
4	Prednisolone	9134835	CTD
5	Prednisone	2263031	CTD
6	Propranolol	7714072 9392993 17462097	CTD
7	Propylthiouracil	View details 1339201 1681385 4172680 7485130 7950664 8909171 9134835 9219172 9392993 9893462 11922496 11956877 12521217 15283191 17462097 18044264 20364568 20575220 26459835	CTD
8	Thyroxine	9392993	CTD
9	alfacalcidol	9322804	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Autoimmune thyroiditis	27.3%
2	Thyrotoxicosis	27%
3	Euthyroid Sick Syndromes	24.7%
4	Hyperthyroxinemia	24.7%
5	Hypothyroidism	24.7%
6	Thyroiditis	24.7%
7	Secondary hypothyroidism	24.7%
8	Primary Hypothyroidism	24.7%
9	Thyroid Neoplasm	20.5%
10	Thyroid carcinoma	20.5%
11	Addison Disease	18.2%
12	Primary Adrenal Insufficiency	18.2%
13	Latent Autoimmune Diabetes in Adults	17.6%
14	Antiphospholipid Syndrome	16.4%
15	Thyroid Hormone Resistance Syndrome	16.2%
16	Adrenal Gland Diseases	14.1%
17	Gonadal Disorders	14.1%
18	Parathyroid Diseases	14.1%
19	Lupus Erythematosus, Systemic	13.8%
20	Overlap syndrome	13.8%
21	Pemphigus	13.6%
22	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	13.6%
23	Autoimmune hepatitis	13.6%
24	Congenital Hypothyroidism	13.5%
25	Myxedema	13.5%
26	Thyroid Nodule	13.3%
27	Autoimmune Lymphoproliferative Syndrome	12.8%
28	Enophthalmos	12.3%
29	Goiter	12.3%
30	Hyperthyroidism	12.3%
31	Orbital Pseudotumor	12.3%
32	Primary Hyperthyroidism	12.3%
33	Hashimoto Disease	12.1%
34	Adrenal Gland Neoplasms	11.8%
35	Bone Diseases, Endocrine	11.8%
36	Endocrine Gland Neoplasms	11.8%
37	Dermatitis Herpetiformis	11.7%
38	Diabetes Mellitus	11.6%
39	Pituitary Diseases	11.6%
40	Uveomeningoencephalitic Syndrome	10.7%
41	Rheumatoid Arthritis	10.3%
42	Parathyroid Neoplasms	10.3%
43	Juvenile arthritis	10.3%
44	Orbital Cellulitis	10.2%
45	Retrobulbar Hemorrhage	10.2%
46	Graves Disease	10.2%
47	Anti-Glomerular Basement Membrane Disease	10%
48	Dwarfism	10%
49	Myasthenia Gravis, Autoimmune, Experimental	9.9%
50	Autoimmune thrombocytopenia	9.7%
51	Immune thrombocytopenic purpura	9.7%
52	Neuromyelitis Optica	8.9%
53	Myasthenia Gravis	8.7%
54	Orbital Myositis	8.7%
55	Granulomatosis with polyangiitis	8.6%
56	Hypersensitivity	8.5%
57	Immunologic Deficiency Syndromes	8.5%
58	Immunoproliferative Disorders	8.5%
59	Immune reconstitution syndrome	8.5%
60	Immune Reconstitution Inflammatory Syndrome	8.5%
61	Adrenal Cortex Diseases	8.2%
62	Hyperparathyroidism	8.2%
63	Hypogonadism	8.2%
64	Hypoparathyroidism	8.2%
65	Delayed Puberty	8.2%
66	Precocious Puberty	8.2%
67	Hypogonadotropic hypogonadism	8.2%
68	Testotoxicosis	8.2%
