MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Precocious Puberty

(UMLS:C0034013)

Definition:: Development of SEXUAL MATURATION in boys and girls at a chronological age that is 2.5 standard deviations below the mean age at onset of PUBERTY in the population. This early maturation of the hypothalamic-pituitary-gonadal axis results in sexual precocity, elevated serum levels of GONADOTROPINS and GONADAL STEROID HORMONES such as ESTRADIOL and TESTOSTERONE.
UMLS ID:: C0034013
MeSH ID:: D011629

Classification:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.693

Synonym(s)

Precocious Puberty

ACCELERATED SEXUAL MATURITY

Early onset of puberty

Early puberty

PRECOCIOUS PUBERTY

PUBERTY PRECOCIOUS

Precocious puberty

Precocious sexual development

Precocious true puberty

10.

Premature puberty

11.

Pubertas praecox

12.

Puberty;precocious

13.

Sexual Precocity

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Testosterone	FAERS: 41	SIDER US FAERS
2	Risperidone	FAERS: 26	SIDER US FAERS
3	Estrogens, Conjugated (USP)	FAERS: 7	US FAERS
4	Atomoxetine Hydrochloride	FAERS: 6	US FAERS
5	Levetiracetam	FAERS: 6	US FAERS
6	montelukast	FAERS: 6	US FAERS
7	Oxcarbazepine	FAERS: 5	US FAERS
8	Aripiprazole	FAERS: 4	US FAERS
9	Paroxetine	FAERS: 4	US FAERS
10	testosterone 17 beta-cypionate	FAERS: 4	OFFSIDES US FAERS
11	Clonazepam	FAERS: 3	US FAERS
12	Estradiol	FAERS: 3	US FAERS
13	Methylphenidate	FAERS: 3 Canada Vigilance: 2	Canada Vigilance US FAERS
14	Rosuvastatin Calcium	FAERS: 3	US FAERS
15	Valproic Acid	FAERS: 3	US FAERS
16	Valproic Acid	FAERS: 3	US FAERS
17	Valproic Acid	FAERS: 3	US FAERS
18	levocetirizine	FAERS: 3	US FAERS
19	Clomifene citrate	FAERS: 2	US FAERS
20	Clomiphene	FAERS: 2	US FAERS
21	Deamino Arginine Vasopressin	FAERS: 2	US FAERS
22	HhAntag691	FAERS: 2	US FAERS
23	Ondansetron	FAERS: 2	US FAERS
24	Anastrozole	FAERS: 1	US FAERS
25	Azithromycin	FAERS: 1	US FAERS
26	Baclofen	FAERS: 1	US FAERS
27	Bleomycin	FAERS: 1	US FAERS
28	Budesonide	FAERS: 1	US FAERS
29	Carbamazepine	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
30	Clonidine	FAERS: 1	US FAERS
31	Danazol	FAERS: 1	US FAERS
32	Ethylene Glycol	FAERS: 1	US FAERS
33	Fluticasone	FAERS: 1	US FAERS
34	Haloperidol	FAERS: 1	US FAERS
35	Leuprolide	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
36	Lisdexamfetamine Dimesylate	FAERS: 1	US FAERS
37	Losartan	FAERS: 1	US FAERS
38	Methylphenidate	FAERS: 1	US FAERS
39	Oxytocin	FAERS: 1	US FAERS
40	Terbinafine	FAERS: 1	US FAERS
41	Thyroxine	FAERS: 1	US FAERS
42	Vigabatrin	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
43	ambrisentan	FAERS: 1	US FAERS
44	desloratadine	FAERS: 1	US FAERS
45	eltrombopag	FAERS: 1	US FAERS
46	etonogestrel	FAERS: 1	US FAERS
47	histrelin	FAERS: 1	US FAERS
48	Aminoglutethimide		SIDER
49	Amlodipine		OFFSIDES
50	Atomoxetine Hydrochloride		OFFSIDES
51	Cinacalcet		OFFSIDES
52	Cyproheptadine		OFFSIDES
53	Daunorubicin		OFFSIDES
54	Fluorouracil		OFFSIDES
55	Fluoxetine		OFFSIDES
56	Lanthanum carbonate hydrate		OFFSIDES
57	Leuprolide		SIDER
58	Melatonin		OFFSIDES
59	Mercaptopurine		OFFSIDES
60	Mycophenolic Acid		OFFSIDES
61	Nandrolone		SIDER
62	Pentamidine		OFFSIDES
63	Sodium Bicarbonate		OFFSIDES
64	Stavudine		OFFSIDES
65	Tamoxifen		SIDER
66	Thioguanine		OFFSIDES
