MetaADEDB 2.0 @ LMMD
Hypogonadism
(UMLS:C0020619)
Definition:
Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
UMLS ID:
C0020619
MeSH ID:
D007006
Classification:
Name:
Endocrine System Diseases
MeSH Tree Number(s):
C19.391.482
Synonym(s)
1.
Hypogonadism
2.
Decreased activity of gonads
3.
Gonadotropin Deficiency
4.
HYPOGONADISM
5.
Hypogonadism, NOS
6.
Hypogonadotropism
7.
hypogonadism
8.
hypogonadotropism
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1FinasterideFAERS: 187
Canada Vigilance: 1		Canada Vigilance
US FAERS
2RisperidoneFAERS: 2711194712CTD
US FAERS
3IsotretinoinFAERS: 15US FAERS
4TestosteroneFAERS: 7

View details

3945252
6777203
9112543
9851674
9934939
12002444
12414868
17961146
18671790
21332999
21486418
 		CTD
SIDER
US FAERS
5AmiodaroneFAERS: 6US FAERS
6Megestrol AcetateFAERS: 6US FAERS
7AtorvastatinFAERS: 5US FAERS
8Imatinib MesylateFAERS: 5US FAERS
94-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 3US FAERS
10CiprofloxacinFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
11MitotaneFAERS: 3
Canada Vigilance: 1		3441014CTD
OFFSIDES
Canada Vigilance
US FAERS
12Morphine sulphateFAERS: 3US FAERS
13PregabalinFAERS: 3US FAERS
14AlendronateFAERS: 2US FAERS
15AmlodipineFAERS: 2US FAERS
16AripiprazoleFAERS: 2
Canada Vigilance: 1		Canada Vigilance
US FAERS
17Aspirin-oxycodone hydrochloride-oxycodone terephthalate combinationFAERS: 2SIDER
US FAERS
18BuprenorphineFAERS: 2US FAERS
19FentanylFAERS: 2SIDER
US FAERS
20MorphineFAERS: 221332999CTD
SIDER
US FAERS
21NuvaRingFAERS: 2US FAERS
22SorafenibFAERS: 2US FAERS
23SunitinibFAERS: 2US FAERS
24ThyroxineFAERS: 2US FAERS
25rofecoxibFAERS: 2OFFSIDES
US FAERS
264-hydroxybutyric acidFAERS: 1US FAERS
27Abiraterone AcetateFAERS: 1US FAERS
28AmiodaroneFAERS: 1US FAERS
29AnastrozoleFAERS: 1US FAERS
30Buprenorphine, Naloxone Drug CombinationFAERS: 1US FAERS
31BusulfanFAERS: 1SIDER
US FAERS
32CeftriaxoneFAERS: 1US FAERS
33ClozapineFAERS: 1US FAERS
34Duloxetine HydrochlorideFAERS: 1US FAERS
35Ezetimibe, Simvastatin Drug CombinationFAERS: 1US FAERS
36FluoxetineFAERS: 1US FAERS
37GoserelinFAERS: 1OFFSIDES
US FAERS
38HydrochlorothiazideFAERS: 1US FAERS
39HydromorphoneFAERS: 1US FAERS
40IrbesartanFAERS: 1US FAERS
41MethylphenidateFAERS: 1US FAERS
42Mycophenolic AcidFAERS: 1US FAERS
43OmeprazoleFAERS: 1US FAERS
44ParoxetineFAERS: 1OFFSIDES
US FAERS
45PhenytoinFAERS: 1US FAERS
46Sildenafil CitrateFAERS: 1US FAERS
47Sitagliptin PhosphateFAERS: 1US FAERS
48TopiramateFAERS: 1US FAERS
49TramadolFAERS: 1US FAERS
50Triamcinolone AcetonideFAERS: 1US FAERS
51Zoledronic AcidFAERS: 1
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
52eltrombopagFAERS: 1US FAERS
53norgestimate, ethinyl estradiol drug combinationFAERS: 1US FAERS
54ponatinibFAERS: 1US FAERS
55ramelteonFAERS: 1US FAERS
56testosterone 17 beta-cypionateFAERS: 1OFFSIDES
US FAERS
57testosterone undecanoateFAERS: 1US FAERS
58venetoclaxFAERS: 1US FAERS
59AmantadineOFFSIDES
60Atazanavir SulfateOFFSIDES
61BenztropineOFFSIDES
62Bromocriptine3079888
11194712		CTD
63BupropionOFFSIDES
64BuspironeOFFSIDES
65Cabergoline11194712CTD
OFFSIDES
66CitalopramOFFSIDES
67CodeineOFFSIDES
68Crizotinib22488744
23686600		CTD
69Deamino Arginine VasopressinOFFSIDES
70DesoximetasoneOFFSIDES
71DidanosineOFFSIDES
72EplerenoneOFFSIDES
73Estrone15483104CTD
74HydromorphoneSIDER
75IndinavirOFFSIDES
76Isoproterenol20307649CTD
77LamotrigineOFFSIDES
78LenalidomideOFFSIDES
79LeuprolideSIDER
80Lithium CarbonateOFFSIDES
81LithiumOFFSIDES
82MegestrolOFFSIDES
83MethadoneSIDER
84MethotrexateOFFSIDES
85MetolazoneOFFSIDES
86Octreotide16449332CTD
SIDER