69	Leukoencephalitis, Acute Hemorrhagic	7.8%
70	Stiff-Person Syndrome	7.7%
71	Polyradiculoneuropathy	7.7%
72	Polyradiculoneuritis	7.7%
73	Felty Syndrome	7.5%
74	Lupus Nephritis	7.5%
75	ovarian neoplasm	7.4%
76	Sicca Syndrome	7.3%
77	Sjogren's Syndrome	7.3%
78	Lupus Vasculitis, Central Nervous System	7.2%
79	Multiple Sclerosis	7.2%
80	Transfusion Reaction	7.1%
81	Hypotensive Transfusion Reaction	7.1%
82	Asthenopia	7%
83	Conjunctival Diseases	7%
84	Corneal Diseases	7%
85	Eyelid Diseases	7%
86	Lacrimal Apparatus Diseases	7%
87	Lens Diseases	7%
88	Ocular Hypertension	7%
89	Ocular Hypotension	7%
90	Retinal Diseases	7%
91	Scleral Diseases	7%
92	Vitreous Detachment	7%
93	Posterior Vitreous Detachment	7%
94	Retinal Degeneration	6.9%
95	Testicular Diseases	6.9%
96	Retinal Dysplasia	6.9%
97	Ovarian Diseases	6.8%
98	Empty Sella Syndrome	6.8%
99	Hyperpituitarism	6.8%
100	Hypopituitarism	6.8%
101	Hypophysitis	6.8%
102	Vasculitis, Central Nervous System	6.7%
103	Testicular Neoplasms	6.7%
104	Rheumatoid Vasculitis	6.6%
105	Pituitary Adenoma	6.6%
106	Pituitary Neoplasms	6.6%
107	Adrenocortical carcinoma	6.6%
108	Multiple Sclerosis, Chronic Progressive	6.4%
109	Multiple Sclerosis, Relapsing-Remitting	6.4%
110	Encephalomyelitis, Acute Disseminated	6.2%
111	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.2%
112	Neuritis, Autoimmune, Experimental	6.2%
113	Aniridia	6.1%
114	Lambert-Eaton Myasthenic Syndrome	6.1%
115	Prolactinoma	5.9%
116	Growth Hormone-Secreting Pituitary Adenoma	5.9%
117	Blepharophimosis	5.9%
118	Eye Abnormalities	5.9%
119	Eye Infection	5.9%
120	Eye Manifestations	5.9%
121	Eye Neoplasms	5.9%
122	Uveal Neoplasms	5.9%
123	Optic Neuropathy	5.9%
124	Eyelid Neoplasms	5.9%
125	Retinal Hemorrhage	5.9%
126	Gestational Diabetes	5.9%
127	Glomerulonephritis, Membranoproliferative	5.8%
128	Diabetes Insipidus	5.8%
129	Diabetes Mellitus, Experimental	5.8%
130	Diabetic Retinopathy	5.8%
131	Xerophthalmia	5.7%
132	Low Tension Glaucoma	5.7%
133	Iridocorneal endothelial syndrome	5.7%
134	Guillain-Barre Syndrome	5.5%
135	Immune Complex Diseases	5.5%
136	Latex allergy	5.5%
137	Cushing Syndrome	5.4%
138	Hyperaldosteronism	5.4%
139	Hyperparathyroidism, Secondary	5.4%
140	Hypoaldosteronism	5.4%
141	Hyperparathyroidism, Primary	5.4%
142	Miller Fisher Syndrome	5.4%
143	Duane Retraction Syndrome	5.1%
144	Hermaphroditism	5.1%
145	Disorders of Sex Development	5.1%
146	Corneal Scar	5.1%
147	Ocular Motility Disorders	5.1%
148	Cyclophoria	5.1%
149	Primary amyloidosis	5%
150	Monoclonal Gammopathy of Undetermined Significance	5%
