MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperaldosteronism

(UMLS:C0020428)

Definition:: A condition caused by the overproduction of ALDOSTERONE. It is characterized by sodium retention and potassium excretion with resultant HYPERTENSION and HYPOKALEMIA.
UMLS ID:: C0020428
MeSH ID:: D006929

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.053.800.604

Synonym(s)

Hyperaldosteronism

Aldosteronism

Aldosteronism, NOS

Elevated plasma aldosterone

HYPERALDOSTERONISM

Hyperaldosteronism, NOS

Hyperaldosteronism, unspecified

Increased aldosterone

Increased aldosterone production

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Topiramate	FAERS: 8		US FAERS
2	Alendronate	FAERS: 5		US FAERS
3	Pantoprazole	FAERS: 3		US FAERS
4	Cyclosporine	FAERS: 2		US FAERS
5	Eplerenone	FAERS: 2		OFFSIDES US FAERS
6	Finasteride	FAERS: 2		US FAERS
7	Hydrochlorothiazide	FAERS: 2	17928827	CTD US FAERS
8	Mycophenolic Acid	FAERS: 2		US FAERS
9	Norgestrel	FAERS: 2		US FAERS
10	Pregabalin	FAERS: 2		US FAERS
11	Spironolactone	FAERS: 2	View details 1103606 7305153 9198849 19224505 20009770	CTD US FAERS
12	rofecoxib	FAERS: 2		OFFSIDES US FAERS
13	Amlodipine	FAERS: 1		US FAERS
14	Digoxin	FAERS: 1		US FAERS
15	Fentanyl	FAERS: 1		US FAERS
16	Imatinib Mesylate	FAERS: 1		US FAERS
17	Indapamide	FAERS: 1		US FAERS
18	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
19	NuvaRing	FAERS: 1		US FAERS
20	Octreotide	FAERS: 1		US FAERS
21	Rosuvastatin Calcium	FAERS: 1		US FAERS
22	Thyroxine	FAERS: 1		US FAERS
23	Valproic Acid	FAERS: 1		US FAERS
24	Aldosterone		6645193	CTD
25	Bendroflumethiazide		20009770	CTD
26	Chlorthalidone		1103606	CTD
27	Dexamethasone		View details 187612 7057836 7609119 11085685	CTD
28	Didanosine			OFFSIDES
29	Dyphylline			OFFSIDES
30	Fenofibrate			OFFSIDES
31	Furosemide		6387403	CTD
32	Gentamicins		5489186	CTD
33	Nevirapine			OFFSIDES
34	Nitrendipine			OFFSIDES
35	Pentamidine			OFFSIDES
36	Phosphates			OFFSIDES
37	Saquinavir			OFFSIDES
38	Streptozocin		2819817	CTD
39	Tamoxifen			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cushing Syndrome	46.7%
2	Adrenal Cortex Diseases	31%
3	Adrenal Gland Neoplasms	20.7%
4	Hypoaldosteronism	20%
5	Gonadal Disorders	18.5%
6	Parathyroid Diseases	18.5%
7	Thyroid Diseases	18.5%
8	Addison Disease	13.6%
9	Primary Adrenal Insufficiency	13.6%
10	Bone Diseases, Endocrine	12.2%
11	Endocrine Gland Neoplasms	12.2%
12	Diabetes Mellitus	11.9%
13	Pituitary Diseases	11.8%
14	Adrenocortical carcinoma	11.3%
15	Euthyroid Sick Syndromes	10.3%
16	Goiter	10.3%
17	Hyperparathyroidism	10.3%
18	Hyperthyroidism	10.3%
19	Hyperthyroxinemia	10.3%
20	Hypogonadism	10.3%