87Oxandrolone17961146CTD
88Oxygen23270704CTD
89PamidronateOFFSIDES
90Penicillin VOFFSIDES
91PenicillinsOFFSIDES
92PergolideSIDER
93PerphenazineOFFSIDES
94Sertraline29850907CTD
95StavudineOFFSIDES
96TadalafilOFFSIDES
97TenofovirOFFSIDES
98ThiotepaSIDER
99TretinoinOFFSIDES
100Triptorelin Pamoate15640438
20463352		CTD
101ZidovudineOFFSIDES
102abacavirOFFSIDES
103bisphenol A24134786CTD
104carbidopa, levodopa drug combinationOFFSIDES
105efavirenzOFFSIDES
106gadoversetamideOFFSIDES
107oleoyl-estrone20339368CTD
108testosterone enanthate9334596
10522995		CTD
109tetrazepamOFFSIDES
110trestolone acetate10522995CTD
Similar ADE(s)
NameSemantic Similarity
1Delayed Puberty42.9%
2Precocious Puberty42.9%
3Testotoxicosis42.9%
4Testicular Diseases28.6%
5Ovarian Diseases27.6%
6Adrenal Gland Diseases23.1%
7Parathyroid Diseases23.1%
8Thyroid Diseases23.1%
9Orchitis20.5%
10Ovarian Hyperstimulation Syndrome20.1%
11Hermaphroditism16.7%
12Disorders of Sex Development16.7%
13Corpus Luteum Cyst15.3%
14Ovarian Cysts15.3%
15Bone Diseases, Endocrine15%
16Endocrine Gland Neoplasms15%
17Anovulation14.9%
18Oophoritis14.9%
19Diabetes Mellitus14.6%
20ovarian neoplasm14.6%
21Pituitary Diseases14.5%
22Adrenal Cortex Diseases14.3%
23Euthyroid Sick Syndromes14.3%
24Goiter14.3%
25Hyperparathyroidism14.3%
26Hyperthyroidism14.3%
27Hyperthyroxinemia14.3%
28Hypoparathyroidism14.3%
29Hypothyroidism14.3%
30Thyroiditis14.3%
31Secondary hypothyroidism14.3%
32Primary Hyperthyroidism14.3%
33Primary Hypothyroidism14.3%
34Adrenal Gland Neoplasms14%
35Testicular Neoplasms12.6%
36Polycystic Ovary Syndrome12.4%
37Cryptorchidism12.3%
38Gonadal Dysgenesis12%
39Adrenogenital Syndrome12%
40Ovotesticular Disorders of Sex Development12%
41Parathyroid Neoplasms11.1%
42Thyroid Neoplasm11.1%
43Thyroid carcinoma11.1%
44Dwarfism10.9%
45Hyperandrogenism10.8%
46Cushing Syndrome10.3%
47Hyperaldosteronism10.3%
48Hyperparathyroidism, Secondary10.3%
49Hypoaldosteronism10.3%
50Thyrotoxicosis10.3%
51Hyperparathyroidism, Primary10.3%
52Thyroid Hormone Resistance Syndrome10.3%
53granulosa cell tumor9.8%
54Carcinoma, Ovarian Epithelial9.8%
55Empty Sella Syndrome9.1%
56Hyperpituitarism9.1%
57Hypopituitarism9.1%
58Hypophysitis9.1%
59Hyperglycemic Hyperosmolar Nonketotic Coma8.5%
60Hashimoto Disease8.5%
61Graves Disease8.2%
62Adrenocortical carcinoma8.2%
63Thyroid Nodule8%
64Congenital Hypothyroidism7.9%
65Leydig Cell Tumor7.5%
66Kallmann Syndrome7.1%
67Addison Disease7%
68Diabetic Angiopathies7%
69Autoimmune thyroiditis7%
70Primary Adrenal Insufficiency7%
71Gestational Diabetes7%
72Latent Autoimmune Diabetes in Adults7%
73Turner Syndrome6.9%
74Carcinoma, Endometrioid6.9%
75Diabetes Insipidus6.8%
76Diabetes Mellitus, Experimental6.8%
77Diabetic Neuropathies6.8%
78Myxedema6.8%
79Diabetic Amyotrophy6.8%
80Diabetic Autonomic Neuropathy6.8%
81Diabetic Cardiomyopathies6.8%
82Hyperprolactinemia6.7%
83Prolactinoma6.6%
84Growth Hormone-Secreting Pituitary Adenoma6.6%
85Diabetic Foot6.6%
86Nelson Syndrome6.5%
87Klinefelter Syndrome6.1%
88Pituitary Adenoma5.9%
89Pituitary Neoplasms5.9%
90Pituitary Apoplexy5.3%
91Gigantism5.1%
92Diabetic Nephropathy5%
93Acromegaly5%
94Diabetic Ketoacidosis5%
95Multiple Endocrine Neoplasia4.7%
96Pancreatic Neoplasm4.7%
97Diabetic Retinopathy4.3%
98Denys-Drash Syndrome3.7%
99Multiple Endocrine Neoplasia Type 13.3%
100Carcinoma, Pancreatic Ductal2.5%
101insulinoma2.3%
102Gastrinoma2.3%
103Glucagonoma2.3%
104Renal Osteodystrophy2%
105Renal rickets2%
106Vipoma2%
107Waterhouse-Friderichsen Syndrome2%
108Adrenoleukodystrophy1.1%
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