151	Pituitary Apoplexy	5%
152	Pupil Disorders	5%
153	Diabetic Foot	5%
154	Eye Hemorrhage	5%
155	Nelson Syndrome	4.9%
156	Vision Disorders	4.9%
157	Metamorphopsia	4.9%
158	Visual Impairment	4.9%
159	Eye Injuries	4.9%
160	Corneal Ulcer	4.9%
161	Choroid Hemorrhage	4.8%
162	Keratoconjunctivitis Sicca	4.8%
163	Environmental Illness	4.7%
164	Kallmann Syndrome	4.7%
165	granulosa cell tumor	4.6%
166	Carcinoma, Ovarian Epithelial	4.6%
167	Lymphoproliferative Disorders	4.6%
168	Multiple Endocrine Neoplasia	4.6%
169	Pancreatic Neoplasm	4.6%
170	Serum Sickness	4.6%
171	Diabetic Angiopathies	4.5%
172	Paraproteinemias	4.5%
173	Lymphopenia	4.5%
174	Thrombocytopenic purpura	4.5%
175	Giant Cell Arteritis	4.5%
176	Temporal Arteritis	4.5%
177	Diabetic Neuropathies	4.5%
178	Keratoconjunctivitis	4.5%
179	Orchitis	4.5%
180	Diabetic Amyotrophy	4.5%
181	Diabetic Autonomic Neuropathy	4.5%
182	Diabetic Cardiomyopathies	4.5%
183	Asthma, Aspirin-Induced	4.5%
184	Ovarian Hyperstimulation Syndrome	4.5%
185	Hyperprolactinemia	4.5%
186	Chorioretinitis	4.4%
187	Retinitis Pigmentosa	4.3%
188	Pigmentary retinopathy	4.3%
189	Retinoblastoma	4.2%
190	Hordeolum	4.2%
191	Color blindness	4.2%
192	Klinefelter Syndrome	4.2%
193	Myelitis, Transverse	4.1%
194	Angioid Streaks	4.1%
195	Anisometropia	4.1%
196	Aphakia	4.1%
197	Astigmatism	4.1%
198	Blepharitis	4.1%
199	Blepharoptosis	4.1%
200	Blepharospasm	4.1%
201	Choroid Diseases	4.1%
202	Conjunctivitis	4.1%
203	Corneal edema	4.1%
204	Corneal Opacity	4.1%
205	Dacryocystitis	4.1%
206	Dry Eye Syndromes	4.1%
207	Ectropion	4.1%
208	Entropion	4.1%
209	Episcleritis	4.1%
210	Glaucoma	4.1%
211	Iris Diseases	4.1%
212	Keratitis	4.1%
213	Keratoconus	4.1%
214	Lacrimal Duct Obstruction	4.1%
215	Lens dislocation	4.1%
216	Lens Subluxation	4.1%
217	Mydriasis	4.1%
218	Myopia	4.1%
219	Presbyopia	4.1%
220	Pterygium	4.1%
221	Retinal Detachment	4.1%
222	Retinitis	4.1%
223	Scleritis	4.1%
224	Uveitis	4.1%
225	Corneal Neovascularization	4.1%
226	Cataract	4.1%
227	Pinguecula	4.1%
228	Trichiasis	4.1%
229	anaphylaxis	4.1%
230	Food Allergy	4.1%
231	Anaphylactic shock	4.1%
232	Hyperglycemic Hyperosmolar Nonketotic Coma	4%
233	Multiple Myeloma	4%
234	Trachoma	4%
235	Hypergammaglobulinemia	3.9%
236	Pars Planitis	3.9%
237	Agammaglobulinemia	3.9%
238	Kounis Syndrome	3.9%
239	HIV Infections	3.9%
240	Transfusion-Related Acute Lung Injury	3.9%
241	Corpus Luteum Cyst	3.9%
242	Ovarian Cysts	3.9%
243	Gigantism	3.8%
244	Diabetic Nephropathy	3.8%
245	Acromegaly	3.8%
246	Anovulation	3.8%
247	Diabetic Ketoacidosis	3.8%
248	Oophoritis	3.8%