21	Hypoparathyroidism	10.3%
22	Hypothyroidism	10.3%
23	Delayed Puberty	10.3%
24	Precocious Puberty	10.3%
25	Thyroiditis	10.3%
26	Hypogonadotropic hypogonadism	10.3%
27	Testotoxicosis	10.3%
28	Secondary hypothyroidism	10.3%
29	Primary Hyperthyroidism	10.3%
30	Primary Hypothyroidism	10.3%
31	Dwarfism	8.9%
32	Parathyroid Neoplasms	8.2%
33	Thyroid Neoplasm	8.2%
34	Thyroid carcinoma	8.2%
35	Testicular Diseases	7%
36	Ovarian Diseases	6.7%
37	Empty Sella Syndrome	6.7%
38	Hyperpituitarism	6.7%
39	Hypopituitarism	6.7%
40	Hypophysitis	6.7%
41	Hyperparathyroidism, Secondary	6.7%
42	Thyrotoxicosis	6.7%
43	Hyperparathyroidism, Primary	6.7%
44	Thyroid Hormone Resistance Syndrome	6.7%
45	Congenital Hypothyroidism	5.6%
46	ovarian neoplasm	5.5%
47	Graves Disease	5.4%
48	Thyroid Nodule	5.3%
49	Gestational Diabetes	5.1%
50	Latent Autoimmune Diabetes in Adults	5.1%
51	Diabetes Insipidus	5%
52	Diabetes Mellitus, Experimental	5%
53	Hyperglycemic Hyperosmolar Nonketotic Coma	4.9%
54	Hashimoto Disease	4.9%
55	Testicular Neoplasms	4.8%
56	Diabetic Angiopathies	4.5%
57	Autoimmune thyroiditis	4.5%
58	Diabetic Neuropathies	4.4%
59	Myxedema	4.4%
60	Orchitis	4.4%
61	Diabetic Amyotrophy	4.4%
62	Diabetic Autonomic Neuropathy	4.4%
63	Diabetic Cardiomyopathies	4.4%
64	Pituitary Adenoma	4.4%
65	Pituitary Neoplasms	4.4%
66	Ovarian Hyperstimulation Syndrome	4.4%
67	Hyperprolactinemia	4.4%
68	Prolactinoma	4.4%
69	Growth Hormone-Secreting Pituitary Adenoma	4.4%
70	Hermaphroditism	4.1%
71	Disorders of Sex Development	4.1%
72	Pituitary Apoplexy	3.9%
73	Diabetic Foot	3.9%
74	Waterhouse-Friderichsen Syndrome	3.9%
75	Nelson Syndrome	3.9%
76	Multiple Endocrine Neoplasia	3.4%
77	Pancreatic Neoplasm	3.4%
78	Corpus Luteum Cyst	3.3%
79	Ovarian Cysts	3.3%
80	Gigantism	3.3%
81	Diabetic Nephropathy	3.3%
82	Kallmann Syndrome	3.3%
83	Acromegaly	3.3%
84	Anovulation	3.3%
85	Diabetic Ketoacidosis	3.3%
86	Oophoritis	3.3%
87	granulosa cell tumor	3.2%
88	Carcinoma, Ovarian Epithelial	3.2%
89	Klinefelter Syndrome	2.8%
90	Cryptorchidism	2.7%
91	Gonadal Dysgenesis	2.6%
92	Adrenogenital Syndrome	2.6%
93	Ovotesticular Disorders of Sex Development	2.6%
94	Diabetic Retinopathy	2.5%
95	Polycystic Ovary Syndrome	2.4%
96	Adrenoleukodystrophy	2.3%
97	Leydig Cell Tumor	2.2%
98	Multiple Endocrine Neoplasia Type 1	2.2%
99	Hyperandrogenism	2.1%
100	Carcinoma, Pancreatic Ductal	1.6%
101	Turner Syndrome	1.4%
102	insulinoma	1.4%
103	Gastrinoma	1.4%
104	Glucagonoma	1.4%
105	Carcinoma, Endometrioid	1.4%
106	Renal Osteodystrophy	1.2%
107	Renal rickets	1.2%
108	Vipoma	1.2%
109	Denys-Drash Syndrome	0.7%

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