67	pimecrolimus		OFFSIDES
68	reviparin		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Hypogonadism	42.9%
2	Delayed Puberty	42.9%
3	Hypogonadotropic hypogonadism	42.9%
4	Testicular Diseases	28.6%
5	Ovarian Diseases	27.6%
6	Adrenal Gland Diseases	23.1%
7	Parathyroid Diseases	23.1%
8	Thyroid Diseases	23.1%
9	Orchitis	20.5%
10	Ovarian Hyperstimulation Syndrome	20.1%
11	Hermaphroditism	16.7%
12	Disorders of Sex Development	16.7%
13	Kallmann Syndrome	15.6%
14	Corpus Luteum Cyst	15.3%
15	Ovarian Cysts	15.3%
16	Bone Diseases, Endocrine	15%
17	Endocrine Gland Neoplasms	15%
18	Anovulation	14.9%
19	Oophoritis	14.9%
20	Diabetes Mellitus	14.6%
21	ovarian neoplasm	14.6%
22	Pituitary Diseases	14.5%
23	Adrenal Cortex Diseases	14.3%
24	Euthyroid Sick Syndromes	14.3%
25	Goiter	14.3%
26	Hyperparathyroidism	14.3%
27	Hyperthyroidism	14.3%
28	Hyperthyroxinemia	14.3%
29	Hypoparathyroidism	14.3%
30	Hypothyroidism	14.3%
31	Thyroiditis	14.3%
32	Secondary hypothyroidism	14.3%
33	Primary Hyperthyroidism	14.3%
34	Primary Hypothyroidism	14.3%
35	Adrenal Gland Neoplasms	14%
36	Klinefelter Syndrome	13.4%
37	Testicular Neoplasms	12.6%
38	Polycystic Ovary Syndrome	12.4%
39	Cryptorchidism	12.3%
40	Gonadal Dysgenesis	12%
41	Adrenogenital Syndrome	12%
42	Ovotesticular Disorders of Sex Development	12%
43	Parathyroid Neoplasms	11.1%
44	Thyroid Neoplasm	11.1%
45	Thyroid carcinoma	11.1%
46	Dwarfism	10.9%
47	Hyperandrogenism	10.8%
48	Cushing Syndrome	10.3%
49	Hyperaldosteronism	10.3%
50	Hyperparathyroidism, Secondary	10.3%
51	Hypoaldosteronism	10.3%
52	Thyrotoxicosis	10.3%
53	Hyperparathyroidism, Primary	10.3%
54	Thyroid Hormone Resistance Syndrome	10.3%
55	granulosa cell tumor	9.8%
56	Carcinoma, Ovarian Epithelial	9.8%
57	Empty Sella Syndrome	9.1%
58	Hyperpituitarism	9.1%
59	Hypopituitarism	9.1%
60	Hypophysitis	9.1%
61	Hyperglycemic Hyperosmolar Nonketotic Coma	8.5%
62	Hashimoto Disease	8.5%
63	Graves Disease	8.2%
64	Adrenocortical carcinoma	8.2%
65	Thyroid Nodule	8%
66	Congenital Hypothyroidism	7.9%
67	Leydig Cell Tumor	7.5%
68	Addison Disease	7%
69	Diabetic Angiopathies	7%
70	Autoimmune thyroiditis	7%
71	Primary Adrenal Insufficiency	7%
72	Gestational Diabetes	7%
73	Latent Autoimmune Diabetes in Adults	7%
74	Turner Syndrome	6.9%
75	Carcinoma, Endometrioid	6.9%
76	Diabetes Insipidus	6.8%
77	Diabetes Mellitus, Experimental	6.8%
78	Diabetic Neuropathies	6.8%
79	Myxedema	6.8%
80	Diabetic Amyotrophy	6.8%
81	Diabetic Autonomic Neuropathy	6.8%
82	Diabetic Cardiomyopathies	6.8%
83	Hyperprolactinemia	6.7%
84	Prolactinoma	6.6%
85	Growth Hormone-Secreting Pituitary Adenoma	6.6%
86	Diabetic Foot	6.6%
87	Nelson Syndrome	6.5%
88	Pituitary Adenoma	5.9%
89	Pituitary Neoplasms	5.9%
90	Pituitary Apoplexy	5.3%
91	Gigantism	5.1%
92	Diabetic Nephropathy	5%
93	Acromegaly	5%
94	Diabetic Ketoacidosis	5%
95	Multiple Endocrine Neoplasia	4.7%
96	Pancreatic Neoplasm	4.7%
97	Diabetic Retinopathy	4.3%
98	Denys-Drash Syndrome	3.7%
99	Multiple Endocrine Neoplasia Type 1	3.3%
100	Carcinoma, Pancreatic Ductal	2.5%
101	insulinoma	2.3%
102	Gastrinoma	2.3%
103	Glucagonoma	2.3%
104	Renal Osteodystrophy	2%
105	Renal rickets	2%
106	Vipoma	2%
107	Waterhouse-Friderichsen Syndrome	2%
108	Adrenoleukodystrophy	1.1%

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