MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypoparathyroidism

(UMLS:C0020626)

Definition:: A condition caused by a deficiency of PARATHYROID HORMONE (or PTH). It is characterized by HYPOCALCEMIA and hyperphosphatemia. Hypocalcemia leads to TETANY. The acquired form is due to removal or injuries to the PARATHYROID GLANDS. The congenital form is due to mutations of genes, such as TBX1; (see DIGEORGE SYNDROME); CASR encoding CALCIUM-SENSING RECEPTOR; or PTH encoding parathyroid hormone.
UMLS ID:: C0020626
MeSH ID:: D007011

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.642.482

Synonym(s)

Hypoparathyroidism

Decreased parathyroid hormone secretion

Deficiency of PTH

Deficiency of parathyrin

Deficiency of parathyroid hormone

HYPOPARATHYROID

HYPOPARATHYROIDISM

Hypoparathyroidism, NOS

Hypoparathyroidism, unspecified

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Omeprazole	FAERS: 29		US FAERS
2	Alendronate	FAERS: 9		US FAERS
3	Pantoprazole	FAERS: 9		US FAERS
4	Teriparatide	FAERS: 5		US FAERS
5	Zoledronic Acid	FAERS: 5		US FAERS
6	Omeprazole	FAERS: 3		US FAERS
7	Sodium iodide I 131	FAERS: 3		US FAERS
8	Clozapine	FAERS: 2		OFFSIDES US FAERS
9	Esomeprazole	FAERS: 2		US FAERS
10	Sorafenib	FAERS: 2		US FAERS
11	Valproic Acid	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
12	Anastrozole	FAERS: 1		US FAERS
13	Calcium Carbonate	FAERS: 1	8667442	CTD US FAERS
14	Calcium Gluconate	FAERS: 1		US FAERS
15	Cinacalcet	FAERS: 1		US FAERS
16	Deferoxamine	FAERS: 1		US FAERS
17	Fluoxetine	FAERS: 1		US FAERS
18	Furosemide	FAERS: 1		US FAERS
19	Imatinib Mesylate	FAERS: 1		US FAERS
20	Lansoprazole	FAERS: 1		US FAERS
21	N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine	FAERS: 1		US FAERS
22	Oxycodone	FAERS: 1		US FAERS
23	Pamidronate	FAERS: 1		US FAERS
24	Risedronic Acid	FAERS: 1		US FAERS
25	Rosuvastatin Calcium	FAERS: 1		US FAERS
26	Ruxolitinib phosphate	FAERS: 1		US FAERS
27	Sunitinib	FAERS: 1		US FAERS
28	Tenofovir	FAERS: 1		US FAERS
29	adefovir dipivoxil	FAERS: 1		US FAERS
30	hydrochlorothiazide, lisinopril drug combination	FAERS: 1		US FAERS
31	5-O-[1-[3,3-Diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydron;chloride			OFFSIDES
32	Acetaminophen			OFFSIDES
33	Amifostine			SIDER
34	Calcitriol		View details 2856045 6687780 6688127 6894567 8667442 26196949	CTD
35	Calcium Compounds		26196949	CTD OFFSIDES
36	Carbimazole			OFFSIDES
37	Ergocalciferols		8528347	CTD
38	Flupenthixol			OFFSIDES
39	Hydroxyzine			OFFSIDES
40	Ibuprofen			OFFSIDES
41	Iodide ion			SIDER
42	Isosorbide			OFFSIDES
43	Letrozole			OFFSIDES
44	Metoclopramide			OFFSIDES
45	Piroxicam			OFFSIDES
46	Prednisolone			SIDER
47	Raloxifene Hydrochloride			OFFSIDES
48	Simvastatin			OFFSIDES
49	Telmisartan			OFFSIDES
50	Urea			OFFSIDES
51	Vitamin D		4642736 11464680	CTD OFFSIDES
52	alfacalcidol		2616424	CTD
53	calcium acetate			OFFSIDES
54	fexofenadine			OFFSIDES
55	gadoversetamide			OFFSIDES
56	paricalcitol			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperparathyroidism	42.9%
2	Hyperparathyroidism, Secondary	31%