249	Sezary Syndrome	3.7%
250	Choroiditis	3.6%
251	Iridocyclitis	3.6%
252	Iritis	3.6%
253	Respiratory Hypersensitivity	3.5%
254	Anophthalmos	3.4%
255	Endophthalmitis	3.4%
256	Microphthalmos	3.4%
257	Optic Atrophy	3.4%
258	Optic Neuritis	3.4%
259	Papilledema	3.4%
260	Pemphigoid, Benign Mucous Membrane	3.4%
261	Retinal Artery Occlusion	3.4%
262	Retinopathy of Prematurity	3.4%
263	Sick Building Syndrome	3.4%
264	Strabismus	3.4%
265	Tolosa-Hunt Syndrome	3.4%
266	Retinal Vasculitis	3.4%
267	Hypertensive Retinopathy	3.4%
268	Multiple Chemical Sensitivity	3.4%
269	Corneal Endothelial Cell Loss	3.4%
270	Acanthamoeba Keratitis	3.4%
271	Cryptorchidism	3.4%
272	Hyphema	3.4%
273	Retinal Neovascularization	3.4%
274	Vitreous Hemorrhage	3.4%
275	Keratitis, Herpetic	3.4%
276	Cytomegalovirus Retinitis	3.4%
277	Plasmacytoma	3.4%
278	Tumor Lysis Syndrome	3.4%
279	Urticaria	3.4%
280	Vasculitis, Leukocytoclastic, Cutaneous	3.4%
281	Milk Allergy	3.4%
282	Schnitzler Syndrome	3.4%
283	Wheat Hypersensitivity	3.4%
284	HTLV-I Infections	3.4%
285	Job Syndrome	3.4%
286	Bacterial conjunctivitis	3.3%
287	Gonadal Dysgenesis	3.3%
288	Adrenogenital Syndrome	3.3%
289	Ovotesticular Disorders of Sex Development	3.3%
290	Corneal Perforation	3.3%
291	Hyperandrogenism	3.3%
292	Leydig Cell Tumor	3.3%
293	Multiple Endocrine Neoplasia Type 1	3%
294	Optic Neuropathy, Ischemic	2.9%
295	Anterior Ischemic Optic Neuropathy	2.9%
296	Retinal Vein Occlusion	2.9%
297	Lymphoma	2.9%
298	Anisocoria	2.9%
299	Mastocytosis	2.9%
300	Tonic Pupil	2.9%
301	Eye pain	2.9%
302	Drug Eruptions	2.9%
303	Diplopia	2.9%
304	Scotoma	2.9%
305	Photophobia	2.9%
306	Amaurosis	2.9%
307	Blindness	2.9%
308	Chronic granulomatous disease	2.9%
309	Heavy Chain Disease	2.9%
310	Dermatitis, Allergic Contact	2.9%
311	HIV Seropositivity	2.9%
312	Polycystic Ovary Syndrome	2.8%
313	Mastocytosis, Systemic	2.8%
314	Angle Closure Glaucoma	2.7%
315	Glaucoma, Open-Angle	2.7%
316	Macular degeneration	2.7%
317	Panuveitis	2.7%
318	Retinal Drusen	2.7%
319	Retinal Necrosis Syndrome, Acute	2.7%
320	Retinoschisis	2.7%
321	Exfoliation Syndrome	2.7%
322	Kernicterus	2.7%
323	Panophthalmitis	2.7%
324	Ophthalmoplegia	2.5%
325	External Ophthalmoplegia	2.5%
326	Acquired Immunodeficiency Syndrome	2.5%
327	AIDS related complex	2.5%
328	Amblyopia	2.5%
329	Infectious Mononucleosis	2.5%
330	Cryoglobulinemia	2.5%
331	POEMS Syndrome	2.5%
332	Ataxia Telangiectasia	2.5%
333	Hydrops Fetalis	2.4%
334	Angioedema	2.4%
335	Carcinoma, Pancreatic Ductal	2.4%
336	Hodgkin Disease	2.4%
337	Leukemia, Plasma Cell	2.4%