3	Hyperparathyroidism, Primary	31%
4	Adrenal Gland Diseases	23.1%
5	Gonadal Disorders	23.1%
6	Thyroid Diseases	23.1%
7	Parathyroid Neoplasms	22.2%
8	Bone Diseases, Endocrine	15%
9	Endocrine Gland Neoplasms	15%
10	Diabetes Mellitus	14.6%
11	Pituitary Diseases	14.5%
12	Adrenal Cortex Diseases	14.3%
13	Euthyroid Sick Syndromes	14.3%
14	Goiter	14.3%
15	Hyperthyroidism	14.3%
16	Hyperthyroxinemia	14.3%
17	Hypogonadism	14.3%
18	Hypothyroidism	14.3%
19	Delayed Puberty	14.3%
20	Precocious Puberty	14.3%
21	Thyroiditis	14.3%
22	Hypogonadotropic hypogonadism	14.3%
23	Testotoxicosis	14.3%
24	Secondary hypothyroidism	14.3%
25	Primary Hyperthyroidism	14.3%
26	Primary Hypothyroidism	14.3%
27	Adrenal Gland Neoplasms	14%
28	Thyroid Neoplasm	11.1%
29	Thyroid carcinoma	11.1%
30	Dwarfism	10.9%
31	Cushing Syndrome	10.3%
32	Hyperaldosteronism	10.3%
33	Hypoaldosteronism	10.3%
34	Thyrotoxicosis	10.3%
35	Thyroid Hormone Resistance Syndrome	10.3%
36	Testicular Diseases	9.5%
37	Ovarian Diseases	9.2%
38	Empty Sella Syndrome	9.1%
39	Hyperpituitarism	9.1%
40	Hypopituitarism	9.1%
41	Hypophysitis	9.1%
42	Hyperglycemic Hyperosmolar Nonketotic Coma	8.5%
43	Hashimoto Disease	8.5%
44	Graves Disease	8.2%
45	Adrenocortical carcinoma	8.2%
46	Thyroid Nodule	8%
47	Congenital Hypothyroidism	7.9%
48	ovarian neoplasm	7.8%
49	Addison Disease	7%
50	Diabetic Angiopathies	7%
51	Autoimmune thyroiditis	7%
52	Primary Adrenal Insufficiency	7%
53	Gestational Diabetes	7%
54	Latent Autoimmune Diabetes in Adults	7%
55	Diabetes Insipidus	6.8%
56	Diabetes Mellitus, Experimental	6.8%
57	Diabetic Neuropathies	6.8%
58	Myxedema	6.8%
59	Orchitis	6.8%
60	Diabetic Amyotrophy	6.8%
61	Diabetic Autonomic Neuropathy	6.8%
62	Diabetic Cardiomyopathies	6.8%
63	Testicular Neoplasms	6.8%
64	Ovarian Hyperstimulation Syndrome	6.7%
65	Hyperprolactinemia	6.7%
66	Prolactinoma	6.6%
67	Growth Hormone-Secreting Pituitary Adenoma	6.6%
68	Diabetic Foot	6.6%
69	Nelson Syndrome	6.5%
70	Renal Osteodystrophy	6.1%
71	Renal rickets	6.1%
72	Pituitary Adenoma	5.9%
73	Pituitary Neoplasms	5.9%
74	Hermaphroditism	5.6%
75	Disorders of Sex Development	5.6%
76	Pituitary Apoplexy	5.3%
77	Kallmann Syndrome	5.2%
78	granulosa cell tumor	5.1%
79	Carcinoma, Ovarian Epithelial	5.1%
80	Corpus Luteum Cyst	5.1%
81	Ovarian Cysts	5.1%
82	Gigantism	5.1%
83	Diabetic Nephropathy	5%
84	Acromegaly	5%
85	Anovulation	5%
86	Diabetic Ketoacidosis	5%
87	Oophoritis	5%
88	Multiple Endocrine Neoplasia	4.7%
89	Pancreatic Neoplasm	4.7%
90	Klinefelter Syndrome	4.5%
91	Diabetic Retinopathy	4.3%
92	Polycystic Ovary Syndrome	4.1%
93	Cryptorchidism	4.1%
94	Gonadal Dysgenesis	4%
95	Adrenogenital Syndrome	4%
96	Ovotesticular Disorders of Sex Development	4%
97	Leydig Cell Tumor	3.8%
98	Hyperandrogenism	3.6%
99	Multiple Endocrine Neoplasia Type 1	3.3%
100	Carcinoma, Pancreatic Ductal	2.5%
101	insulinoma	2.3%
102	Gastrinoma	2.3%
103	Glucagonoma	2.3%
104	Turner Syndrome	2.3%
105	Carcinoma, Endometrioid	2.3%
106	Vipoma	2%
107	Waterhouse-Friderichsen Syndrome	2%
108	Denys-Drash Syndrome	1.2%
109	Adrenoleukodystrophy	1.1%

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