338	Lymphoma, Non-Hodgkin	2.4%
339	Leukemia, T-Cell	2.4%
340	Acute Generalized Exanthematous Pustulosis	2.4%
341	Leukemia, B-Cell	2.4%
342	Turner Syndrome	2.3%
343	AIDS-Related Opportunistic Infections	2.3%
344	Dermatitis, Atopic	2.2%
345	Esotropia	2.2%
346	Exotropia	2.2%
347	Choroidal Neovascularization	2.2%
348	HIV Wasting Syndrome	2.2%
349	AIDS Dementia Complex	2.2%
350	AIDS-Associated Nephropathy	2.2%
351	Asthma, Exercise-Induced	2.1%
352	Status Asthmaticus	2.1%
353	Asthma	2.1%
354	Lymphoma, Follicular	2.1%
355	T-Cell Lymphoma	2.1%
356	Mantle cell lymphoma	2.1%
357	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.1%
358	Leukemia, Large Granular Lymphocytic	2.1%
359	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.1%
360	Optic Atrophy, Hereditary, Leber	2.1%
361	Composite Lymphoma	2.1%
362	Erythema Nodosum	2.1%
363	Dermatitis, Photoallergic	2.1%
364	Lymphangioleiomyomatosis	2.1%
365	Aicardi's syndrome	2%
366	Anterior uveitis	2%
367	Uveitis, Posterior	2%
368	Waterhouse-Friderichsen Syndrome	2%
369	Waldenstrom Macroglobulinemia	2%
370	Hereditary Angioedema Type III	2%
371	Hereditary Angioedema Types I and II	2%
372	Wiskott-Aldrich Syndrome	2%
373	Lymphoma, T-Cell, Cutaneous	2%
374	Lymphoma, AIDS-Related	2%
375	Enteropathy-Associated T-Cell Lymphoma	2%
376	Primary Effusion Lymphoma	2%
377	Ophthalmia Neonatorum	2%
378	HIV-Associated Lipodystrophy Syndrome	2%
379	insulinoma	2%
380	Gastrinoma	2%
381	Glucagonoma	2%
382	Carcinoma, Endometrioid	2%
383	CHARGE Syndrome	1.9%
384	Congenital nystagmus	1.9%
385	Mycosis Fungoides	1.9%
386	Lymphomatoid Papulosis	1.9%
387	Plasmablastic lymphoma	1.9%
388	Herpes Zoster Ophthalmicus	1.9%
389	Asthma, Occupational	1.9%
390	Hemianopsia	1.9%
391	Amaurosis Fugax	1.9%
392	Blindness, Cortical	1.9%
393	Farmer's Lung	1.9%
394	Angioedemas, Hereditary	1.9%
395	Hay fever	1.9%
396	Rhinitis, Allergic, Perennial	1.9%
397	Aspergillosis, Allergic Bronchopulmonary	1.9%
398	Opsoclonus-Myoclonus Syndrome	1.8%
399	Albinism	1.8%
400	Renal Osteodystrophy	1.8%
401	Renal rickets	1.8%
402	Vipoma	1.8%
403	Lymphomatoid Granulomatosis	1.8%
404	Horner Syndrome	1.7%
405	Mandibulofacial Dysostosis	1.7%
406	Toxic Epidermal Necrolysis	1.7%
407	Stevens-Johnson Syndrome	1.7%
408	Burkitt Lymphoma	1.6%
409	Adrenoleukodystrophy	1.3%
410	Kearns-Sayre syndrome	1.3%
411	Denys-Drash Syndrome	1.2%
412	Ophthalmoplegic Migraine	1.2%
413	Progressive supranuclear palsy	1.2%
414	Alstrom Syndrome	1%
415	Optic Nerve Glioma	0.9%
416	Behcet Syndrome	0.8%

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